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Journal Articles

Single Cell Analysis of Pre-Treatment Peripheral Immune Composition Can Predict CAR-T Outcomes in Patients with Diffuse Large B-Cell Lymphoma

Anna Gurevich Shapiro, Eitan Winter, Pascale Zwicky, Mor Zada, Noam Shapira, Oren Barboy, Paulina Chalan, Reut Sharet-Eshed, Merav Kedmi, Eyal David, Irit Mazza Avivi, Assaf Weiner, Ron Ram, Ido Amit
Journal: Blood
Blood (2024) 144 (Supplement 1): 4788.
https://doi.org/10.1182/blood-2024-203893
Published: 2024
Journal Articles

Towards a Decision Engine for Therapeutic Optimization of Relapsed Refractory Multiple Myeloma

Yael C. Cohen, Mor Zada, Shuang-Yin Wang, Assaf Weiner, Natan Melamed, Polina Stepensky, Moshe E Gatt, Shlomit Kfir-Erenfeld, Nathalie Asherie, Eyal Lebel, Irit Avivi Mazza, Anna Gurevich Shapiro, Iuliana Vaxman, Tamir Shragai, Paulina Chalan, Eyal David, Ido Amit
Journal: Blood
Blood (2023) 142 (Supplement 1): 341.
https://doi.org/10.1182/blood-2023-190178
Published: 2023
Journal Articles

Daratumumab Carfilzomib Lenalidomide Dexamethasone Provides Effective Salvage for Functionally and Cytogenetically High-Risk Myeloma Patients, Except Those Expressing Module-1 Transcriptional Signature: Extended Follow-up from Kydar Multicenter Clinical/Translational Trial.

Yael C Cohen, Moshe E Gatt, Efrat Luttwak, Noa Lavi, Chezi Ganzel, Evgeni Chubar, Ory Rouvio, Iuliana Vaxman, Oren Pasvolsky, Mouna Ballan, Tamar Tadmor, Anatoly Nemets, Osnat Jarchowsky, Olga Shvetz, Ofer Shpilberg, Najib Dally, Merav Leiba, Assaf Weiner, Mor Zada, Shuang-Yin Wang, Chamutal Gur, Noa Lowenton-Spier, Liron Goor-Porges, Ido Amit, Irit Avivi
Journal: Blood
Blood (2022) 140 (Supplement 1): 4426–4427.
https://doi.org/10.1182/blood-2022-164572
Published: 2022
Journal Articles

Single Cell RNA Sequencing in Patients Enrolled in a Selinexor Clinical Trial Reveals Overexpression of Alternative Nuclear Export Pathways Associated with Resistance to Selinexor in Refractory Multiple Myeloma

Yael C Cohen, Mor Zada, Shuang-Yin Wang, Ohad S. Bentur, Evgeni Chubar, Amos Cohen, Noa Lavi, Hila Magen, Moshe Gatt, Miri Zektser, Merav Leiba, Galia Stemer, Tamir Shragai, Irit Avivi, Assaf Weiner, Ido Amit
Journal: Blood
Blood (2021) 138 (Supplement 1): 2725.
https://doi.org/10.1182/blood-2021-149701
Published: 2021
Journal Articles

Tumor cells in light-chain amyloidosis and myeloma show distinct transcriptional rewiring of normal plasma cell development

CME Brief Report
Daniel Alameda, Ibai Goicoechea, Marco Vicari, Elena Arriazu, Alice Nevone, Sara Rodriguez, Marta Lasa, Noemi Puig, Maria Teresa Cedena, Diego Alignani, Sonia Garate, David Lara-Astiaso, Amaia Vilas-Zornoza, Sarai Sarvide, Enrique M. Ocio, Ramon Lecumberri, Alfonso Garcia de Coca, Jorge Labrador, Maria-Esther Gonzalez, Luis Palomera, Mercedes Gironella, Valentin Cabañas, Maria Casanova, Albert Oriol, Isabel Krsnik, Albert Perez-Montaña, Javier de la Rubia, Jose-Enrique de la Puerta, Felipe de Arriba, Vito Michele Fazio, Joaquin Martinez-Lopez, Juan-Jose Lahuerta, Maria-Victoria Mateos, Maria-Dolores Odero, Felipe Prosper, Assaf Weiner, Ido Amit, Mario Nuvolone, Jesus F. San Miguel, Bruno Paiva
Journal: Blood
Blood (2021) 138 (17): 1583–1589.
https://doi.org/10.1182/blood.2020009754
Published: 2021
Includes: Supplemental data
Journal Articles

