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Francesco Maura
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Journal Articles

Impact of soluble BCMA and non–T-cell factors on refractoriness to BCMA-targeting T-cell engagers in multiple myeloma

CME
Holly Lee, Michael Durante, Sheri Skerget, Deeksha Vishwamitra, Sacha Benaoudia, Sungwoo Ahn, Mansour Poorebrahim, Elie Barakat, David Jung, Noémie Leblay, Bachisio Ziccheddu, Benjamin Diamond, Marios Papadimitriou, Adam D. Cohen, Ola Landgren, Paola Neri, Francesco Maura, Nizar J. Bahlis
Journal: Blood
Blood (2024) 144 (25): 2637–2651.
https://doi.org/10.1182/blood.2024026212
Published: 2024
Includes: Supplemental data
Journal Articles

Using Synthetic Data Produced By Artificial Intelligence (AI) to Generate Insights for Chimeric Antigen Receptor T-Cell (CAR T-Cell) Clinical Trials

Penelope Lafeuille, Afrah Shafquat, Chao Sang, Mandis Beigi, Francesco Maura, Jacob Aptekar
Journal: Blood
Blood (2024) 144 (Supplement 1): 7484.
https://doi.org/10.1182/blood-2024-203356
Published: 2024
Journal Articles

Cyclin D1 Induces Global Epigenetic and Transcriptional Changes in Multiple Myeloma with t(11;14)(q13;q32)

Huihuang Yan, Suganti Shivaram, Hongwei Tang, Hans Anderson, Shulan Tian, Michael D Howe, Abiola Bolarinwa, Cinthya Zepeda Mendoza, Stacey Lehman, Leif Bergsagel, Esteban Braggio, Rafael Fonseca, Shaji Kumar, Francesco Maura, Linda B. Baughn
Journal: Blood
Blood (2024) 144 (Supplement 1): 6822.
https://doi.org/10.1182/blood-2024-208503
Published: 2024
Journal Articles

Selinexor, Venetoclax, and Dexamethasone in t(11;14)-Positive Relapsed/Refractory Multiple Myeloma (SELVEDge Study)

Dickran Kazandjian, Kellye Koubek, Andrew Kowalski, Stephanie Mompoint, Rabia Bukhari, Maila Wilson, Jeremy Deni, Sydney Jackson, Yahirini Rodriguez-Martinez, Justin Llano, Michelle Armogan, Stephanie Fernandes, Maurizio Affer, Sana Chaudhry, Tulasigeri M Totiger, Catalina Amador, Melinda Boone, Jennifer Rose Chapman-Fredricks, Mike Georgiou, Russ Kuker, Katie Thoren, Yi Zhou, David G. Coffey, Marcella Kaddoura, Francesco Maura, Benjamin Diamond, James Edward Hoffman, Justin Taylor, Ola Landgren
Journal: Blood
Blood (2024) 144 (Supplement 1): 7049.
https://doi.org/10.1182/blood-2024-193966
Published: 2024
Journal Articles

Decoding the Pivotal Roles of BCL10 Activating Mutations in DLBCL Drug Resistance and Lymphomagenesis

Caroline A. Coughlin, Dhanvantri Chahar, Marianna Lekakis, Hsuan-Ting Huang, Abdessamad Youssfi Alaoui, Lingxiao Li, Evan Roberts, Natalia Campos Gallego, Claude-Henry Volmar, Ola Landgren, Shaun Brothers, Anthony Griswold, Catalina Amador, Daniel Bilbao, Francesco Maura, Jonathan H. Schatz
Journal: Blood
Blood (2024) 144 (Supplement 1): 829.
https://doi.org/10.1182/blood-2024-203545
Published: 2024
Journal Articles

Genomic Determinants of Clinical Outcomes in Multiple Myeloma with t(11;14)(CCND1;IGH) Treated with Venetoclax

