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Isere Kuiatse
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Journal Articles

Elucidation of Molecular Mechanisms of Iberdomide and Mezigdomide Resistance in Cell Line Models of Multiple Myeloma

Wei Tan, Minghao Dang, Upasana Ray, Luz Yurany Moreno Rueda, Maria Jose Acevedo-Calado, Hua Wang, Jun Wei, Li Qin, Isere Kuiatse, Robert Z. Orlowski
Journal: Blood
Blood (2024) 144 (Supplement 1): 4640.
https://doi.org/10.1182/blood-2024-207917
Published: 2024
Journal Articles

Inhibition of Rho-Associated Coiled-Coil Containing Protein Kinases with Belumosudil Mesylate Shows Anti-Tumor and Immune Modulatory Properties in Models of Multiple Myeloma

Pankaj Kumar Singh, Frances N. Cervoni Curet, Cody T. Clayhold, Isere Kuiatse, Wei Tan, Marco Meloni, Monsif Bouaboula, Kamlesh Bisht, Helgi J. Van de Velde, Marielle Chiron, Angela Virone-Oddos, Robert Z. Orlowski
Journal: Blood
Blood (2023) 142 (Supplement 1): 4689.
https://doi.org/10.1182/blood-2023-188317
Published: 2023
Journal Articles

Caseinolytic Mitochondrial Matrix Peptidase Proteolytic Subunit (CLPP) As a Novel Mediator of, and Target in High Risk Multiple Myeloma

Li Qin, Luz Yurany Moreno Rueda, Iqbal Mahmud, Isere Kuiatse, Wei Tan, Hans C. Lee, Krina K. Patel, David E. Symer, Elisabet E. Manasanch, Robert Z. Orlowski
Journal: Blood
Blood (2023) 142 (Supplement 1): 3302.
https://doi.org/10.1182/blood-2023-190766
Published: 2023
Journal Articles

A Novel Antibody Drug Conjugate (ADC) Targeting Cell Surface Heat Shock Protein 70 (csHSP70) Is Active Against Pre-Clinical Models of Peripheral T-Cell Lymphoma (PTCL)

Rajan Kumar Choudhary, Richard J. Jones, Isere Kuiatse, Hua Wang, Francisco Vega, Alyssa C. Bouska, Waseem G. Lone, Javeed Iqbal, Robert Z. Orlowski
Journal: Blood
Blood (2021) 138 (Supplement 1): 870.
https://doi.org/10.1182/blood-2021-150842
Published: 2021
Journal Articles

The Anti-B-Cell Maturation Antigen (BCMA) Antibody-α-Amanitin Conjugate Hdp-101 Induces Immunogenic Cell Death and Immunologic Memory in Models of Multiple Myeloma

Ram Kumar Singh, PhD, Richard J. Jones, PhD, Fazal M. Shirazi, PhD, Jianxuan M. Zou, PhD, Hua Wang, PhD, Hans C. Lee, MD, Elisabet E. Manasanch, MD, Isere Kuiatse, PhD, Andreas Pahl, PhD, Robert Z. Orlowski, MDPhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 9–10.
https://doi.org/10.1182/blood-2020-141615
Published: 2020
Journal Articles

Ubiquitin-activating enzyme inhibition induces an unfolded protein response and overcomes drug resistance in myeloma

Junling Zhuang, Fazal Shirazi, Ram Kumar Singh, Isere Kuiatse, Hua Wang, Hans C. Lee, Zuzana Berkova, Allison Berger, Marc Hyer, Nibedita Chattopadhyay, Sakeena Syed, Judy Qiuju Shi, Jie Yu, Vaishali Shinde, Stephen Tirrell, Richard Julian Jones, Zhiqiang Wang, R. Eric Davis, Robert Z. Orlowski
Journal: Blood
Blood (2019) 133 (14): 1572–1584.
https://doi.org/10.1182/blood-2018-06-859686
Published: 2019
Includes: Supplemental data
Journal Articles

Activating KRAS , NRAS , and BRAF Mutants Enhance Proteasome Capacity and Reduce Endoplasmic Reticulum Stress in Multiple Myeloma, Thereby Promoting Plasma Cell Survival and Proteasome Inhibitor Resistance

Fazal Shirazi, PhD, Richard J. Jones, PhD, Isere Kuiatse, PhD, Zuzana Berkova, PhD, Hua Wang, PhD, Hans C. Lee, MD, Samuel Hong, PhD, Ram Kumar Singh, PhD, Lawrence Robert Dick, PhD, Nibedita Chattopadhyay, PhD, Robert Z. Orlowski, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 406.
https://doi.org/10.1182/blood-2018-99-117577
Published: 2018
Journal Articles

HDP101, a Novel B-Cell Maturation Antigen (BCMA)-Targeted Antibody Conjugated to α-Amanitin, Is Active Against Myeloma with Preferential Efficacy Against Pre-Clinical Models of Deletion 17p

Ram Kumar Singh, PhD, Richard J. Jones, PhD, Samuel Hong, PhD, Fazal Shirazi, PhD, Hua Wang, PhD, Isere Kuiatse, PhD, Andreas Pahl, Robert Z. Orlowski, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 593.
https://doi.org/10.1182/blood-2018-99-118412
Published: 2018
Journal Articles

Protein Homeostatic Modulators, a Novel Class of Cereblon-Targeting Small Molecules As Potential Clinical Candidates in Multiple Myeloma

