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Philip L. Lorenzi
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Journal Articles

Amino acid metabolism in hematologic malignancies and the era of targeted therapy

Yoko Tabe, Philip L. Lorenzi, Marina Konopleva
Journal: Blood
Blood (2019) 134 (13): 1014–1023.
https://doi.org/10.1182/blood.2019001034
Published: 2019
Journal Articles

Mitochondrial Complex I Inhibitor Iacs-010759 Reverses the NOTCH1-Driven Metabolic Reprogramming in T-ALL Via Blockade of Oxidative Phosphorylation: Synergy with Chemotherapy and Glutaminase Inhibition

Natalia Baran, PhDMD, Alessia Lodi, PhD, Shannon Renee Sweeney, MS, Pandey Renu, PhD, Vinitha Mary Kuruvilla, Antonio Cavazos, MSc, Daniel Herranz, PharmD, Anna Skwarska, PhD, Marc Warmoes, PhD, R. Eric Davis, MD, Karine Harutyunyan, PhD, Ningping Feng, PhD, Jason P Gay, MS, Sergej Naumovich Konoplev, MD PhD, Marcin Kaminski, PhD, Jeffrey J Kovacs, PhD, Di Du, PhD, Elias J. Jabbour, MD, Adolfo A. Ferrando, MD PhD, Maria E Di Francesco, PhD, Philip L Lorenzi, PhD, Joseph R Marszalek, PhD, Stefano Tiziani, PhD, Marina Y. Konopleva, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 4020.
https://doi.org/10.1182/blood-2018-99-117310
Published: 2018
Journal Articles

Contribution of Amino Acid Metabolism to Hematologic Malignancies

Marina Y. Konopleva, MD PhD, Philip L Lorenzi, PhD, Sanaz Ghotbaldini, Yoko Tabe, MD PhD, Tianyu Cai, PhD, Stefano Tiziani, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): SCI-10.
https://doi.org/10.1182/blood-2018-99-109469
Published: 2018
Journal Articles

Mcl-1/CDK9 Targeting By AZD5991/AZD4573 Overcomes Intrinsic and Acquired Venetoclax Resistance in Vitro and In Vivo in PDX Model of AML through Modulation of Cell Death and Metabolic Functions

Bing Z Carter, PhD, Po Yee Mak, Wenjing Tao, Mark Warmoes, Philip L Lorenzi, PhD, Duncan Mak, BSc, MPhil, Vivian Ruvolo, MS, Xiangmeng Wang, Huaxian Ma, MS, Hong Mu, MD PhD, Justin Cidado, PhD, Lisa Drew, PhD, Michael Andreeff, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 768.
https://doi.org/10.1182/blood-2018-99-113491
Published: 2018
Journal Articles

The Glutaminase Activity of L-Asparaginase Mediates Suppression of Asns Upregulation

Wai Kin Chan, PhD, Lin Tan, MS, Karine Harutyunyan, PhD, Di Du, PhD, Leona Martin, MS, Eric Yin, MS, Marina Y. Konopleva, MD PhD, John Weinstein, MD PhD, Philip L Lorenzi, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 3959.
https://doi.org/10.1182/blood-2018-99-117818
Published: 2018
Journal Articles

Red Blood Cell-Encapsulation of L-Asparaginase Favorably Modulates Target Selectivity and Pharmacodynamics

Philip L Lorenzi, PhD, Thomas D Horvath, PhD, Leona A Martin, M.S., Wai Kin Chan, PhD, Di Du, PhD, David H. Hawke, PhD, John N Weinstein, MD,PhD, Kenneth J Swart, PhD, Iman El-Hariry, MD PhD
Journal: Blood
Blood (2016) 128 (22): 1266.
https://doi.org/10.1182/blood.V128.22.1266.1266
Published: 2016
Journal Articles

BRD4 Proteolysis Targeting Chimera (PROTAC) ARV-825, Causes Sustained Degradation of BRD4 and Modulation of Chemokine Receptors, Cell Adhesion and Metabolic Targets in Leukemia Resulting in Profound Anti-Leukemic Effects

Sujan Piya, PhD, Seemana Bhattacharya, PhD, Hong Mu, MD PhD, Philip L Lorenzi, PhD, Teresa McQueen, MS, Eric Richard Davis, MD, Vivian Ruvolo, MS, Natalia Baran, PhD, Yimin Qian, PhD, Craig Crews, PhD, Hagop M. Kantarjian, MD, Michael Andreeff, MD PhD, Gautam Borthakur, MD
Journal: Blood
Blood (2016) 128 (22): 748.
https://doi.org/10.1182/blood.V128.22.748.748
Published: 2016
Journal Articles

Gls Inhibitor CB-839 Modulates Cellular Metabolism in AML and Potently Suppresses AML Cell Growth When Combined with 5-Azacitidine

Tianyu Cai, PhD, Philip L Lorenzi, PhD, Dinesh Rakheja, MD, Michael A Pontikos, Alessia Lodi, Lina Han, MD PhD, Qi Zhang, MD PhD, Helen Ma, MS, Mohamed Rahmani, PhD, Tushar Damodar Bhagat, PhD, Thomas D Horvath, PhD, Courtney D. DiNardo, MD MSCE, Steven Grant, MD, Stefano Tiziani, PhD, Amit Verma, MD, Marina Konopleva, MD PhD
Journal: Blood
Blood (2016) 128 (22): 4064.
https://doi.org/10.1182/blood.V128.22.4064.4064
Published: 2016
Journal Articles

The glutaminase activity of l-asparaginase is not required for anticancer activity against ASNS-negative cells

Wai Kin Chan, Philip L. Lorenzi, Andriy Anishkin, Preeti Purwaha, David M. Rogers, Sergei Sukharev, Susan B. Rempe, John N. Weinstein
Journal: Blood
Blood (2014) 123 (23): 3596–3606.
https://doi.org/10.1182/blood-2013-10-535112
Published: 2014
Includes: Supplemental data
Journal Articles

The Glutaminase Activity Of L-Asparaginase Is Not Required For Anticancer Activity Against Asns-Negative Cell Lines

Philip L Lorenzi, Wai Kin Chan, Andriy Anishkin, Preeti Purwaha, David M Rogers, Sergei Sukharev, Susan B Rempe, John N Weinstein
Journal: Blood
Blood (2013) 122 (21): 4912.
https://doi.org/10.1182/blood.V122.21.4912.4912
Published: 2013