Marcella Kaddoura, J Erin Wiedmeier-Nutor, Vikas A. Gupta, Bachisio Ziccheddu, Suganti Shivaram, Hongwei Tang, Rodrigo Fonseca, Michael Durante, Shannon M Matulis, Tomas Jelinek, Ola Landgren, Constantine S Mitsiades, P. Leif Bergsagel, Esteban Braggio, Lawrence H. Boise, Rafael Fonseca, Shaji Kumar, Francesco Maura, Linda B. Baughn
Journal: Blood
Blood (2024) 144 (Supplement 1): 249.
https://doi.org/10.1182/blood-2024-204071
Published: 2024
Journal Articles

Genomic Complexity Correlates with the Degree of Marrow Independence of Malignant Plasma Cells in the Context of Extramedullary Disease

Kylee H Maclachlan, Juan-Jose Garces, Tala Shekarkhand, Sridevi Rajeeve, Hamza Hashmi, Hani Hassoun, Malin Hultcrantz, Neha Korde, Carlyn Rose Tan, Sham Mailankody, Anish Simhal, David J. Chung, Gunjan L. Shah, Michael Scordo, Sergio Giralt, Alexandra Maria Poos, Lukas John, Yanming Zhang, Robert Cimera, Maria E. Arcila, Juan E Arango Ossa, Umesh Bhanot, Mala Jain, Tala Merghoub, Heather J. Landau, Alexander M. Lesokhin, Saad Z. Usmani, Niels Weinhold, Francesco Maura, Urvi A. Shah
Journal: Blood
Blood (2024) 144 (Supplement 1): 248.
https://doi.org/10.1182/blood-2024-204341
Published: 2024
Journal Articles

Genomic Determinants of Resistance to Anti-BCMA Chimeric Antigen Receptor T-Cell (CART) Therapies in Patients with Relapsed/Refractory Multiple Myeloma

Francesco Maura, Ciara Louise Freeman, Holly Lee, Kylee H Maclachlan, Michael Durante, Bachisio Ziccheddu, Meghan Menges, Benjamin Diamond, Marios Papadimitriou, Ariosto Siqueira Silva, Praneeth Reddy Sudalagunta, Noemie Leblay, Sungwoo Ahn, Ethan Fuller, Edward Briercheck, Phaedra Agius, Doris K. Hansen, Xiaofei Song, Xiaohong Zhao, Mark B. Meads, Jamie Teer, Ross S Firestone, Juan-Jose Garces, Tomas Jelinek, Rachid Baz, Melissa Alsina, Anusuyam Ramasubramanian, Eric Smith, Sergio Giralt, Sham Mailankody, Paola Neri, Saad Z. Usmani, Frederick Locke, Nizar J. Bahlis, Ola Landgren, Kenneth H. Shain
Journal: Blood
Blood (2024) 144 (Supplement 1): 247.
https://doi.org/10.1182/blood-2024-201288
Published: 2024
Journal Articles

Whole Genome Sequencing Reveals Lower Apobec-Mutational Activity in Multiple Myeloma Patients with African Ancestry Compared with Those Having European Ancestry

Kylee H Maclachlan, Marios Papadimitriou, Patrick Blaney, Tala Shekarkhand, Timothy R. Chu, Alexandra Maria Poos, Elizabeth Brown, Antje Hoering, Benjamin Diamond, Bachisio Ziccheddu, Marc S. Raab, Niels Weinhold, Ola Landgren, Faith E Davies, Alexander M. Lesokhin, Saad Z. Usmani, Francesco Maura, Gareth Morgan
Journal: Blood
Blood (2024) 144 (Supplement 1): 766.
https://doi.org/10.1182/blood-2024-203675
Published: 2024
Journal Articles

Immune-MRD Status Informs Tumor-MRD Outcome Prognostication in Multiple Myeloma Patients on Lenalidomide Maintenance

