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Journal Articles

Ubiquitin-activating enzyme inhibition induces an unfolded protein response and overcomes drug resistance in myeloma

Junling Zhuang, Fazal Shirazi, Ram Kumar Singh, Isere Kuiatse, Hua Wang, Hans C. Lee, Zuzana Berkova, Allison Berger, Marc Hyer, Nibedita Chattopadhyay, Sakeena Syed, Judy Qiuju Shi, Jie Yu, Vaishali Shinde, Stephen Tirrell, Richard Julian Jones, Zhiqiang Wang, R. Eric Davis, Robert Z. Orlowski
Journal: Blood
Blood (2019) 133 (14): 1572–1584.
https://doi.org/10.1182/blood-2018-06-859686
Published: 2019
Includes: Supplemental data
Journal Articles

TAK-243 Is a Selective UBA1 Inhibitor That Displays Preclinical Activity in Acute Myeloid Leukemia (AML)

Samir H. Barghout, BSPharm, MSc, Parasvi Patel, BSc (Hons), Xiaoming Wang, G. Wei Xu, Simon Kavanagh, Marcela Gronda, MSc, Rose Hurren, BSc, Danny V. Jeyaraju, PhD, Neil MacLean, Marc Hyer, PhD, Allison Berger, PhD, Tary Traore, Michael Sintchak, Michael Milhollen, Mark D. Minden, MD PhD, Razq Hakem, PhD, Aaron D. Schimmer, MDPhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 814.
https://doi.org/10.1182/blood.V130.Suppl_1.814.814
Published: 2017
Journal Articles

The Anti-Tumor Effect of the Ubiquitin-Activating Enzyme (UAE) Inhibitor TAK-243 on Pre-Clinical Models of Multiple Myeloma

Junling Zhuang, MD PhD, Hans Lee, MD, Isere Kuiatse, PhD, Hua Wang, PhD, Fazal Shirazi, PhD, Allison Berger, PhD, Marc Hyer, PhD, Nibedita Chattopadhyay, PhD, Sakeena Syed, Judy Qiuju Shi, Jie Yu, M.S., Vaishali Shinde, Anna Kreshock, Stephen Tirrell, PhD, Saurabh Menon, PhD, Richard Julian Jones, PhD, Robert Z. Orlowski, MD PhD
Journal: Blood
Blood (2016) 128 (22): 3296.
https://doi.org/10.1182/blood.V128.22.3296.3296
Published: 2016
Journal Articles

The Investigational Aurora A Kinase Inhibitor MLN8237 in Combination with Vincristine Demonstrates Robust Anti-Tumor Activity in Preclinical B-Cell Non-Hodgkin's Lymphoma Models

Mengkun Zhang, Jessica Huck, Marc Hyer, Karuppian Kannan, Wen Chyi Shyu, Susan Chen, Mark Manfredi, Jeffrey Ecsedy
Journal: Blood
Blood (2011) 118 (21): 2733.
https://doi.org/10.1182/blood.V118.21.2733.2733
Published: 2011