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Anthony G. Letai
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Journal Articles

Feasibility, Safety and Efficacy of Oral Maintenance Therapy with Venetoclax Plus Decitabine/Cedazuridine after Venetoclax Plus FluBu2 for High Risk MDS/AML Undergoing RIC Allo-HCT

Jacqueline S. Garcia, Haesook T. Kim, Jennifer Brock, H. Moses Murdock, Mahasweta Gooptu, Vincent T. Ho, Roman M. Shapiro, Christopher J. Gibson, Amar H. Kelkar, Corey S. Cutler, Denbaa Bat-Erdene, Jeremy Ryan, Anna Bosch-Vilaseca, Anthony G. Letai, Jerome Ritz, Coleman Lindsley, Robert J. Soiffer, Joseph Antin
Journal: Blood
Blood (2024) 144 (Supplement 1): 1045.
https://doi.org/10.1182/blood-2024-194170
Published: 2024
Journal Articles

Failure to Execute Caspase Activation Drives Therapy Resistance in TP53 Mutated AML

Ahmed M Mamdouh, Fang Qi Lim, Yang Mi, Elyse A Olesinski, Yichen Wang, Shaista Shabbir Jasdanwala, Karanpreet Singh Bhatia, Xiao Xian Lin, Valeriia Sapozhnikova, Philipp Mertins, Brandon D. Brown, Yihua Qiu, Anthony G. Letai, Alexandre Puissant, Steven M. Kornblau, Jan Krönke, Edward Ayoub, Koji Itahana, Michael Andreeff, Shruti Bhatt
Journal: Blood
Blood (2024) 144 (Supplement 1): 53.
https://doi.org/10.1182/blood-2024-211997
Published: 2024
Journal Articles

Identifying Novel Drug Vulnerabilities in Specified Molecular Subsets of Chronic Lymphocytic Leukemia

Salma Parvin, Binyamin Knisbacher, Aditi Aryal, Stacey M. Fernandes, Shlomi Medalion, Guy Leib, Johan Gustafsson, Shir Amit, Eden C Meidan, Nadav Y Klein, Savion Nafussy, Donna S. Neuberg, Catherine J. Wu, Jennifer R. Brown, Gad Getz, Anthony G. Letai
Journal: Blood
Blood (2024) 144 (Supplement 1): 76.
https://doi.org/10.1182/blood-2024-201594
Published: 2024
Journal Articles

Dual Bclxl and BCL2 Inhibition with Navitoclax (NAV), Venetoclax (VEN), and Decitabine (DEC) for Advanced Myeloid Neoplasms (MN): Safety and Biological Activity in a Phase 1 Study

Evan C. Chen, Yiwen Liu, Hayden L. Bell, Ilene A. Galinsky, Marlise R. Luskin, Eric S. Winer, Maximilian Stahl, Rahul Vedula, Virginia O. Volpe, Daniel J. DeAngelo, Karen Quillen, Jeremy Ryan, Emma-Jayne Minihane, Matthew Hersch, Rebecca Leonard, Donna S. Neuberg, Richard M. Stone, Anthony G. Letai, Andrew A. Lane, Jacqueline S. Garcia
Journal: Blood
Blood (2024) 144 (Supplement 1): 4580.
https://doi.org/10.1182/blood-2024-198284
Published: 2024
Journal Articles

Final Analysis of a Phase I Study of Escalating Doses of the BCL-2 Inhibitor Venetoclax in Combination with Daunorubcin/Cytarabine Induction and High Dose Cytarabine Consolidation in Previously Untreated Adults with Acute Myeloid Leukemia

Richard M Stone, Daniel J. DeAngelo, Anthony G. Letai, Ilene A. Galinsky, Howard Weiner, Austen Halpin, Lexi Noyes, Hunter Smith, Carter Lombardi, Rebecca Leonard, Geoffrey Fell, Yael Flammand, Jeremy Ryan, Marina Konopleva, Martha Wadleigh, Maximilian Stahl, Evan Chen, Virginia O. Volpe, Eric S. Winer, Jacqueline S. Garcia, Marlise R. Luskin, Anand Ashwin Patel
Journal: Blood
Blood (2024) 144 (Supplement 1): 4261.
https://doi.org/10.1182/blood-2024-203683
Published: 2024
Journal Articles

Mini-Hyper-CVD Plus Venetoclax for Treatment of Older Adults with Newly Diagnosed Ph-Negative B-ALL or T-ALL

Marlise R. Luskin, Shai Shimony, Julia Keating, Wendy Stock, Hanno Hock, Jacqueline S. Garcia, Maximilian Stahl, Ilene Galinksy, Rebecca Leonard, Howard Weiner, Yael Flamand, Donna S. Neuberg, Richard M Stone, Anthony G. Letai, Eric S. Winer, Marina Y. Konopleva, Nitin Jain, Daniel J. DeAngelo
Journal: Blood
Blood (2023) 142 (Supplement 1): 2875.
https://doi.org/10.1182/blood-2023-174269
Published: 2023
Journal Articles

Targeting Mitochondrial Apoptotic Priming State to Personalize Therapy for Relapsed Acute Myeloid Leukemia

