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Xiao Xian Lin
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Journal Articles

Dissection of non-genetic resistance mechanisms by lineage tracing and single cell multiomics reveals drug-specific persister programs in Acute Myeloid Leukemia

Free
Karanpreet Bhatia, Xiao Xian Lin, Ankit Jana, Emanuelle Grody, Ryan Jeremy Lim Jing Wei, Shawn Koh Jia Jun, Elisha Teh Jia Yu, Cin thet Kyi, Prasad Iyer, Greg Kellogg, Yogesh Goyal, Lawrence Boise, Yaara Oren, Shruti Bhatt
Journal: Blood
Blood (2025) 146 (Supplement 1): 640.
https://doi.org/10.1182/blood-2025-640
Published: 2025
Journal Articles

CD43 functions as a CD47 independent “don't eat me” signal and novel immune checkpoint in AML

Free
Yun Li, Chuqi Wang, Javier Sanmartín‑Martínez, Bob vangasteren, Jordan Yong Ming Tan, Shaista Jasdanwala, Karanpreet Bhatia, Ankit Jana, Xiao Xian Lin, Yuhan Wang, Peter Miller, Adam Sperling, Anna Marneth, Shruti Bhatt
Journal: Blood
Blood (2025) 146 (Supplement 1): 5025.
https://doi.org/10.1182/blood-2025-5025
Published: 2025
Journal Articles

Integrated multiomics identifies inhibitors of apoptosis (IAPs) and death-inducing signaling complex (DISC) components as novel vulnerabilities to overcome immune evasion in TP53-inactivated Acute Myeloid Leukemia

Free
Jordan Yong Ming Tan, Chuqi Wang, Clara Kai Ting Koh, Yash Manish Agrawal, Wen Kang Soh, Fang Qi Lim, Yuhan Wang, Nishtha Chitkara, Xiao Xian Lin, Jia Chi Tan, Ahmed M Mamdouh, Gloryn Chia, Nicholas RJ Gascoigne, Shruti Bhatt
Journal: Blood
Blood (2025) 146 (Supplement 1): 386.
https://doi.org/10.1182/blood-2025-386
Published: 2025
Journal Articles

Mapping the Drug Combination Landscape for AML: An Integrative Ex Vivo Functional and Computational Approach

Free
Xiao Xian Lin, Christopher A. Eide, Stephen E. Kurtz, Vedant Sandhu, Noor Rashidha Binte Meera Sahib, Disha Malani, Melissa Gaik-Ming Ooi, Edward Chow, Sanjukta Das, Jeffrey W. Tyner, Shruti Bhatt
Journal: Blood
Blood (2024) 144 (Supplement 1): 271.
https://doi.org/10.1182/blood-2024-202802
Published: 2024
Journal Articles

Failure to Execute Caspase Activation Drives Therapy Resistance in TP53 Mutated AML

Free
Ahmed M Mamdouh, Fang Qi Lim, Yang Mi, Elyse A Olesinski, Yichen Wang, Shaista Shabbir Jasdanwala, Karanpreet Singh Bhatia, Xiao Xian Lin, Valeriia Sapozhnikova, Philipp Mertins, Brandon D. Brown, Yihua Qiu, Anthony G. Letai, Alexandre Puissant, Steven M. Kornblau, Jan Krönke, Edward Ayoub, Koji Itahana, Michael Andreeff, Shruti Bhatt
Journal: Blood
Blood (2024) 144 (Supplement 1): 53.
https://doi.org/10.1182/blood-2024-211997
Published: 2024
Journal Articles

Integrating Genomics and Functional Phenotypes to Refine Risk Assessment in Acute Myeloid Leukemia across the Age Spectrum: Insights from Singapore

Free
Prasad Iyer, Shaista Shabbir Jasdanwala, Xiao Xian Lin, Karanpreet Singh Bhatia, Germaine Shimin Liew, Si Ting Tai, Jameelah Sheik Mohamed, Wei-Ying Jen, Melissa Gaik-Ming Ooi, Allen Eng Juh Yeoh, Shruti Bhatt
Journal: Blood
Blood (2024) 144 (Supplement 1): 4305.
https://doi.org/10.1182/blood-2024-212029
Published: 2024
Journal Articles

Targeting Mitochondrial Apoptotic Priming State to Personalize Therapy for Relapsed Acute Myeloid Leukemia

Free
Elyse Olesinski, Karanpreet Bhatia, Chuqi Wang, Marissa Pioso, Shu Xuan Ng, Xiao Xian Lin, Vedant Sandhu, Binyam Yilma, Stephan Rainer Maximilian Bohl, Jeremy Ryan, Disha Malani, Marlise R. Luskin, Olli Kallioniemi, Kimmo Porkka, Allen Yeoh, Sophia Adamia, Wee Joo Chng, Motomi Osato, David M. Weinstock, Jacqueline S. Garcia, Anthony G. Letai, Shruti Bhatt
Journal: Blood
Blood (2023) 142 (Supplement 1): 48.
https://doi.org/10.1182/blood-2023-189156
Published: 2023
Journal Articles

Computational Approach Based on Independent Drug Action Identifies Clinically Relevant Combinations for Acute Myeloid Leukemia

Free
Xiao Xian Lin, Vedant Sandhu, Christopher A. Eide, Stephen E. Kurtz, Disha Malani, Tom Erkers, Olli Kallioniemi, Jeffrey W Tyner, Shruti Bhatt
Journal: Blood
Blood (2023) 142 (Supplement 1): 5015.
https://doi.org/10.1182/blood-2023-188731
Published: 2023