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Journal Articles

Heme promotes venetoclax resistance in multiple myeloma through MEK-ERK signaling and purine biosynthesis

Blood blood.2024025690.

https://doi.org/10.1182/blood.2024025690

Published: 2024

Includes: Supplemental data

Journal Articles

Genomic Determinants of Clinical Outcomes in Multiple Myeloma with t(11;14)(CCND1;IGH) Treated with Venetoclax

Marcella Kaddoura, J Erin Wiedmeier-Nutor, Vikas A. Gupta, Bachisio Ziccheddu, Suganti Shivaram, Hongwei Tang, Rodrigo Fonseca, Michael Durante, Shannon M Matulis, Tomas Jelinek, Ola Landgren, Constantine S Mitsiades, P. Leif Bergsagel, Esteban Braggio, Lawrence H. Boise, Rafael Fonseca, Shaji Kumar, Francesco Maura, Linda B. Baughn

Blood (2024) 144 (Supplement 1): 249.

https://doi.org/10.1182/blood-2024-204071

Published: 2024

Journal Articles

Mitochondrial Priming Is Heterogenous in t(4;14) Multiple Myeloma and Can be Induced By Inhibition of NSD2

Shannon M Matulis, Robert M Chavez, Rebecca Owens, Arun P Wiita, Mala Shanmugam, Ricardo De Matos Simoes, Constantine S Mitsiades, Nisha S. Joseph, Craig C. Hofmeister, Jonathan L. Kaufman, Madhav V. Dhodapkar, Sagar Lonial, Ajay K. Nooka, Vikas A. Gupta, Jonathan D. Licht, Benjamin G. Barwick, Lawrence H. Boise

Blood (2024) 144 (Supplement 1): 4663.

https://doi.org/10.1182/blood-2024-210441

Published: 2024

Journal Articles

Mitochondrial Electron Transport Chain Inhibition Promotes Resistance to Proteasome Inhibitors in Multiple Myeloma

Aditi Sharma, Abhinav Achreja, Remya Nair, Pulkit Gupta, Claudia L Edgar, Olamide Animasahun, Anjali Mittal, Bhakti Dwivedi, Manoj Bhasin, Vikas A Gupta, Benjamin G Barwick, Shannon M Matulis, Sagar Lonial, Lawrence H. Boise, David L Jaye, Arun P Wiita, Ajay K. Nooka, Deepak Nagrath, Mala Shanmugam

Blood (2021) 138 (Supplement 1): 1611.

https://doi.org/10.1182/blood-2021-153744

Published: 2021

Journal Articles

Venetoclax sensitivity in multiple myeloma is associated with B-cell gene expression

Vikas A. Gupta, Benjamin G. Barwick, Shannon M. Matulis, Ryosuke Shirasaki, David L. Jaye, Jonathan J. Keats, Benjamin Oberlton, Nisha S. Joseph, Craig C. Hofmeister, Leonard T. Heffner, Madhav V. Dhodapkar, Ajay K. Nooka, Sagar Lonial, Constantine S. Mitsiades, Jonathan L. Kaufman, Lawrence H. Boise

Blood (2021) 137 (26): 3604–3615.

https://doi.org/10.1182/blood.2020007899

Published: 2021

Includes: Supplemental data

Journal Articles

Chromatin Accessibility Identifies Regulatory Elements Predictive of Oncogene Expression in Multiple Myeloma

Benjamin G Barwick, PhD, Vikas A. Gupta, MD PhD, Shannon M Matulis, PhD, Jonathan C Patton, B.S., Doris R Powell, MA, Yanyan Gu, MD PhD, David L. Jaye, MD, Karen N Conneely, PhD, Yin C Lin, PhD, Craig C Hofmeister, MDMPH, Ajay Nooka, MDMPH, Jonathan J Keats, PhD, Sagar Lonial, MD FACP, Paula M Vertino, PhD, Larry H. Boise, PhD

Blood (2020) 136 (Supplement 1): 31–32.

https://doi.org/10.1182/blood-2020-140717

Published: 2020

Journal Articles

Myeloma Patient-Derived MCL1 Point Mutations Can Influence MCL1-Inhibitor Function

Brandon Chen, Wong Pamela, B.S., Daniel Auclair, PhD, Jonathan J Keats, PhD, Paul Secrist, PhD, Justin Cidado, PhD, Adriana E. Tron, PhD, Christine M Dunham, PhD, Sagar Lonial, MD, Joseph Opferman, PhD, Shannon M Matulis, PhD, Lawrence H. Boise, PhD

Blood (2018) 132 (Supplement 1): 951.