A Novel Therapy-Resistance Transcriptional Signature Based on Single Cell Analysis in Kydar Clinical Trial

Yael C Cohen, MD, Mor Zada, MSc, Shuang-Yin Wang, Chamutal Bornstein, PhD, Eyal David, Adi Moshe, PhD, Baoguo Li, PhD, Shir Shlomi, Moshe Gatt, MD, Noa Lavi, MD, Chezi Ganzel, MD, Efrat Lutwak, MD, Ory Rouvio, MD, Iuliana Vaxman, MDBA, Oren Pasvolsky, MD, Mouna Ballan, Tamar Tadmor, MD, Anatoly Nemets, Osnat Jarchowcky Dolberg, Yevgeny Chober, Olga Shvetz, MD, Merav Leiba, Ofer Shpilberg, MD MPH, Nagib Deli, Irit Avivi, MD, Assaf Weiner, PhD, Ido Amit, PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 19–20.
https://doi.org/10.1182/blood-2020-139670
Published: 2020
Journal Articles

Kydar Multicenter Trial of Quadruple Regimen for Induction Resistant Myeloma Combined with Translational Single-Cell Analysis Identifies Potential Drivers of Advanced Resistance, Including Novel Immune Checkpoints

Yael C Cohen, MD, Mor Zada, MSc, Moshe E. Gatt, MD, Noa Lavi, MD, Chezi Ganzel, MD, Shuang-Yin Wang, Assaf Weiner, PhD, Guy Ledergor, MD, Evgeni Chubar, MD, Ory Rouvio, MD, Iuliana Vaxman, MDBA, Mouna Ballan, MD, Tamar Tadmor, MD, Anatoly Nemets, MD, Osnat Jarchowcky Dolberg, Olga Shvetz, MD, Ofer Shpilberg, MD MPH, Nagib Deli, MD, Irit Avivi, Ido Amit, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 982.
https://doi.org/10.1182/blood-2019-129618
Published: 2019
Journal Articles

A niche-dependent myeloid transcriptome signature defines dormant myeloma cells

Weng Hua Khoo, Guy Ledergor, Assaf Weiner, Daniel L. Roden, Rachael L. Terry, Michelle M. McDonald, Ryan C. Chai, Kim De Veirman, Katie L. Owen, Khatora S. Opperman, Kate Vandyke, Justine R. Clark, Anja Seckinger, Natasa Kovacic, Akira Nguyen, Sindhu T. Mohanty, Jessica A. Pettitt, Ya Xiao, Alexander P. Corr, Christine Seeliger, Mark Novotny, Roger S. Lasken, Tuan V. Nguyen, Babatunde O. Oyajobi, Dana Aftab, Alexander Swarbrick, Belinda Parker, Duncan R. Hewett, Dirk Hose, Karin Vanderkerken, Andrew C. W. Zannettino, Ido Amit, Tri Giang Phan, Peter I. Croucher
Journal: Blood
Blood (2019) 134 (1): 30–43.
https://doi.org/10.1182/blood.2018880930
Published: 2019
Includes: Supplemental data
Journal Articles

Understanding the Cellular Origin and Pathogenic Transcriptional Programs in Multiple Myeloma (MM) and Light-Chain Amyloidosis (AL) through the Dissection of the Normal Plasma Cell (PC) Development

Daniel Alameda, PhD, Marco Vicari, MD, David Lara-Astiaso, PhD, Marta Lasa, Noemi Puig, MD PhD, Maria Teresa Cedena Romero, MD PhD, Idoia Rodriguez, Diego Alignani, PhD, Amaia Vilas-Zornoza, PhD, Ibai Goicoechea, PhD, Sarai Sarvide, Enrique M. Ocio, MD, Ramon Lecumberri, MD PhD, Alfonso García de Coca, MD PhD, Jorge Labrador, MD, Esther González Garcia, MD, Luis Palomera, MD PhD, Mercedes Gironella, MD, Valentin Cabañas, MD, Maria Casanova, MD, Albert Oriol, MD, Isabel Krsnik, MD PhD, Albert Pérez, MD, Joaquin Martinez Lopez, MD PhD, Maria-Victoria Mateos, MD PhD, Juan-José Lahuerta, MD PhD, Felipe Prosper, MD PhD, Assaf Weiner, PhD, Ido Amit, PhD, Jesús F San-Miguel, MD, Bruno Paiva, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 188.
https://doi.org/10.1182/blood-2018-188
Published: 2018