Elyse Olesinski, Karanpreet Bhatia, Chuqi Wang, Marissa Pioso, Shu Xuan Ng, Xiao Xian Lin, Vedant Sandhu, Binyam Yilma, Stephan Rainer Maximilian Bohl, Jeremy Ryan, Disha Malani, Marlise R. Luskin, Olli Kallioniemi, Kimmo Porkka, Allen Yeoh, Sophia Adamia, Wee Joo Chng, Motomi Osato, David M. Weinstock, Jacqueline S. Garcia, Anthony G. Letai, Shruti Bhatt
Journal: Blood
Blood (2023) 142 (Supplement 1): 48.
https://doi.org/10.1182/blood-2023-189156
Published: 2023
Journal Articles

A Phase I Study of Venetoclax in Combination with Inotuzumab Ozogamicin for Relapsed or Refractory ALL in Adults

Marlise R. Luskin, Shai Shimony, Julia Keating, Yael Flamand, Jacqueline S. Garcia, Rebecca Leonard, Thomas Reardon, Taylor Robertson, Chase M Weizer, Ilene Galinsky, Donna S. Neuberg, Richard M Stone, Eric S. Winer, Anthony G. Letai, Mark Alan Murakami, Daniel J. DeAngelo
Journal: Blood
Blood (2023) 142 (Supplement 1): 1509.
https://doi.org/10.1182/blood-2023-174216
Published: 2023
Journal Articles

Integrating High-Throughput Dynamic BH3 Profiling and Molecular Phenotyping to Identify Therapeutic Vulnerabilities in CLL

Salma Parvin, Binyamin A. Knisbacher, Aditi Aryal, Stacey M. Fernandes, Donna S. Neuberg, Catherine J. Wu, Jennifer R. Brown, Gad Getz, Anthony G. Letai
Journal: Blood
Blood (2022) 140 (Supplement 1): 6983–6984.
https://doi.org/10.1182/blood-2022-169352
Published: 2022
Journal Articles

Cellular Plasticity As Mechanisms to Escape from NOTCH1-Inhibition in T-ALL

Valeriya Dimitrova, Noori Sotudeh, Birgit Knoechel, Jens G. Lohr, Anna Montanaro, Sayalee V. Potdar, Julia Frede, Alexandria Van Scoyk, Shruti Bhatt, Praveen Anand, Jon C. Aster, David M Weinstock, Anthony G. Letai
Journal: Blood
Blood (2022) 140 (Supplement 1): 3461–3462.
https://doi.org/10.1182/blood-2022-170319
Published: 2022
Journal Articles

Maintenance Therapy with Venetoclax/Azacitidine Can be Safely Given after Venetoclax/FluBu2 RIC Allogeneic Transplantation for the Treatment of High Risk MDS/AML: Results of a Phase 1 Study

Jacqueline S. Garcia, Haesook T Kim, Jennifer Brock, H. Moses Murdock, Corey S. Cutler, Daniel J. DeAngelo, Christopher J. Gibson, Mahasweta Gooptu, Vincent Ho, John Koreth, Marlise R. Luskin, Sarah Nikiforow, Rizwan Romee, Roman M Shapiro, Richard M. Stone, Martha Wadleigh, Eric S. Winer, Michela Ansuinelli, Eliza Elliot, Geoffrey Fell, Hannah Karp, Jeremy Ryan, Anthony G. Letai, Coleman Lindsley, Robert J Soiffer, Joseph H. Antin, Fiona Loschi, Jerome Ritz
Journal: Blood
Blood (2022) 140 (Supplement 1): 917–919.
https://doi.org/10.1182/blood-2022-157611
Published: 2022
Journal Articles

Maturity State and MCL-1 Dependence Predetermines Response to NOTCH1 Inhibition in T-ALL

Valeriya Dimitrova, Noori Sotudeh, Anna Montanaro, Huiyoung Yun, Sayalee V. Potdar, Alexandria Van Scoyk, Shruti Bhatt, Praveen Anand, Antonis Kokkalis, Jake A. Kloeber, Julia Frede, Johannes M Waldschmidt, Anthony G. Letai, David M. Weinstock, Jens G. Lohr, Birgit Knoechel
Journal: Blood
Blood (2021) 138 (Supplement 1): 3484.
https://doi.org/10.1182/blood-2021-153829
Published: 2021
Journal Articles

Identification of Novel Targets Based on Splicing Alterations for Undruggable RAS/CDK Signaling Cascade in Multiple Myeloma

Sophia Adamia, Zuzana Chyra, Morgan O'Keefe, Shruti Bhatt, Kenneth Wen, Geoffrey G Fell, Yu-Tzu Tai, Anthony G. Letai, Ivane Abiatari, David M. Dorfman, Teru Hideshima, Kenneth C. Anderson
Journal: Blood
Blood (2021) 138 (Supplement 1): 2688.
https://doi.org/10.1182/blood-2021-152986
Published: 2021
Journal Articles

B Cell-Restricted Depletion of Dnmt3a Activates Notch Signaling and Causes Chronic Lymphocytic Leukemia

