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Journal Articles

Targeted Protein Degradation Reveals a Repressive Role of Mecom at the CEBPA Locus to Prevent Differentiation in High-Risk Acute Myeloid Leukemia

Travis Fleming, Richard A Voit, Mateusz Antoszewski, Sander Lambo, Michael Gundry, Riccardo Piussi, Sanjana Shah, Lara Wahlster, Andrea Arruda, Volker Hovestadt, Mark D. Minden, Vijay G. Sankaran

Blood (2024) 144 (Supplement 1): 953.

https://doi.org/10.1182/blood-2024-199697

Published: 2024

Journal Articles

Multiparameter Flow Cytometry-Based Measurable Residual Disease Assessment in the Patients with CCAAT Enhancer-Binding Protein a Gene (CEBPA) Mutated Acute Myeloid Leukemia

Swe Mar Linn, Nihar Desai, Steven M. Chan, Andre C. Schuh, Aniket Banker, Marta Beata Davidson, Guillaume Richard-Carpentier, Aron Shimmer, Dawn C. Maze, Karen Yee, Mark D. Minden, Vikas Gupta, Tracy Stockley, Hassan Sibai, Jose-Mario Capo-Chichi, Anne Maria Tierens, Dennis Dong Hwan Kim

Blood (2024) 144 (Supplement 1): 1570.

https://doi.org/10.1182/blood-2024-211434

Published: 2024

Journal Articles

Single-Cell Proteogenomic Analysis of Clonal Evolution in Patient-Derived Xenograft Models of AML Treated with IDH Inhibitors

Alex Liu, Severine Cathelin, Yitong Yang, Farzaneh Aboualizadeh, Amina Abow, Gurbaksh Basi, Lance Li, David L Dai, Abdula Maher, Eric Grignano, Mohsen Hosseini, Dhanoop Manikoth Ayyathan, Vivian Wang, Troy Ketela, Dylan Marchione, Adriana Tron, Andrea Arruda, Mark D. Minden, Steven M. Chan

Blood (2024) 144 (Supplement 1): 4995.

https://doi.org/10.1182/blood-2024-211634

Published: 2024

Journal Articles

Leptin-Enhanced JAK-STAT Signaling in Acute Myeloid Leukemia-Derived Mesenchymal Stromal Cells and Its Implications for Disease Progression

Muzaffar Bhatti, Anthea Travas, Oyeronke Ayansola, Amirthagowri Ambalavanan, Jaeyoon John Kim, Danielle Pyne, Troy Ketela, Andrea Arruda, Mark D. Minden, Armand Keating, Dennis Dong Hwan Kim

Blood (2024) 144 (Supplement 1): 5664.

https://doi.org/10.1182/blood-2024-211349

Published: 2024

Journal Articles

What Is the Prognostic Relevance of Responses Less Than a CR(Sub-CR) to Initial AML Treatment?

Akhil Rajendra, Elliot Smith, Eshetu Atenafu, Aniket Bankar, Steven M. Chan, Marta Beata Davidson, Vikas Gupta, Mark D. Minden, Maria Agustina Perusini, Guillaume Richard-Carpentier, Aaron D Schimmer, Andre C. Schuh, Hassan Sibai, Karen Yee, Dawn C. Maze

Blood (2024) 144 (Supplement 1): 5193.

https://doi.org/10.1182/blood-2024-208884

Published: 2024

Journal Articles

Blood-Based Proteomic Profiling Identifies Osmr As a Novel Biomarker

Hussein A. Abbas, Bofei Wang, Jennifer Marvin-Peek, Bin Yuan, Araceli Isabella Garza, Jessica Lynn Root, Andrea Arruda, Yiwei Liu, Courtney D. DiNardo, Tapan M. Kadia, Naval Daver, Philip L Lorenzi, Koji Sasaki, Steven M. Kornblau, Mark D. Minden, Farhad Ravandi, Hagop M. Kantarjian, Patrick K. Reville

Blood (2024) 144 (Supplement 1): 2912.

https://doi.org/10.1182/blood-2024-201725

Published: 2024

Journal Articles

Intensive Chemotherapy Vs. Azacitidine + Venetoclax for AML with Secondary Mutations

Elliot Smith, Akhil Rajendra Kurup, Eshetu Atenafu, Aniket Bankar, Steven M. Chan, Marta Beata Davidson, Vikas Gupta, Mark D. Minden, Guillaume Richard-Carpentier, Aaron D Schimmer, Andre C. Schuh, Hassan Sibai, Karen Yee, Dawn C. Maze

Blood (2024) 144 (Supplement 1): 1483.

https://doi.org/10.1182/blood-2024-202069

Published: 2024

Journal Articles

Inhibition of Peroxisome Proliferation-Activated Receptor Delta (PPARδ) Selectively Kills Acute Myeloid Leukemia Cells

