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Journal Articles

Measurable residual disease by mass spectrometry and next-generation flow to assess treatment response in myeloma

Clinical Trials & Observations Brief Report
Noemí Puig, Cristina Agulló, Teresa Contreras, María-Teresa Cedena, Joaquín Martínez-López, Albert Oriol, María-Jesús Blanchard, Rafael Ríos, María-Belén Íñigo, Anna Sureda, Sunil Lakhwani, Javier de la Rubia, Verónica González-Calle, Valentín Cabañas, Luis Palomera, José-María Moraleda, Joan Bargay, Sergio Castro, Laura Rosiñol, Joan Bladé, Jesús F. San-Miguel, Juan-José Lahuerta, Bruno Paiva, María-Victoria Mateos
Journal: Blood
Blood (2024) 144 (23): 2432–2438.
https://doi.org/10.1182/blood.2024024995
Published: 2024
Includes: Supplemental data
Journal Articles

Unraveling Long-Term Survival of Multiple Myeloma Patients, the GEM2000 Experience

Rafael Alonso Fernandez, Andrés Arroyo Barea, Maria Teresa Cedena Romero, Laura Rosiñol Dachs, Javier de la Rubia, Sara Miqueleiz, Veronica Gonzalez-Calle, Felipe De Arriba, Luis Felipe Casado Montero, Miguel Teodoro Hernandez, Maria Mas Esteve, Pascual Fernandez, Paula Rodríguez-Otero, Carmen Calle Primo, Eugenia Abella, Paz Ribas, Adrian Alegre, Juan Miguel Bergua, Irene Gomez-Catalan, Jose Maria Arguiñano Perez, Luis Palomera, Enrique M Ocio, Maria Jose Busto Medina, Nieves Somolinos, Jose Maria Alonso Alonso, Aránzazu García Mateo, Joan Bargay, Pilar Delgado, Dunia De Miguel Llorente, Javier de la Cruz, Maria Victoria Mateos, Jesús F. San-Miguel, Joan Bladé, Juan-Jose Lahuerta Palacios, Joaquin Martinez Lopez
Journal: Blood
Blood (2024) 144 (Supplement 1): 1957.
https://doi.org/10.1182/blood-2024-211383
Published: 2024
Journal Articles

Reevaluating the IMWG Multiple Myeloma Complete Response Criterion in the Era of Mass Spectrometry: A Critical Analysis

Noemi Puig, Cristina Agullo, Bruno Paiva, María T Cedena, Laura Rosiñol Dachs, Teresa Contreras, Joaquín Martínez-Lopez, Albert Oriol, María-Jesús Blanchard, Rafael Rios Tamayo, Ana Maria Sureda Balari, Miguel Teodoro Hernández Garcia, Javier de la Rubia, Valentin Cabanas Perianes, Felipe De Arriba, Luis Palomera, Maria Belen Inigo Rodriguez, Veronica Gonzalez-Calle, Enrique M Ocio, Sergio Castro, Joan Bargay, Joan Bladé, Jesús F. San-Miguel, Juan-Jose Lahuerta Palacios, Maria- Victoria Mateos
Journal: Blood
Blood (2024) 144 (Supplement 1): 489.
https://doi.org/10.1182/blood-2024-210198
Published: 2024
Journal Articles

Importance of Early Rescue and Relative Dose-Intensity in the Salvage Therapy with Tafasitamab-Lenalidomide in Diffuse Large B-Cell Lymphoma: Real-Life Study in Spain (GELTAMO)

Antonio Gutiérrez, Izaskun Zeberio, Pilar Martinez-Barranco, Francisco Javier Peñalver, Sandra Pérez, Daniel Morillo, Xabier Mart N Martitegui, Concepción Nicolás, Ainara Ferrero, Ana Jiménez Ubieto, Mariana Bastos-Oreiro, Julio Dávila-Valls, Maria Victoria Calle Gordo, María Pérez Sala, Guillermo Rodríguez Garcia, Aranzazu Alonso Alonso, Ana Garcia Noblejas, Diana Sanchez Arguello, Teresa Knight Asorey, Maria Angeles Fernandez Fernandez, Javier López Marin, Jaime Perez de Oteyza, Sonia González De Villambrosia, Elena Perez Ceballos, Alejandro Marin, Belén Navarro, Ruben Fernandez Alvarez, Pilar Gómez, Jose Antonio Hueso, Maria Jesus Penarrubia Ponce, Pilar Bravo, Daniel García Belmonte, Haridian De La Nuez Melian, Sara Nistal, Pau Abrisqueta Costa, Fernanda Ibañez, Luis Palomera, Eva Donato, Andrea Provencio Rincon, Maria Stefania Infante, Eva Gonzalez Barca
Journal: Blood
Blood (2024) 144 (Supplement 1): 2356.
https://doi.org/10.1182/blood-2024-210868
Published: 2024
Journal Articles

