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Journal Articles

Measurable residual disease by mass spectrometry and next-generation flow to assess treatment response in myeloma

Clinical Trials & Observations Brief Report
Noemí Puig, Cristina Agulló, Teresa Contreras, María-Teresa Cedena, Joaquín Martínez-López, Albert Oriol, María-Jesús Blanchard, Rafael Ríos, María-Belén Íñigo, Anna Sureda, Sunil Lakhwani, Javier de la Rubia, Verónica González-Calle, Valentín Cabañas, Luis Palomera, José-María Moraleda, Joan Bargay, Sergio Castro, Laura Rosiñol, Joan Bladé, Jesús F. San-Miguel, Juan-José Lahuerta, Bruno Paiva, María-Victoria Mateos
Journal: Blood
Blood (2024) 144 (23): 2432–2438.
https://doi.org/10.1182/blood.2024024995
Published: 2024
Includes: Supplemental data
Journal Articles

Impact of Transfusion Dependency on Patients Diagnosed with Myelodysplastic Syndrome According to IPSS-M Risk Group

Elena Bechtold Javier, Helena Pomares, Sandra Castaño-Díez, Guillermo Ramil López, Ivan Martín, Ana Perez Gonzalez, Blanca Xicoy, Joan Bargay, Ferran Vall-Llovera Calmet, Tzu Hua Chen, Jordi Vila Bou, Clara Maluquer Artigal, Ines Zugasti, Mercedes Galiano, Shiomara Quiñones, Mar Tormo, Guadalupe Onate, Esther Alonso, Neus Ruiz Xiville, Lurdes Zamora, Jordi Esteve, Marina Diaz Beya, Anna Sureda Balari, Montserrat Arnan
Journal: Blood
Blood (2024) 144 (Supplement 1): 1838.
https://doi.org/10.1182/blood-2024-205407
Published: 2024
Journal Articles

GEM2017Fit Phase 3 Trial in Fit Elderly Patients (Aged 65-80) with Newly Diagnosed Myeloma: Impact of Daratumumab at Induction and/or Consolidation

Maria- Victoria Mateos, Bruno Paiva, Maria Teresa Cedena Romero, Noemi Puig, Anna Sureda Balari, Albert Oriol, Enrique M Ocio, Laura Rosiñol, Yolanda González-Montes, Joan Bargay, Esther Gonzalez Garcia, Miguel Teodoro Hernández Garcia, Angel Ramirez, Alexia Suarez-Cabrera, María-Jesús Blanchard, Sebastián Garzón, Luis Felipe Casado, Valentin Cabanas Perianes, Jaime Perez de Oteyza, Mercedes Gironella, Joaquin Martínez-López, Ana-Isabel -Teruel, Pilar Delgado, Elena Prieto, Juan-Jose Lahuerta Palacios, Joan Bladé, Jesús F. San-Miguel
Journal: Blood
Blood (2024) 144 (Supplement 1): 678.
https://doi.org/10.1182/blood-2024-203170
Published: 2024
Journal Articles

Reevaluating the IMWG Multiple Myeloma Complete Response Criterion in the Era of Mass Spectrometry: A Critical Analysis

Noemi Puig, Cristina Agullo, Bruno Paiva, María T Cedena, Laura Rosiñol Dachs, Teresa Contreras, Joaquín Martínez-Lopez, Albert Oriol, María-Jesús Blanchard, Rafael Rios Tamayo, Ana Maria Sureda Balari, Miguel Teodoro Hernández Garcia, Javier de la Rubia, Valentin Cabanas Perianes, Felipe De Arriba, Luis Palomera, Maria Belen Inigo Rodriguez, Veronica Gonzalez-Calle, Enrique M Ocio, Sergio Castro, Joan Bargay, Joan Bladé, Jesús F. San-Miguel, Juan-Jose Lahuerta Palacios, Maria- Victoria Mateos
Journal: Blood
Blood (2024) 144 (Supplement 1): 489.
https://doi.org/10.1182/blood-2024-210198
Published: 2024
Journal Articles

Survival Improvement of Transplant Eligible Patients with Newly Diagnosed Multiple Myeloma in Two Consecutive Randomized Phase III Trials: Long-Term Follow up of GEM05 and GEM12 Trials

