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Journal Articles

Lenalidomide and dexamethasone maintenance with or without ixazomib, tailored by residual disease status in myeloma

Clinical Trials & Observations
Laura Rosiñol, Albert Oriol, Rafael Ríos, María Jesús Blanchard, Isidro Jarque, Joan Bargay, Miguel Teodoro Hernández, Valentín Cabañas, Estrella Carrillo-Cruz, Anna Sureda, Joaquín Martínez-López, Isabel Krsnik, Maria Esther González, Luis Felipe Casado, Josep María Martí, Cristina Encinas, Felipe de Arriba, Luis Palomera, Antonia Sampol, Yolanda González-Montes, Elena Cabezudo, Bruno Paiva, Noemí Puig, María Teresa Cedena, Javier de la Cruz, María-Victoria Mateos, Jesús San Miguel, Juan José Lahuerta, Joan Bladé
Journal: Blood
Blood (2023) 142 (18): 1518–1528.
https://doi.org/10.1182/blood.2022019531
Published: 2023
Journal Articles

Sustained Recovery of Uninvolved Heavy/Light Chain Pair Immunoparesis during Maintenance Discriminates Patients with Sustained Negative Minimal Residual Disease

Sunil Lakhwani, Laura Rosiñol, Noemi Puig, Miguel Angel Pico Picos, Laura Medina-González, Joaquin Martinez Lopez, Bruno Paiva, Maria Teresa Cedena Romero, Albert Oriol, Rafael Ríos, María Jesús Blanchard, Isidro Jarque, Joan Bargay, Jose Maria Moraleda, Estrella Carrillo-Cruz, Anna Maria Sureda Balari, Isabel Krsnik, Esther Gonzalez Garcia, Luis Felipe Casado Montero, Josep Maria Marti Tutusaus, Cristina Encinas Rodriguez, Felipe De Arriba, Luis Palomera, Antonia Sampol Mayol, Yolanda González-Montes, Cristina Motlló, Javier De la Cruz, Rafael Alonso Fernández, Maria-Victoria Mateos, Joan Blade Creixenti, Juan Jose Lahuerta Palacios, Jesus San Miguel, Miguel Teodoro Hernández Garcia
Journal: Blood
Blood (2023) 142 (Supplement 1): 1958.
https://doi.org/10.1182/blood-2023-179452
Published: 2023
Journal Articles

Recovery of Uninvolved Heavy/Light Chain Pair Immunoparesis during Maintenance Is an Independent Prognostic Factor for Multiple Myeloma and Could Complement Prognosis Value of Minimal Residual Disease

Sunil Lakhwani, Laura Rosinol Dachs, Noemi Puig, Miguel Angel Pico Picos, Laura Medina-González, Joaquín Martínez-López, Bruno Paiva, Albert Oriol, Rafael Rios, María Jesús Blanchard, Isidro Jarque, Joan Bargay, Jose Maria Moraleda, Estrella Carrillo-Cruz, Anna Sureda, Isabel Krsnik, Esther González Garcia, Luis Felipe Casado Montero, Josep M Marti, Cristina Encinas, Felipe De Arriba, Luis Palomera, Antonia Sampol, Yolanda Gonzalez-Montes, Cristina Motllo, Javier De La Cruz, Rafael Alonso Fernández, María-Victoria Mateos, Joan Bladé Creixenti, Juan-José Lahuerta, Jesús San-Miguel, Miguel-Teodoro Hernández
Journal: Blood
Blood (2022) 140 (Supplement 1): 2101–2103.
https://doi.org/10.1182/blood-2022-167247
Published: 2022
Journal Articles

Immunoparesis Recovery in Transplant-Ineligible Newly Diagnosis Multiple Myeloma Patients: An Independent Prognosis Factor That Could Complement Prognostic Value of Minimal Residual Disease

