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Mala Shanmugam
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Journal Articles

NSD2 expression remodels DNA methylation, creating a targetable epigenetic dependency in t(4;14) multiple myeloma

Free
Anna Baj, Jonathan Patton, Robert Chavez, Shannon Matulis, Doris Powell, Mala Shanmugam, Arun Wiita, Constantine Mitsiades, Jonathan Keats, Jonathan Licht, Sagar Lonial, Lawrence Boise, Benjamin Barwick
Journal: Blood
Blood (2025) 146 (Supplement 1): 572.
https://doi.org/10.1182/blood-2025-572
Published: 2025
Journal Articles

Impact of extrinsic heme on adoptive T cell therapy

Free
Dejah Blake, Pulkit Gupta, Remya Nair, Ruby Freeman, Heather Lin, Sagar Lonial, Benjamin Barwick, Ajay Nooka, Jean Koff, Sarwish Rafiq, Mala Shanmugam
Journal: Blood
Blood (2025) 146 (Supplement 1): 7628.
https://doi.org/10.1182/blood-2025-7628
Published: 2025
Journal Articles

NSD2 inhibition suppresses t(4;14) gene expression and oncogenic signaling to impair proliferation in multiple myeloma

Free
Robert Chavez, Jonathan Patton, James Ackley, Mala Shanmugam, Constantine Mitsiades, Arun Wiita, Jonathan Licht, Erin Flynt, Terry Connolly, Karen Conneely, Sagar Lonial, Lawrence Boise, Benjamin Barwick
Journal: Blood
Blood (2025) 146 (Supplement 1): 3956.
https://doi.org/10.1182/blood-2025-3956
Published: 2025
Journal Articles

Inhibition of NSD2 in t(4;14) myeloma induces changes in mitochondrial priming

Free
Shannon Matulis, Jonathan Patton, Rebecca Owens, Robert Chavez, Arun Wiita, Mala Shanmugam, Constantine Mitsiades, Vikas Gupta, Jonathan Licht, Benjamin Barwick, Lawrence Boise
Journal: Blood
Blood (2025) 146 (Supplement 1): 2177.
https://doi.org/10.1182/blood-2025-2177
Published: 2025
Journal Articles

Starving lymphoma with α-KG supplementation

Free
Mala Shanmugam
Journal: Blood
Blood (2025) 146 (18): 2151–2153.
https://doi.org/10.1182/blood.2025030695
Published: 2025
Journal Articles

Targeting high-risk multiple myeloma genotypes with optimized anti-CD70 CAR T cells

Available to Purchase
Corynn Kasap, Adila Izgutdina, Bonell Patiño-Escobar, Amrik S. Kang, Nikhil Chilakapati, Naomi Akagi, Ananya Manoj, Haley Johnson, Tasfia Rashid, Juwita Werner, Abhilash Barpanda, Huimin Geng, Yu-Hsiu T. Lin, Sham Rampersaud, Daniel Gil-Alós, Amin Sobh, Daphné Dupéré-Richer, Adolfo Aleman, Gianina Wicaksono, K. M. Kawehi Kelii, Radhika Dalal, Emilio Ramos, Anjanaa Vijayanarayanan, Kiran Lakhani, Fernando Salangsang, Paul Phojanakong, Juan Antonio Camara Serrano, Ons Zakraoui, Isa Tariq, Ajai Chari, Alfred Chung, Anupama D. Kumar, Thomas G. Martin, III, Jeffrey Wolf, Sandy W. Wong, Veronica Steri, Mala Shanmugam, Lawrence H. Boise, Tanja Kortemme, Samir Parekh, Elliot Stieglitz, Jonathan D. Licht, William J. Karlon, Benjamin G. Barwick, Arun P. Wiita
Journal: Blood
Blood (2025) 146 (7): 819–833.
https://doi.org/10.1182/blood.2024025536
Published: 2025
Includes: Supplemental data
Journal Articles

Heme promotes venetoclax resistance in multiple myeloma through MEK-ERK signaling and purine biosynthesis