Yingying Yang, Ekaterina Parfenova, Nikolina Vrdoljak, Mark D. Minden, Jessica Luc, Andrew Doxey, Paul A. Spagnuolo

Blood (2024) 144 (Supplement 1): 2762.

https://doi.org/10.1182/blood-2024-210432

Published: 2024

Journal Articles

Real-World Experience with CPX-351 for Secondary Acute Myeloid Leukemia: Comparison with FLAG-IDA in a Propensity Score Matching Analysis

Blood (2024) 144 (Supplement 1): 1506.

https://doi.org/10.1182/blood-2024-204004

Published: 2024

Journal Articles

The Exportin, CSE1L, Regulates Ribosome Biogenesis and Is a Selective Dependency in Childhood and Young Adult Acute Myeloid Leukemia

Grace Egan, Amit Kumar, Veronique Voisin, Rose Hurren, Ali Chegini, Dakai Ling, Geethu Emily Thomas, Youngran Yan, Yue Feng, Suraj Bansal, Andy G.X. Zeng, Andrea Arruda, John Edgar Dick, Gary D Bader, Mark D. Minden, Aaron D Schimmer

Blood (2024) 144 (Supplement 1): 2724.

https://doi.org/10.1182/blood-2024-200148

Published: 2024

Journal Articles

AML Cells Have Increased Mitochondrial RNA Degradation and Inhibiting This Degradation Promotes Cell Differentiation, Decreases Viability, and Increases Sensitivity to Immune-Mediated Killing

Geethu Emily Thomas, Kazem Nouri, Rose Hurren, JongBok Lee, Veronique Voisin, Yongran Yan, Neil Maclean, Marcela Gronda, Yulia Jitkova, Taylor Barbieri, Li Ma, Xiaoming Wang, Andrea Arruda, Mark D. Minden, Li Zhang, Aaron D Schimmer

Blood (2024) 144 (Supplement 1): 2723.

https://doi.org/10.1182/blood-2024-194861

Published: 2024

Journal Articles

Examining the Clinical Relevance of the AML Plasma Metabolome

Cristiana O'Brien, Nirvana Nursimulu, Rachel Culp-Hill, Julie A Reisz Haines, Andrea Arruda, Mark D. Minden, Angelo D'Alessandro, Sushant Kumar, Kristin J. Hope, Courtney Jones

Blood (2024) 144 (Supplement 1): 2937.

https://doi.org/10.1182/blood-2024-203960

Published: 2024

Journal Articles

The Mitochondrial Unfolded Protein Response (UPR mt ) Is Upregulated in Acute Myeloid Leukemia (AML) and Inhibiting the UPR mt Protease, LONP1, Leads to Mitochondrial Protein Aggregation and Cell Death Selectively in AML

Matthew Tcheng, Veronique Voisin, Marcela Gronda, Rose Hurren, Dakai Ling, Yongran Yan, Lan Xin Zhang, Yue Feng, Zaynab Mamai, Yulia Jitkova, Chaitra Sarathy, Andrea Arruda, Steven M. Kornblau, Mark D. Minden, Aaron D Schimmer

Blood (2024) 144 (Supplement 1): 2778.

https://doi.org/10.1182/blood-2024-205308

Published: 2024

Journal Articles

FLAG-IDA Plus Venetoclax in High-Risk Newly Diagnosed and Relapsed or Refractory Acute Myeloid Leukemia: The Princess Margaret Cancer Center Experience

Eshrak Al-Shaibani, Marta Beata Davidson, Aniket Bankar, Steven M. Chan, Hassan Sibai, Dawn C. Maze, Aaron D Schimmer, Mark D. Minden, Karen Yee, Vikas Gupta, Andre C. Schuh, Guillaume Richard-Carpentier

Blood (2024) 144 (Supplement 1): 4273.

https://doi.org/10.1182/blood-2024-209476

Published: 2024

Journal Articles

Intracellular IL-23 Receptor (IL-23R) Is a Regulator of Mitotic Spindle and Centrosome Formation and Is Essential for AML Viability

Blood (2023) 142 (Supplement 1): 5694.

https://doi.org/10.1182/blood-2023-174536

Published: 2023

Journal Articles

Presence of Recurrent Somatic Mutations in Mesenchymal Stromal Cell Fractions Isolated from Acute Myeloid Leukemia As an Evidence of Clonality

Muzaffar Bhatti, Taehyung Kim, Jenny Warrington, Amirthagowri Ambalavanan, Sarah Zarabi, Anthea Travas, Jaeyoon John Kim, Danielle Pyne, Troy Ketela, Andrea Arruda, Mark D. Minden, Armand Keating, Dennis Dong Hwan Kim