Laura Rosiñol Dachs, Albert Oriol, María-Jesús Blanchard, Javier de la Rubia, Rafael Ríos, Joan Bargay, Miguel Teodoro Hernández Garcia, Valentín Cabanas Perianes, Ana López de la Guía, Estrella Carrillo-Cruz, Anna Sureda Balari, Joaquin Martínez-López, Jose Maria Arguiñano, Esther González García, Luis Felipe Casado, Josep Maria Marti Tutusaus, Cristina Encinas, Felipe De Arriba, Luis Palomera, Antonia Sampol Mayol, Yolanda González-Montes, Jordi López-Pardo, Maialen Sirvent, Maria Belen Inigo Rodriguez, Bruno Paiva, Noemi Puig, Maria Teresa Cedena Romero, Norma C. Gutierrez, Javier De la Cruz, Maria-Victoria Mateos, Jesús F. San-Miguel, Juan-Jose Lahuerta Palacios, Joan Bladé
Journal: Blood
Blood (2024) 144 (Supplement 1): 3374.
https://doi.org/10.1182/blood-2024-205453
Published: 2024
Journal Articles

Clinical Value of Peripheral Residual Disease (PRD) and Measurable Residual Disease (MRD) in Newly Diagnosed Elderly Patients in the GEM2017FIT Trial

Noemi Puig, Bruno Paiva, María T Cedena, Cristina Agullo, Teresa Contreras, Sergio Castro, Ana Maria Sureda Balari, Veronica Gonzalez-Calle, Albert Oriol, Enrique M Ocio, Laura Rosiñol Dachs, Yolanda González-Montes, Joan Bargay, Esther González García, Miguel Teodoro Hernández Garcia, Angel Ramirez, Alexia Suarez-Cabrera, María-Jesús Blanchard, Sebastián Garzón, Luis Felipe Casado Montero, Valentin Cabanas Perianes, Jaime Perez de Oteyza, Mercedes Gironella, Joaquín Martínez-Lopez, Pilar Delgado, Elena Prieto, Juan-Jose Lahuerta Palacios, Joan Bladé, Jesús F. San-Miguel, Maria- Victoria Mateos
Journal: Blood
Blood (2024) 144 (Supplement 1): 365.
https://doi.org/10.1182/blood-2024-209748
Published: 2024
Journal Articles

Unraveling Long-Term Survival of Multiple Myeloma Patients, the GEM2000 Experience

Rafael Alonso Fernandez, Andrés Arroyo Barea, Maria Teresa Cedena Romero, Laura Rosiñol Dachs, Javier de la Rubia, Sara Miqueleiz, Veronica Gonzalez-Calle, Felipe De Arriba, Luis Felipe Casado Montero, Miguel Teodoro Hernandez, Maria Mas Esteve, Pascual Fernandez, Paula Rodríguez-Otero, Carmen Calle Primo, Eugenia Abella, Paz Ribas, Adrian Alegre, Juan Miguel Bergua, Irene Gomez-Catalan, Jose Maria Arguiñano Perez, Luis Palomera, Enrique M Ocio, Maria Jose Busto Medina, Nieves Somolinos, Jose Maria Alonso Alonso, Aránzazu García Mateo, Joan Bargay, Pilar Delgado, Dunia De Miguel Llorente, Javier de la Cruz, Maria Victoria Mateos, Jesús F. San-Miguel, Joan Bladé, Juan-Jose Lahuerta Palacios, Joaquin Martinez Lopez
Journal: Blood
Blood (2024) 144 (Supplement 1): 1957.
https://doi.org/10.1182/blood-2024-211383
Published: 2024
Journal Articles

Predictors of unsustained measurable residual disease negativity in transplant-eligible patients with multiple myeloma

Clinical Trials & Observations Brief Report
Camila Guerrero, Noemi Puig, María-Teresa Cedena, María-José Calasanz, Norma C. Gutierrez, Manuela Fernandez, Albert Oriol, Rafael Ríos-Tamayo, Miguel-Teodoro Hernandez, Rafael Martínez-Martínez, Joan Bargay, Felipe de Arriba, Luis Palomera, Ana Pilar Gonzalez-Rodriguez, Marta-Sonia Gonzalez Perez, Alberto Orfao, María-Victoria Mateos, Joaquin Martinez-Lopez, Laura Rosiñol, Joan Bladé, Juan-Jose Lahuerta, Jesus F. San-Miguel, Bruno Paiva
Journal: Blood
Blood (2024) 143 (7): 597–603.
https://doi.org/10.1182/blood.2023022083
Published: 2024
Includes: Supplemental data
Journal Articles

Lenalidomide and dexamethasone maintenance with or without ixazomib, tailored by residual disease status in myeloma