Survival Improvement of Transplant Eligible Patients with Newly Diagnosed Multiple Myeloma in Two Consecutive Randomized Phase III Trials: Long-Term Follow up of GEM05 and GEM12 Trials

Laura Rosiñol Dachs, Albert Oriol, María-Jesús Blanchard, Javier de la Rubia, Rafael Ríos, Joan Bargay, Miguel Teodoro Hernández Garcia, Valentín Cabanas Perianes, Ana López de la Guía, Estrella Carrillo-Cruz, Anna Sureda Balari, Joaquin Martínez-López, Jose Maria Arguiñano, Esther González García, Luis Felipe Casado, Josep Maria Marti Tutusaus, Cristina Encinas, Felipe De Arriba, Luis Palomera, Antonia Sampol Mayol, Yolanda González-Montes, Jordi López-Pardo, Maialen Sirvent, Maria Belen Inigo Rodriguez, Bruno Paiva, Noemi Puig, Maria Teresa Cedena Romero, Norma C. Gutierrez, Javier De la Cruz, Maria-Victoria Mateos, Jesús F. San-Miguel, Juan-Jose Lahuerta Palacios, Joan Bladé
Journal: Blood
Blood (2024) 144 (Supplement 1): 3374.
https://doi.org/10.1182/blood-2024-205453
Published: 2024
Journal Articles

Predictors of unsustained measurable residual disease negativity in transplant-eligible patients with multiple myeloma

Clinical Trials & Observations Brief Report
Camila Guerrero, Noemi Puig, María-Teresa Cedena, María-José Calasanz, Norma C. Gutierrez, Manuela Fernandez, Albert Oriol, Rafael Ríos-Tamayo, Miguel-Teodoro Hernandez, Rafael Martínez-Martínez, Joan Bargay, Felipe de Arriba, Luis Palomera, Ana Pilar Gonzalez-Rodriguez, Marta-Sonia Gonzalez Perez, Alberto Orfao, María-Victoria Mateos, Joaquin Martinez-Lopez, Laura Rosiñol, Joan Bladé, Juan-Jose Lahuerta, Jesus F. San-Miguel, Bruno Paiva
Journal: Blood
Blood (2024) 143 (7): 597–603.
https://doi.org/10.1182/blood.2023022083
Published: 2024
Includes: Supplemental data
Journal Articles

Analysis of Peripheral Blood and Bone Marrow Residual Disease Dynamics during Intensive Treatment and Maintenance in Patients with Multiple Myeloma Included in the GEM12MENOS65 and GEM14MAIN Clinical Trials

Noemi Puig, Cristina Agullo, Teresa Contreras, Bruno Paiva, María T Cedena, Laura Rosiñol, Ramon Garcia-Sanz, Joaquin Martinez-Lopez, Albert Oriol Rocafiguera, María-Jesús Blanchard, Rafael Ríos, Anna Maria Sureda Balari, Miguel Teodoro Hernández Garcia, Javier De La Rubia, Felipe De Arriba, Luis Palomera, Valentín Cabañas, Maria Belen Inigo Rodriguez, José Juan Pérez, Sergio Castro, Bargay Joan, Joan Bladé, Juan Jose Lahuerta Palacios, Jesús San Miguel, Maria Victoria Mateos
Journal: Blood
Blood (2023) 142 (Supplement 1): 3324.
https://doi.org/10.1182/blood-2023-184837
Published: 2023
Journal Articles

Renal Sub-Study (GEM-KyCyDex): Cystatin C Improves the Proficiency of Creatinine Alone in the Detection and Management of Myeloma-Related Renal Impairment

Javier Cepeda-Piorno, Borja Puertas Martínez, Laura Rosiñol, Albert Oriol, Felipe De Arriba, Luis Palomera, Miguel Teodoro Hernandez, Jaime Pérez De Oteyza, Ana Pilar Gonzalez, David Carballo, Veronica Gonzalez-Calle, Paula Chavez, Vanesa Garcia-Moreira, Enrique M Ocio, Maria Victoria Mateos, Esther Gonzalez Garcia
Journal: Blood
Blood (2023) 142 (Supplement 1): 4758.
https://doi.org/10.1182/blood-2023-185012
Published: 2023
Journal Articles

Sustained Recovery of Uninvolved Heavy/Light Chain Pair Immunoparesis during Maintenance Discriminates Patients with Sustained Negative Minimal Residual Disease