Sunil Lakhwani, María Victoria Mateos, Joaquín Martínez-López, Bruno Paiva, Laura Rosinol Dachs, Rafael Martínez, Albert Oriol, Joan Bargay, Yolanda Gonzalez-Montes, Mercedes Gironella, Cristina Encinas, Jesus Martin, Isidro Jarque, Miquel Granell, Eugenia Abella, Aránzazu García Mateo, José Ángel Hernández-Rivas, Elena Ramila, Isabel Krsnik, Luis Felipe Casado Montero, Felipe De Arriba, Luis Palomera, Antonia Sampol, Jose Maria Moraleda, Maria Casanova, Pilar Delgado, Ana Lafuente, Elena Amutio, Aurelio Lopez Martínez, Albert Altés, M. Ángeles Ruíz, Lucia Lopez-Anglada, Joan Bladé Creixenti, Juan-José Lahuerta, Jesús San-Miguel, Miguel-Teodoro Hernández
Journal: Blood
Blood (2022) 140 (Supplement 1): 2344–2346.
https://doi.org/10.1182/blood-2022-166826
Published: 2022
Journal Articles

Machine Learning Model Defines Higher Risk of Venous Thromboembolism in Young Adults with Multiple Myeloma

Inés Martínez-Alfonzo, Diego Velasco, Pablo Mínguez Paniagua, Ignacio Mahillo-Fernández, Elham Askari, Rosa Vidal Laso, Cristina Fernández Maqueda, Alberto Velasco, Ana González-Teomiro, Maria Civeira-Marín, Elena Prieto-Pareja, Sara Martín-Herrero, José Manuel Calvo Villas, Isabel Krsnik, Joaquín Sánchez-Garcia, Miguel Angel Alvarez, María Pilar Llamas Sillero, Juana Serrano-López
Journal: Blood
Blood (2022) 140 (Supplement 1): 2811–2812.
https://doi.org/10.1182/blood-2022-167058
Published: 2022
Journal Articles

Ixazomib Plus Lenalidomide/Dexamethasone (IRd) Versus Lenalidomide /Dexamethasone (Rd) Maintenance after Autologous Stem Cell Transplant in Patients with Newly Diagnosed Multiple Myeloma: Results of the Spanish GEM2014MAIN Trial

Laura Rosinol, Albert Oriol, Rafael Ríos Tamayo, María Jesús Blanchard, Isidro Jarque, Joan Bargay, Miguel-Teodoro Hernández, Jose Maria Moraleda, Estrella Carrillo-Cruz, Anna Sureda, Joaquín Martínez-López, Isabel Krsnik, Esther González Garcia, Felipe Casado, Josep M Marti, Cristina Encinas, Felipe De Arriba, Luis Palomera, Antonia Sampol, Yolanda Gonzalez-Montes, Elena Cabezudo, Maria-Victoria Mateos, Jesus San-Miguel, Juan Jose Lahuerta, Joan Bladé Creixenti
Journal: Blood
Blood (2021) 138 (Supplement 1): 466.
https://doi.org/10.1182/blood-2021-146798
Published: 2021
Journal Articles

Assessment of Treatment Response By Ife, Next Generation Flow Cytometry and Mass Spectrometry Coupled with Liquid Chromatography in the GEM2012MENOS65 Clinical Trial

Noemi Puig, Teresa Contreras Sanfeliciano, Bruno Paiva, María Teresa Cedena, Laura Rosinol, Ramón Garcia-Sanz, Joaquín Martínez-López, Albert Oriol, María Jesús Blanchard, Rafael Rios, Jesus Martin, Anna Sureda, Miguel Hernández, Javier De La Rubia, Isabel Krsnik, Jose Maria Moraleda, Belén Iñigo, Luis Palomera, Cristina Agulló, Joan Bargay, Joan Bladé Creixenti, Jesús San-Miguel, Juan-José Lahuerta, Maria-Victoria Mateos
Journal: Blood
Blood (2021) 138 (Supplement 1): 544.
https://doi.org/10.1182/blood-2021-151557
Published: 2021
Journal Articles

Definition and Clinical Significance of the MGUS-like Phenotype: A Study in 5,114 Patients (Pts) with Monoclonal Gammopathies

