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Journal Articles

The Transcriptional Impact of 5q Deletion in MDS at Single Cell Resolution

Aintzane Diaz-Mazkiaran, Guillermo Serrano, Nerea Berastegui, Paula Garcia-Olloqui, Sofia Huerga, Ana Alfonso Pierola, Asier Ullate-Agote, Beñat Ariceta, Marina Ainciburu, Amaia Vilas-Zornoza, Patxi San-Martin, Paula Aguirre-Ruiz, Jose Maria Lamo De Espinosa, Pamela Acha, Oriol Calvete, Tamara Jimenez, Antonieta Molero, Julia Montoro, Maria Diez-Campelo, David Valcarcel, Francesc Sole, Idoia Ochoa, Teresa Ezponda, Felipe Prosper, Mikel Hernaez
Journal: Blood
Blood (2023) 142 (Supplement 1): 1850.
https://doi.org/10.1182/blood-2023-186173
Published: 2023
Journal Articles

Early Molecular Steps in Human Bone Marrow Stem Cell Differentiation Trajectories

Hana Komic, Weijia Yu, Catia Simoes, Tessa Schmachtel, Malin S. Nilsson, Felipe Prosper, Bruno Paiva, Fredrik B. Thorén, Michael A. Rieger
Journal: Blood
Blood (2023) 142 (Supplement 1): 4047.
https://doi.org/10.1182/blood-2023-185490
Published: 2023
Journal Articles

Longitudinal Transcriptomic Analysis of CAR-T Cells at Single-Cell Level Allows the Identification of Molecular Mechanisms Promoting Long-Term CAR-T Cell Persistence in MM

Juan Roberto Rodriguez-Madoz, Lorea Jordana-Urriza, Guillermo Serrano, Aina Oliver-Caldes, Maria Erendira Calleja-Cervantes, Patxi San-Martin, Amaia Vilas-Zornoza, Asier Ullate-Agote, Aintzane Zabaleta, Diego Alignani, Teresa Lozano, Valentin Cabanas Perianes, Juan Luis Reguera, Almudena Navarro-Bailon, Marta Español-Rego, Mariona Pascal, Jose Maria Moraleda, Jose A. Perez-Simon, Maria Victoria Mateos, Fermin Sanchez-Guijo Martin, Alvaro Urbano-Ispizua, Manel Juan, Ana Alfonso Pierola, Jose J. Rifon, Paula Rodriguez Otero, Bruno Paiva, Susana Inogés, Ascensión López-Díaz De Cerio, Juan J Lasarte, Jesús San Miguel, Carlos Fernández de Larrea, Mikel Hernaez, Felipe Prosper
Journal: Blood
Blood (2023) 142 (Supplement 1): 2069.
https://doi.org/10.1182/blood-2023-182933
Published: 2023
Journal Articles

Bone Marrow Cytokines Concentrations in Myelodysplastic Neoplasms: Its Correlation with the Immune Populations and Clonal Hematopoiesis

Antonieta Molero Yordi, Soraya Peralta Garzón, Laura Gallur, Barbara Tazon, Daniel Medina, Victor Navarro Garces, Maria Julia Montoro, Silvia Saumell, Tamara Jimenez, Félix López Cadenas, Teresa Ezponda, Ana Alfonso Pierola, Felipe Prosper, Maria Diez-Campelo, Olga Salamero, Ana Pérez González, Sara Garrido Paniagua, David Valcarcel
Journal: Blood
Blood (2023) 142 (Supplement 1): 6457.
https://doi.org/10.1182/blood-2023-185616
Published: 2023
Journal Articles

ARI0002h (Cesnicabtagene Autoleucel), an Academic Point-of-Care B-Cell Maturation Antigen (BCMA)-Directed Chimeric Antigen Receptor (CAR) T-Cell Strategy: Activity and Safety after Fractionated Initial Therapy and Booster Dose in 60 Patients with Relapsed/Refractory Multiple Myeloma

Aina Oliver-Caldes, Veronica Gonzalez-Calle, Valentín Cabañas, Nieves Lopez-Muñoz, Paula Rodriguez Otero, Juan Luis Reguera, Marta Español-Rego, Susana Inoges, Aintzane Zabaleta, Lucia Lopez Corral, Beatriz Martin-Antonio, Lorena Perez-Amill, Bruno Paiva, Laura Rosiñol, Ascensión López-Díaz De Cerio, Sergio Navarro, Joan Cid, Natalia Tovar, Joaquin Saez-Peñataro, Miriam Lopez Parra, Eulalia Olesti, Elena Guillén, Sara Varea, Julio Delgado, Jose Maria Sanchez Pina, Anthony Battram, Marta Sonia Gonzalez Perez, Andres Sanchez Salinas, Valentin Ortiz-Maldonado, Felipe Prosper, Manel Juan, Joaquin Martinez Lopez, Jose Maria Moraleda, Maria Victoria Mateos, Mariona Pascal, Alvaro Urbano-Ispizua, Carlos Fernández de Larrea
Journal: Blood
Blood (2023) 142 (Supplement 1): 1026.
https://doi.org/10.1182/blood-2023-180828
Published: 2023
Journal Articles