Sunil Lakhwani, Laura Rosiñol, Noemi Puig, Miguel Angel Pico Picos, Laura Medina-González, Joaquin Martinez Lopez, Bruno Paiva, Maria Teresa Cedena Romero, Albert Oriol, Rafael Ríos, María Jesús Blanchard, Isidro Jarque, Joan Bargay, Jose Maria Moraleda, Estrella Carrillo-Cruz, Anna Maria Sureda Balari, Isabel Krsnik, Esther Gonzalez Garcia, Luis Felipe Casado Montero, Josep Maria Marti Tutusaus, Cristina Encinas Rodriguez, Felipe De Arriba, Luis Palomera, Antonia Sampol Mayol, Yolanda González-Montes, Cristina Motlló, Javier De la Cruz, Rafael Alonso Fernández, Maria-Victoria Mateos, Joan Blade Creixenti, Juan Jose Lahuerta Palacios, Jesus San Miguel, Miguel Teodoro Hernández Garcia
Journal: Blood
Blood (2023) 142 (Supplement 1): 1958.
https://doi.org/10.1182/blood-2023-179452
Published: 2023
Journal Articles

Minimally Invasive Assessment of Measurable Residual Disease (MRD) in Multiple Myeloma (MM)

Carmen Gonzalez, Marta Lasa, Laura Notarfranchi, Cristina Agullo, Natalia Buenache Cuenda, Anastasiia Zherniakova, Sergio Castro, José Juan Pérez, Veronica Gonzalez-Calle, Maria Teresa Cedena Romero, Santiago Barrio, Alejandro Martín-Muñoz, Leire Burgos, Diego Alignani, Maria Jose Calasanz, Paula Rodriguez Otero, Laura Rosiñol, Felipe De Arriba, Enrique M Ocio, Albert Oriol Rocafiguera, Luis Palomera, Yolanda González-Montes, Anna Maria Sureda Balari, Miguel Teodoro Hernandez Garcia, Maria Esther Clavero Sanchez, Angela Ibanez Garcia, Clara Gomez, Alberto Orfao, Maria Victoria Mateos, Juan Jose Lahuerta Palacios, Joan Bladé, Jesus San-Miguel, Joaquin Martinez-Lopez, Noemi Puig, Bruno Paiva
Journal: Blood
Blood (2023) 142 (Supplement 1): 339.
https://doi.org/10.1182/blood-2023-186916
Published: 2023
Journal Articles

Isolated and Dynamic Peripheral Blood Residual Disease Status Characterized By Mass Spectrometry Predicts Outcome in Patients with High Risk Smoldering Multiple Myeloma Treated in the GEM-CESAR Trial

Noemi Puig, Cristina Agullo, Teresa Contreras, Bruno Paiva, Maria Teresa Cedena Romero, José Juan Pérez, Irene Aires, Joaquin Martinez-Lopez, Paula Rodriguez Otero, Veronica Gonzalez-Calle, Marta Sonia Gonzalez Perez, Norma C. Gutierrez, Albert Oriol Rocafiguera, Rafael Ríos, Laura Rosiñol, Miguel Angel Alvarez Rivas, Maria Jose Calasanz, Bargay Joan, Ramon Garcia-Sanz, Ana Pilar Gonzalez, Adrián Alegre, Fernando Escalante, Rafael Martínez, Javier De La Rubia, Ana Isabel Teruel, Felipe De Arriba, Luis Palomera, Sergio Castro, Miguel Teodoro Hernández Garcia, Javier López, Aránzazu García Mateo, Enrique M Ocio, Joan Bladé, Juan Jose Lahuerta Palacios, Jesús San Miguel, Maria Victoria Mateos
Journal: Blood
Blood (2023) 142 (Supplement 1): 645.
https://doi.org/10.1182/blood-2023-182964
Published: 2023
Journal Articles

Longitudinal Screening of Mutant Hematopoietic Progenitor Cells (HPC) in Multiple Myeloma (MM) and Its Association with Secondary Primary Malignancies (SPM)

Cristina Perez, Maria Jose Larrayoz, Iria Vazquez, Irache Erdozain, Noemi Puig, María T Cedena, Catarina Maia, Amagoia Mañu, Natalia Gordillo, Oihane Churruca, Diego Alignani, Sarai Sarvide, Albert Oriol Rocafiguera, Laura Rosiñol, Rafael Ríos, Marta Sonia Gonzalez Perez, Ana Pilar Gonzalez-Rodriguez, Felipe De Arriba, Jose Maria Moraleda, Jesus Martin Sanchez, Luis Palomera, Valentin Cabanas Perianes, Maria Jose Calasanz, Joaquin Martinez-Lopez, Maria Victoria Mateos, Joan Bladé, Juan Jose Lahuerta Palacios, Jesus San-Miguel, Bruno Paiva
Journal: Blood
Blood (2023) 142 (Supplement 1): 533.
https://doi.org/10.1182/blood-2023-185737
Published: 2023
Journal Articles