Leire Burgos, Luis Esteban Tamariz-Amador, Noemí Puig, María Teresa Cedena, Tomas Jelinek, Sarah K Johnson, Paolo Milani, Lourdes Cordon, José J Pérez, Marta Lasa, Rosalinda Termini, Albert Oriol, Miguel-Teodoro Hernández, Luis Palomera, Rafael Martinez Martinez, Javier de la Rubia, Felipe De Arriba, Rafael Rios, Maria Esther González, Mercedes Gironella, Valentin Cabañas, Maria Casanova, Isabel Krsnik, Albert Pérez, Veronica Gonzalez De La Calle, Paula Rodríguez-Otero, Vladimir Maisnar, Roman Hajek, Frits van Rhee, Victor H Jimenez-Zepeda, Giovanni Palladini, Paolo Milani, Alberto Orfao, Laura Rosinol, Joan Bladé Creixenti, Joaquín Martínez-López, Juan-José Lahuerta, Maria-Victoria Mateos, Jesús F. San-Miguel, Bruno Paiva
Journal: Blood
Blood (2021) 138 (Supplement 1): 541.
https://doi.org/10.1182/blood-2021-150092
Published: 2021
Journal Articles

Compassionate Use of Belantamab Mafodotin for Treatment of Patients with Relapsed/Refractory Multiple Myeloma Heavily Treated. Spanish Experience

Adrian Alegre, Gonzalo Benzo Callejo, Rafael Alonso Fernández, Joaquin Martínez-López, Ana Jimenez-Ubieto, Clara Cuellar, Elham Askari, Elena Prieto, Concha Alaez, Beatriz Aguado, Alberto Velasco, Isabel Krsnik, Laura Llorente, Cristina Muñoz-Linares, Ana Morales, Eugenio Gimenez Mesa, Rebeca Iglesias, Carmen Martínez-Chamorro, Arancha Alonso, Carmen Jiménez-Montes, María Jesús Blanchard
Journal: Blood
Blood (2021) 138 (Supplement 1): 3775.
https://doi.org/10.1182/blood-2021-151267
Published: 2021
Journal Articles

Tumor cells in light-chain amyloidosis and myeloma show distinct transcriptional rewiring of normal plasma cell development

CME Brief Report
Daniel Alameda, Ibai Goicoechea, Marco Vicari, Elena Arriazu, Alice Nevone, Sara Rodriguez, Marta Lasa, Noemi Puig, Maria Teresa Cedena, Diego Alignani, Sonia Garate, David Lara-Astiaso, Amaia Vilas-Zornoza, Sarai Sarvide, Enrique M. Ocio, Ramon Lecumberri, Alfonso Garcia de Coca, Jorge Labrador, Maria-Esther Gonzalez, Luis Palomera, Mercedes Gironella, Valentin Cabañas, Maria Casanova, Albert Oriol, Isabel Krsnik, Albert Perez-Montaña, Javier de la Rubia, Jose-Enrique de la Puerta, Felipe de Arriba, Vito Michele Fazio, Joaquin Martinez-Lopez, Juan-Jose Lahuerta, Maria-Victoria Mateos, Maria-Dolores Odero, Felipe Prosper, Assaf Weiner, Ido Amit, Mario Nuvolone, Jesus F. San Miguel, Bruno Paiva
Journal: Blood
Blood (2021) 138 (17): 1583–1589.
https://doi.org/10.1182/blood.2020009754
Published: 2021
Includes: Supplemental data
Journal Articles

Deep MRD profiling defines outcome and unveils different modes of treatment resistance in standard- and high-risk myeloma

