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Journal Articles

Mapping Disease Transitions from Premalignant, Asymptomatic to Advanced Myeloma through Integrative Epigenomic and Transcriptional Analyses

Aleksandra Kurowska, Azari Bantan, Raghad Shuwaikan, Itziar Cenzano, Paula Aguirre-Ruiz, Estíbaliz Miranda, Leire Garate, Amaia Vilas-Zornoza, Patxi San-Martin, Marta Larrayoz, Nahia Gómez-Echarte, Beñat Ariceta, Daniel Soto Ortiz, Turki Sobahy, José Ignacio Martín-Subero, Vincenzo Lagani, Jesper Tegnér, Jose A. Martinez-Climent, Xabier Agirre, Mikel Hernáez Arrazola, Felipe Prosper, David Gomez-Cabrero
Journal: Blood
Blood (2024) 144 (Supplement 1): 1889.
https://doi.org/10.1182/blood-2024-209833
Published: 2024
Journal Articles

An IFNγ-Mediated Immune Inflamed Microenvironment State in Multiple Myeloma with TP53 Loss That Can be Therapeutically Exploited

Marta Larrayoz, Elena Arriazu, Aintzane Zabaleta, Carmen Roncal, Ibon Tamayo, Diana Llopiz, Maddalen Jimenez, Carla Castro, Jon Celay, Carmen Vicente, Camila Guerrero, Sonia Sanz, Maria J Garcia-Barchino, Naroa Barrena, Noemi Puig, Maria Teresa Cedena Romero, Maria Jose Calasanz, Paula Rodríguez-Otero, Jesús F. San-Miguel, Mikel Hernaez, Xabier Agirre, Pablo Sarobe, Felipe Prosper, Bruno Paiva, Jose A. Martinez-Climent
Journal: Blood
Blood (2024) 144 (Supplement 1): 670.
https://doi.org/10.1182/blood-2024-194041
Published: 2024
Journal Articles

Light Chain Amyloidosis Plasma Cells Show Specific Chromatin Accessibility and Transcriptome

Beñat Ariceta, Alice Nevone, Itziar Cenzano, Ane Amundarain, Amaia Vilas-Zornoza, Leire Garate, Paula Aguirre-Ruiz, Estibaliz Miranda, Patxi San-Martin, Paolo Milani, Ramon Lecumberri Villamediana, Diego Alignani, Giovanni Palladini, Bruno Paiva, Jose Ignacio Martin-Subero, Giampaolo Merlini, Jesus San-Miguel, Mikel Hernaez, David Gomez-Cabrero, Xabier Agirre, Mario Nuvolone, Felipe Prosper
Journal: Blood
Blood (2023) 142 (Supplement 1): 4676.
https://doi.org/10.1182/blood-2023-185614
Published: 2023
Journal Articles

IRF2 Regulates De Novo Active Chromatin Regions and Participates in the Development and Pathogenesis of Multiple Myeloma

Nahia Gomez-Echarte, Arantxa Carrasco-León, Alba Maiques-Diaz, Estibaliz Miranda, Leire Garate, Patxi San-Martin, Stella Charalampopoulou, Luis Vitores Valcárcel, Inaki Martin-Subero, Edurne San josé-Eneriz, Xabier Agirre, Felipe Prosper
Journal: Blood
Blood (2023) 142 (Supplement 1): 1928.
https://doi.org/10.1182/blood-2023-185599
Published: 2023
Journal Articles

Comprehensive Characterization of the Bone Marrow Microenvironment Transcriptional Remodeling in the Progression from MGUS to Smoldering and Multiple Myeloma

Itziar Cenzano, Miguel Cocera, Azari Bantan, Marta Larrayoz, Amaia Vilas-Zornoza, Patxi San-Martin, Paula Aguirre-Ruiz, Beñat Ariceta, Jin Ye, Diego Alignani, Aitziber Lopez, Aleksandra Kurowska, Fatimah AlSultan, Raghad Shuwaikan, Vincenzo Lagani, Jesper Tegner, Iñaki I. Martin Subero, Jose A. A Martinez-Climent, Xabier Agirre, Borja Saez-Ochoa, Bruno Paiva, Jesus San-Miguel, Mikel Hernaez, Isabel A Calvo, David Gomez-Cabrero, Felipe Prosper
Journal: Blood
Blood (2023) 142 (Supplement 1): 88.
https://doi.org/10.1182/blood-2023-178534
Published: 2023
Journal Articles