https://doi.org/10.1182/blood-2018-99-113444

Published: 2018

Journal Articles

Preclinical Activity of Novel MCL1 Inhibitor AZD5991 in Multiple Myeloma

Shannon M Matulis, PhD, Vikas A. Gupta, MD PhD, Izabelle Brown, Jonathan J Keats, PhD, Paul Secrist, PhD, Justin Cidado, PhD, Adriana E. Tron, PhD, Paola Neri, MD, Nizar Bahlis, MD, Jonathan L Kaufman, MD, Leonard Heffner, MD, Sagar Lonial, MD, Ajay K Nooka, MDMPH, Lawrence H. Boise, PhD

Blood (2018) 132 (Supplement 1): 952.

https://doi.org/10.1182/blood-2018-99-113504

Published: 2018

Journal Articles

Bone marrow microenvironment–derived signals induce Mcl-1 dependence in multiple myeloma

Vikas A. Gupta, Shannon M. Matulis, Jason E. Conage-Pough, Ajay K. Nooka, Jonathan L. Kaufman, Sagar Lonial, Lawrence H. Boise

Blood (2017) 129 (14): 1969–1979.

https://doi.org/10.1182/blood-2016-10-745059

Published: 2017

Includes: Supplemental data

Journal Articles

MLN4924, an NAE inhibitor, suppresses AKT and mTOR signaling via upregulation of REDD1 in human myeloma cells

Yanyan Gu, Jonathan L. Kaufman, Leon Bernal, Claire Torre, Shannon M. Matulis, R. Donald Harvey, Jing Chen, Shi-Yong Sun, Lawrence H. Boise, Sagar Lonial

Blood (2014) 123 (21): 3269–3276.

https://doi.org/10.1182/blood-2013-08-521914

Published: 2014

Includes: Supplemental data

Journal Articles

Dual Inhibition Of Mcl-1 By The Combination Of Carfilzomib and TG02 In Multiple Myeloma

Katelyn G. Barnhart, Shannon M. Matulis, Ph.D., Sadae Hitosugi, MS, Cathy Sharp, R.N., Francis Burrows, PhD, Ajay K. Nooka, MD, MPH, Jonathan L. Kaufman, MD, Sagar Lonial, M.D., Lawrence H. Boise, PhD

Blood (2013) 122 (21): 3171.

https://doi.org/10.1182/blood.V122.21.3171.3171

Published: 2013

Journal Articles

Using RNA-Seq, SNP-CN and Targeted Deep Sequencing To Improve The Diagnostic Paradigm In Multiple Myeloma

Michael R Rossi, PhD, Scott Newman, PhD, Ajay K. Nooka, MD, MPH, Jonathan L. Kaufman, MD, Nizar J. Bahlis, MD, Paola Neri, MD, PhD, Shannon M. Matulis, Ph.D., Leon Bernal-Mizrachi, M.D., Vikas A. Gupta, MD, PhD, Anjana Varma, M.S., Malania Wilson, M.S., Juliana DaSilva, B.S., Robert Benjamin Isett, M.S., Linsheng Zhang, MB, PhD, Debra Saxe, Ph.D., Karen P. Mann, MD, PhD, David L Jaye, MD, Lawrence H. Boise, PhD, Sagar Lonial, M.D.

Blood (2013) 122 (21): 1856.

https://doi.org/10.1182/blood.V122.21.1856.1856

Published: 2013

Journal Articles

Transcriptional and Post-Translational Regulation Of The Bcl-2 Family By IL-6 Mediates Resistance To ABT-737 In Multiple Myeloma

Vikas A. Gupta, MD, PhD, Shannon M. Matulis, Ph.D., Jason E. Conage-Pough, Ajay K. Nooka, MD, MPH, Jonathan L. Kaufman, MD, Sagar Lonial, M.D., Lawrence H. Boise, PhD

Blood (2013) 122 (21): 1924.

https://doi.org/10.1182/blood.V122.21.1924.1924

Published: 2013

Journal Articles

P38 Is a Negative Regulator Of The Bortezomib-Induced Heat Shock Response In Multiple Myeloma

Shardule P. Shah, Vikas A. Gupta, MD, PhD, Shannon M. Matulis, Ph.D., Ajay K. Nooka, MD, MPH, Sagar Lonial, M.D., Lawrence H. Boise, PhD

Blood (2013) 122 (21): 1929.

https://doi.org/10.1182/blood.V122.21.1929.1929

Published: 2013

Journal Articles

Phosphorylation Influences The Binding Of Bim To Anti-Apoptotic Proteins In Multiple Myeloma

Jason E. Conage-Pough, Vikas A. Gupta, MD, PhD, Shannon M. Matulis, Ph.D., Lawrence H. Boise, PhD

Blood (2013) 122 (21): 4446.

https://doi.org/10.1182/blood.V122.21.4446.4446

Published: 2013

Journal Articles

Efficacy Of ABT-199 In Multiple Myeloma

Shannon M. Matulis, Ph.D., Cathy Sharp, R.N., Ajay K. Nooka, MD, MPH, Jonathan L. Kaufman, MD, Sagar Lonial, M.D., Lawrence H. Boise, PhD