Clinical Trials & Observations
Ibai Goicoechea, Noemi Puig, Maria-Teresa Cedena, Leire Burgos, Lourdes Cordón, María-Belén Vidriales, Juan Flores-Montero, Norma C. Gutierrez, Maria-Jose Calasanz, Maria-Luisa Martin Ramos, David Lara-Astiaso, Amaia Vilas-Zornoza, Diego Alignani, Idoia Rodriguez, Sarai Sarvide, Daniel Alameda, Juan José Garcés, Sara Rodriguez, Vicente Fresquet, Jon Celay, Ramón Garcia-Sanz, Joaquin Martinez-Lopez, Albert Oriol, Rafael Rios, Jesus Martin-Sanchez, Rafael Martinez-Martinez, Josep Sarra, Miguel-Teodoro Hernandez, Javier de la Rubia, Isabel Krsnik, Jose-Maria Moraleda, Luis Palomera, Joan Bargay, Jose-Angel Martinez-Climent, Alberto Orfao, Laura Rosiñol, Maria-Victoria Mateos, Juan-José Lahuerta, Joan Blade, Jesús San Miguel, Bruno Paiva
Journal: Blood
Blood (2021) 137 (1): 49–60.
https://doi.org/10.1182/blood.2020006731
Published: 2021
Includes: Supplemental data
Journal Articles

Clinical Significance and Biomarkers to Predict Unsustained Complete Remission in Transplant-Eligible Multiple Myeloma

Ana Jimenez-Ubieto, Bruno Paiva, PhD, Joaquin Martinez Lopez, María Teresa Cedena, MD, Noemi Puig, MD PhD, Albert Oriol, MD, Maria Jesús Blanchard, MD, Rafael Rios, MD PhD, Lucia Lopez-Anglada, PhD, Jesús Martín, Rafael Martínez, Anna Sureda Balari, MD PhD, Miguel Hernández, Javier de la Rubia, Isabel Krsnik, MD PhD, Valentin Cabañas, MD, Luis Palomera, MD PhD, Joan Bargay, MD, Jose Maria Moraleda, MD PhD, Laura Rosiñol, María-Victoria Mateos, MD PhD, Jesus F. San-Miguel, MD PhD, Joan Bladé, MD PhD, Juan-José Lahuerta, MD PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 5–6.
https://doi.org/10.1182/blood-2020-136181
Published: 2020
Journal Articles

Bortezomib, lenalidomide, and dexamethasone as induction therapy prior to autologous transplant in multiple myeloma

Laura Rosiñol, Albert Oriol, Rafael Rios, Anna Sureda, María Jesús Blanchard, Miguel Teodoro Hernández, Rafael Martínez-Martínez, Jose M. Moraleda, Isidro Jarque, Juan Bargay, Mercedes Gironella, Felipe de Arriba, Luis Palomera, Yolanda González-Montes, Josep M. Martí, Isabel Krsnik, Jose M. Arguiñano, Maria Esther González, Ana Pilar González, Luis Felipe Casado, Lucia López-Anglada, Bruno Paiva, Maria-Victoria Mateos, Jesus F. San Miguel, Juan-José Lahuerta, Joan Bladé
Journal: Blood
Blood (2019) 134 (16): 1337–1345.
https://doi.org/10.1182/blood.2019000241
Published: 2019
Includes: Supplemental data
Journal Articles

Role of urine immunofixation in the complete response assessment of MM patients other than light-chain-only disease

CME Clinical Trials & Observations Brief Report
Juan-José Lahuerta, Ana Jiménez-Ubieto, Bruno Paiva, Joaquín Martínez-López, José González-Medina, Lucía López-Anglada, María-Teresa Cedena, Noemi Puig, Albert Oriol, María-Jesús Blanchard, Rafael Ríos, Jesús Martin, Rafael Martínez, Anna Sureda, Miguel Teodoro Hernández, Javier de la Rubia, Isabel Krsnik, Valentín Cabañas, Luis Palomera, Joan Bargay, María-Victoria Mateos, Laura Rosiñol, Jesús F. San Miguel, Joan Blade
Journal: Blood
Blood (2019) 133 (25): 2664–2668.
https://doi.org/10.1182/blood.2019000671
Published: 2019
Journal Articles

