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Ruben D. Carrasco
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Journal Articles

Establishment of a Novel Waldenström's Macroglobulinemia (WM) Cell Line Bcwm.2 with Del6q and Unique MYD88 S243N , LYN I297N , SPI1 Q227E Mutations and That Shows Robust In Vivo Engraftment in SCID NOD Mice

Shirong Liu, Xia Liu, Choudhury Fabliha Binte Yusuf, Amanda Kofides, Kara M Soroko, Johany Penailillo, Alexa G Canning, Yang Cao, Guang Yang, Lian Xu, Nickolas Tsakmaklis, Maria Luisa Guerrera, Christopher J Patterson, Ruben D. Carrasco, Prafulla C. Gokhale, Shayna R Sarosiek, Jorge J. Castillo, Zachary R Hunter, Steven P. Treon
Journal: Blood
Blood (2024) 144 (Supplement 1): 5834.
https://doi.org/10.1182/blood-2024-211381
Published: 2024
Journal Articles

Discovery of Undocumented, Cancer-Specific and Pro-Inflammatory Isoforms of WNK2 That Are Highly Expressed in MYD88 Mutated Waldenström's Macroglobulinemia and Represent Novel Therapeutic Targets.

Maria Luisa Guerrera, Xia Liu, John M Hatcher, Nickolas Tsakmaklis, Amanda Kofides, Abigail Peachey, Hao Sun, Shirong Liu, Christopher J Patterson, Eugenio Morelli, Jorge J. Castillo, Shayna R Sarosiek, Catherine A. Flynn, Kirsten Meid, Andrew R. Branagan, Ruben D. Carrasco, Kenneth C. Anderson, Nikhil C. Munshi, Steven P. Treon, Zachary R Hunter
Journal: Blood
Blood (2024) 144 (Supplement 1): 2972.
https://doi.org/10.1182/blood-2024-211759
Published: 2024
Journal Articles

Bone Marrow Spatial Signatures Predict Survival Outcomes and Toxicities after CAR-T Therapy in Patients with Relapsed/Refractory Multiple Myeloma

Yoshinobu Konishi, David M. Cordas Dos Santos, Jacopo U. Verga, Patrick Costello, Sujal I. Shah, Qanber Raze, Liang S. Lim, Arnaldo G. Barican, David Howell, David King, Katherine Towle, Ruben D. Carrasco, Scott J. Rodig, Jon C. Aster, Adam S. Sperling, Eric L. Smith, Jacob Laubach, Nikhil C. Munshi, Kenneth C. Anderson, Omar Nadeem, Irene Ghobrial
Journal: Blood
Blood (2024) 144 (Supplement 1): 590.
https://doi.org/10.1182/blood-2024-204144
Published: 2024
Journal Articles

A Novel Ribonuclease Targeting Small Molecule RNA-Degrader (MYC-RiboTAC) Overcomes MYC Dependency in Multiple Myeloma

Domenico Maisano, Tenghui Wang, Yuquan Tong, Vanessa Favasuli, Na Liu, Claire Gao, Chandraditya Chakraborty, Giulia Giorgetti, Francesco Ladisa, Marcello Turi, Francesca Barello, Michela Cumerlato, Anil Aktas-Samur, Mehmet K. Samur, Michael Cameron, Filip Garbicz, Ruben D. Carrasco, Mariateresa Fulciniti, Annamaria Gulla, Jessica Childs-Disney, Matthew D. Disney, Eugenio Morelli, Nikhil C. Munshi
Journal: Blood
Blood (2024) 144 (Supplement 1): 3268.
https://doi.org/10.1182/blood-2024-205528
Published: 2024
Journal Articles

Loss of GABARAP mediates resistance to immunogenic chemotherapy in multiple myeloma

Annamaria Gulla, Eugenio Morelli, Megan Johnstone, Marcello Turi, Mehmet K. Samur, Cirino Botta, Selma Cifric, Pietro Folino, Delaney Vinaixa, Francesca Barello, Cole Clericuzio, Vanessa Katia Favasuli, Domenico Maisano, Srikanth Talluri, Rao Prabhala, Giada Bianchi, Mariateresa Fulciniti, Kenneth Wen, Keiji Kurata, Jiye Liu, Johany Penailillo, Alberto Bragoni, Anna Sapino, Paul G. Richardson, Dharminder Chauhan, Ruben D. Carrasco, Teru Hideshima, Nikhil C. Munshi, Kenneth C. Anderson
Journal: Blood
Blood (2024) 143 (25): 2612–2626.
https://doi.org/10.1182/blood.2023022777
Published: 2024
Includes: Supplemental data
Journal Articles