Ross S Firestone, Anish Kumar Simhal, Devin McAvoy, Eric M Jurgens, Juan-José Garcés, David Nemirovsky, Andriy Derkach, Kylee H Maclachlan, Malin Hultcrantz, Sham Mailankody, Urvi A. Shah, Carlyn Rose Tan, Neha Korde, Hani Hassoun, Sridevi Rajeeve, Hamza Hashmi, Heather J. Landau, Michael Scordo, Gunjan L. Shah, Sergio Giralt, Benjamin Diamond, Francesco Maura, Kinga K. Hosszu, David J. Chung, Ola Landgren, Saad Z. Usmani, Alexander M. Lesokhin
Journal: Blood
Blood (2024) 144 (Supplement 1): 672.
https://doi.org/10.1182/blood-2024-206646
Published: 2024
Journal Articles

Intrinsic Tumor Drivers and Immune Escape Mechanisms in CD19 CAR T-Cell Therapy Resistance for Aggressive Large B Cell Lymphoma

Bachisio Ziccheddu, Michael D. Jain, Monika Chojnacka, Michael Durante, Venu Venkatarame Gowda Saralamma, Austin Daniel Newsam, Jerald Noble, Nicholas B Figura, Meghan Menges, Ola Landgren, Marco Davila, Jonathan H. Schatz, Francesco Maura, Frederick L. Locke
Journal: Blood
Blood (2024) 144 (Supplement 1): 232.
https://doi.org/10.1182/blood-2024-208372
Published: 2024
Journal Articles

BCMA Extracellular Domain Functional Hotspots and Resistance to Variable Anti-BCMA T Cell Engagers in Multiple Myeloma

Holly Lee, David Jung, Mansour Poorebrahim, Sacha Benaoudia, Sungwoo Ahn, Noémie Leblay, Eric Letouzé, Philippe Moreau, Herve Avet-Loiseau, Leo Rasche, Jonathan J Keats, Francesco Maura, Paola Neri, Nizar J. Bahlis
Journal: Blood
Blood (2024) 144 (Supplement 1): 4651.
https://doi.org/10.1182/blood-2024-211833
Published: 2024
Journal Articles

The Cyclin-G Associated Kinase (GAK) Is a Critical Targetable Dependency for Successful Mitosis By Diffuse Large B-Cell Lymphomas Linked to Retinoblastoma Loss of Function

Olivia Barbara Lightfuss, Preet Kumar, Austin Daniel Newsam, Lingxiao Li, Pierre A. Younes, Toral Shastri, Abdessamad Youssfi Alaoui, Diego E. Hernandez Parets, Paola Manara, Daniel Bilbao, Stephan Schürer, Vance P. Lemmon, Francesco Maura, Yangbo Feng, Hassan A. Ali, Jonathan H. Schatz
Journal: Blood
Blood (2024) 144 (Supplement 1): 2781.
https://doi.org/10.1182/blood-2024-206073
Published: 2024
Journal Articles

Mutationally Enriched Regions of the Non-Coding Genome Harbor Functionally Impactful Mutations That Dysregulate Key Genes Involved in Multiple Myeloma Pathogenesis

Patrick Blaney, Kylee H Maclachlan, Marios Papadimitriou, Aneta Mikulasova, Dylan C Gagler, Marc J Braunstein, Oscar B Lahoud, David Kaminetzky, Yubao Wang, Sanxiong Liu, Di Zhang, Anthony Cirrincione, Alexandra Maria Poos, Bachisio Ziccheddu, Marcella Kaddoura, Monika Chojnacka, Benjamin Diamond, Neha Korde, Alexander M. Lesokhin, Saad Z. Usmani, Leo Rasche, Elias K. Mai, Marc S. Raab, Niels Weinhold, Elizabeth E. Brown, Nicolas Robine, Leif Bergsagel, Brian A. Walker, Ola Landgren, Francesco Maura, Faith E Davies, Gareth Morgan
Journal: Blood
Blood (2024) 144 (Supplement 1): 4655.
https://doi.org/10.1182/blood-2024-211012
Published: 2024
Journal Articles