Available to Purchase
Remya Nair, An H. Vu, Abigail K. Freer, Karanpreet S. Bhatia, Dongxue Wang, Milan R. Savani, Shannon M. Matulis, Sagar Lonial, David L. Jaye, Lawrence H. Boise, Seung-Yong Seo, Timothy W. Corson, Ajay K. Nooka, Shruti Bhatt, Samuel K. McBrayer, Vikas A. Gupta, Xin Hu, Benjamin G. Barwick, Amit R. Reddi, Mala Shanmugam
Journal: Blood
Blood (2025) 145 (7): 732–747.
https://doi.org/10.1182/blood.2024025690
Published: 2025
Includes: Supplemental data
Journal Articles

Mitochondrial Priming Is Heterogenous in t(4;14) Multiple Myeloma and Can be Induced By Inhibition of NSD2

Free
Shannon M Matulis, Robert M Chavez, Rebecca Owens, Arun P Wiita, Mala Shanmugam, Ricardo De Matos Simoes, Constantine S Mitsiades, Nisha S. Joseph, Craig C. Hofmeister, Jonathan L. Kaufman, Madhav V. Dhodapkar, Sagar Lonial, Ajay K. Nooka, Vikas A. Gupta, Jonathan D. Licht, Benjamin G. Barwick, Lawrence H. Boise
Journal: Blood
Blood (2024) 144 (Supplement 1): 4663.
https://doi.org/10.1182/blood-2024-210441
Published: 2024
Journal Articles

Heme Attenuates T Cell Exhaustion and Drives Effector Function: Implications for Immune and Adoptive T Cell Therapy

Free
Pulkit Gupta, Heather Lin, Remya Nair, Ruby Freeman, Dejah Blake, Kiran Lakhani, Doris R. Powell, Sagar Lonial, Benjamin G. Barwick, Ajay K. Nooka, Sarwish Rafiq, Mala Shanmugam
Journal: Blood
Blood (2023) 142 (Supplement 1): 6807.
https://doi.org/10.1182/blood-2023-186634
Published: 2023
Journal Articles

Discovery and Development of CD70 As a Cellular Therapy Target in High Risk Multiple Myeloma

Free
Corynn Kasap, Adila Izgutdina, Bonell Patino Escobar, Yu-Hsiu Tony Lin, Huimin Geng, Gianina Wicaksono, Daphne Dupere-Richer, Emilio Ramos, Abhilash Barpanda, Anjanaa Vijayanarayanan, Fernando Salangsang, Paul Phojanakong, Juan Antonio Camara Serrano, Veronica Steri, William Karlon, Mala Shanmugam, Lawrence H. Boise, Benjamin G. Barwick, Jonathan D. Licht, Arun P Wiita
Journal: Blood
Blood (2023) 142 (Supplement 1): 465.
https://doi.org/10.1182/blood-2023-182578
Published: 2023
Journal Articles

Engineering Novel Multi-Cytokine Backpacks for Manufacturing Functionally Improved CAR T Cell Products

Free
Heather Lin, A K M Nawshad Hossian, Biaggio Uricoli, Ruby Mei Freeman, Dejah A Blake, Jonathan Legier, Remya Nair, Jean L. Koff, Mala Shanmugam, Erik Dreaden, Sarwish Rafiq
Journal: Blood
Blood (2022) 140 (Supplement 1): 10245–10246.
https://doi.org/10.1182/blood-2022-162498
Published: 2022
Journal Articles

PI3Kδ/γ inhibition promotes human CART cell epigenetic and metabolic reprogramming to enhance antitumor cytotoxicity

Free
Christopher Ronald Funk, Shuhua Wang, Kevin Z. Chen, Alexandra Waller, Aditi Sharma, Claudia L. Edgar, Vikas A. Gupta, Shanmuganathan Chandrakasan, Jaquelyn T. Zoine, Andrew Fedanov, Sunil S. Raikar, Jean L. Koff, Christopher R. Flowers, Silvia Coma, Jonathan A. Pachter, Sruthi Ravindranathan, H. Trent Spencer, Mala Shanmugam, Edmund K. Waller
Journal: Blood
Blood (2022) 139 (4): 523–537.
https://doi.org/10.1182/blood.2021011597
Published: 2022
Includes: Supplemental data
Journal Articles

Mitochondrial Electron Transport Chain Inhibition Promotes Resistance to Proteasome Inhibitors in Multiple Myeloma

