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Journal Articles

Multimodal Spatial Transcriptomic Profiling Elucidates Niche-Specific Dynamics in Medullary and Extramedullary Acute Myeloid Leukemia

Enes Dasdemir, Ivo Veletic, Christopher P. Ly, Andres E Quesada, Fatima Z Jelloul, Pamella Borges, Sreyashi Basu, Sonali Jindal, Zhiqiang Wang, Alexander J Lazar, Khalida M Wani, Dinler A Antunes, Patrick K. Reville, Preethi Gunaratne, Robert J Tower, Padmanee Sharma, Hussein A. Abbas

Blood (2024) 144 (Supplement 1): 1059.

https://doi.org/10.1182/blood-2024-201932

Published: 2024

Journal Articles

SHC014748M, a Novel Selective Inhibitor of PI3Kδ, Demonstrates Promising Pre-Clinical Antitumor Activity in B Cell Lymphomas and CLL

Lei Fan, MD PhD, Chao Wang, Zhiqiang Wang, Xian Zhang, Lei Cao, Yi Miao, MD PhD, Xinyi Du, Wei Xu, MD PhD, Jianyong Li, MD

Blood (2019) 134 (Supplement_1): 5306.

https://doi.org/10.1182/blood-2019-129469

Published: 2019

Journal Articles

Preliminary Results from a Phase I Study of SHC014748M in Patients with Relapsed or Refractory Indolent B-Cell Lymphomas

Wei Xu, MD PhD, Jie Jin, MD PhD, Keshu Zhou, MD, Li Wang, MD, Huayuan Zhu, Jiejing Qian, Jianying Huang, Fuling Zhou, MD, Xiaohong Xu, Zhiqiang Wang, Wei Guo, Jianyong Li, MD

Blood (2019) 134 (Supplement_1): 4000.

https://doi.org/10.1182/blood-2019-126707

Published: 2019

Journal Articles

Ubiquitin-activating enzyme inhibition induces an unfolded protein response and overcomes drug resistance in myeloma

Junling Zhuang, Fazal Shirazi, Ram Kumar Singh, Isere Kuiatse, Hua Wang, Hans C. Lee, Zuzana Berkova, Allison Berger, Marc Hyer, Nibedita Chattopadhyay, Sakeena Syed, Judy Qiuju Shi, Jie Yu, Vaishali Shinde, Stephen Tirrell, Richard Julian Jones, Zhiqiang Wang, R. Eric Davis, Robert Z. Orlowski

Blood (2019) 133 (14): 1572–1584.

https://doi.org/10.1182/blood-2018-06-859686

Published: 2019

Includes: Supplemental data

Journal Articles

Tonic B-cell receptor signaling in diffuse large B-cell lymphoma

Ondrej Havranek, Jingda Xu, Stefan Köhrer, Zhiqiang Wang, Lisa Becker, Justin M. Comer, Jared Henderson, Wencai Ma, John Man Chun Ma, Jason R. Westin, Dipanjan Ghosh, Nicholas Shinners, Luhong Sun, Allen F. Yi, Anusha R. Karri, Jan A. Burger, Tomasz Zal, R. Eric Davis

Blood (2017) 130 (8): 995–1006.

https://doi.org/10.1182/blood-2016-10-747303

Published: 2017

Includes: Multimedia, Supplemental data

Journal Articles

Ibrutinib inhibits pre-BCR + B-cell acute lymphoblastic leukemia progression by targeting BTK and BLK

Ekaterina Kim, Christian Hurtz, Stefan Koehrer, Zhiqiang Wang, Sriram Balasubramanian, Betty Y. Chang, Markus Müschen, R. Eric Davis, Jan A. Burger

Blood (2017) 129 (9): 1155–1165.

https://doi.org/10.1182/blood-2016-06-722900

Published: 2017

Includes: Supplemental data

Journal Articles

Molecular Aspects of Tonic B-Cell Receptor Signaling in Diffuse Large B-Cell Lymphoma Provide Biomarkers and Targets for Specific Inhibition