The Role of NOXA in Venetoclax Treatment Response in Multiple Myeloma

Suganti Shivaram, Huihuang Yan, Hongwei Tang, Hans M. Anderson, Marcella Kaddoura, J Erin Wiedmeier-Nutor, Shulan Tian, Michael D Howe, Abiola Bolarinwa, Cinthya Zepeda Mendoza, Vikas A Gupta, Stacey Lehman, Constantine S Mitsiades, P. Leif Bergsagel, Esteban Braggio, Lawrence H. Boise, Rafael Fonseca, Francesco Maura, Shaji Kumar, Linda B. Baughn
Journal: Blood
Blood (2024) 144 (Supplement 1): 4635.
https://doi.org/10.1182/blood-2024-205385
Published: 2024
Journal Articles

Convergent Evolution Towards CD38 Biallelic Loss Is a Recurrent Mechanism of Resistance to Anti-CD38 Antibodies in Multiple Myeloma

Benjamin Diamond, Linda B. Baughn, Mansour Poorebrahim, Alexandra Maria Poos, Holly Lee, Marcella Kaddoura, J Erin Wiedmeier-Nutor, Michael Durante, Gregory Otteson, Dragan Jevremovic, Hongwei Tang, Stefan Frohling, Marios Papadimitriou, Bachisio Ziccheddu, Tomas Jelinek, Ola Landgren, Paola Neri, P. Leif Bergsagel, Esteban Braggio, Shaji Kumar, Marc S. Raab, Rafael Fonseca, Nizar J. Bahlis, Niels Weinhold, Francesco Maura
Journal: Blood
Blood (2024) 144 (Supplement 1): 592.
https://doi.org/10.1182/blood-2024-201056
Published: 2024
Journal Articles

NF-Kb Pathway Activation Driven By TRAF3 Loss Mediates Resistance to Anti-BCMA T-Cell Based Therapies in Multiple Myeloma

David Jung, Holly Lee, Sejal Chikhale, Mansour Poorebrahim, Sungwoo Ahn, Sacha Benaoudia, Noemie Leblay, Francesco Maura, Nizar J. Bahlis, Paola Neri
Journal: Blood
Blood (2024) 144 (Supplement 1): 591.
https://doi.org/10.1182/blood-2024-206347
Published: 2024
Journal Articles

Tocilizumab Prophylaxis for Patients with Relapsed or Refractory Multiple Myeloma Treated with Teclistamab, Elranatamab or Talquetamab

Andrew Kowalski, Jill Lykon, Benjamin Diamond, David G. Coffey, Marcella Kaddoura, Francesco Maura, James E. Hoffman, Dickran Kazandjian, Ola Landgren
Journal: Blood
Blood (2024) 144 (Supplement 1): 932.
https://doi.org/10.1182/blood-2024-203426
Published: 2024
Journal Articles

Comparison of Debulking Regimens (EPOCH and DCEP) for the Treatment of Relapsed or Refractory Multiple Myeloma

Andrew Kowalski, David G. Coffey, Benjamin Diamond, James E. Hoffman, Marcella Kaddoura, Jill Lykon, Francesco Maura, Yahirini Rodriguez-Martinez, Suzan Rosen, Faika Shah, Dennis Verducci, Ola Landgren, Dickran Kazandjian
Journal: Blood
Blood (2024) 144 (Supplement 1): 2389.
https://doi.org/10.1182/blood-2024-203763
Published: 2024
Journal Articles

Clonal Evolution of Lymphoid Malignancies Following the Mutagenic Impact of Radiotherapy

Benjamin Diamond, Dhanvantri Chahar, Michael D. Jain, Alexandra Maria Poos, Michael Durante, Bachisio Ziccheddu, Marcella Kaddoura, Marios Papadimitriou, Kylee H Maclachlan, Tomas Jelinek, Faith E Davies, Nicholas B Figura, Gareth Morgan, Elias K. Mai, Hartmut Goldschmidt, Katja C. Weisel, Roland Fenk, Saad Z. Usmani, Ola Landgren, Frederick Locke, Marc S. Raab, Jonathan H. Schatz, Niels Weinhold, Francesco Maura
Journal: Blood
Blood (2024) 144 (Supplement 1): 1607.
https://doi.org/10.1182/blood-2024-200927
Published: 2024