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Federico Gaiti
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Journal Articles

Multiome Single Cell Analyses Identify a Distinct CD8+ T Cell Phenotype Linked to Treatment Response in PTLD

Tomohiro Aoki, Davidson Zhao, Noémie Lang, Yifan Yin, Ting Liu, Michael Hong, Johanna Regala, Troy Ketela, Anca Prica, John Kuruvilla, Pedro Farinha, Jan Delabie, Federico Gaiti, Kerry J. Savage, David W. Scott, Robert Kridel
Journal: Blood
Blood (2024) 144 (Supplement 1): 4385.
https://doi.org/10.1182/blood-2024-194926
Published: 2024
Journal Articles

Decoding the Epigenetic and Transcriptional Signatures of Pathogenic B-Cells in Patients at High Risk of Transformation to Lymphoma

Arghavan Ashouri, Pathum Kossinna, Xuyao Li, Jianfan Nie, Mohamed Ghaith Majjani, Joanna Kokalovski, Leandro Venturutti, Zahi Touma, Federico Gaiti
Journal: Blood
Blood (2024) 144 (Supplement 1): 2971.
https://doi.org/10.1182/blood-2024-202826
Published: 2024
Journal Articles

Topic Modeling of Genotyping of Transcriptomes Reveals Collaboration between BTK C481S -Mutant and Wild Type Cells in Btki-Resistant Chronic Lymphocytic Leukemia

Ramon Massoni-Badosa, Joshua S. Schiffman, Barun Pradhan, Rebecca M. Murray, Andrew H. Lipsky, Debra Van Egeren, Danny Luan, Shirley Chen, Ronan Chaligne, Kai Beattie, Alyssa Indart, Nada Chraiki, Neville Dusaj, Erica B. Bhavsar, Chelston Ang, Anna S. Nam, Federico Gaiti, Paulina Chamely, Nathaniel D. Omans, Preeti Trisal, Anita K. Gandhi, Kyu-Tae Kim, Rafael Schulman, Franco Izzo, Gavriel Mullokandov, Chingiz Underbayev, Jan A. Burger, Adrian Wiestner, Elisa Ten Hacken, John N. Allan, Jennifer A. Woyach, Richard R. Furman, Dan A. Landau
Journal: Blood
Blood (2024) 144 (Supplement 1): 4610.
https://doi.org/10.1182/blood-2024-205727
Published: 2024
Journal Articles

Multi-Omic Insights into the Mutational Landscape and Dysregulated Transcriptional Programs of Autoimmune B-Cells in Systemic Lupus Erythematosus

Arghavan Ashouri, Pathum Kossinna, Xuyao Li, Jahin Kabir, Jianfan Nie, Artem Kushnirenko, Ilham Abbasi, Leandro Venturutti, Zahi Touma, Federico Gaiti
Journal: Blood
Blood (2023) 142 (Supplement 1): 2552.
https://doi.org/10.1182/blood-2023-182314
Published: 2023
Journal Articles

Single-Cell Multi-Omics Defines the Cell-Type Specific Impact of SF3B1 Splicing Factor Mutations on Hematopoietic Differentiation in Human Clonal Hematopoiesis and Myelodysplastic Syndromes

Federico Gaiti, Allegra Hawkins, Paulina Chamely, Ariel Swett, Xiaoguang Dai, Lloyd Kluegel, Celine Chen, John Beaulaurier, Alex Drong, Scott Hickey, Tarek H Mouhieddine, Franco Izzo, Neville Dusaj, Ronan Chaligne, Sissel Juul, Daniel H Wiseman, Eoghan Harrington, Justin Taylor, Irene M. Ghobrial, Omar Abdel-Wahab, Dan A. Landau
Journal: Blood
Blood (2021) 138 (Supplement 1): 145.
https://doi.org/10.1182/blood-2021-147529
Published: 2021
Journal Articles

Single-Cell Multi-Omics in Human Clonal Hematopoiesis Reveals That DNMT3A R882 Mutations Perturb Early Progenitor States through Selective Hypomethylation

