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Matthew Tcheng
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Journal Articles

The Mitochondrial Unfolded Protein Response (UPR mt ) Is Upregulated in Acute Myeloid Leukemia (AML) and Inhibiting the UPR mt Protease, LONP1, Leads to Mitochondrial Protein Aggregation and Cell Death Selectively in AML

Matthew Tcheng, Veronique Voisin, Marcela Gronda, Rose Hurren, Dakai Ling, Yongran Yan, Lan Xin Zhang, Yue Feng, Zaynab Mamai, Yulia Jitkova, Chaitra Sarathy, Andrea Arruda, Steven M. Kornblau, Mark D. Minden, Aaron D Schimmer
Journal: Blood
Blood (2024) 144 (Supplement 1): 2778.
https://doi.org/10.1182/blood-2024-205308
Published: 2024
Journal Articles

Serine Phosphorylation Marks Proteins for Degradation By the Mitochondrial Serine Protease Complex, Clpxp

Yue Feng, Yulia Jitkova, Alexander Keszei, Chaitra Sarathy, Vincent Trudel, Jonathan St-Germain, Matthew Tcheng, Monica M Goncalves, Yongran Yan, Rose Hurren, Matthew Schultz, Siavash Vahidi, Brian Raught, Andrei Yudin, Mohammad Mazhab-Jafari, Aaron D. Schimmer
Journal: Blood
Blood (2023) 142 (Supplement 1): 5675.
https://doi.org/10.1182/blood-2023-173385
Published: 2023
Journal Articles

Mitophagy As a Novel Cell-Protective Mechanism Against Mitochondrial Ferroptosis in Acute Myeloid Leukemia

Hiroki Akiyama, Matthew Tcheng, Priyanka Sharma, Ran Zhao, Lauren B. Ostermann, Samar Yazdani, Arman Moayed, Zdzislaw Szulc, Natalia Oleinik, Po Yee Mak, Vivian Ruvolo, Bing Z. Carter, Besim Ogretmen, Gautam Borthakur, Aaron D. Schimmer, Michael Andreeff, Jo Ishizawa
Journal: Blood
Blood (2023) 142 (Supplement 1): 2804.
https://doi.org/10.1182/blood-2023-181410
Published: 2023
Journal Articles

The Atpase Domain of LONP1 Is Necessary for Mitochondrial Protein Solubility and the Viability of Acute Myeloid Leukemia (AML) Cells

Matthew Tcheng, Aaron D. Schimmer, Marcela Gronda, Rose Hurren, Shahbaz Khan, Lan Xin Zhang, Chaitra Sarathy, Yongran Yan, Andrea Arruda, Thomas Kislinger, Mark D. Minden
Journal: Blood
Blood (2023) 142 (Supplement 1): 1420.
https://doi.org/10.1182/blood-2023-178399
Published: 2023
Journal Articles

Inhibiting Mitochondrial Complex II Exposes a Novel Metabolic Vulnerability in Acute Myeloid Leukemia

Alessia Roma, Matthew Tcheng, Nawaz Ahmed, Sarah Walker, Preethi Jayanth, Mark D. Minden, Kristin Hope, Praveen P. Nekkar Rao, Jessica Luc, Andrew C. Doxey, Julie A. Reisz, Angelo D'Alessandro, Paul A. Spagnuolo
Journal: Blood
Blood (2021) 138 (Supplement 1): 1300.
https://doi.org/10.1182/blood-2021-148708
Published: 2021
Journal Articles

Very long chain fatty acid metabolism is required in acute myeloid leukemia

Matthew Tcheng, Alessia Roma, Nawaz Ahmed, Richard W. Smith, Preethi Jayanth, Mark D. Minden, Aaron D. Schimmer, David A. Hess, Kristin Hope, Kevin A. Rea, Tariq A. Akhtar, Eric Bohrnsen, Angelo D’Alessandro, Al-Walid Mohsen, Jerry Vockley, Paul A. Spagnuolo
Journal: Blood
Blood (2021) 137 (25): 3518–3532.
https://doi.org/10.1182/blood.2020008551
Published: 2021
Includes: Supplemental data
Journal Articles

Inhibiting Very Long Chain Acyl-CoA Dehydrogenase (VLCAD) Induces Selective Leukemia Cell Death

Matthew Tcheng, BSc, Alessia Roma, BSc, Nawaz Ahmed, MSc, Richard Smith, PhD, Preethi Jayanth, PhD, Mark D. Minden, MD PhD, Rose Hurren, BSc, Aaron D Schimmer, MD PhD, Gale Bozzo, PhD, David Hess, PhD, Kristin Hope, PhD, Kevin Rea, MSc, Tariq A. Akhtar, PhD, Al-Walid Mohsen, PhD, Jerry Vockley, MD PhD, Paul A. Spagnuolo, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3922.
https://doi.org/10.1182/blood-2019-122262
Published: 2019