Ondrej Havranek, MD PhD, Jingda Xu, PhD, Stefan Koehrer, MD, Zhiqiang Wang, PhD, Justin M Comer, Lisa Becker, Allen F Yi, Jan A. Burger, MD PhD, Jason R. Westin, MD, Tomasz Zal, PhD, Richard Eric Davis, MD

Blood (2016) 128 (22): 779.

https://doi.org/10.1182/blood.V128.22.779.779

Published: 2016

Journal Articles

B-Cell Receptor Signaling in Diffuse Large B-Cell Lymphoma: Tonic Alone in the Germinal Center B-Cell Subtype, Plus Self Antigen-Induced in the Activated B-Cell Subtype

Ondrej Havranek, MDPhD, Stefan Koehrer, MD, Jingda Xu, PhD, Lisa Becker, Justin M Comer, Anusha R Karri, Zhiqiang Wang, PhD, Wencai Ma, PhD, Jason R Westin, MD, Tomasz Zal, PhD, Jan A Burger, MD PhD, R Eric Davis, MD

Blood (2015) 126 (23): 464.

https://doi.org/10.1182/blood.V126.23.464.464

Published: 2015

Journal Articles

Gene Expression Profiling for Molecular Features of Response in a Phase I Trial of Alisertib Plus Romidepsin for Relapsed/Refractory Aggressive B- and T-Cell Lymphomas

Blood (2015) 126 (23): 2705.

https://doi.org/10.1182/blood.V126.23.2705.2705

Published: 2015

Journal Articles

RNA Polymerase I Inhibition with CX-5461 As a Novel Strategy to Target MYC in Multiple Myeloma

Hans Lee, MD, Hua Wang, PhD, Heather Lin, M.S., Veera Baladandayuthapani, PhD, Jin He, Richard Julian Jones, PhD, Isere Kuiatse, PhD, Dongmin Gu, MD, PhD, Zhiqiang Wang, PhD, Sean O'Brien, PhD, Jonathan J Keats, PhD, Jing Yang, PhD, Richard Eric Davis, MD, Robert Z. Orlowski, PhD, MD

Blood (2015) 126 (23): 3010.

https://doi.org/10.1182/blood.V126.23.3010.3010

Published: 2015

Journal Articles

ONC201 Induces p53-Independent Apoptosis and Abrogates Stem Cell Function in Hematological Malignancies By Induction of ATF4 through Integrated Stress Response

Blood (2015) 126 (23): 2051.

https://doi.org/10.1182/blood.V126.23.2051.2051

Published: 2015

Journal Articles

Antileukemia activity of the novel peptidic CXCR4 antagonist LY2510924 as monotherapy and in combination with chemotherapy

Byung-Sik Cho, Zhihong Zeng, Hong Mu, Zhiqiang Wang, Sergej Konoplev, Teresa McQueen, Marina Protopopova, Jorge Cortes, Joseph R. Marszalek, Sheng-Bin Peng, Wencai Ma, R. Eric Davis, Donald E. Thornton, Michael Andreeff, Marina Konopleva

Blood (2015) 126 (2): 222–232.

https://doi.org/10.1182/blood-2015-02-628677

Published: 2015

Includes: Supplemental data

Journal Articles

The B-Cell Receptor Is Required for Optimal Viability, Growth, and Chemotherapy Resistance of Diffuse Large B-Cell Lymphoma Cell Lines of the Germinal Center B-Cell Subtype

Ondrej Havranek, MDPhD, Stefan Koehrer, MD, Justin M Comer, Zhiqiang Wang, PhD, Jingda Xu, PhD, Dipanjan Ghosh, PhD, Nicholas Shinners, PhD, Luhong Sun, MD PhD, Wencai Ma, PhD, Jan A Burger, MDPhD, R Eric Davis, MD