Jianxuan Zou, PhD, Richard J. Jones, PhD, Janet E. Mertz, PhD, Hua Wang, PhD, Isere Kuiatse, PhD, Bob Sullivan, PhD, Leah Fung, PhD, Normand Richard, PhD, Paul Erdman, PhD, Eduardo Torres, PhD, Aparajita Hoskote Chourasia, PhD, Kyle WH Chan, PhD, Frank Mercurio, PhD, David I Stirling, PhD, Robert Z. Orlowski, MD PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 4418.
https://doi.org/10.1182/blood.V130.Suppl_1.4418.4418
Published: 2017
Journal Articles

The Anti-Tumor Effect of the Ubiquitin-Activating Enzyme (UAE) Inhibitor TAK-243 on Pre-Clinical Models of Multiple Myeloma

Junling Zhuang, MD PhD, Hans Lee, MD, Isere Kuiatse, PhD, Hua Wang, PhD, Fazal Shirazi, PhD, Allison Berger, PhD, Marc Hyer, PhD, Nibedita Chattopadhyay, PhD, Sakeena Syed, Judy Qiuju Shi, Jie Yu, M.S., Vaishali Shinde, Anna Kreshock, Stephen Tirrell, PhD, Saurabh Menon, PhD, Richard Julian Jones, PhD, Robert Z. Orlowski, MD PhD
Journal: Blood
Blood (2016) 128 (22): 3296.
https://doi.org/10.1182/blood.V128.22.3296.3296
Published: 2016
Journal Articles

RNA Polymerase I Inhibition with CX-5461 As a Novel Strategy to Target MYC in Multiple Myeloma

Hans Lee, MD, Hua Wang, PhD, Heather Lin, M.S., Veera Baladandayuthapani, PhD, Jin He, Richard Julian Jones, PhD, Isere Kuiatse, PhD, Dongmin Gu, MD, PhD, Zhiqiang Wang, PhD, Sean O'Brien, PhD, Jonathan J Keats, PhD, Jing Yang, PhD, Richard Eric Davis, MD, Robert Z. Orlowski, PhD, MD
Journal: Blood
Blood (2015) 126 (23): 3010.
https://doi.org/10.1182/blood.V126.23.3010.3010
Published: 2015
Journal Articles

Studies of the Proteasome Inhibitor Sensitivity Modulator Tight Junction Protein 1 Highlight a Role for Signaling through the Epidermal Growth Factor Receptor in Determining Proteasome Capacity

Xing-Ding Zhang, PhD, Veerabhadran Baladandayuthapani, PhD, Heather Yan Lin, PhD, George Mulligan, PhD, Bin Li, PhD, Dixie-Lee Esseltine, MD, Lin Qi, PhD, Jian-Liang Xu, PhD, Walter Hunziker, PhD, Bart Barlogie, MD, PhD, Saad Z. Usmani, MD, Qing Zhang, PhD, John Crowley, PhD, Antje Hoering, PhD, Bing-Zong Li, MD, PhD, Huihan Wang, MD, PhD, Jiexin Zhang, M.S., Isere Kuiatse, PhD, Jin-Le Tang, PhD, Jin He, Jing Yang, PhD, Richard Eric Davis, MD, Wencai Ma, PhD, Zhiqiang Wang, PhD, Lin Yang, MD, PhD, Robert Z. Orlowski, PhD MD
Journal: Blood
Blood (2014) 124 (21): 3414.
https://doi.org/10.1182/blood.V124.21.3414.3414
Published: 2014
Journal Articles

Mucin 20 (MUC20) Modulates Proteasome Assembly Chaperones through the c-MET Pathway and Is a Biomarker of Proteasome Inhibitor Sensitivity in Myeloma

Huihan Wang, MD, PhD, Veerabhadran Baladandayuthapani, PhD, Heather Yan Lin, PhD, Xiaobin Wang, MD, Bingzong Li, MD, PhD, Xing-Ding Zhang, PhD, Isere Kuiatse, PhD, Hua Wang, PhD, Dongmin Gu, MD, PhD, Liye Zhong, PhD, Wencai Ma, PhD, Richard E. Davis, MD, Robert Z. Orlowski, MD, PhD
Journal: Blood
Blood (2014) 124 (21): 274.
https://doi.org/10.1182/blood.V124.21.274.274
Published: 2014
Journal Articles

Inhibition of Spleen Tyrosine Kinase with Fostamatinib Shows Pre-Clinical Activity Against Models of Waldenström Macroglobulinemia

Isere Kuiatse, Ph.D., Sheeba K. Thomas, MD, Donna M. Weber, M.D., Adam M. Stein, B.S., Michael Wang, M.D., Jatin J. Shah, M.D., Steven P. Treon, M.D., Ph.D., Stephen M. Ansell, M.D., Ph.D., Robert Z. Orlowski, M.D., Ph.D.
Journal: Blood
Blood (2012) 120 (21): 3723.
https://doi.org/10.1182/blood.V120.21.3723.3723
Published: 2012
Journal Articles

Targeting the Wnt/β-Catenin Signaling Pathway and CD44-Mediated Adhesion As a Rational Approach to Overcome Lenalidomide Resistance in Multiple Myeloma

Chad C. Bjorklund, Ph.D., Sharon Lea Aukerman, PhD, Antonia Lopez-Girona, Ph.D., Mohamad Hussein, MD, Rajesh Chopra, PhD, Isere Kuiatse, Ph.D., Deborah J. Kuhn, Ph.D., Caimiao Wei, PhD, Robert Z. Orlowski, MD, PhD
Journal: Blood
Blood (2011) 118 (21): 928.
https://doi.org/10.1182/blood.V118.21.928.928
Published: 2011