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Troy Ketela
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Journal Articles

Single-Cell Proteogenomic Analysis of Clonal Evolution in Patient-Derived Xenograft Models of AML Treated with IDH Inhibitors

Alex Liu, Severine Cathelin, Yitong Yang, Farzaneh Aboualizadeh, Amina Abow, Gurbaksh Basi, Lance Li, David L Dai, Abdula Maher, Eric Grignano, Mohsen Hosseini, Dhanoop Manikoth Ayyathan, Vivian Wang, Troy Ketela, Dylan Marchione, Adriana Tron, Andrea Arruda, Mark D. Minden, Steven M. Chan
Journal: Blood
Blood (2024) 144 (Supplement 1): 4995.
https://doi.org/10.1182/blood-2024-211634
Published: 2024
Journal Articles

Leptin-Enhanced JAK-STAT Signaling in Acute Myeloid Leukemia-Derived Mesenchymal Stromal Cells and Its Implications for Disease Progression

Muzaffar Bhatti, Anthea Travas, Oyeronke Ayansola, Amirthagowri Ambalavanan, Jaeyoon John Kim, Danielle Pyne, Troy Ketela, Andrea Arruda, Mark D. Minden, Armand Keating, Dennis Dong Hwan Kim
Journal: Blood
Blood (2024) 144 (Supplement 1): 5664.
https://doi.org/10.1182/blood-2024-211349
Published: 2024
Journal Articles

Multiome Single Cell Analyses Identify a Distinct CD8+ T Cell Phenotype Linked to Treatment Response in PTLD

Tomohiro Aoki, Davidson Zhao, Noémie Lang, Yifan Yin, Ting Liu, Michael Hong, Johanna Regala, Troy Ketela, Anca Prica, John Kuruvilla, Pedro Farinha, Jan Delabie, Federico Gaiti, Kerry J. Savage, David W. Scott, Robert Kridel
Journal: Blood
Blood (2024) 144 (Supplement 1): 4385.
https://doi.org/10.1182/blood-2024-194926
Published: 2024
Journal Articles

Presence of Recurrent Somatic Mutations in Mesenchymal Stromal Cell Fractions Isolated from Acute Myeloid Leukemia As an Evidence of Clonality

Muzaffar Bhatti, Taehyung Kim, Jenny Warrington, Amirthagowri Ambalavanan, Sarah Zarabi, Anthea Travas, Jaeyoon John Kim, Danielle Pyne, Troy Ketela, Andrea Arruda, Mark D. Minden, Armand Keating, Dennis Dong Hwan Kim
Journal: Blood
Blood (2023) 142 (Supplement 1): 6042.
https://doi.org/10.1182/blood-2023-185149
Published: 2023
Journal Articles

Single-Cell Proteogenomic Sequencing Allows Early Detection of Relapse Clone with CN-LOH at FLT3 -ITD Locus from Initial Diagnosis in AML

Taehyung Kim, Hyewon Lee, Jose-Mario Capo-Chichi, Myung Hee Chang, Young Seok Yoo, Gurbaksh Basi, Troy Ketela, Adam C. Smith, Anne Tierens, Mark D. Minden, Zhaolei Zhang, Dennis Dong Hwan Kim
Journal: Blood
Blood (2021) 138 (Supplement 1): 3428.
https://doi.org/10.1182/blood-2021-146572
Published: 2021
Journal Articles

Mitochondrial carrier homolog 2 is necessary for AML survival

Dilshad H. Khan, Michael Mullokandov, Yan Wu, Veronique Voisin, Marcela Gronda, Rose Hurren, Xiaoming Wang, Neil MacLean, Danny V. Jeyaraju, Yulia Jitkova, G. Wei Xu, Rob Laister, Ayesh Seneviratne, Zachary M. Blatman, Troy Ketela, Gary D. Bader, Sajid A. Marhon, Daniel D. De Carvalho, Mark D. Minden, Atan Gross, Aaron D. Schimmer
Journal: Blood
Blood (2020) 136 (1): 81–92.
https://doi.org/10.1182/blood.2019000106
Published: 2020
Includes: Supplemental data
Journal Articles