Lenalidomide and dexamethasone maintenance with or without ixazomib, tailored by residual disease status in myeloma

Clinical Trials & Observations
Laura Rosiñol, Albert Oriol, Rafael Ríos, María Jesús Blanchard, Isidro Jarque, Joan Bargay, Miguel Teodoro Hernández, Valentín Cabañas, Estrella Carrillo-Cruz, Anna Sureda, Joaquín Martínez-López, Isabel Krsnik, Maria Esther González, Luis Felipe Casado, Josep María Martí, Cristina Encinas, Felipe de Arriba, Luis Palomera, Antonia Sampol, Yolanda González-Montes, Elena Cabezudo, Bruno Paiva, Noemí Puig, María Teresa Cedena, Javier de la Cruz, María-Victoria Mateos, Jesús San Miguel, Juan José Lahuerta, Joan Bladé
Journal: Blood
Blood (2023) 142 (18): 1518–1528.
https://doi.org/10.1182/blood.2022019531
Published: 2023
Journal Articles

Progression Risk and Long-Term Survival Trends of 915 Patients with Asymptomatic IgM Monoclonal Gammopathy

David F. Moreno, Cristina Jiménez, Fernando Escalante Barrigón, Elham Askari, Mario Arnao, Ángela Heredia, Magdalena Alcalá, Arancha Bermúdez, Ana Saus Carreres, Maria Casanova, Luis Palomera, Cristina Motllo, Ricarda Belen Garcia Sanchez, Ramón García-Sanz, Carlos Fernández De Larrea
Journal: Blood
Blood (2022) 140 (Supplement 1): 259–260.
https://doi.org/10.1182/blood-2022-163008
Published: 2022
Journal Articles

Immunoparesis Recovery in Transplant-Ineligible Newly Diagnosis Multiple Myeloma Patients: An Independent Prognosis Factor That Could Complement Prognostic Value of Minimal Residual Disease

Sunil Lakhwani, María Victoria Mateos, Joaquín Martínez-López, Bruno Paiva, Laura Rosinol Dachs, Rafael Martínez, Albert Oriol, Joan Bargay, Yolanda Gonzalez-Montes, Mercedes Gironella, Cristina Encinas, Jesus Martin, Isidro Jarque, Miquel Granell, Eugenia Abella, Aránzazu García Mateo, José Ángel Hernández-Rivas, Elena Ramila, Isabel Krsnik, Luis Felipe Casado Montero, Felipe De Arriba, Luis Palomera, Antonia Sampol, Jose Maria Moraleda, Maria Casanova, Pilar Delgado, Ana Lafuente, Elena Amutio, Aurelio Lopez Martínez, Albert Altés, M. Ángeles Ruíz, Lucia Lopez-Anglada, Joan Bladé Creixenti, Juan-José Lahuerta, Jesús San-Miguel, Miguel-Teodoro Hernández
Journal: Blood
Blood (2022) 140 (Supplement 1): 2344–2346.
https://doi.org/10.1182/blood-2022-166826
Published: 2022
Journal Articles

Curative Strategy (GEM-CESAR) for High-Risk Smoldering Myeloma (SMM): Post-Hoc Analysis of Sustained Undetectable Measurable Residual Disease (MRD)

Maria-Victoria Mateos, Joaquín Martínez-López, Paula Rodríguez-Otero, Jesús San-Miguel, Veronica Gonzalez-Calle, Marta Sonia Gonzalez, Albert Oriol, Norma C. Gutierrez, Rafael Rios, Laura Rosinol Dachs, Miguel Angel Alvarez, Joan Bargay, Ana Pilar Gonzalez, Fernando Escalante, Adrian Alegre, Belén Iñigo, Javier de la Rubia, Ana Isabel Teruel, Felipe De Arriba, Luis Palomera, Miguel-Teodoro Hernández, Javier Lopez Jimenez, Marta Reinoso Segura, Aránzazu García Mateo, Enrique M. Ocio, Joan Bladé, Juan-José Lahuerta, María Teresa Cedena, Noemi Puig, Bruno Paiva
Journal: Blood
Blood (2022) 140 (Supplement 1): 292–294.
https://doi.org/10.1182/blood-2022-159606
Published: 2022
Journal Articles

