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Shruti Bhatt
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Journal Articles

Targeting TP53 promotes anti-leukemia immunity and enhances CD70 CAR-T efficacy in AML by transcriptionally upregulating CD70

Free
Chuqi Wang, Jordan Yong Ming Tan, Previtha Vale, Nishtha Chitkara, Yuhan Wang, Yuan Song, Fang Qi Lim, Yun Li, Karanpreet Bhatia, Yash Manish Agrawal, Haiyan Liu, Nicholas RJ Gascoigne, Shruti Bhatt
Journal: Blood
Blood (2025) 146 (Supplement 1): 2349.
https://doi.org/10.1182/blood-2025-2349
Published: 2025
Journal Articles

Dissection of non-genetic resistance mechanisms by lineage tracing and single cell multiomics reveals drug-specific persister programs in Acute Myeloid Leukemia

Free
Karanpreet Bhatia, Xiao Xian Lin, Ankit Jana, Emanuelle Grody, Ryan Jeremy Lim Jing Wei, Shawn Koh Jia Jun, Elisha Teh Jia Yu, Cin thet Kyi, Prasad Iyer, Greg Kellogg, Yogesh Goyal, Lawrence Boise, Yaara Oren, Shruti Bhatt
Journal: Blood
Blood (2025) 146 (Supplement 1): 640.
https://doi.org/10.1182/blood-2025-640
Published: 2025
Journal Articles

CD43 functions as a CD47 independent “don't eat me” signal and novel immune checkpoint in AML

Free
Yun Li, Chuqi Wang, Javier Sanmartín‑Martínez, Bob vangasteren, Jordan Yong Ming Tan, Shaista Jasdanwala, Karanpreet Bhatia, Ankit Jana, Xiao Xian Lin, Yuhan Wang, Peter Miller, Adam Sperling, Anna Marneth, Shruti Bhatt
Journal: Blood
Blood (2025) 146 (Supplement 1): 5025.
https://doi.org/10.1182/blood-2025-5025
Published: 2025
Journal Articles

Integrated multiomics identifies inhibitors of apoptosis (IAPs) and death-inducing signaling complex (DISC) components as novel vulnerabilities to overcome immune evasion in TP53-inactivated Acute Myeloid Leukemia

Free
Jordan Yong Ming Tan, Chuqi Wang, Clara Kai Ting Koh, Yash Manish Agrawal, Wen Kang Soh, Fang Qi Lim, Yuhan Wang, Nishtha Chitkara, Xiao Xian Lin, Jia Chi Tan, Ahmed M Mamdouh, Gloryn Chia, Nicholas RJ Gascoigne, Shruti Bhatt
Journal: Blood
Blood (2025) 146 (Supplement 1): 386.
https://doi.org/10.1182/blood-2025-386
Published: 2025
Journal Articles

Heme promotes venetoclax resistance in multiple myeloma through MEK-ERK signaling and purine biosynthesis

Available to Purchase
Remya Nair, An H. Vu, Abigail K. Freer, Karanpreet S. Bhatia, Dongxue Wang, Milan R. Savani, Shannon M. Matulis, Sagar Lonial, David L. Jaye, Lawrence H. Boise, Seung-Yong Seo, Timothy W. Corson, Ajay K. Nooka, Shruti Bhatt, Samuel K. McBrayer, Vikas A. Gupta, Xin Hu, Benjamin G. Barwick, Amit R. Reddi, Mala Shanmugam
Journal: Blood
Blood (2025) 145 (7): 732–747.
https://doi.org/10.1182/blood.2024025690
Published: 2025
Includes: Supplemental data
Journal Articles

Mapping the Drug Combination Landscape for AML: An Integrative Ex Vivo Functional and Computational Approach

Free
Xiao Xian Lin, Christopher A. Eide, Stephen E. Kurtz, Vedant Sandhu, Noor Rashidha Binte Meera Sahib, Disha Malani, Melissa Gaik-Ming Ooi, Edward Chow, Sanjukta Das, Jeffrey W. Tyner, Shruti Bhatt
Journal: Blood
Blood (2024) 144 (Supplement 1): 271.
https://doi.org/10.1182/blood-2024-202802
Published: 2024
Journal Articles

Failure to Execute Caspase Activation Drives Therapy Resistance in TP53 Mutated AML

