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Journal Articles

Failure to Execute Caspase Activation Drives Therapy Resistance in TP53 Mutated AML

Ahmed M Mamdouh, Fang Qi Lim, Yang Mi, Elyse A Olesinski, Yichen Wang, Shaista Shabbir Jasdanwala, Karanpreet Singh Bhatia, Xiao Xian Lin, Valeriia Sapozhnikova, Philipp Mertins, Brandon D. Brown, Yihua Qiu, Anthony G. Letai, Alexandre Puissant, Steven M. Kornblau, Jan Krönke, Edward Ayoub, Koji Itahana, Michael Andreeff, Shruti Bhatt
Journal: Blood
Blood (2024) 144 (Supplement 1): 53.
https://doi.org/10.1182/blood-2024-211997
Published: 2024
Journal Articles

Mapping the Drug Combination Landscape for AML: An Integrative Ex Vivo Functional and Computational Approach

Xiao Xian Lin, Christopher A. Eide, Stephen E. Kurtz, Vedant Sandhu, Noor Rashidha Binte Meera Sahib, Disha Malani, Melissa Gaik-Ming Ooi, Edward Chow, Sanjukta Das, Jeffrey W. Tyner, Shruti Bhatt
Journal: Blood
Blood (2024) 144 (Supplement 1): 271.
https://doi.org/10.1182/blood-2024-202802
Published: 2024
Journal Articles

Integrating Genomics and Functional Phenotypes to Refine Risk Assessment in Acute Myeloid Leukemia across the Age Spectrum: Insights from Singapore

Prasad Iyer, Shaista Shabbir Jasdanwala, Xiao Xian Lin, Karanpreet Singh Bhatia, Germaine Shimin Liew, Si Ting Tai, Jameelah Sheik Mohamed, Wei-Ying Jen, Melissa Gaik-Ming Ooi, Allen Eng Juh Yeoh, Shruti Bhatt
Journal: Blood
Blood (2024) 144 (Supplement 1): 4305.
https://doi.org/10.1182/blood-2024-212029
Published: 2024
Journal Articles

Targeting Mitochondrial Apoptotic Priming State to Personalize Therapy for Relapsed Acute Myeloid Leukemia

Elyse Olesinski, Karanpreet Bhatia, Chuqi Wang, Marissa Pioso, Shu Xuan Ng, Xiao Xian Lin, Vedant Sandhu, Binyam Yilma, Stephan Rainer Maximilian Bohl, Jeremy Ryan, Disha Malani, Marlise R. Luskin, Olli Kallioniemi, Kimmo Porkka, Allen Yeoh, Sophia Adamia, Wee Joo Chng, Motomi Osato, David M. Weinstock, Jacqueline S. Garcia, Anthony G. Letai, Shruti Bhatt
Journal: Blood
Blood (2023) 142 (Supplement 1): 48.
https://doi.org/10.1182/blood-2023-189156
Published: 2023
Journal Articles

Computational Approach Based on Independent Drug Action Identifies Clinically Relevant Combinations for Acute Myeloid Leukemia

Xiao Xian Lin, Vedant Sandhu, Christopher A. Eide, Stephen E. Kurtz, Disha Malani, Tom Erkers, Olli Kallioniemi, Jeffrey W Tyner, Shruti Bhatt
Journal: Blood
Blood (2023) 142 (Supplement 1): 5015.
https://doi.org/10.1182/blood-2023-188731
Published: 2023