RROL lncRNA role in multiple myeloma

Xabier Agirre
Journal: Blood
Blood (2023) 141 (4): 328–330.
https://doi.org/10.1182/blood.2022018471
Published: 2023
Journal Articles

A Multimodal Single Cell Atlas of Human Tonsils Reveals New Insights into T and B Cell Differentiation

Sergio Aguilar, Ramon Massoni, Paula Soler-Vila, Juan C Nieto, Marc Elosua-Bayes, Domenica Marchese, Marta Kulis, Amaia Vilas-Zornoza, Marco Matteo Bühler, Sonal Rashmi, Clara Alsinet, Ginevra Caratù, Catia Moutinho, Sara Ruiz, Patricia Lorden, Giulia Lunazzi, Dolors Colomer, Gerard Frigola, Will Blevins, Sara Palomino, Gomez-Cabrero David, Xabier Agirre, Marc Weniger, Federico Marini, Francisco Javier Cervera Paz, Peter M Baptista, Isabel Vilaseca, Felipe Prósper, Ralf Küppers, Elías Campo, Holger Heyn, Ivo Gut, José I. Martín-Subero
Journal: Blood
Blood (2022) 140 (Supplement 1): 8358–8359.
https://doi.org/10.1182/blood-2022-160140
Published: 2022
Journal Articles

Cereblon enhancer methylation and IMiD resistance in multiple myeloma

Clinical Trials & Observations Brief Report
Larissa Haertle, Santiago Barrio, Umair Munawar, Seungbin Han, Xiang Zhou, Cornelia Vogt, Rafael Alonso Fernández, Max Bittrich, Yanira Ruiz-Heredia, Matteo Da Viá, Josip Zovko, Andoni Garitano-Trojaola, Niccolò Bolli, Anna Ruckdeschel, Thorsten Stühmer, Manik Chatterjee, Miriam Kull, Jan Krönke, Xabier Agirre, Jose I. Martin-Subero, Peter Raab, Hermann Einsele, Leo Rasche, Joaquin Martinez-Lopez, Thomas Haaf, K. Martin Kortüm
Journal: Blood
Blood (2021) 138 (18): 1721–1726.
https://doi.org/10.1182/blood.2020010452
Published: 2021
Includes: Supplemental data
Journal Articles

Clinical Validation of a NGS Capture Panel to Identify Mutations, Copy Number Variations and Translocations in Patients with Multiple Myeloma

Isabel Cuenca, MSc, Alejandro Medina, MD, Laura Rosinol, MD PhD, Iria Vazquez, PhD BSc, Ricardo Sanchez, Norma C. Gutierrez, MD PhD, Yanira Ruiz-Heredia, Santiago Barrio, Albert Oriol, MD, Maria Luisa Martin-Ramos, Manuela Fernández-Guijarro, María Jesús Blanchard, Rafael Rios, MD PhD, Anna Sureda Balari, MD PhD, Miguel T Hernández, Javier de la Rubia, Gorka Alkorta, Xabier Agirre, PhD, Gonzalo R Ordóñez, Rafael Valdés-Mas, Maria-Victoria Mateos, MD PhD, Joan Blade Creixenti, Juan Jose Lahuerta, MD PhD, Jesus F. San-Miguel, MD PhD, Maria Jose Calasanz, PhD BSc, Ramon Garcia-Sanz, Joaquin Martinez-Lopez, MD PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 13–14.
https://doi.org/10.1182/blood-2020-140711
Published: 2020
Journal Articles

Immunogenomic identification and characterization of granulocytic myeloid-derived suppressor cells in multiple myeloma