Atypical Stem Cell, Pre-B-Cell, T-Cell and Myeloid Gene Expression Characterizes Early Waldenstrom's Macroglobulinemia Clones Which Diminishes with Advancing Disease and Has Therapeutic Implications

Zachary R Hunter, Maria Luisa Guerrera, Ruben D. Carrasco, Nickolas Tsakmaklis, Kris Richardson, Amanda Kofides, Xia Liu, Shirong Liu, Catherine A. Flynn, Kirsten Meid, Joshua Gustine, Christopher J Patterson, Mariateresa Fulciniti, Mehmet K. Samur, Tomasz Sewastianik, Kenneth C. Anderson, Nikhil C Munshi, Shayna R Sarosiek, Jorge J. Castillo, Steven P Treon
Journal: Blood
Blood (2023) 142 (Supplement 1): 756.
https://doi.org/10.1182/blood-2023-190685
Published: 2023
Journal Articles

Establishment of the Bcwm.2 Cell Line As a BTK-Inhibitor Resistant, BCL2 Inhibitor Sensitive in Vitro and In Vivo Study Model for Waldenström's Macroglobulinemia

Shirong Liu, Xia Liu, Kara M Soroko, Alexa G Canning, Amanda Kofides, Choudhury Fabliha Binte Yusuf, Johany Penailillo, Nickolas Tsakmaklis, Christopher J Patterson, Ruben D. Carrasco, Zachary R Hunter, Prafulla C. Gokhale, Shayna R Sarosiek, Jorge J. Castillo, Steven P Treon
Journal: Blood
Blood (2023) 142 (Supplement 1): 6613.
https://doi.org/10.1182/blood-2023-190147
Published: 2023
Journal Articles

Transcriptomic Features Influencing Anti-Myeloma Drug Resistance in Human Multiple Myeloma Cell Lines

Filip Garbicz, Irena Misiewicz-Krzeminska, Ruben D. Carrasco, Przemysław Juszczyński
Journal: Blood
Blood (2023) 142 (Supplement 1): 1943.
https://doi.org/10.1182/blood-2023-190247
Published: 2023
Journal Articles

Aberrant Expression of Spliced WNK2 Is an Early Event in MYD88 Mutated WM That Activates ERK1/2 and Supports Tumor Growth

Maria Luisa Guerrera, Zachary R Hunter, Kris Richardson, Nickolas Tsakmaklis, Amanda Kofides, Shirong Liu, Christopher J Patterson, Eugenio Morelli, Jorge J. Castillo, Shayna R Sarosiek, Catherine A. Flynn, Kirsten Meid, Andrew R. Branagan, Ruben D. Carrasco, Kenneth C. Anderson, Nikhil C Munshi, Steven P Treon, Xia Liu
Journal: Blood
Blood (2023) 142 (Supplement 1): 3303.
https://doi.org/10.1182/blood-2023-190880
Published: 2023
Journal Articles

Ubiquitin receptor PSMD4/Rpn10 is a novel therapeutic target in multiple myeloma

Ting Du, Yan Song, Arghya Ray, Xueping Wan, Yao Yao, Mehmet K. Samur, Chen Shen, Johany Penailillo, Tomasz Sewastianik, Yu-Tzu Tai, Mariateresa Fulciniti, Nikhil C. Munshi, Hao Wu, Ruben D. Carrasco, Dharminder Chauhan, Kenneth C. Anderson
Journal: Blood
Blood (2023) 141 (21): 2599–2614.
https://doi.org/10.1182/blood.2022017897
Published: 2023
Includes: Supplemental data
Journal Articles

Super-Enhancer-Driven PIM Kinase Upregulation in Multiple Myeloma Maintains the Plasma Cell-Specific Oncogenic and Microenvironmental Circuits, and Can be Efficiently Targeted By the Pan-PIM Inhibitor MEN1703