Free
Aditi Sharma, Abhinav Achreja, Remya Nair, Pulkit Gupta, Claudia L Edgar, Olamide Animasahun, Anjali Mittal, Bhakti Dwivedi, Manoj Bhasin, Vikas A Gupta, Benjamin G Barwick, Shannon M Matulis, Sagar Lonial, Lawrence H. Boise, David L Jaye, Arun P Wiita, Ajay K. Nooka, Deepak Nagrath, Mala Shanmugam
Journal: Blood
Blood (2021) 138 (Supplement 1): 1611.
https://doi.org/10.1182/blood-2021-153744
Published: 2021
Journal Articles

BRAF Mutations and Inflammatory Gene Expression in Myeloma Cells from Patients with Renal Dysfunction

Free
Theodora Alese, Benjamin G Barwick, Vikas A. Gupta, Nisha Joseph, Craig C. Hofmeister, Mala Shanmugam, Jonathan L. Kaufman, Madhav V Dhodapkar, Sagar Lonial, Ajay K. Nooka, Lawrence H. Boise
Journal: Blood
Blood (2021) 138 (Supplement 1): 1624.
https://doi.org/10.1182/blood-2021-154092
Published: 2021
Journal Articles

Duvelisib Promotes Mitochondrial Fusion and Epigenetic Reprogramming to Drive Therapeutic T Cell Persistence and Function

Free
Kevin Z. Chen, Christopher R. Funk, Shuhua Wang, Aditi Sharma, Edmund K. Waller, Mala Shanmugam
Journal: Blood
Blood (2021) 138 (Supplement 1): 1714.
https://doi.org/10.1182/blood-2021-153446
Published: 2021
Journal Articles

The Role of Proteasome Activator PA28α in Multiple Myeloma

Free
Yanyan Gu, MD PhD, Benjamin G Barwick, PhD, Mala Shanmugam, PhD, Craig C Hofmeister, MDMPH, Jonathan L. Kaufman, MD, Ajay K Nooka, MDMPH, Vikas A. Gupta, MD PhD, Madhav V Dhodapkar, MBBS, Lawrence H. Boise, PhD, Sagar Lonial
Journal: Blood
Blood (2019) 134 (Supplement_1): 5499.
https://doi.org/10.1182/blood-2019-128216
Published: 2019
Journal Articles

Succinate Ubiquinone Reductase Activity Predicts Multiple Myeloma Sensitivity to Venetoclax

Free
Richa Bajpai, PhD, Changyong Wei, PhD BS, Shannon Matulis, PhD, Ajay K. Nooka, MDMPH, Samuel McBrayer, PhD, Sagar Lonial, MD, Vikas A. Gupta, MD PhD, Lawrence H. Boise, PhD, Mala Shanmugam, PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 4409.
https://doi.org/10.1182/blood.V130.Suppl_1.4409.4409
Published: 2017
Journal Articles

Glutamine Catabolism Maintains MCL-1 Expression in Glucose-Deprived Multiple Myeloma

Free
Changyong Wei, PhD BS, Richa Bajpai, PhD, Alisha D Hunter, MS, Darius Mahboubi, MS, Mala Shanmugam, PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 3076.
https://doi.org/10.1182/blood.V130.Suppl_1.3076.3076
Published: 2017
Journal Articles

Targeting Glycolysis and Compensatory Mitochondrial Metabolism In An In Vivo Xenograft Model Of Multiple Myeloma With FDA Approved Ritonavir and Metformin

Free
Sevim Dalva-Aydemir, MS, Kehinde U.A. Adekola, MBBS, Jennifer Koblinski, PhD, Noopur Raje, MD, Steven T. Rosen, MD, FRCPA, Mala Shanmugam, PhD
Journal: Blood
Blood (2013) 122 (21): 1922.
https://doi.org/10.1182/blood.V122.21.1922.1922
Published: 2013
Journal Articles

Targeting Glucose Metabolism and Compensatory Metabolic Resistance in Chronic Lymphocytic Leukemia

Free
Kehinde U.A. Adekola, MBBS, Vivian Liu, Shuo Ma, MD, PhD, Steven T. Rosen, MD, FRCPA, Mala Shanmugam, PhD
Journal: Blood
Blood (2012) 120 (21): 1801.
https://doi.org/10.1182/blood.V120.21.1801.1801
Published: 2012