Shanye Yin, Anat Biran, Helene Kretzmer, Elisa Ten Hacken, Salma Parvin, Fabienne Lucas, Mohamed Uduman, Catherine Gutierrez, Nathan J Dangle, Leah Billington, Fara Regis, Laura Z. Rassenti, Arman W. Mohammad, Mei Zheng, Elizabeth Witten, Thomas J. Kipps, Jon C. Aster, Andreas Gnirke, Donna S. Neuberg, Anthony G. Letai, Lili Wang, Ruben D. Carrasco, Alexander Meissner, Catherine J. Wu
Journal: Blood
Blood (2021) 138 (Supplement 1): 249.
https://doi.org/10.1182/blood-2021-150789
Published: 2021
Journal Articles

Dissecting Richter's Syndrome in a Multiplexed CRISPR-Based Mouse Model Reveals Key Changes in MYC, Interferon and BCR Signaling Underlying Transformation

Elisa Ten Hacken, Shanye Yin, Tomasz Sewastianik, Livius Penter, Neil Ruthen, Michaela Gruber, Erin Michelle Parry, Romain Guieze, Robert A. Redd, Mohamed Uduman, Shuqiang Li, Jackson Southard, Maria Hernandez-Sanchez, Salma Parvin, Fen Zhu, Gabriela Brunsting Hoffmann, Elizabeth Witten, Kenneth J. Livak, Matthew S. Davids, Anthony G. Letai, Donna S. Neuberg, Ruben D. Carrasco, Catherine J. Wu
Journal: Blood
Blood (2021) 138 (Supplement 1): 251.
https://doi.org/10.1182/blood-2021-148614
Published: 2021
Journal Articles

Pre-Clinical Validation of a Novel Erk1/2 and CDK4/6 Inhibitor Combination in Multiple Myeloma (MM)

Sophia Adamia, PhD, Shruti Bhatt, PhD, Yu-Tzu Tai, PhD, Kenneth Wen, Catherine A Nicholas, Marissa S Pioso, Ivane Abiatari, MD, Anthony G. Letai, MD PhD, Kenneth Anderson, MD
Journal: Blood
Blood (2020) 136 (Supplement 1): 22–23.
https://doi.org/10.1182/blood-2020-142596
Published: 2020
Journal Articles

CCR2 Expression Signature Can Classify and Predict Outcome in a Subpopulation of Chronic Lymphocytic Leukemia (CLL) Patients

Salma Parvin, PhD, Aditi Aryal, BA, Matthew S. Davids, MD, Anthony G. Letai, MD PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 13–14.
https://doi.org/10.1182/blood-2020-141642
Published: 2020
Journal Articles

Results of Venetoclax and Azacitidine Combination in Chemotherapy Ineligible Untreated Patients with Acute Myeloid Leukemia with FLT3 Mutations

Marina Konopleva, MD PhD, Michael Thirman, MD, Keith W. Pratz, MD, Anthony G. Letai, MD PhD, Christian Recher, MD PhD, Vinod A. Pullarkat, MD, Hagop M. Kantarjian, MD, Monique Dail, PhD, Yinghui Duan, PhD, Brenda J. Chyla, Jalaja Potluri, MD, Catherine Miller, PharmD, Courtney D. Dinardo, MDMSc, Andrew H. Wei, MBBS, PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 8–10.
https://doi.org/10.1182/blood-2020-134100
Published: 2020
Journal Articles

Maximal Tolerated Dose of the BCL-2 Inhibitor Venetoclax in Combination with Daunorubicin/Cytarabine Induction in Previously Untreated Adults with Acute Myeloid Leukemia (AML)

Richard M. Stone, MD, Daniel J. DeAngelo, MD PhD, Anthony G. Letai, MD PhD, Jeremy M. Stewart, BA, Michael McGinnis, Francis Brown, JD, Geoffrey Fell, Yael Flammand, Marina Konopleva, MD PhD, Jacqueline S. Garcia, MD, Marlise R Luskin, MDMS
Journal: Blood
Blood (2020) 136 (Supplement 1): 40–41.
https://doi.org/10.1182/blood-2020-140646
Published: 2020
Journal Articles

MCL-1 and PKA/AMPK Axis Fuel Venetoclax Resistance in Lymphoid Cancers

Vivian M. Liu, MD, Romain Guièze, MD, Daniel Rosebrock, Alexis A Jourdain, PhD, María Hernández-Sánchez, PhD, Aina Zurita Martinez, Elisa Ten Hacken, PhD, Philip A. Thompson, MBBS, Julian Bryan Iorgulescu, MD PhD, Shuqiang Li, PhD, Matthew S. Davids, MD, Jennifer R. Brown, MD PhD, Ana Lako, Zoe B. Ciantra, Matthew A. Lawlor, William G. Wierda, MD PhD, Anthony G. Letai, MD PhD, Donna S Neuberg, ScD, Christopher J. Ott, PhD, Ignaty Leshchiner, PhD, Vamsi Mootha, MD, Gad Getz, PhD, Catherine J. Wu, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1284.
https://doi.org/10.1182/blood-2019-131336
Published: 2019