Free
Ahmed M Mamdouh, Fang Qi Lim, Yang Mi, Elyse A Olesinski, Yichen Wang, Shaista Shabbir Jasdanwala, Karanpreet Singh Bhatia, Xiao Xian Lin, Valeriia Sapozhnikova, Philipp Mertins, Brandon D. Brown, Yihua Qiu, Anthony G. Letai, Alexandre Puissant, Steven M. Kornblau, Jan Krönke, Edward Ayoub, Koji Itahana, Michael Andreeff, Shruti Bhatt
Journal: Blood
Blood (2024) 144 (Supplement 1): 53.
https://doi.org/10.1182/blood-2024-211997
Published: 2024
Journal Articles

Integrating Genomics and Functional Phenotypes to Refine Risk Assessment in Acute Myeloid Leukemia across the Age Spectrum: Insights from Singapore

Free
Prasad Iyer, Shaista Shabbir Jasdanwala, Xiao Xian Lin, Karanpreet Singh Bhatia, Germaine Shimin Liew, Si Ting Tai, Jameelah Sheik Mohamed, Wei-Ying Jen, Melissa Gaik-Ming Ooi, Allen Eng Juh Yeoh, Shruti Bhatt
Journal: Blood
Blood (2024) 144 (Supplement 1): 4305.
https://doi.org/10.1182/blood-2024-212029
Published: 2024
Journal Articles

PPM1D modulates hematopoietic cell fitness and response to DNA damage and is a therapeutic target in myeloid malignancy

Free
Peter G. Miller, Adam S. Sperling, Christina Mayerhofer, Marie E. McConkey, Jana M. Ellegast, Carmen Da Silva, Drew N. Cohen, Chuqi Wang, Azeem Sharda, Ni Yan, Subha Saha, Cameron Schluter, Ilexa Schechter, Mikołaj Słabicki, Brittany Sandoval, Josephine Kahn, Steffen Boettcher, Christopher J. Gibson, David T. Scadden, Kimberly Stegmaier, Shruti Bhatt, R. Coleman Lindsley, Benjamin L. Ebert
Journal: Blood
Blood (2023) 142 (24): 2079–2091.
https://doi.org/10.1182/blood.2023020331
Published: 2023
Includes: Supplemental data
Journal Articles

Targeting Mitochondrial Apoptotic Priming State to Personalize Therapy for Relapsed Acute Myeloid Leukemia

Free
Elyse Olesinski, Karanpreet Bhatia, Chuqi Wang, Marissa Pioso, Shu Xuan Ng, Xiao Xian Lin, Vedant Sandhu, Binyam Yilma, Stephan Rainer Maximilian Bohl, Jeremy Ryan, Disha Malani, Marlise R. Luskin, Olli Kallioniemi, Kimmo Porkka, Allen Yeoh, Sophia Adamia, Wee Joo Chng, Motomi Osato, David M. Weinstock, Jacqueline S. Garcia, Anthony G. Letai, Shruti Bhatt
Journal: Blood
Blood (2023) 142 (Supplement 1): 48.
https://doi.org/10.1182/blood-2023-189156
Published: 2023
Journal Articles

Mitochondrial Functional Profiling Links Apoptotic Sensitivity to Treatment Outcomes Based on Age and Cell Lineage in Acute Leukemia

Free
Prasad Ramanakrishnan Iyer, Shaista Shabbir Jasdanwala, Jameelah Binte Sekh Mohamed, Si Ting Tai, Wei-Ying Jen, Melissa Ooi, Allen Eng Juh Yeoh, Shruti Bhatt
Journal: Blood
Blood (2023) 142 (Supplement 1): 5966.
https://doi.org/10.1182/blood-2023-188541
Published: 2023
Journal Articles

Computational Approach Based on Independent Drug Action Identifies Clinically Relevant Combinations for Acute Myeloid Leukemia

Free
Xiao Xian Lin, Vedant Sandhu, Christopher A. Eide, Stephen E. Kurtz, Disha Malani, Tom Erkers, Olli Kallioniemi, Jeffrey W Tyner, Shruti Bhatt
Journal: Blood
Blood (2023) 142 (Supplement 1): 5015.
https://doi.org/10.1182/blood-2023-188731
Published: 2023
Journal Articles

Cellular Plasticity As Mechanisms to Escape from NOTCH1-Inhibition in T-ALL

Free
Valeriya Dimitrova, Noori Sotudeh, Birgit Knoechel, Jens G. Lohr, Anna Montanaro, Sayalee V. Potdar, Julia Frede, Alexandria Van Scoyk, Shruti Bhatt, Praveen Anand, Jon C. Aster, David M Weinstock, Anthony G. Letai
Journal: Blood
Blood (2022) 140 (Supplement 1): 3461–3462.
https://doi.org/10.1182/blood-2022-170319
Published: 2022
Journal Articles

Identification of Novel Targets Based on Splicing Alterations for Undruggable RAS/CDK Signaling Cascade in Multiple Myeloma