Sequential Scmultiomics of In Vivo CAR-T Cells Allows Characterization of Transcriptional Differences between Patients, and Identifies IL10 As a Potential Mechanism of Resistance to CAR-T Cells in MM

Juan Roberto Rodriguez-Madoz, Lorea Jordana-Urriza, Guillermo Serrano, Aina Oliver-Caldes, Maria Erendira Calleja-Cervantes, Patxi San-Martin, Amaia Vilas-Zornoza, Asier Ullate-Agote, Aintzane Zabaleta, Diego Alignani, Teresa Lozano, Valentin Cabanas Perianes, Juan Luis Reguera, Almudena Navarro-Bailon, Marta Español-Rego, Mariona Pascal, Jose Maria Moraleda, Jose A. Perez-Simon, Maria Victoria Mateos, Fermin Sanchez-Guijo Martin, Alvaro Urbano-Ispizua, Manel Juan, Ana Alfonso Pierola, Jose J. Rifon, Paula Rodriguez Otero, Bruno Paiva, Susana Inogés, Ascensión López-Díaz De Cerio, Juan J Lasarte, Jesús San Miguel, Carlos Fernández de Larrea, Mikel Hernaez, Felipe Prosper
Journal: Blood
Blood (2023) 142 (Supplement 1): 3433.
https://doi.org/10.1182/blood-2023-182887
Published: 2023
Journal Articles

A CD38/CD28xCD3 Trispecific T-Cell Engager (TCE) As a Potentially Active Agent for the Treatment of Older Patients with Acute Myeloid Leukemia (AML)

Aintzane Zabaleta, Esperanza Martín-Sánchez, Laura Blanco, Peter Kim, Kamlesh Bisht, Hongfang Wang, Helgi J. Van de Velde, Tomas Jelinek, Catia Simoes, Felipe Prosper, Jesus San-Miguel, David Martinez-Cuadron, Pau Montesinos, Bruno Paiva
Journal: Blood
Blood (2023) 142 (Supplement 1): 4178.
https://doi.org/10.1182/blood-2023-184797
Published: 2023
Journal Articles

Biological and Clinical Significance of Undetectable Circulating Tumor Cells (CTCs) in Patients (Pts) with Multiple Myeloma (MM)

Juan-José Garcés, Rosalinda Termini, Esperanza Martín-Sánchez, Marta Lasa, Jose J Perez, Norma C. Gutierrez, Manuela Fernández, Maria Jose Calasanz, Laura Rosiñol, Miguel Teodoro Hernández Garcia, Albert Oriol, Anna Maria Sureda Balari, Albert Perez Montaña, Enrique M Ocio, Maria Casanova Espinosa, Felipe Prosper, Joaquin Martinez-Lopez, Jorge Labrador, Esther Gonzalez Garcia, Rafael Ríos, Fernando Escalante, Joan Bargay, Elena Cabezudo, Valentín Cabañas, Niels Weinhold, Aldo Roccaro, Herve Avet-Loiseau, Alberto Orfao, Joan Blade Creixenti, Maria Victoria Mateos, Juan Jose Lahuerta Palacios, Jesus San-Miguel, María T Cedena, Noemi Puig, Bruno Paiva
Journal: Blood
Blood (2023) 142 (Supplement 1): 646.
https://doi.org/10.1182/blood-2023-186411
Published: 2023
Journal Articles

Light Chain Amyloidosis Plasma Cells Show Specific Chromatin Accessibility and Transcriptome

Beñat Ariceta, Alice Nevone, Itziar Cenzano, Ane Amundarain, Amaia Vilas-Zornoza, Leire Garate, Paula Aguirre-Ruiz, Estibaliz Miranda, Patxi San-Martin, Paolo Milani, Ramon Lecumberri Villamediana, Diego Alignani, Giovanni Palladini, Bruno Paiva, Jose Ignacio Martin-Subero, Giampaolo Merlini, Jesus San-Miguel, Mikel Hernaez, David Gomez-Cabrero, Xabier Agirre, Mario Nuvolone, Felipe Prosper
Journal: Blood
Blood (2023) 142 (Supplement 1): 4676.
https://doi.org/10.1182/blood-2023-185614
Published: 2023
Journal Articles

Data-Driven Multiparameter Flow Cytometry (MFC) Classification of Blast Differentiation in Elderly Patients with Acute Myeloid Leukemia (AML)