Filip Garbicz, Sonia Debek, Anna Szumera-Ciećkiewicz, Joanna Barankiewicz, Dorota Komar, Michał Pawlak, Aleksandra Matrejek, Thorsten Stuehmer, Aleksander Salomon-Perzynski, Agata Malenda, Julia Ostrowska, Julia Dudkiewicz, Krzysztof Brzózka, Tomasz Rzymski, Daniela Bellarosa, Ewa Lech-Marańda, Monika Prochorec-Sobieszek, Zofia Pilch, Dominika Nowis, Jakub Golab, Helen Tanton, Teru Hideshima, David M. Dorfman, Irena Misiewicz-Krzeminska, Tomasz Sewastianik, Ruben D. Carrasco, Maciej Szydlowski, Przemyslaw Juszczynski
Journal: Blood
Blood (2022) 140 (Supplement 1): 4189–4190.
https://doi.org/10.1182/blood-2022-168770
Published: 2022
Journal Articles

26S Proteasome Non-Atpase Subunit 1, PSMD1/Rpn2, Is a Potential Therapeutic Target in Multiple Myeloma

Ting Du, Xueping Wan, Arghya Ray, Yao Yao, Ruben D. Carrasco, Mariateresa Fulciniti, Nikhil C Munshi, Dharminder Chauhan, Kenneth C. Anderson
Journal: Blood
Blood (2022) 140 (Supplement 1): 8853–8854.
https://doi.org/10.1182/blood-2022-163749
Published: 2022
Journal Articles

The ERK1/2 Regulator WNK2 Shows Novel Alternative Splicing Aberrations That Support Tumor Growth in MYD88 Mutated Waldenström's Macroglobulinemia

Maria Luisa Guerrera, Xia Liu, Eugenio Morelli, Kris Richardson, Nickolas Tsakmaklis, Amanda Kofides, Manit Munshi, Shirong Liu, Guang Yang, Christopher J Patterson, Jorge J. Castillo, Shayna Sarosiek, Catherine A. Flynn, Kirsten Meid, Joshua Gustine, Andrew R. Branagan, Alessandra Trojani, Alessandra Tedeschi, Roberto Cairoli, Tomasz Sewastianik, Ruben D. Carrasco, Kenneth C. Anderson, Nikhil C Munshi, Steven P Treon, Zachary R Hunter
Journal: Blood
Blood (2022) 140 (Supplement 1): 1549–1550.
https://doi.org/10.1182/blood-2022-169863
Published: 2022
Journal Articles

Targeting Autophagy to Overcome Resistance to Immunogenic Chemotherapy in High-Risk Multiple Myeloma

Annamaria Gulla, Eugenio Morelli, Mehmet K. Samur, Megan Johnstone, Cirino Botta, Delaney Vinaixa, Marcello Turi, Mariateresa Fulciniti, Kenneth Wen, Selma Cifric, Srikanth Talluri, Giada Bianchi, Rao Prabhala, Paul G. Richardson, Dharminder Chauhan, Ruben D. Carrasco, Teru Hideshima, Nikhil C Munshi, Kenneth C. Anderson
Journal: Blood
Blood (2022) 140 (Supplement 1): 7114–7115.
https://doi.org/10.1182/blood-2022-162653
Published: 2022
Journal Articles

The ERK1/2 Regulator WNK2 Shows Differential Expression and Isoform Usage, Primarily Driven By Aberrant Methylation, in MYD88 Mutated Waldenström's Macroglobulinemia

Maria Luisa Guerrera, Guang Yang, Xia Liu, Nickolas Tsakmaklis, Maria G Demos, Amanda Kofides, Manit Munshi, Lian Xu, Christopher J Patterson, Jorge J. Castillo, Shayna Sarosiek, Catherine A Flynn, Kirsten Meid, Joshua Gustine, Tomasz Sewastianik, Ruben D. Carrasco, Steven P Treon, Zachary R Hunter
Journal: Blood
Blood (2021) 138 (Supplement 1): 2692.
https://doi.org/10.1182/blood-2021-154160
Published: 2021
Journal Articles

Ubiquitin Receptor PSMD4/Rpn10 Is a Novel Therapeutic Target in Myeloma

Ting DU, Yan Song, Arghya Ray, Ruben D. Carrasco, Sirano Dhe-Paganon, Dharminder Chauhan, Kenneth C. Anderson
Journal: Blood
Blood (2021) 138 (Supplement 1): 1591.
https://doi.org/10.1182/blood-2021-151377
Published: 2021
Journal Articles