Blood (2023) 142 (Supplement 1): 6042.

https://doi.org/10.1182/blood-2023-185149

Published: 2023

Journal Articles

Identification of Unexpected Responders to Gilteritinib in a Cohort of FLT3-WT AML Patients Using Ex-Vivo Testing

Blood (2023) 142 (Supplement 1): 7132.

https://doi.org/10.1182/blood-2023-181119

Published: 2023

Journal Articles

The Atpase Domain of LONP1 Is Necessary for Mitochondrial Protein Solubility and the Viability of Acute Myeloid Leukemia (AML) Cells

Matthew Tcheng, Aaron D. Schimmer, Marcela Gronda, Rose Hurren, Shahbaz Khan, Lan Xin Zhang, Chaitra Sarathy, Yongran Yan, Andrea Arruda, Thomas Kislinger, Mark D. Minden

Blood (2023) 142 (Supplement 1): 1420.

https://doi.org/10.1182/blood-2023-178399

Published: 2023

Journal Articles

Inflammatory Signatures Define a New High-Risk T-Lineage ALL Subtype

Blood (2023) 142 (Supplement 1): 2969.

https://doi.org/10.1182/blood-2023-182412

Published: 2023

Journal Articles

DNA Methylation Instability: A Novel Biomarker for Aging, Clonality, and Cancer

Salman Basrai, Robert Kridel, Mehran Bakhtiari, Dennis D. H. Kim, Fernando L. Scolari, Filio Billia, Andrea Arruda, Mark D. Minden, Sagi Abelson

Blood (2023) 142 (Supplement 1): 4059.

https://doi.org/10.1182/blood-2023-173489

Published: 2023

NARROW

Targeted Protein Degradation Reveals a Repressive Role of Mecom at the CEBPA Locus to Prevent Differentiation in High-Risk Acute Myeloid Leukemia

Multiparameter Flow Cytometry-Based Measurable Residual Disease Assessment in the Patients with CCAAT Enhancer-Binding Protein a Gene (CEBPA) Mutated Acute Myeloid Leukemia

Single-Cell Proteogenomic Analysis of Clonal Evolution in Patient-Derived Xenograft Models of AML Treated with IDH Inhibitors

Leptin-Enhanced JAK-STAT Signaling in Acute Myeloid Leukemia-Derived Mesenchymal Stromal Cells and Its Implications for Disease Progression

What Is the Prognostic Relevance of Responses Less Than a CR(Sub-CR) to Initial AML Treatment?

Blood-Based Proteomic Profiling Identifies Osmr As a Novel Biomarker

Intensive Chemotherapy Vs. Azacitidine + Venetoclax for AML with Secondary Mutations

Inhibition of Peroxisome Proliferation-Activated Receptor Delta (PPARδ) Selectively Kills Acute Myeloid Leukemia Cells

Real-World Experience with CPX-351 for Secondary Acute Myeloid Leukemia: Comparison with FLAG-IDA in a Propensity Score Matching Analysis

The Exportin, CSE1L, Regulates Ribosome Biogenesis and Is a Selective Dependency in Childhood and Young Adult Acute Myeloid Leukemia

AML Cells Have Increased Mitochondrial RNA Degradation and Inhibiting This Degradation Promotes Cell Differentiation, Decreases Viability, and Increases Sensitivity to Immune-Mediated Killing

Examining the Clinical Relevance of the AML Plasma Metabolome

The Mitochondrial Unfolded Protein Response (UPR mt ) Is Upregulated in Acute Myeloid Leukemia (AML) and Inhibiting the UPR mt Protease, LONP1, Leads to Mitochondrial Protein Aggregation and Cell Death Selectively in AML

FLAG-IDA Plus Venetoclax in High-Risk Newly Diagnosed and Relapsed or Refractory Acute Myeloid Leukemia: The Princess Margaret Cancer Center Experience

Intracellular IL-23 Receptor (IL-23R) Is a Regulator of Mitotic Spindle and Centrosome Formation and Is Essential for AML Viability

Presence of Recurrent Somatic Mutations in Mesenchymal Stromal Cell Fractions Isolated from Acute Myeloid Leukemia As an Evidence of Clonality

Identification of Unexpected Responders to Gilteritinib in a Cohort of FLT3-WT AML Patients Using Ex-Vivo Testing

The Atpase Domain of LONP1 Is Necessary for Mitochondrial Protein Solubility and the Viability of Acute Myeloid Leukemia (AML) Cells

Inflammatory Signatures Define a New High-Risk T-Lineage ALL Subtype

DNA Methylation Instability: A Novel Biomarker for Aging, Clonality, and Cancer

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American Society of Hematology

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ASH Publications

American Society of Hematology

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