Cristina Perez, Cirino Botta, Aintzane Zabaleta, Noemi Puig, Maria-Teresa Cedena, Ibai Goicoechea, Daniel Alameda, Edurne San José-Eneriz, Juana Merino, Paula Rodríguez-Otero, Catarina Maia, Diego Alignani, Patricia Maiso, Irene Manrique, David Lara-Astiaso, Amaia Vilas-Zornoza, Sarai Sarvide, Caterina Riillo, Marco Rossi, Laura Rosiñol, Albert Oriol, María-Jesús Blanchard, Rafael Rios, Anna Sureda, Jesus Martin, Rafael Martinez, Joan Bargay, Javier de la Rubia, Miguel-Teodoro Hernandez, Joaquin Martinez-Lopez, Alberto Orfao, Xabier Agirre, Felipe Prosper, Maria-Victoria Mateos, Juan-José Lahuerta, Joan Blade, Jesús F. San-Miguel, Bruno Paiva
Journal: Blood
Blood (2020) 136 (2): 199–209.
https://doi.org/10.1182/blood.2019004537
Published: 2020
Includes: Supplemental data
Journal Articles

A Computational Based Approach for Identification and Validation of Gene Mutations As Surrogate Markers of Gene Essentiality in Acute Myeloid Leukemia

Fernando Carazo, Edurne San Jose, Leire Garate, Estibaliz Miranda, Ana Alfonso Pierola, MD PhD, Sara Villar, Jose J. Rifon Roca, MD, Bruno Paiva, PhD, Jesús San-Miguel, Xabier Agirre, PhD, Felipe Prósper, MD PhD, Angel Rubio
Journal: Blood
Blood (2019) 134 (Supplement_1): 1414.
https://doi.org/10.1182/blood-2019-126506
Published: 2019
Journal Articles

Computational Systems Biology Models for the Identification of Metabolic Vulnerabilities in Multiple Myeloma

Luis Vitores V. Valcárcel, MSc, Raquel Ordoñez, PhD, Iñigo Apaolaza, MSc, Ana Valcárcel, Leire Garate, Cem Meydan, PhD, Bruno Paiva, PhD, Ari M Melnick, MD, Jesús San-Miguel, Francisco J. Planes, Xabier Agirre, PhD, Felipe Prosper, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3084.
https://doi.org/10.1182/blood-2019-123970
Published: 2019
Journal Articles

Circulating Tumor Cells (CTCs) for Comprehensive and Multiregional Non-Invasive Genetic Characterization of Multiple Myeloma (MM)

Juan José Garcés, Gabriel Bretones, Leire Burgos, Rafael Valdes-Mas, Diego Alignani, PhD, Diana Álvarez Puente, Ibai Goicoechea, PhD, Miguel García Álvarez, Sonia Garate, Idoia Rodriguez, Maria Jose Calasanz, PhD BSc, Paula Rodriguez, MD, Rafael Rios, MD PhD, Joaquin Martinez-Lopez, MD PhD, Pamela Millacoy, Luis Palomera, MD PhD, Rafael Del Orbe, MD PhD, Albert Pérez, MD, Xabier Agirre, PhD, Juan Flores-Montero, Luzalba Sanoja-Flores, Alberto Orfao, MD PhD, Halima El Omri, Felipe Prosper, MD PhD, Carlos Lopez-Otin, Jesús San-Miguel, Bruno Paiva, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3064.
https://doi.org/10.1182/blood-2019-126527
Published: 2019
Journal Articles

Differentiation Therapy with Novel Epigenetic Inhibitors in Acute Myeloid Leukemia

Edurne San Jose, Naroa Gimenez-Camino, Obdulia Rabal, Estibaliz Miranda, Leire Garate, Fernando Garcia, Ana Alfonso Pierola, MD PhD, Sara Villar, Jose J. Rifon Roca, MD, Antonio Pineda-Lucena, Bruno Paiva, PhD, Javier Muñoz, Jesús San-Miguel, Julen Oyarzabal, PhD, Xabier Agirre, PhD, Felipe Prósper, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3762.
https://doi.org/10.1182/blood-2019-125578
Published: 2019
Journal Articles

Characterization of Complete Lncrnas Transcriptome Reveals Expression of Lncrnas As a Prognostic Factor and Linc-Smilo As a Potential Therapeutic Target in Multiple Myeloma