B Cell-Restricted Depletion of Dnmt3a Activates Notch Signaling and Causes Chronic Lymphocytic Leukemia

Shanye Yin, Anat Biran, Helene Kretzmer, Elisa Ten Hacken, Salma Parvin, Fabienne Lucas, Mohamed Uduman, Catherine Gutierrez, Nathan J Dangle, Leah Billington, Fara Regis, Laura Z. Rassenti, Arman W. Mohammad, Mei Zheng, Elizabeth Witten, Thomas J. Kipps, Jon C. Aster, Andreas Gnirke, Donna S. Neuberg, Anthony G. Letai, Lili Wang, Ruben D. Carrasco, Alexander Meissner, Catherine J. Wu
Journal: Blood
Blood (2021) 138 (Supplement 1): 249.
https://doi.org/10.1182/blood-2021-150789
Published: 2021
Journal Articles

Dissecting Richter's Syndrome in a Multiplexed CRISPR-Based Mouse Model Reveals Key Changes in MYC, Interferon and BCR Signaling Underlying Transformation

Elisa Ten Hacken, Shanye Yin, Tomasz Sewastianik, Livius Penter, Neil Ruthen, Michaela Gruber, Erin Michelle Parry, Romain Guieze, Robert A. Redd, Mohamed Uduman, Shuqiang Li, Jackson Southard, Maria Hernandez-Sanchez, Salma Parvin, Fen Zhu, Gabriela Brunsting Hoffmann, Elizabeth Witten, Kenneth J. Livak, Matthew S. Davids, Anthony G. Letai, Donna S. Neuberg, Ruben D. Carrasco, Catherine J. Wu
Journal: Blood
Blood (2021) 138 (Supplement 1): 251.
https://doi.org/10.1182/blood-2021-148614
Published: 2021
Journal Articles

miR-15a/16-1 deletion in activated B cells promotes plasma cell and mature B-cell neoplasms

Tomasz Sewastianik, Juerg R. Straubhaar, Jian-Jun Zhao, Mehmet K. Samur, Keith Adler, Helen E. Tanton, Vignesh Shanmugam, Omar Nadeem, Peter S. Dennis, Vinodh Pillai, Jianli Wang, Meng Jiang, Jianhong Lin, Ying Huang, Daniel Brooks, Mary Bouxsein, David M. Dorfman, Geraldine S. Pinkus, Davide F. Robbiani, Irene M. Ghobrial, Bogdan Budnik, Petr Jarolim, Nikhil C. Munshi, Kenneth C. Anderson, Ruben D. Carrasco
Journal: Blood
Blood (2021) 137 (14): 1905–1919.
https://doi.org/10.1182/blood.2020009088
Published: 2021
Includes: Supplemental data
Journal Articles

RPS15 and TP53 Co-Mutation Drives B Cell Malignancy through Altered Translation and MYC Activation in a Murine Model

Catherine Gutierrez, Tamara Ouspenskaia, PhD, Doris Fu, Peyton Waddicor, B.S., Anat Biran, PhD, Aviv Liani, Gregory Lazarian, PharmD, Elisa Ten Hacken, PhD, Elizabeth Witten, Fara Faye Regis, BS, Heather Joyal, Leah Billington, BA, Fabienne Lucas, MDPhD, Mei Zheng, Blake Tye, PhD, Maria Hernandez-Sanchez, PhD, Miguel Quijada Álamo, MSc, Shuqiang Li, PhD, Binyamin A. Knisbacher, PhD, Ziao Lin, BS, Aziz Al'Khafaji, PhD, Lili Wang, MDPhD, Kenneth J. Livak, PhD, Donna S. Neuberg, ScD, Florence Cymbalista, MD PhD, Gad Getz, PhD, Stirling Churchman, PhD, Ruben D. Carrasco, MD PhD, Sichen Shao, PhD, Aviv Regev, PhD, Catherine J. Wu, MD
Journal: Blood
Blood (2020) 136 (Supplement 1): 28–29.
https://doi.org/10.1182/blood-2020-138900
Published: 2020