Carmen Gonzalez, Catia Simoes, Beñat Ariceta, David Martinez-Cuadron, Juan Miguel Bergua Burgues, Susana Vives, Lorenzo Algarra, Mar Tormo, Pilar Martinez Sanchez, Josefina Serrano, Pilar Herrera, Fernando Ramos, Olga Salamero, Esperanza Lavilla, Cristina Gil, Jose Luiz Lopez Lorenzo, Maria Vidriales Vicente, Carmen Chillon, Jorge Labrador, Jose Francisco Falantes, Maria Jose Sayas Lloris, Rosa Ayala, Joaquin Martinez-Lopez, Sara Villar, Maria Jose Calasanz, Felipe Prosper, Jesus San Miguel, Miguel A. Sanz, Pau Montesinos, Bruno Paiva
Journal: Blood
Blood (2023) 142 (Supplement 1): 1571.
https://doi.org/10.1182/blood-2023-180646
Published: 2023
Journal Articles

Uncovering the Cis-Regulatory Program of Early Human B-Cell Commitment and Its Implications in the Pathogenesis of B-Cell Acute Lymphoblastic Leukemia

Nuria Planell, Xabier Martínez-de-Morentin, Daniel Mouzo, David Lara-Astiaso, Amaia Vilas-Zornoza, Patxi San-Martin, Diego Alignani, Bruno Paiva, Alberto Maillo, Aleksandra Kurowska, Arantxa Urdangarin, Peri Noori, Asier Ortega-Legarreta, Mikel Hernaez, Vincenzo Lagani, Narsis Kiani, Iñaki I. Martin Subero, Ricardo N. Ramírez, Jesper Tegner, Felipe Prosper, David Gomez-Cabrero
Journal: Blood
Blood (2023) 142 (Supplement 1): 4044.
https://doi.org/10.1182/blood-2023-185799
Published: 2023
Journal Articles

Deep Characterization of Immune Dysfunction in Patients with Multiple Myeloma (MM) and Identification of Cellular Biomarkers for Tailored Vaccination Strategies

Esperanza Martín-Sánchez, Camila Guerrero, Luis-Esteban Tamariz-Amador, Anastasiia Zherniakova, Aintzane Zabaleta, Catarina Maia, Laura Blanco, Maria-Antonia Fortuño, Carlos Grande, Andrea Manubens, Jose Maria Arguiñano, Clara Gomez, Ernesto Perez-Persona, Iñigo Olazabal, Itziar Oiartzabal, Carlos Panizo, Felipe Prosper, Jesús San Miguel, Paula Rodriguez Otero, Bruno Paiva, Basque-Navarre Association of Hematology and Hemotherapy Asovasna
Journal: Blood
Blood (2023) 142 (Supplement 1): 643.
https://doi.org/10.1182/blood-2023-181747
Published: 2023
Journal Articles

Multiomics Characterization of Normal CD34+ Hematopoietic Progenitor Cells (HPC) and Blasts in the Bone Marrow (BM) and Peripheral Blood (PB) of Patients with Acute Myeloid Leukemia (AML)

Catia Simoes, Carmen Gonzalez, Leire Burgos, Sarai Sarvide, Diego Alignani, Aitziber Lopez, Ivan Quispe, Jose A. Pérez-Simón, María García-Fortes, Teresa Bernal Del Castillo, Mercedes Colorado, Teresa Olave, Ana Alfonso Pierola, Felipe Prosper, Pau Montesinos, Bruno Paiva
Journal: Blood
Blood (2023) 142 (Supplement 1): 2951.
https://doi.org/10.1182/blood-2023-185760
Published: 2023
Journal Articles

Combined Single-Cell and Spatial Transcriptomics Unveil the Complex Organization of the Non-Immune Human Bone Marrow Microenvironment during Aging

Itziar Cenzano, Miguel Cocera, Robert Lehmann, Jin Ye, Amaia Vilas-Zornoza, Patxi San-Martin, Paula Aguirre-Ruiz, Diego Alignani, Aitziber Lopez, Bruno Paiva, Marta Miñana Barrios, Ignacio Sancho Gonzalez, Javier Ruiz, Sarai Sarvide, Purificacion Ripalda-Cemborain, Laura Sudupe, Emma Muiños-Lopez, Vincenzo Lagani, Jesper Tegner, Borja Saez-Ochoa, Isabel A Calvo, David Gomez-Cabrero, Felipe Prosper
Journal: Blood
Blood (2023) 142 (Supplement 1): 2706.
https://doi.org/10.1182/blood-2023-179730
Published: 2023
Journal Articles

Single Cell Analysis Identifies Expression of PD-L2 on Human Bone Marrow Hematopoietic Stem Cells

