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Journal Articles

Glutaredoxin 2 is essential for AML survival through mitochondrial permeability transition pore regulation

Blood blood.2025028933.

https://doi.org/10.1182/blood.2025028933

Published: 2025

Includes: Supplemental data

Journal Articles

Identification of XPO1 interactors and modulation by selinexor in diffuse large B cell lymphoma

Kyla Trkulja, Will Tong, Daisy Tran, Li Meng, Jonathan St-Germain, Faith Yeung, Evelyn Teh, Susanne Penny, Brian Raught, Devanand Pinto, Armand Keating, John Kuruvilla, Rob Laister

Blood (2025) 146 (Supplement 1): 3315.

https://doi.org/10.1182/blood-2025-3315

Published: 2025

Journal Articles

Polyamines Are Required for AML LSC Function through Their Role in Regulating eIF5A Dependent Protein Synthesis

Vincent Rondeau, Rachel Culp-Hill, Julie A Reisz, Duhan Yendi, Aarushi Gupta, Jacob Berman, Cristiana O'Brien, Tianyi Ling, Aleksandra Bourdine, Mary Shi, Jonathan St-Germain, Soheil Jahangiri, Anastasia N. Tikhonova, Andrea Arruda, Mark D. Minden, Brian Raught, Angelo D'Alessandro, Courtney L Jones

Blood (2023) 142 (Supplement 1): 585.

https://doi.org/10.1182/blood-2023-187283

Published: 2023

Journal Articles

Intracellular IL-23 Receptor (IL-23R) Is a Regulator of Mitotic Spindle and Centrosome Formation and Is Essential for AML Viability

Blood (2023) 142 (Supplement 1): 5694.

https://doi.org/10.1182/blood-2023-174536

Published: 2023

Journal Articles

XPO2 Is Essential for a Subset of AML Cells and Is a Biomarker for Poor Response and Survival in Pediatric and AYA AML

Grace Egan, Geethu Emily Thomas, Rose Hurren, Suraj Bansal, Andy G.X. Zeng, Chaitra Sarathy, Dilshad H. Khan, Yongran Yan, Yue Feng, Jonathan St-Germain, Brian Raught, John E. Dick, Aaron D. Schimmer

Blood (2023) 142 (Supplement 1): 5681.

https://doi.org/10.1182/blood-2023-180968

Published: 2023

Journal Articles

Serine Phosphorylation Marks Proteins for Degradation By the Mitochondrial Serine Protease Complex, Clpxp

Yue Feng, Yulia Jitkova, Alexander Keszei, Chaitra Sarathy, Vincent Trudel, Jonathan St-Germain, Matthew Tcheng, Monica M Goncalves, Yongran Yan, Rose Hurren, Matthew Schultz, Siavash Vahidi, Brian Raught, Andrei Yudin, Mohammad Mazhab-Jafari, Aaron D. Schimmer

Blood (2023) 142 (Supplement 1): 5675.

https://doi.org/10.1182/blood-2023-173385

Published: 2023

Journal Articles

Simultaneous Inhibition of SIRT3 and Cholesterol Homeostasis Targets AML Stem Cells By Perturbing Fatty Acid β-Oxidation and Inducing Lipotoxicity

Blood (2022) 140 (Supplement 1): 104–106.

https://doi.org/10.1182/blood-2022-157794

Published: 2022

Journal Articles

Intracellular IL-23 Receptor (IL-23R) Is Necessary for AML Viability and Regulates Mitotic Spindle and Centrosome Formation

Nathan Duong, Dilshad H. Khan, Geethu Emily Thomas, Rose Hurren, Jong Bok Lee, Jonathan St-Germain, Lily Drimmer, Yongran Yan, Neil MacLean, Marcela Gronda, Brandon D Brown, Brian Raught, Andrea Arruda, Mark D. Minden, Li Zhang, Steven M. Kornblau, Vito Spadevecchio, Aaron D. Schimmer

Blood (2022) 140 (Supplement 1): 3005–3006.

https://doi.org/10.1182/blood-2022-157626

Published: 2022

Journal Articles

Phosphorylated Serine Marks Proteins for Degradation By the Mitochondrial Matrix Protease, Clpxp

Yue Feng, Yulia Jitkova, Alexander Keszei, Jonathan St-Germain, Yongran Yan, Brian Raught, Mohammad Mazhab-Jafari, Aaron D. Schimmer

Blood (2022) 140 (Supplement 1): 3023–3024.

https://doi.org/10.1182/blood-2022-157338

Published: 2022

Journal Articles

IPO11 Regulates the Nuclear Import of BZW1/2 and Is Necessary for AML Cells and Stem Cells

Boaz Nachmias, MDPhD, Veronique Voisin, PhD, Geethu Emily Thomas, PhDMSc,BSc, Dilshad H. Khan, Rose Hurren, BSc, Aaron Botham, Xiaoming Wang, Neil Maclean, Ayesh K Seneviratne, BSc, MSc, Changjiang Xu, Jonathan St-Germain, Andrea Arruda, MSc, Elias Orouji, Liran I. Shlush, MD, Mark D. Minden, Brian Raught, Gary D Bader, Aaron D Schimmer, MD PhD

Blood (2020) 136 (Supplement 1): 22–23.

https://doi.org/10.1182/blood-2020-134787

Published: 2020

Journal Articles

The Mitochondrial Protease, Neurolysin (NLN), Regulates Respiratory Chain Complex and Supercomplex Formation and Is Necessary for AML Viability

Blood (2019) 134 (Supplement_1): 729.

https://doi.org/10.1182/blood-2019-122784

Published: 2019

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Glutaredoxin 2 is essential for AML survival through mitochondrial permeability transition pore regulation

Identification of XPO1 interactors and modulation by selinexor in diffuse large B cell lymphoma

Polyamines Are Required for AML LSC Function through Their Role in Regulating eIF5A Dependent Protein Synthesis

Intracellular IL-23 Receptor (IL-23R) Is a Regulator of Mitotic Spindle and Centrosome Formation and Is Essential for AML Viability

XPO2 Is Essential for a Subset of AML Cells and Is a Biomarker for Poor Response and Survival in Pediatric and AYA AML

Serine Phosphorylation Marks Proteins for Degradation By the Mitochondrial Serine Protease Complex, Clpxp

Simultaneous Inhibition of SIRT3 and Cholesterol Homeostasis Targets AML Stem Cells By Perturbing Fatty Acid β-Oxidation and Inducing Lipotoxicity

Intracellular IL-23 Receptor (IL-23R) Is Necessary for AML Viability and Regulates Mitotic Spindle and Centrosome Formation

Phosphorylated Serine Marks Proteins for Degradation By the Mitochondrial Matrix Protease, Clpxp

IPO11 Regulates the Nuclear Import of BZW1/2 and Is Necessary for AML Cells and Stem Cells

The Mitochondrial Protease, Neurolysin (NLN), Regulates Respiratory Chain Complex and Supercomplex Formation and Is Necessary for AML Viability

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