Understanding the Cellular Origin and Pathogenic Transcriptional Programs in Multiple Myeloma (MM) and Light-Chain Amyloidosis (AL) through the Dissection of the Normal Plasma Cell (PC) Development

Daniel Alameda, PhD, Marco Vicari, MD, David Lara-Astiaso, PhD, Marta Lasa, Noemi Puig, MD PhD, Maria Teresa Cedena Romero, MD PhD, Idoia Rodriguez, Diego Alignani, PhD, Amaia Vilas-Zornoza, PhD, Ibai Goicoechea, PhD, Sarai Sarvide, Enrique M. Ocio, MD, Ramon Lecumberri, MD PhD, Alfonso García de Coca, MD PhD, Jorge Labrador, MD, Esther González Garcia, MD, Luis Palomera, MD PhD, Mercedes Gironella, MD, Valentin Cabañas, MD, Maria Casanova, MD, Albert Oriol, MD, Isabel Krsnik, MD PhD, Albert Pérez, MD, Joaquin Martinez Lopez, MD PhD, Maria-Victoria Mateos, MD PhD, Juan-José Lahuerta, MD PhD, Felipe Prosper, MD PhD, Assaf Weiner, PhD, Ido Amit, PhD, Jesús F San-Miguel, MD, Bruno Paiva, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 188.
https://doi.org/10.1182/blood-2018-188
Published: 2018
Journal Articles

Multidimensional Immunophenotyping Identifies Hallmarks of Systemic Light-Chain Amyloidosis (AL) and Maps the Disease in the Crossroad between MGUS and Multiple Myeloma (MM)

Noemi Puig, MD PhD, Bruno Paiva, MD PhD, Marta Lasa, Leire Burgos, José J Pérez, Juana Merino, Cristina Moreno, Maria-Belen Vidriales, MD, Dolores Gómez, María Teresa Cedena, Enrique M. Ocio, MD, Ramon Lecumberri, MD PhD, Alfonso García de Coca, MD PhD, Jorge Labrador, MD, Esther González Garcia, MD, Luis Palomera, MD PhD, Mercedes Gironella, MD, Valentin Cabañas, MD, Maria Casanova, MD, Albert Oriol, MD, Isabel Krsnik, MD PhD, Albert Pérez, MD, Javier De La Rubia, MD, José Enrique de la Puerta, Felipe De Arriba, PhD, Felipe Prosper, MD PhD, Joaquin Martinez Lopez, MD PhD, Quentin Lecrevisse, Javier Verde, Maria-Victoria Mateos, MD PhD, Juan Jose Lahuerta, MD PhD, Alberto Orfao, MD PhD, Jesús F San-Miguel, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 3170.
https://doi.org/10.1182/blood-2018-99-119281
Published: 2018
Journal Articles

Clinical Significance and Transcriptional Profiling of Persistent Minimal Residual Disease (MRD) in Multiple Myeloma (MM) Patients with Standard-Risk (SR) and High-Risk (HR) Cytogenetics

Ibai Goicoechea, PhD, Noemi Puig, MD PhD, María Teresa Cedena, Lourdes Cordon, Maria-Belen Vidriales, MD, Leire Burgos, Juan Flores-Montero, Norma C. Gutierrez, MD PhD, Maria Jose Calasanz, BSc, PhD, Maria Luisa Martin-Ramos, David Lara-Astiaso, PhD, Amaia Vilas-Zornoza, PhD, Diego Alignani, PhD, Idoia Rodriguez, Sarai Sarvide, Ramon Garcia-Sanz, MD PhD, Joaquin Martinez-Lopez, MD PhD, Albert Oriol, MD, Rafael Rios, MD PhD, Jesús Martín, Rafael Martínez, Josep Sarra, Miguel T Hernández, MD PhD, Javier De La Rubia, MD, Isabel Krsnik, Jose Maria Moraleda, Luis Palomera, MD PhD, Joan Bargay, MD PhD, Alberto Orfao, MD PhD, Laura Rosiñol, Maria-Victoria Mateos, MD PhD, Juan Jose Lahuerta, MD PhD, Joan Bladé, MD PhD, Jesus F San-Miguel, MD PhD, Bruno Paiva, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 112.
https://doi.org/10.1182/blood-2018-99-113312
Published: 2018
Journal Articles