Blood (2014) 124 (21): 493.

https://doi.org/10.1182/blood.V124.21.493.493

Published: 2014

Journal Articles

Prosurvival and Chemoprotective Effects of Tumor-Associated Macrophages Reversed By Anti-CSF-1R Monoclonal Antibody in B-Cell Lymphomas

Anupama Gopisetty, PhD, Myriam Foglietta, MD PhD, Min Zhang, PhD, Zhiqiang Wang, Nathan Fowler, MD, Richard E. Davis, MD, Sattva S Neelapu, MD

Blood (2014) 124 (21): 498.

https://doi.org/10.1182/blood.V124.21.498.498

Published: 2014

Journal Articles

Immunoglobulin Heavy Chain (IgH) Knockout Inhibits Proliferation of Pre-BCR + B-Cell Acute Lymphoblastic Leukemia (B-ALL) Via a FOXO1 and MYC Dependent Mechanism

Stefan Koehrer, MD, Ondrej Havranek, MDPhD, R Eric Davis, MD, Felix Seyfried, MD, Greg Coffey, PhD, Ekaterina Kim, MS, Nathalie Y. Rosin, PhD, Elisa ten Hacken, PhD, Ulrich Jäger, MD, Katrina Vanura, PhD, Susan O'Brien, MD, Deborah A. Thomas, MD, Hagop M. Kantarjian, MD, Dipanjan Ghosh, PhD, Zhiqiang Wang, Lüder Hinrich Meyer, MD, Hassan Jumaa, PhD, Jan A. Burger, MDPhD

Blood (2014) 124 (21): 287.

https://doi.org/10.1182/blood.V124.21.287.287

Published: 2014

Journal Articles

Studies of the Proteasome Inhibitor Sensitivity Modulator Tight Junction Protein 1 Highlight a Role for Signaling through the Epidermal Growth Factor Receptor in Determining Proteasome Capacity

Blood (2014) 124 (21): 3414.

https://doi.org/10.1182/blood.V124.21.3414.3414

Published: 2014

Journal Articles

Selinexor (KPT-330) Is Not Cross-Resistant with Chemotherapy and Demonstrates Strong Synergy with Targeted Therapy in DLBCL

Jingda Xu, PhD, R Eric Davis, MD, Zhiqiang Wang, PhD, Jason R. Westin, MD

Blood (2014) 124 (21): 4503.

https://doi.org/10.1182/blood.V124.21.4503.4503

Published: 2014

Journal Articles

Ablation of Autophagy-Related E1 Ligase Atg7 Primes Acute Myelogenous Leukemia Cells to Apoptosis, Sensitizes to Chemotherapy and Overcomes Stroma Mediated Protection

Sujan Piya, PhD, Vivian R Ruvolo, MA, Peter P. Ruvolo, PhD, Richard E. Davis, MD, Zhiqiang Wang, Teresa McQueen, BS, Wendy D Schober, PhD, Michael Andreeff, MD PhD, Gautam Borthakur, MD

Blood (2014) 124 (21): 901.

https://doi.org/10.1182/blood.V124.21.901.901

Published: 2014

Journal Articles

AML Genotype-Specific and Non-Specific Regulation of Mesenchymal Stromal Cell Transcriptome in the Bone Marrow Microenvironment

Rodrigo Jacamo, PhD, Xiaoyang Ling, PhD, Zhiqiang Wang, Wencai Ma, PhD, Min Zhang, PhD, Peter P. Ruvolo, PhD, Vivian R Ruvolo, MA, Scott W. Lowe, PhD, Johannes Zuber, MD, Marina Konopleva, MD PhD, R Eric Davis, MD, Michael Andreeff, MD PhD

Blood (2014) 124 (21): 1586.

