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Sirano Dhe-Paganon
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Journal Articles

Pharmacological Targeting of IRF4 As a Therapeutic Strategy for Multiple Myeloma

Michael P. Agius, Laura Hevenor, N Connor Payne, Qi Liu, Hyuk-Soo Seo, Romanos Sklavenitis-Pistofidis, Daniel Heilpern-Mallory, Puspalata Bashyal, Michelle P. Aranha, Elizabeth D. Lightbody, Ralph Mazitschek, Sirano Dhe-Paganon, Jun Qi, Irene Ghobrial
Journal: Blood
Blood (2024) 144 (Supplement 1): 155.
https://doi.org/10.1182/blood-2024-203381
Published: 2024
Journal Articles

Stapled BAD BH3 Helices Effectively Target BCL-2 Mutants That Cause Venetoclax Resistance

Thomas M. Deangelo, Utsarga Adhikary, Kyle J. Korshavn, Clara R. Brotzen-Smith, Hyuk-Soo Seo, Kijun Song, Luke Sebastian, Sirano Dhe-Paganon, Thomas E. Wales, Gregory H. Bird, Loren D. Walensky
Journal: Blood
Blood (2024) 144 (Supplement 1): 7472.
https://doi.org/10.1182/blood-2024-208553
Published: 2024
Journal Articles

Discovery of First-in-Class Small Molecule Inhibitors of the IRF4-PU.1/Spi-B Interaction

Mike P. Agius, Laura Hevenor, N Connor Payne, Ralph Mazitschek, Hyuk-Soo Seo, Sirano Dhe-Paganon, Jun Qi, Irene M. Ghobrial
Journal: Blood
Blood (2023) 142 (Supplement 1): 3635.
https://doi.org/10.1182/blood-2023-186864
Published: 2023
Journal Articles

Ubiquitin Receptor PSMD4/Rpn10 Is a Novel Therapeutic Target in Myeloma

Ting DU, Yan Song, Arghya Ray, Ruben D. Carrasco, Sirano Dhe-Paganon, Dharminder Chauhan, Kenneth C. Anderson
Journal: Blood
Blood (2021) 138 (Supplement 1): 1591.
https://doi.org/10.1182/blood-2021-151377
Published: 2021
Journal Articles

p53-related protein kinase confers poor prognosis and represents a novel therapeutic target in multiple myeloma

Clinical Trials & Observations
Teru Hideshima, Francesca Cottini, Yoshihisa Nozawa, Hyuk-Soo Seo, Hiroto Ohguchi, Mehmet K. Samur, Diana Cirstea, Naoya Mimura, Yoshikazu Iwasawa, Paul G. Richardson, Nikhil C. Munshi, Dharminder Chauhan, Walter Massefski, Teruhiro Utsugi, Sirano Dhe-Paganon, Kenneth C. Anderson
Journal: Blood
Blood (2017) 129 (10): 1308–1319.
https://doi.org/10.1182/blood-2016-09-738500
Published: 2017
Includes: Supplemental data
Journal Articles

Structure-Guided Design of DOT1L Methyltransferase Inhibitors By a Novel, Label Free Assay Platform

Joanna S. Yi, MD, Alex Federation, Jun Qi, PhD, Sirano Dhe-Paganon, PhD, Michael Hadler, MSc, Xiang Xu, PhD, Anthony Varca, Roodolph St. Pierre, Scott A. Armstrong, MD PhD, James E. Bradner
Journal: Blood
Blood (2014) 124 (21): 4811.
https://doi.org/10.1182/blood.V124.21.4811.4811
Published: 2014
Journal Articles

Mutations In UBA3 Confer Resistance To The NEDD8-Activating Enzyme Inhibitor MLN4924 In Human Leukemic Cells

G. Wei Xu, MD, PhD, Julia I. Toth, PhD, Sara R. da Silva, BSc, Stacey-Lynn Paiva, BSc, Julie L. Lukkarila, PhD, Rose Hurren, Neil Maclean, BSc, Mahadeo A. Sukhai, PhD, Rabindra N. Bhattacharjee, PhD, Carolyn A. Goard, PhD, Bruno C Medeiros, MD, Patrick T. Gunning, PhD, Sirano Dhe-Paganon, PhD, Matthew D. Petroski, PhD, Aaron Schimmer, PhD, MD
Journal: Blood
Blood (2013) 122 (21): 2527.
https://doi.org/10.1182/blood.V122.21.2527.2527
Published: 2013
Journal Articles

The ubiquitin-activating enzyme E1 as a therapeutic target for the treatment of leukemia and multiple myeloma

G. Wei Xu, Mohsin Ali, Tabitha E. Wood, Derek Wong, Neil Maclean, Xiaoming Wang, Marcela Gronda, Marko Skrtic, Xiaoming Li, Rose Hurren, Xinliang Mao, Meenakshi Venkatesan, Reza Beheshti Zavareh, Troy Ketela, John C. Reed, David Rose, Jason Moffat, Robert A. Batey, Sirano Dhe-Paganon, Aaron D. Schimmer
Journal: Blood
Blood (2010) 115 (11): 2251–2259.
https://doi.org/10.1182/blood-2009-07-231191
Published: 2010
Includes: Supplemental data