Clinical Trials & Observations
Laura Rosiñol, Albert Oriol, Rafael Ríos, María Jesús Blanchard, Isidro Jarque, Joan Bargay, Miguel Teodoro Hernández, Valentín Cabañas, Estrella Carrillo-Cruz, Anna Sureda, Joaquín Martínez-López, Isabel Krsnik, Maria Esther González, Luis Felipe Casado, Josep María Martí, Cristina Encinas, Felipe de Arriba, Luis Palomera, Antonia Sampol, Yolanda González-Montes, Elena Cabezudo, Bruno Paiva, Noemí Puig, María Teresa Cedena, Javier de la Cruz, María-Victoria Mateos, Jesús San Miguel, Juan José Lahuerta, Joan Bladé
Journal: Blood
Blood (2023) 142 (18): 1518–1528.
https://doi.org/10.1182/blood.2022019531
Published: 2023
Journal Articles

Clinical Characteristics, Treatment Approach and Long-Term Outcomes of 678 Patients with Symptomatic Waldenstrom's Macroglobulinemia: Comprehensive Insights from a Spanish Registry of IgM Gammapathies

Elham Askari, David F. Moreno, Fernando Escalante, Amalia Domingo-González, Angela Heredia, Arancha Bermúdez, Miguel Canales, Mario Arnao Herraiz, Maria Magdalena Alcala Peña, Ana Saus Carreres, Pablo Ríos Rull, María Casanova, Mercedes Gironella, Paz Ribas Garcia, Javier De La Rubia, Belén Navarro, María-Jesús Blanchard, Cristina Motlló, Ricarda García Sánchez, Francisco Taboada Alameda, Antonio Garcia, Eugenio Abella, Miguel Angel Alvarez Rivas, Joan Bargay, Laura Abril Sabater, Amanda Lopez Picado, Carlos Fernández de Larrea, Ramon Garcia-Sanz
Journal: Blood
Blood (2023) 142 (Supplement 1): 4406.
https://doi.org/10.1182/blood-2023-189581
Published: 2023
Journal Articles

Sustained Recovery of Uninvolved Heavy/Light Chain Pair Immunoparesis during Maintenance Discriminates Patients with Sustained Negative Minimal Residual Disease

Sunil Lakhwani, Laura Rosiñol, Noemi Puig, Miguel Angel Pico Picos, Laura Medina-González, Joaquin Martinez Lopez, Bruno Paiva, Maria Teresa Cedena Romero, Albert Oriol, Rafael Ríos, María Jesús Blanchard, Isidro Jarque, Joan Bargay, Jose Maria Moraleda, Estrella Carrillo-Cruz, Anna Maria Sureda Balari, Isabel Krsnik, Esther Gonzalez Garcia, Luis Felipe Casado Montero, Josep Maria Marti Tutusaus, Cristina Encinas Rodriguez, Felipe De Arriba, Luis Palomera, Antonia Sampol Mayol, Yolanda González-Montes, Cristina Motlló, Javier De la Cruz, Rafael Alonso Fernández, Maria-Victoria Mateos, Joan Blade Creixenti, Juan Jose Lahuerta Palacios, Jesus San Miguel, Miguel Teodoro Hernández Garcia
Journal: Blood
Blood (2023) 142 (Supplement 1): 1958.
https://doi.org/10.1182/blood-2023-179452
Published: 2023
Journal Articles

Biological and Clinical Significance of Undetectable Circulating Tumor Cells (CTCs) in Patients (Pts) with Multiple Myeloma (MM)

Juan-José Garcés, Rosalinda Termini, Esperanza Martín-Sánchez, Marta Lasa, Jose J Perez, Norma C. Gutierrez, Manuela Fernández, Maria Jose Calasanz, Laura Rosiñol, Miguel Teodoro Hernández Garcia, Albert Oriol, Anna Maria Sureda Balari, Albert Perez Montaña, Enrique M Ocio, Maria Casanova Espinosa, Felipe Prosper, Joaquin Martinez-Lopez, Jorge Labrador, Esther Gonzalez Garcia, Rafael Ríos, Fernando Escalante, Joan Bargay, Elena Cabezudo, Valentín Cabañas, Niels Weinhold, Aldo Roccaro, Herve Avet-Loiseau, Alberto Orfao, Joan Blade Creixenti, Maria Victoria Mateos, Juan Jose Lahuerta Palacios, Jesus San-Miguel, María T Cedena, Noemi Puig, Bruno Paiva
Journal: Blood
Blood (2023) 142 (Supplement 1): 646.
https://doi.org/10.1182/blood-2023-186411
Published: 2023
Journal Articles