Free
Sophia Adamia, Zuzana Chyra, Morgan O'Keefe, Shruti Bhatt, Kenneth Wen, Geoffrey G Fell, Yu-Tzu Tai, Anthony G. Letai, Ivane Abiatari, David M. Dorfman, Teru Hideshima, Kenneth C. Anderson
Journal: Blood
Blood (2021) 138 (Supplement 1): 2688.
https://doi.org/10.1182/blood-2021-152986
Published: 2021
Journal Articles

Maturity State and MCL-1 Dependence Predetermines Response to NOTCH1 Inhibition in T-ALL

Free
Valeriya Dimitrova, Noori Sotudeh, Anna Montanaro, Huiyoung Yun, Sayalee V. Potdar, Alexandria Van Scoyk, Shruti Bhatt, Praveen Anand, Antonis Kokkalis, Jake A. Kloeber, Julia Frede, Johannes M Waldschmidt, Anthony G. Letai, David M. Weinstock, Jens G. Lohr, Birgit Knoechel
Journal: Blood
Blood (2021) 138 (Supplement 1): 3484.
https://doi.org/10.1182/blood-2021-153829
Published: 2021
Journal Articles

Pre-Clinical Validation of a Novel Erk1/2 and CDK4/6 Inhibitor Combination in Multiple Myeloma (MM)

Free
Sophia Adamia, PhD, Shruti Bhatt, PhD, Yu-Tzu Tai, PhD, Kenneth Wen, Catherine A Nicholas, Marissa S Pioso, Ivane Abiatari, MD, Anthony G. Letai, MD PhD, Kenneth Anderson, MD
Journal: Blood
Blood (2020) 136 (Supplement 1): 22–23.
https://doi.org/10.1182/blood-2020-142596
Published: 2020
Journal Articles

Enhancer Rewiring Dependent Switch from BCL2 to MCL1 Dependency Predicts NOTCH1 Inhibition Response in T-ALL

Free
Valeriya Dimitrova, Huiyoung Yun, PhD, Sayalee Potdar, Alexandria Nicole Van Scoyk, BS, Shruti Bhatt, PhD, Praveen Anand, PhD, Monica S. Nair, Jake A. Kloeber, Antonis Kokkalis, PhD MSc, Julia Frede, PhD MPhil, Johannes M. Waldschmidt, MD, Anthony G. Letai, MD PhD, David M. Weinstock, MD, Jon C. Aster, MD PhD, Jens G. Lohr, MD PhD, Birgit Knoechel, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3948.
https://doi.org/10.1182/blood-2019-131148
Published: 2019
Journal Articles

Individualized Mitochondrial Functional Approach to Combination of BCL-2 and MCL-1 Antagonism in Acute Myeloid Leukemia

Free
Shruti Bhatt, PhD, Marissa Pioso, Elyse Ann Olesinski, Binyam Yilma, Leutz Buon, Sophia Adamia, PhD, Holly Zhu, Jeremy Ryan, Youzhen Wang, Morris Erick, Ensar Halilovic, David M. Weinstock, MD, Jacqueline S Garcia, MD, Anthony Letai
Journal: Blood
Blood (2019) 134 (Supplement_1): 2551.
https://doi.org/10.1182/blood-2019-131101
Published: 2019
Journal Articles

Patterns of substrate affinity, competition, and degradation kinetics underlie biological activity of thalidomide analogs

Free
Adam S. Sperling, Michael Burgess, Hasmik Keshishian, Jessica A. Gasser, Shruti Bhatt, Max Jan, Mikołaj Słabicki, Rob S. Sellar, Emma C. Fink, Peter G. Miller, Brian J. Liddicoat, Quinlan L. Sievers, Rohan Sharma, Dylan N. Adams, Elyse A. Olesinski, Mariateresa Fulciniti, Namrata D. Udeshi, Eric Kuhn, Anthony Letai, Nikhil C. Munshi, Steven A. Carr, Benjamin L. Ebert
Journal: Blood
Blood (2019) 134 (2): 160–170.
https://doi.org/10.1182/blood.2019000789
Published: 2019
Includes: Supplemental data
Journal Articles

Dynamic BH3 Profiling Predicts for Clinical Response to Lenalidomide Plus Chemotherapy in Relapsed Acute Myeloid Leukemia

Free
Jacqueline S Garcia, MD, Shruti Bhatt, PhD, Geoffrey Fell, PhD, Traci M. Blonquist, MS, Jack Taw, David Iberri, MD, Anthony Letai, MD PhD, Bruno C. Medeiros, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 4058.
https://doi.org/10.1182/blood-2018-99-117428
Published: 2018