https://doi.org/10.1182/blood.V124.21.1586.1586

Published: 2014

Journal Articles

GCS-100 Induces Apoptosis of Acute Myeloid Leukemia Cells By Disrupting Galectin-Mediated Survival Signaling

Richard E. Davis, MD, Vivian R Ruvolo, MA, Zhiqiang Wang, Wencai Ma, PhD, Wendy D. Schober, MLT (ASCP), James Rolke, George Tidmarsh, MD PhD, Michael Andreeff, MD PhD, Peter P. Ruvolo, PhD

Blood (2014) 124 (21): 904.

https://doi.org/10.1182/blood.V124.21.904.904

Published: 2014

NARROW

Multimodal Spatial Transcriptomic Profiling Elucidates Niche-Specific Dynamics in Medullary and Extramedullary Acute Myeloid Leukemia

SHC014748M, a Novel Selective Inhibitor of PI3Kδ, Demonstrates Promising Pre-Clinical Antitumor Activity in B Cell Lymphomas and CLL

Preliminary Results from a Phase I Study of SHC014748M in Patients with Relapsed or Refractory Indolent B-Cell Lymphomas

Ubiquitin-activating enzyme inhibition induces an unfolded protein response and overcomes drug resistance in myeloma

Tonic B-cell receptor signaling in diffuse large B-cell lymphoma

Ibrutinib inhibits pre-BCR + B-cell acute lymphoblastic leukemia progression by targeting BTK and BLK

Molecular Aspects of Tonic B-Cell Receptor Signaling in Diffuse Large B-Cell Lymphoma Provide Biomarkers and Targets for Specific Inhibition

B-Cell Receptor Signaling in Diffuse Large B-Cell Lymphoma: Tonic Alone in the Germinal Center B-Cell Subtype, Plus Self Antigen-Induced in the Activated B-Cell Subtype

Gene Expression Profiling for Molecular Features of Response in a Phase I Trial of Alisertib Plus Romidepsin for Relapsed/Refractory Aggressive B- and T-Cell Lymphomas

RNA Polymerase I Inhibition with CX-5461 As a Novel Strategy to Target MYC in Multiple Myeloma

ONC201 Induces p53-Independent Apoptosis and Abrogates Stem Cell Function in Hematological Malignancies By Induction of ATF4 through Integrated Stress Response

Antileukemia activity of the novel peptidic CXCR4 antagonist LY2510924 as monotherapy and in combination with chemotherapy

The B-Cell Receptor Is Required for Optimal Viability, Growth, and Chemotherapy Resistance of Diffuse Large B-Cell Lymphoma Cell Lines of the Germinal Center B-Cell Subtype

Prosurvival and Chemoprotective Effects of Tumor-Associated Macrophages Reversed By Anti-CSF-1R Monoclonal Antibody in B-Cell Lymphomas

Immunoglobulin Heavy Chain (IgH) Knockout Inhibits Proliferation of Pre-BCR + B-Cell Acute Lymphoblastic Leukemia (B-ALL) Via a FOXO1 and MYC Dependent Mechanism

Studies of the Proteasome Inhibitor Sensitivity Modulator Tight Junction Protein 1 Highlight a Role for Signaling through the Epidermal Growth Factor Receptor in Determining Proteasome Capacity

Selinexor (KPT-330) Is Not Cross-Resistant with Chemotherapy and Demonstrates Strong Synergy with Targeted Therapy in DLBCL

Ablation of Autophagy-Related E1 Ligase Atg7 Primes Acute Myelogenous Leukemia Cells to Apoptosis, Sensitizes to Chemotherapy and Overcomes Stroma Mediated Protection

AML Genotype-Specific and Non-Specific Regulation of Mesenchymal Stromal Cell Transcriptome in the Bone Marrow Microenvironment

GCS-100 Induces Apoptosis of Acute Myeloid Leukemia Cells By Disrupting Galectin-Mediated Survival Signaling

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American Society of Hematology

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American Society of Hematology

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