Usefulness of Peripheral Blood Samples in Diagnosis and Prognosis Assessment of Myelodysplastic Syndromes and Chronic Myelomonocytic Leukemia Low Risk Patients Using Next Generation Sequencing

Pamela Acha, Ana Manzanares, Blanca Xicoy, Lurdes Zamora, Cristina de la Fuente, Marta Julià, Martin Mascaro Riera, Joan Bargay, Alfonso García, Maria Julia Montoro, Laura Palomo, Helena Pomares, Montserrat Arnan Sangerman, Francisco Fuster-Tormo, Mar Mallo, Oriol Calvete, Julia Mestre, Isabel Granada, Mercedes Berenguer, Francesc Sole
Journal: Blood
Blood (2023) 142 (Supplement 1): 6477.
https://doi.org/10.1182/blood-2023-180680
Published: 2023
Journal Articles

Recovery of Uninvolved Heavy/Light Chain Pair Immunoparesis during Maintenance Is an Independent Prognostic Factor for Multiple Myeloma and Could Complement Prognosis Value of Minimal Residual Disease

Sunil Lakhwani, Laura Rosinol Dachs, Noemi Puig, Miguel Angel Pico Picos, Laura Medina-González, Joaquín Martínez-López, Bruno Paiva, Albert Oriol, Rafael Rios, María Jesús Blanchard, Isidro Jarque, Joan Bargay, Jose Maria Moraleda, Estrella Carrillo-Cruz, Anna Sureda, Isabel Krsnik, Esther González Garcia, Luis Felipe Casado Montero, Josep M Marti, Cristina Encinas, Felipe De Arriba, Luis Palomera, Antonia Sampol, Yolanda Gonzalez-Montes, Cristina Motllo, Javier De La Cruz, Rafael Alonso Fernández, María-Victoria Mateos, Joan Bladé Creixenti, Juan-José Lahuerta, Jesús San-Miguel, Miguel-Teodoro Hernández
Journal: Blood
Blood (2022) 140 (Supplement 1): 2101–2103.
https://doi.org/10.1182/blood-2022-167247
Published: 2022
Journal Articles

Immunoparesis Recovery in Transplant-Ineligible Newly Diagnosis Multiple Myeloma Patients: An Independent Prognosis Factor That Could Complement Prognostic Value of Minimal Residual Disease

Sunil Lakhwani, María Victoria Mateos, Joaquín Martínez-López, Bruno Paiva, Laura Rosinol Dachs, Rafael Martínez, Albert Oriol, Joan Bargay, Yolanda Gonzalez-Montes, Mercedes Gironella, Cristina Encinas, Jesus Martin, Isidro Jarque, Miquel Granell, Eugenia Abella, Aránzazu García Mateo, José Ángel Hernández-Rivas, Elena Ramila, Isabel Krsnik, Luis Felipe Casado Montero, Felipe De Arriba, Luis Palomera, Antonia Sampol, Jose Maria Moraleda, Maria Casanova, Pilar Delgado, Ana Lafuente, Elena Amutio, Aurelio Lopez Martínez, Albert Altés, M. Ángeles Ruíz, Lucia Lopez-Anglada, Joan Bladé Creixenti, Juan-José Lahuerta, Jesús San-Miguel, Miguel-Teodoro Hernández
Journal: Blood
Blood (2022) 140 (Supplement 1): 2344–2346.
https://doi.org/10.1182/blood-2022-166826
Published: 2022
Journal Articles

RAS Mutations in Adult Acute Myeloid Leukemia (AML). Frequency, Mutational Spectrum, and Identification of a Comutation Bias for KRAS K117 ( TET2 / ASXL1 )

Alícia Artigas-Baleri, Helena Castellet, Marta Pratcorona, Lurdes Zamora, Monica Lopez-Guerra, Bárbara Tazón, Susana Vives, Mar Tormo, Montserrat Arnan, Antoni Garcia-Guiñon, Rosa Coll., Antonia Sampol, Joan Bargay, Ferran Vall-Llovera, Olga Salamero, Felix Lopez-Cadenas, Ana Garrido Díaz, Jordi Esteve, Jorge Sierra, Josep F Nomdedeu
Journal: Blood
Blood (2022) 140 (Supplement 1): 11821–11823.
https://doi.org/10.1182/blood-2022-164718
Published: 2022
Journal Articles