Immunofixation (IF) in Urine Is Really Necessary to Define Complete Remission in Multiple Myeloma (MM)? a Subanalysis from the Pethema/GEM2012MENOS65 Phase III Clinical Trial

Ana Jiménez Ubieto, MD PhD, Bruno Paiva, MD PhD, Joaquin Martínez-López, MD PhD, Laura Rosinol, MD PhD, Maria Teresa Cedena Romero, MD PhD, Maria Jose Calasanz, BSc, PhD, Noemi Puig, MD PhD, Ramon Garcia-Sanz, MD PhD, Norma C. Gutierrez, MD PhD, Maria Luisa Martin-Ramos, Albert Oriol, MD, José Gonzalez Medina, Rafael Alonso Fernandez, Jesús Blanchard, MD, Rafael Rios, MD PhD, Jesús Martín, Rafael Martinez Martinez, Josep Sarra, Miguel-Teodoro Hernández, Javier De La Rubia, MD, Isabel Krsnik, MD PhD, Jose Maria Moraleda, Luis Palomera, MD PhD, Maria-Victoria Mateos, MD PhD, Jesús F San-Miguel, MD, Joan Bladé, MD, Juan-José Lahuerta, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 474.
https://doi.org/10.1182/blood-2018-99-115050
Published: 2018
Journal Articles

Absence of Contribution to a Differential Outcome of the Stringent Complete Response IMWG Category Respect to the Conventional CR in Multiple Myeloma. a Validation Analysis Based on the Pethema/GEM2012MENOS65 Phase III Clinical Trial

Ana Jiménez Ubieto, MDPhD, Joaquin Martinez Lopez, MD PhD, Laura Rosinol, MD PhD, Bruno Paiva, MD PhD, María Teresa Cedena, Noemi Puig, MD PhD, Maria Jose Calasanz, BSc, PhD, José Gonzalez Medina, Maria Luisa Martin-Ramos, Rafael Alonso Fernandez, Albert Oriol, MD, Jesús Blanchard, MD, Enrique M. Ocio, MD, Javier De La Rubia, MD, Rafael Rios, MD PhD, Jesús Martín, Miguel-Teodoro Hernández, Isabel Krsnik, MD PhD, Jose Maria Moraleda, Luis Palomera, MD PhD, Joan Bargay, MD PhD, Maria-Victoria Mateos, MD PhD, Jesús F San-Miguel, MD, Joan Bladé, MD, Juan-José Lahuerta, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 1943.
https://doi.org/10.1182/blood-2018-99-116604
Published: 2018
Journal Articles

Bortezomib, Lenalidomide and Dexamethasone (VRD-GEM) As Induction Therapy Prior Autologous Stem Cell Transplantation (ASCT) in Multiple Myeloma (MM): Results of a Prospective Phase III Pethema/GEM Trial

Laura Rosinol, MD PhD, Albert Oriol, MD, Rafael Rios, Anna Sureda, MD PhD, M Jesús Blanchard, Miguel T Hernández, Rafael Martínez-Martínez, Jose M Moraleda, Isidro Jarque, Juan Bargay, Mercedes Gironella, Dra., Maria José Moreno, Luis Palomera, Yolanda Gonzalez-Montes, Josep M Marti, Isabel Krsnik, Jose M Arguiñano, Maria Esther González, Ana Pilar González, Felipe Casado, Lucía Lopez-Anglada, Bruno Paiva, PhD, Maria-Victoria Mateos, MD PhD, Jesus F. San Miguel, MD, Juan-José Lahuerta, Joan Blade, MD
Journal: Blood
Blood (2017) 130 (Supplement 1): 2017.
https://doi.org/10.1182/blood.V130.Suppl_1.2017.2017
Published: 2017