Arantxa Carrasco, Teresa Ezponda, Cem Meydan, PhD, Luis Vitores Valcárcel, MSc, Raquel Ordoñez, PhD, Marta Kulis, PhD, Leire Garate, Estíbaliz Miranda, Victor Segura, PhD, Elizabeth Guruceaga, Amaia Vilas-Zornoza, PhD, Diego Alignani, PhD, Laura Castro, Marien Pascual, PhD, Ane Amundarain, Halima El Omri, Ruba Yasin, MBBS, MRCP, Maria Jose Calasanz, PhD BSc, Francisco J Planes, Bruno Paiva, PhD, Christopher Mason, PhD, Jesús San-Miguel, Inaki Martin Subero, PhD, Ari M Melnick, MD, Felipe Prosper, MD PhD, Xabier Agirre, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 4323.
https://doi.org/10.1182/blood-2019-123008
Published: 2019
Journal Articles

Lncrnas As New Partners of Novel Chimeric Transcripts in Multiple Myeloma

Ane Amundarain, Luis Vitores Valcárcel, MSc, Raquel Ordoñez, PhD, Leire Garate, Estíbaliz Miranda, Xabier Cendoya, Maria Jose Calasanz, PhD BSc, Bruno Paiva, PhD, Jesús San-Miguel, Francisco J Planes, Felipe Prósper, MD PhD, Xabier Agirre, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 4356.
https://doi.org/10.1182/blood-2019-122568
Published: 2019
Journal Articles

Transcriptomic Profiling of Circulating Tumor Cells (CTCs) in Multiple Myeloma (MM): A New Model to Understand Disease Dissemination

Juan José Garcés, Michal Šimíček, Marco Vicari, Lucie Brozova, MSc, Leire Burgos, Renata Bezděková, MSc., Diego Alignani, PhD, Maria Jose Calasanz, BSc, PhD, Katerina Growkova, Ludek Pour, MD, Rafael Rios, MD PhD, Joaquin Martinez-Lopez, MD PhD, Pamela Millacoy, Luis Palomera, MD PhD, Rafael Del Orbe, Sonia Garate, Laura Blanco, Patricia Maiso, PhD, Zuzana Chyra, Alexander Vdovin, Tomas Jelinek, Cirino Botta, MD, Halima El Omri, Xabier Agirre, PhD, Felipe Prosper, MD PhD, Roman Hajek, MD PhD, Jesus F San-Miguel, MD PhD, Bruno Paiva, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 245.
https://doi.org/10.1182/blood-2018-99-113331
Published: 2018
Journal Articles

Extracellular vesicles in DLBCL provide abundant clues to aberrant transcriptional programming and genomic alterations

e-blood
Sarah C. Rutherford, Angela A. Fachel, Sheng Li, Seema Sawh, Ashlesha Muley, Jennifer Ishii, Ashish Saxena, Pilar M. Dominguez, Eloisi Caldas Lopes, Xabier Agirre, Nyasha Chambwe, Fabian Correa, Yanwen Jiang, Kristy L. Richards, Doron Betel, Rita Shaknovich
Journal: Blood
Blood (2018) 132 (7): e13–e23.
https://doi.org/10.1182/blood-2017-12-821843
Published: 2018
Includes: Supplemental data
Journal Articles

ZFP36L1, a Novel Potential Tumor Supressor Gene in Myelofibrosis, Epigenetically Deregulated By Methylation of the Enhancer Region

Nicolas Martinez-Calle, MD MSc, Marien Pascual, PhD, Raquel Ordoñez, MSc, Edurne San Jose Eneriz, PhD, Victor Segura, PhD, Giancarlo Castellano, PhD, Jose J. Rifon, MD, Maria Jose Calasanz, BSc, PhD, José I. Martin-Subero, PhD, Xabier Agirre, PhD, Felipe Prosper, MDPhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 2936.
https://doi.org/10.1182/blood.V130.Suppl_1.2936.2936
Published: 2017
Journal Articles

Whole-Genome Analysis of the Chromatin Structure in Multiple Myeloma

Marta Kulis, Raquel Ordoñez, Nuria Russiñol, Renée Beekman, Núria Verdaguer-Dot, Teresa Ezponda, Arantxa Carrasco, Joost H.A. Martens, Hendrik G. Stunnenberg, Bruno Paiva, PhD, Jesus San Miguel, MDPhD, Elias Campo, Felipe Prosper, MD, Xabier Agirre, PhD, José I. Martin-Subero
Journal: Blood
Blood (2016) 128 (22): 118.
https://doi.org/10.1182/blood.V128.22.118.118
Published: 2016