Blood (2013) 122 (21): 4453.

https://doi.org/10.1182/blood.V122.21.4453.4453

Published: 2013

Journal Articles

Interleukin-6 Enhances the Survival of Myeloma Cells by Regulating Bim Binding to Anti-Apoptotic Bcl-2 Proteins

Shannon M. Matulis, Ph.D., Jiangxia Liu, Ph.D., Vikas A. Gupta, MD, PhD, Jason E. Conage-Pough, Ajay K. Nooka, MD, MPH, FACP, Edmund K. Waller, MD, PhD, Jonathan L. Kaufman, MD, Sagar Lonial, MD, Lawrence H. Boise, PhD

Blood (2012) 120 (21): 4024.

https://doi.org/10.1182/blood.V120.21.4024.4024

Published: 2012

Journal Articles

Bone Marrow Stromal Cells Enforce MCL-1 Dependence In Multiple Myeloma Through the Secretion of A Soluble Factor,

Shannon M Matulis, PhD, Jonathan L. Kaufman, MD, Sagar Lonial, MD, Lawrence H. Boise, PhD

Blood (2011) 118 (21): 3950.

https://doi.org/10.1182/blood.V118.21.3950.3950

Published: 2011

Journal Articles

Distribution of Bim determines Mcl-1 dependence or codependence with Bcl-x L /Bcl-2 in Mcl-1–expressing myeloma cells

Alejo A. Morales, Metin Kurtoglu, Shannon M. Matulis, Jiangxia Liu, David Siefker, Delia M. Gutman, Jonathan L. Kaufman, Kelvin P. Lee, Sagar Lonial, Lawrence H. Boise

Blood (2011) 118 (5): 1329–1339.

https://doi.org/10.1182/blood-2011-01-327197

Published: 2011

Includes: Supplemental data

Journal Articles

Distribution of Bim Determines MCL-1 Dependence or Co-Dependence on BCL-x L /BCL-2 In Multiple Myeloma

Lawrence H. Boise, PhD, Alejo A Morales, PhD, Metin Kurtoglu, MD, PhD, Shannon M Matulis, PhD, Rebecca Markovitz, Kelvin P Lee, MD, Sagar Lonial, MD

Blood (2010) 116 (21): 4054.

https://doi.org/10.1182/blood.V116.21.4054.4054

Published: 2010

NARROW

Heme promotes venetoclax resistance in multiple myeloma through MEK-ERK signaling and purine biosynthesis

Genomic Determinants of Clinical Outcomes in Multiple Myeloma with t(11;14)(CCND1;IGH) Treated with Venetoclax

Mitochondrial Priming Is Heterogenous in t(4;14) Multiple Myeloma and Can be Induced By Inhibition of NSD2

Mitochondrial Electron Transport Chain Inhibition Promotes Resistance to Proteasome Inhibitors in Multiple Myeloma

Venetoclax sensitivity in multiple myeloma is associated with B-cell gene expression

Chromatin Accessibility Identifies Regulatory Elements Predictive of Oncogene Expression in Multiple Myeloma

Myeloma Patient-Derived MCL1 Point Mutations Can Influence MCL1-Inhibitor Function

Preclinical Activity of Novel MCL1 Inhibitor AZD5991 in Multiple Myeloma

Bone marrow microenvironment–derived signals induce Mcl-1 dependence in multiple myeloma

MLN4924, an NAE inhibitor, suppresses AKT and mTOR signaling via upregulation of REDD1 in human myeloma cells

Dual Inhibition Of Mcl-1 By The Combination Of Carfilzomib and TG02 In Multiple Myeloma

Using RNA-Seq, SNP-CN and Targeted Deep Sequencing To Improve The Diagnostic Paradigm In Multiple Myeloma

Transcriptional and Post-Translational Regulation Of The Bcl-2 Family By IL-6 Mediates Resistance To ABT-737 In Multiple Myeloma

P38 Is a Negative Regulator Of The Bortezomib-Induced Heat Shock Response In Multiple Myeloma

Phosphorylation Influences The Binding Of Bim To Anti-Apoptotic Proteins In Multiple Myeloma

Efficacy Of ABT-199 In Multiple Myeloma

Interleukin-6 Enhances the Survival of Myeloma Cells by Regulating Bim Binding to Anti-Apoptotic Bcl-2 Proteins

Bone Marrow Stromal Cells Enforce MCL-1 Dependence In Multiple Myeloma Through the Secretion of A Soluble Factor,

Distribution of Bim determines Mcl-1 dependence or codependence with Bcl-x L /Bcl-2 in Mcl-1–expressing myeloma cells

Distribution of Bim Determines MCL-1 Dependence or Co-Dependence on BCL-x L /BCL-2 In Multiple Myeloma

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American Society of Hematology

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American Society of Hematology

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