Mitochondrial Carrier Homolog 2 (MTCH2) Regulates the Differentiation of AML Cells By Controlling Pyruvate Entry into the Mitochondria, Nuclear Localization of Pyruvate Dehydrogenase Complex and H3 and H4 Histone Acetylation

Dilshad H. Khan, Michael Mullokandov, Yan Wu, Marcela Gronda, MSc, Rose Hurren, BSc, Xiaoming Wang, Neil MacLean, Danny V. Jeyaraju, PhD, G. Wei Xu, Rob C. Laister, PhD, Zachary Blatman, Troy Ketela, Mark D. Minden, MD PhD, Atan Gross, PhD, Aaron D. Schimmer, MDPhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 299.
https://doi.org/10.1182/blood.V130.Suppl_1.299.299
Published: 2017
Journal Articles

Targeting Mitochondrial Translation Overcomes Venetoclax Resistance in Acute Myeloid Leukemia (AML) through Activation of the Integrated Stress Response

David Sharon, PhD, Severine Cathelin, PhD, Amit Subedi, PhD, Ryan Williams, Mariana Benicio, PhD, Troy Ketela, Steven M. Chan, MDPhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 297.
https://doi.org/10.1182/blood.V130.Suppl_1.297.297
Published: 2017
Journal Articles

Inhibition of Mitochondrial Translation As a Therapeutic Strategy for Acute Myeloid Leukemia (AML)

Marko Skrtic, BSc, Shrivani Sriskanthadevan, PhD, Bozhena Livak, BSc, Marinella Gebbia, PhD, Xiaoming Wang, Zezhou Wang, PhD, Rose Hurren, BSc, Yulia Jitkova, PhD, Marcela Gronda, MSc, Neil Maclean, BSc, Courteney Lai, BSc, Yanina Eberhard, BSc, PhD, Justyna Bartoszko, BSc, Paul A. Spagnuolo, PhD, Angela Rutledge, PhD, Alessandro Datti, PhD, Troy Ketela, Jason Moffat, Brian H Robinson, PhD, Jessie M Cameron, PhD, Jeff L. Wrana, PhD, Connie J. Eaves, PhD, Mark D. Minden, MD, PhD, Jean C.Y. Wang, MD, PhD, John E. Dick, PhD, R. Keith Humphries, MD, PhD, Corey Nislow, PhD, Guri Giaever, PhD, Aaron D Schimmer, MD, PhD
Journal: Blood
Blood (2011) 118 (21): 233.
https://doi.org/10.1182/blood.V118.21.233.233
Published: 2011
Journal Articles

Genome-Wide shRNA Screen for DNA Damage Response Regulators in Human Hematopoietic Stem and Progenitor Cells

Olga I Gan, Michael Milyavsky, Mark F van Delft, Alla Buzina, Irina Kalatskaya, Troy Ketela, Lincoln Stein, Jason Moffat, John E. Dick, PhD
Journal: Blood
Blood (2011) 118 (21): 1289.
https://doi.org/10.1182/blood.V118.21.1289.1289
Published: 2011
Journal Articles

The ubiquitin-activating enzyme E1 as a therapeutic target for the treatment of leukemia and multiple myeloma

G. Wei Xu, Mohsin Ali, Tabitha E. Wood, Derek Wong, Neil Maclean, Xiaoming Wang, Marcela Gronda, Marko Skrtic, Xiaoming Li, Rose Hurren, Xinliang Mao, Meenakshi Venkatesan, Reza Beheshti Zavareh, Troy Ketela, John C. Reed, David Rose, Jason Moffat, Robert A. Batey, Sirano Dhe-Paganon, Aaron D. Schimmer
Journal: Blood
Blood (2010) 115 (11): 2251–2259.
https://doi.org/10.1182/blood-2009-07-231191
Published: 2010
Includes: Supplemental data