Tessa Schmachtel, Marius Külp, Weijia Yu, Hana Komic, Catia Simoes, Malin S. Nilsson, Felipe Prosper, Timm Schroeder, Halvard Bonig, Bruno Paiva, Fredrik B. Thorén, Michael A. Rieger
Journal: Blood
Blood (2023) 142 (Supplement 1): 2671.
https://doi.org/10.1182/blood-2023-188684
Published: 2023
Journal Articles

Remodeling of the Immune Microenvironment By Oncogenic MYD88 Dictates Immunotherapy Responses across Indolent and Aggressive B-Cell Lymphomas

Jon Celay, Miriam Recalde, María Victoria Revuelta, Marta Larrayoz, Sara Rodriguez, Maria J Garcia-Barchino, Jennifer R. Chapman-Fredricks, Teresa Lozano, Juan J Lasarte, Ming Q. Du, Izidore S. Lossos, Sergio Roa, Aldo Roccaro, Miguel Canales, Felipe Prosper, Bruno Paiva, Leandro Cerchietti, Jose A. Martinez-Climent
Journal: Blood
Blood (2023) 142 (Supplement 1): 431.
https://doi.org/10.1182/blood-2023-173394
Published: 2023
Journal Articles

A Multi-Omic Study Unveils a Clonal Population of TET2-Mutated Infiltrating T-Cells in Germinal Center B Cell Lymphomas (DLBCL and FL)

Sofia Huerga, Beñat Ariceta, Paula Aguirre-Ruiz, Patxi San-Martin, Sarai Sarvide, Marta Abengozar-Muela, Diego Alignani, Rocio Figueroa, Carlos Grande, Alvaro Lopez-Janeiro, Emma Muiños-Lopez, Juan Roberto Rodriguez-Madoz, Amaia Vilas-Zornoza, Felipe Prosper, Miguel Canales
Journal: Blood
Blood (2023) 142 (Supplement 1): 3003.
https://doi.org/10.1182/blood-2023-182830
Published: 2023
Journal Articles

IRF2 Regulates De Novo Active Chromatin Regions and Participates in the Development and Pathogenesis of Multiple Myeloma

Nahia Gomez-Echarte, Arantxa Carrasco-León, Alba Maiques-Diaz, Estibaliz Miranda, Leire Garate, Patxi San-Martin, Stella Charalampopoulou, Luis Vitores Valcárcel, Inaki Martin-Subero, Edurne San josé-Eneriz, Xabier Agirre, Felipe Prosper
Journal: Blood
Blood (2023) 142 (Supplement 1): 1928.
https://doi.org/10.1182/blood-2023-185599
Published: 2023
Journal Articles

Optimization of a Universal Allogeneic CAR-T Cells Combining CRISPR and Transposon-Based Technologies for Treatment of Acute Myeloid Leukemia

Candela Ceballos Bolaños, Cristina Calviño, Ana Alfonso Pierola, Patricia Jauregui, Maria Erendira Calleja-Cervantes, Patxi San-Martin, Paula Rodríguez Márquez, Ángel Martin Mallo, Elena Iglesias, Gloria Abizanda, Saray Rodríguez Diaz, Rebeca Martínez Turrillas, Jorge Illarramendi Esteban, Ana Margarita Redondo, MC Viguria-Alegría, Carlos Panizo, Jose J. Rifon, Sara Villar, Juan J Lasarte, Susana Inogés, Ascensión López-Díaz De Cerio, Mikel Hernaez, Felipe Prosper, Juan Roberto Rodriguez-Madoz
Journal: Blood
Blood (2023) 142 (Supplement 1): 3457.
https://doi.org/10.1182/blood-2023-189410
Published: 2023
Journal Articles

Comprehensive Characterization of the Bone Marrow Microenvironment Transcriptional Remodeling in the Progression from MGUS to Smoldering and Multiple Myeloma

Itziar Cenzano, Miguel Cocera, Azari Bantan, Marta Larrayoz, Amaia Vilas-Zornoza, Patxi San-Martin, Paula Aguirre-Ruiz, Beñat Ariceta, Jin Ye, Diego Alignani, Aitziber Lopez, Aleksandra Kurowska, Fatimah AlSultan, Raghad Shuwaikan, Vincenzo Lagani, Jesper Tegner, Iñaki I. Martin Subero, Jose A. A Martinez-Climent, Xabier Agirre, Borja Saez-Ochoa, Bruno Paiva, Jesus San-Miguel, Mikel Hernaez, Isabel A Calvo, David Gomez-Cabrero, Felipe Prosper
Journal: Blood
Blood (2023) 142 (Supplement 1): 88.
https://doi.org/10.1182/blood-2023-178534
Published: 2023