Anna S Nam, MD, Neville Dusaj, MS, Franco Izzo, PhD, Rekha Murali, MS, Tarek H Mouhieddine, MD, Robert M Myers, Jesus Sotelo, Salima Benbarche, PhD, Federico Gaiti, PhD, Sabrin Tahri, MD MSc, Omar Abdel-Wahab, MD, Irene M. Ghobrial, MD, Ronan Chaligne, PhD, Dan A. Landau, MD PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 1–2.
https://doi.org/10.1182/blood-2020-142574
Published: 2020
Journal Articles

Single-Cell Multi-Omics Reveals Distinct Paths to Survival of Admixed BTK C481 Mutant Vs. Wild-Type Cells in Clinically Progressing Chronic Lymphocytic Leukemia

Andrew Lipsky, MD, Danny Luan, MPH, Shirley Chen, BSc, Ronan Chaligne, PhD, Neville Dusaj, MS, Erica B Bhavsar, BS, Chelston Ang, MS, Anna S Nam, MD, Federico Gaiti, PhD, Paulina Chamely, MSc, Nathaniel D. Omans, MS, Preeti Trisal, MS, Anita K Gandhi, PhD, Kyu-Tae Kim, PhD, Rafael Schulman, BS, Joshua S. Schiffman, PhD, Franco Izzo, PhD, Gregory Mullokandov, MD PhD, Chingiz Underbayev, MD PhD, Adrian Wiestner, MD PhD, John N. Allan, MD, Richard R. Furman, MD, Dan A. Landau, MD PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 40–42.
https://doi.org/10.1182/blood-2020-138374
Published: 2020
Journal Articles

Multimodal Single-Cell Profiling Defines the Epigenetic Determinants of Chronic Lymphocytic Leukemia Evolution

Ronan Chaligne, PhD, Federico Gaiti, PhD, Franco Izzo, PhD, Steven Kothen-Hill, MS, Hongcang Gu, Kevin Huang, BS, Davide Risso, PhD, Rafael Schulman, BS, Ryan M Brand, Stanley C Lee, PhD, Asaf Poran, Kye-Tae Kim, PhD, Alessandro Pastore, Alicia Alonso, Andreas Gnirke, Catherine J. Wu, MD, Omar I Abdel-Wahab, MD, Alexander Meissner, PhD, Dan A. Landau, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 1312.
https://doi.org/10.1182/blood-2018-99-115596
Published: 2018
Journal Articles

Single-Cell Joint Methylomics and Transcriptomics Define the Epigenetic Evolution and Lineage Histories of Chronic Lymphocytic Leukemia

Ronan Chaligne, PhD, Federico Gaiti, PhD, Steven Kothen-Hill, MS, Hongcang Gu, Kevin Huang, BS, Rafael Schulman, Kye-Tae Kim, PhD, Evan Biederstedt, Lili Wang, MD PhD, Martin J. Aryee, PhD, Andreas Gnirke, Catherine J. Wu, MD, Alexander Meissner, PhD, Dan A. Landau, MD
Journal: Blood
Blood (2017) 130 (Supplement 1): 55.
https://doi.org/10.1182/blood.V130.Suppl_1.55.55
Published: 2017
Journal Articles

Single-Cell Methylome and Transcriptome High-Resolution Maps Define the Effects of Epigenetic Modifiers on the Landscape of Hematopoietic Differentiation

Franco Izzo, PhD, Asaf Poran, Stanley Chun-Wei Lee, PhD, Ronan Chaligne, PhD, Federico Gaiti, PhD, Steven Kothen-Hill, MS, Rafael Schulman, BS, Michelle Ki, Kenigsberg Ephraim, PhD, Omar Abdel-Wahab, MD, Dan A. Landau, MD PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 559.
https://doi.org/10.1182/blood.V130.Suppl_1.559.559
Published: 2017
Journal Articles

Integrative Epigenomics Reveals Novel Chronic Lymphocytic Leukemia-Specific Chromatin States Associated with Epigenetic and Transcriptional Heterogeneity

Alessandro Pastore, MD, Federico Gaiti, PhD, Sydney X. Lu, MDPhD, Omar Abdel-Wahab, MD, Dan A. Landau, MD
Journal: Blood
Blood (2017) 130 (Supplement 1): 1723.
https://doi.org/10.1182/blood.V130.Suppl_1.1723.1723
Published: 2017