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Loren D. Walensky
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Journal Articles

Stapled BAD BH3 Helices Effectively Target BCL-2 Mutants That Cause Venetoclax Resistance

Thomas M. Deangelo, Utsarga Adhikary, Kyle J. Korshavn, Clara R. Brotzen-Smith, Hyuk-Soo Seo, Kijun Song, Luke Sebastian, Sirano Dhe-Paganon, Thomas E. Wales, Gregory H. Bird, Loren D. Walensky
Journal: Blood
Blood (2024) 144 (Supplement 1): 7472.
https://doi.org/10.1182/blood-2024-208553
Published: 2024
Journal Articles

Dissecting the Role of Individual Bcl-2 Members in Response and Resistance to Ibrutinib or Venetoclax in CLL

Fabio Brocco, Hanneke ter Burg, Stacey Fernandes, Constantine S. Tam, MBBS, MD FRACP, FRCPA, Francesco Forconi, MD DM, PhD FRCPath, Rachel M Guerra, Gregory Bird, Loren D Walensky, Jennifer R. Brown, MD PhD, Arnon P Kater, Eric Eldering
Journal: Blood
Blood (2017) 130 (Supplement 1): 262.
https://doi.org/10.1182/blood.V130.Suppl_1.262.262
Published: 2017
Journal Articles

SOX11 Cooperates with CCND1 in Mantle Cell Lymphoma Pathogenesis

Pei-Yu Kuo, MS, Zewei Jiang, MD, Deepak Perumal, PhD, Violetta V Leshchenko, PhD, Alessandro Lagana', PhD, Samuel G. Katz, MD PhD, Loren D. Walensky, MD PhD, Rita Shaknovich, MD, PhD, B. Hilda Ye, PhD, Samir Parekh, MD
Journal: Blood
Blood (2015) 126 (23): 1253.
https://doi.org/10.1182/blood.V126.23.1253.1253
Published: 2015
Journal Articles

Mantle cell lymphoma in cyclin D1 transgenic mice with Bim -deficient B cells

Samuel G. Katz, James L. LaBelle, Hailong Meng, Regina P. Valeriano, Jill K. Fisher, Heather Sun, Scott J. Rodig, Steven H. Kleinstein, Loren D. Walensky
Journal: Blood
Blood (2014) 123 (6): 884–893.
https://doi.org/10.1182/blood-2013-04-499079
Published: 2014
Includes: Supplemental data
Journal Articles

A Stapled BIM BH3 Helix Restores Apoptosis In Bim -Null Mantle Cell Lymphoma

Samuel G Katz, MD, PhD, James L Labelle, MD, PhD, Marina Godes, Jill Fisher, Gregory H. Bird, PhD, Loren D. Walensky, MD, PhD
Journal: Blood
Blood (2010) 116 (21): 437.
https://doi.org/10.1182/blood.V116.21.437.437
Published: 2010
Journal Articles

Dissecting the Activation Pathway of Pro-Apoptotic BAX: Mechanistic Insights and Pharmacologic Opportunities.

Evripidis Gavathiotis, PhD, Marguerite Davis, Denis Reyna Ruiz, Gregory H. Bird, PhD, Loren D. Walensky, MD, PhD
Journal: Blood
Blood (2009) 114 (22): 768.
https://doi.org/10.1182/blood.V114.22.768.768
Published: 2009
Journal Articles

A Stapled BIM BH3 Helix Overcomes the MCL-1-Mediated Apoptotic Blockade of Refractory Hematologic Cancers

James L. Labelle, MD, PhD, Chelsea E. Lawrence, Gregory H. Bird, Ph.D., Loren D. Walensky, M.D., Ph.D.
Journal: Blood
Blood (2008) 112 (11): 862.
https://doi.org/10.1182/blood.V112.11.862.862
Published: 2008
Journal Articles

Structural Analysis of a BAX-BIM SAHB Complex Reveals a Novel BH3 Interaction Site on BAX for Therapeutic Activation of Apoptosis

Evripidis Gavathiotis, Ph.D., Motoshi Suzuki, Ph.D., Marguerite L. Davis, Kenneth Pitter, Gregory H. Bird, PhD, Samuel G. Katz, MD, PhD, Ho-Chou Tu, Hyungjin Kim, Emily Cheng, M.D., Ph.D., Nico Tjandra, Ph.D., Loren D. Walensky, MD, PhD
Journal: Blood
Blood (2008) 112 (11): 300.
https://doi.org/10.1182/blood.V112.11.300.300
Published: 2008
Journal Articles

A Stapled p53 Helix Targets HDMX to Overcome Nutlin-3 Resistance and Reactivate the p53 Tumor Suppressor Pathway in Cancer

Federico Bernal, Ph.D., Mark Wade, Ph.D., Amy M. Silverstein, Gregory L. Verdine, Ph.D., Geoffrey M. Wahl, Ph.D., Loren D. Walensky, M.D., Ph.D.
Journal: Blood
Blood (2008) 112 (11): 2645.
https://doi.org/10.1182/blood.V112.11.2645.2645
Published: 2008
Journal Articles

Pharmacologic Replacement of BIM BH3 Reactivates Apoptosis in Hematologic Cancer and Lymphoproliferative Disease.

James L. LaBelle, MD, PhD, Jill K. Fisher, Samuel G. Katz, MD, PhD, Gregory H. Bird, PhD, Chelsea E. Lawrence, Amy M. Silverstein, Loren D. Walensky, MD, PhD
Journal: Blood
Blood (2007) 110 (11): 524.
https://doi.org/10.1182/blood.V110.11.524.524
Published: 2007
Journal Articles

Selective Targeting of the p53-hDM2 Interaction Using Hydrocarbon-Stapled p53 Peptides.

Federico Bernal, PhD, Loren D. Walensky, MD,PhD, Andrew F. Tyler, Stanley J. Korsmeyer, MD, Gregory L. Verdine, PhD
Journal: Blood
Blood (2006) 108 (11): 525.
https://doi.org/10.1182/blood.V108.11.525.525
Published: 2006
Journal Articles

Anti-Leukemic Potency of Stapled BH3 Helices Correlates with Their Capacity for Bifunctional Activation of Apoptotic Pathways.

Loren D. Walensky, MD, PhD, Kenneth Pitter, Joel G. Morash, Gregory L. Verdine, PhD, Stanley J. Korsmeyer, MD
Journal: Blood
Blood (2006) 108 (11): 711.
https://doi.org/10.1182/blood.V108.11.711.711
Published: 2006