Clinical Impact of Next Generation Flow in Bone Marrow Vs Qip-Mass Spectrometry in Peripheral Blood to Assess Minimal Residual Disease in Newly Diagnosed Multiple Myeloma Patients Receiving Maintenance As Part of the GEM2014MAIN Trial

Noemi Puig, Cristina Agulló, Teresa Contreras Sanfeliciano, Bruno Paiva, María Teresa Cedena, Laura Rosinol Dachs, Ramón García-Sanz, Joaquín Martínez-López, Albert Oriol, María Jesús Blanchard, Rafael Rios, Jesus Martin, Anna Sureda, Miguel Hernández, Javier de la Rubia, Jose Maria Moraleda, Felipe De Arriba, Luis Palomera, Belén Iñigo, Joan Bargay, Joan Bladé Creixenti, Jesús San-Miguel, Juan Jose Lahuerta, María-Victoria Mateos
Journal: Blood
Blood (2022) 140 (Supplement 1): 2098–2100.
https://doi.org/10.1182/blood-2022-165441
Published: 2022
Journal Articles

Ultra-Sensitive Assessment of Measurable Residual Disease (MRD) in Peripheral Blood (PB) of Multiple Myeloma (MM) Patients Using Bloodflow

Laura Notarfranchi, Anastasiia Zherniakova, Marta Lasa, Noemi Puig, María Teresa Cedena, Joaquin Martinez-Lopez, María José Calasanz, Diego Alignani, Leire Burgos, Irene Manrique, Yi-Ju Huang, Jochen Fracowiak, Clara Gomez, Felipe De Arriba, Paula Rodríguez-Otero, Luis Palomera, Anna Sureda, Maria Esther Clavero Sanchez, Miguel Angel Alvarez, Angela Ibanez Garcia, Miguel-Teodoro Hernández, Albert Perez, Ana Pilar Gonzalez, Enrique M. Ocio, Juan Flores-Montero, Alberto Orfao, Juan Jose Lahuerta, María-Victoria Mateos, Laura Rosiñol, Joan Bladé Creixenti, Jesús San-Miguel, Bruno Paiva
Journal: Blood
Blood (2022) 140 (Supplement 1): 2095–2097.
https://doi.org/10.1182/blood-2022-167382
Published: 2022
Journal Articles

Recovery of Uninvolved Heavy/Light Chain Pair Immunoparesis during Maintenance Is an Independent Prognostic Factor for Multiple Myeloma and Could Complement Prognosis Value of Minimal Residual Disease

Sunil Lakhwani, Laura Rosinol Dachs, Noemi Puig, Miguel Angel Pico Picos, Laura Medina-González, Joaquín Martínez-López, Bruno Paiva, Albert Oriol, Rafael Rios, María Jesús Blanchard, Isidro Jarque, Joan Bargay, Jose Maria Moraleda, Estrella Carrillo-Cruz, Anna Sureda, Isabel Krsnik, Esther González Garcia, Luis Felipe Casado Montero, Josep M Marti, Cristina Encinas, Felipe De Arriba, Luis Palomera, Antonia Sampol, Yolanda Gonzalez-Montes, Cristina Motllo, Javier De La Cruz, Rafael Alonso Fernández, María-Victoria Mateos, Joan Bladé Creixenti, Juan-José Lahuerta, Jesús San-Miguel, Miguel-Teodoro Hernández
Journal: Blood
Blood (2022) 140 (Supplement 1): 2101–2103.
https://doi.org/10.1182/blood-2022-167247
Published: 2022
Journal Articles

Thrombogenesis Mechanisms of High Doses of Ponatinib in Patients with Chronic Myeloid Leukemia (CML) Compared to Tyrosine Kinase Inhibitors

Sonia Aguila, Ernesto J Cuenca, Maria Jose Lys, Carmen Garcia-Hernandez, Maria Jose Fernández, Maria Noya, Valentín García Gutiérrez, Luis Palomera, Alicia Senín, Raul Perez Lopez, Manuel Pérez-Encinas, Anna Angona, Jose M Puerta, Rolando Vallansot, Venancio Conesa, Juan Carlos Hernandez Boluda, Ana Rosell, Montse Cortes, Guillermo Ortí, Blanca Xicoy, Gonzalo Carreño, Elvira Mora Castera, Pilar Giraldo, Maria Luisa Lozano, Luis Felipe Casado, Francisca Ferrer Marin, on Behalf Of Gelmc
Journal: Blood
Blood (2022) 140 (Supplement 1): 6730–6732.
https://doi.org/10.1182/blood-2022-163070
Published: 2022