Curative Strategy (GEM-CESAR) for High-Risk Smoldering Myeloma (SMM): Post-Hoc Analysis of Sustained Undetectable Measurable Residual Disease (MRD)

Maria-Victoria Mateos, Joaquín Martínez-López, Paula Rodríguez-Otero, Jesús San-Miguel, Veronica Gonzalez-Calle, Marta Sonia Gonzalez, Albert Oriol, Norma C. Gutierrez, Rafael Rios, Laura Rosinol Dachs, Miguel Angel Alvarez, Joan Bargay, Ana Pilar Gonzalez, Fernando Escalante, Adrian Alegre, Belén Iñigo, Javier de la Rubia, Ana Isabel Teruel, Felipe De Arriba, Luis Palomera, Miguel-Teodoro Hernández, Javier Lopez Jimenez, Marta Reinoso Segura, Aránzazu García Mateo, Enrique M. Ocio, Joan Bladé, Juan-José Lahuerta, María Teresa Cedena, Noemi Puig, Bruno Paiva
Journal: Blood
Blood (2022) 140 (Supplement 1): 292–294.
https://doi.org/10.1182/blood-2022-159606
Published: 2022
Journal Articles

Clinical Impact of Next Generation Flow in Bone Marrow Vs Qip-Mass Spectrometry in Peripheral Blood to Assess Minimal Residual Disease in Newly Diagnosed Multiple Myeloma Patients Receiving Maintenance As Part of the GEM2014MAIN Trial

Noemi Puig, Cristina Agulló, Teresa Contreras Sanfeliciano, Bruno Paiva, María Teresa Cedena, Laura Rosinol Dachs, Ramón García-Sanz, Joaquín Martínez-López, Albert Oriol, María Jesús Blanchard, Rafael Rios, Jesus Martin, Anna Sureda, Miguel Hernández, Javier de la Rubia, Jose Maria Moraleda, Felipe De Arriba, Luis Palomera, Belén Iñigo, Joan Bargay, Joan Bladé Creixenti, Jesús San-Miguel, Juan Jose Lahuerta, María-Victoria Mateos
Journal: Blood
Blood (2022) 140 (Supplement 1): 2098–2100.
https://doi.org/10.1182/blood-2022-165441
Published: 2022
Journal Articles

Evaluation of Lenalidomide (LEN) Vs Placebo in Non-Transfusion Dependent Low Risk Del(5q) MDS Patients. Final Results of Sintra-REV Phase III International Multicenter Clinical Trial

Félix López Cadenas, Eva Lumbreras, Teresa González, Blanca Xicoy, Joaquín Sánchez-García, Rosa Coll, Bohrane Slama, José Ángel Hernández-Rivas, Sylvain Thepot, Teresa Bernal, Agnès Guerci-Bresler, Guillermo Sanz, Joan Bargay, Maria Luz Amigo, Raquel De Paz Arias, Claude Preudhomme, Aristoteles Giagounidis, Uwe Platzbecker, Stefan Wickenhauser, Katharina S. Goetze, Ali Arar, Jesús M Hernández Rivas, Sofía M Toribio Castelló, Pierre Fenaux, Consuelo Del Cañizo, Maria Diez-Campelo
Journal: Blood
Blood (2022) 140 (Supplement 1): 1109–1111.
https://doi.org/10.1182/blood-2022-168718
Published: 2022
Journal Articles

Belantamab Mafodotin in Combination with Vrd for the Treatment of Newly Diagnosed Transplant Eligible Multiple Myeloma Patients: Results from the Phase II, Open Label, Multicenter, GEM-BELA-Vrd Trial

Veronica Gonzalez-Calle, Paula Rodriguez Otero, Beatriz Rey-Bua, Javier De La Rubia, Felipe De Arriba, Valentin Cabañas, Esther González Garcia, Enrique M. Ocio, Cristina Encinas, Alexia Suarez Cabrera, Joan Bargay, Joaquin Martinez Lopez, Marta Sonia Gonzalez, Jose Angel Hernandez-Rivas, Laura Rosiñol, Miguel-Teodoro Hernández, Bruno Paiva, Maria Teresa Cedena Romero, Noemi Puig, Juan-José Lahuerta, Joan Bladé, Jesús San-Miguel, Maria-Victoria Mateos
Journal: Blood
Blood (2022) 140 (Supplement 1): 7286–7288.
https://doi.org/10.1182/blood-2022-162584
Published: 2022