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Journal Articles

Measurable residual disease by mass spectrometry and next-generation flow to assess treatment response in myeloma

Clinical Trials & Observations Brief Report
Noemí Puig, Cristina Agulló, Teresa Contreras, María-Teresa Cedena, Joaquín Martínez-López, Albert Oriol, María-Jesús Blanchard, Rafael Ríos, María-Belén Íñigo, Anna Sureda, Sunil Lakhwani, Javier de la Rubia, Verónica González-Calle, Valentín Cabañas, Luis Palomera, José-María Moraleda, Joan Bargay, Sergio Castro, Laura Rosiñol, Joan Bladé, Jesús F. San-Miguel, Juan-José Lahuerta, Bruno Paiva, María-Victoria Mateos
Journal: Blood
Blood (2024) 144 (23): 2432–2438.
https://doi.org/10.1182/blood.2024024995
Published: 2024
Includes: Supplemental data
Journal Articles

Comparative Effectiveness of Linvoseltamab Versus Current Real-World Standard of Care Therapies in Triple-Class Exposed Relapsed/Refractory Multiple Myeloma Treated at IMWG Sites

Shaji Kumar, Sundar Jagannath, Katja C. Weisel, Laura Rosiñol Dachs, Meletios-Athanasios Dimopoulos, David S. Siegel, Jorge Monge, Xavier Leleu, Juan Du, Javier de la Rubia, Jae Hoon Lee, María-Victoria Mateos, Alessandro Gozzetti, Dominik Dytfeld, Enrique M. Ocio, Joan Bladé, Shuji Ozaki, Madhu Nagaraj, Rafla Hassan, Jeannette Green, Glenn S. Kroog, Karen Rodriguez Lorenc, Christian Hampp, Qiufei Ma, Brian G.M. Durie
Journal: Blood
Blood (2024) 144 (Supplement 1): 7039.
https://doi.org/10.1182/blood-2024-210376
Published: 2024
Journal Articles

Epidemiology of Hereditary Thrombotic Thrombocytopenic Purpura (TTP) in Spain: Preliminary Results of a Study of the Spanish TTP Registry (REPTT)

Inés Gómez Seguí, Maria Cristina Pascual Izquierdo, Maria Eva Mingot, Amanda Lopez Picado, Guillermo Sanz, Javier de la Rubia, Ramon Salinas Argente, Julio Del Rio Garma
Journal: Blood
Blood (2024) 144 (Supplement 1): 3999.
https://doi.org/10.1182/blood-2024-203666
Published: 2024
Journal Articles

Current Challenges in the Assessment of Related Donors for Hematopoietic Stem Cell Transplantation

Brais Lamas Rodriguez, Marta Santiago, Pedro Asensi, Aitana Balaguer Rosello, Pedro Chorao, Ana Belén Gálvez, Alessandro Liquori, Pilar Lloret, Juan Montoro, Clara Sopeña Pell-Ilderton, Esperanza Such, Marta Villalba, Jose M. Fernández, Guillermo Sanz, José Cervera, Pilar Solves, Jaime Sanz, Javier de la Rubia, Inés Gómez Seguí
Journal: Blood
Blood (2024) 144 (Supplement 1): 2111.
https://doi.org/10.1182/blood-2024-207015
Published: 2024
Journal Articles

Unraveling Long-Term Survival of Multiple Myeloma Patients, the GEM2000 Experience

Rafael Alonso Fernandez, Andrés Arroyo Barea, Maria Teresa Cedena Romero, Laura Rosiñol Dachs, Javier de la Rubia, Sara Miqueleiz, Veronica Gonzalez-Calle, Felipe De Arriba, Luis Felipe Casado Montero, Miguel Teodoro Hernandez, Maria Mas Esteve, Pascual Fernandez, Paula Rodríguez-Otero, Carmen Calle Primo, Eugenia Abella, Paz Ribas, Adrian Alegre, Juan Miguel Bergua, Irene Gomez-Catalan, Jose Maria Arguiñano Perez, Luis Palomera, Enrique M Ocio, Maria Jose Busto Medina, Nieves Somolinos, Jose Maria Alonso Alonso, Aránzazu García Mateo, Joan Bargay, Pilar Delgado, Dunia De Miguel Llorente, Javier de la Cruz, Maria Victoria Mateos, Jesús F. San-Miguel, Joan Bladé, Juan-Jose Lahuerta Palacios, Joaquin Martinez Lopez
Journal: Blood
Blood (2024) 144 (Supplement 1): 1957.
https://doi.org/10.1182/blood-2024-211383
Published: 2024
Journal Articles

First-in-Human Phase 1 Study of SAR442257 in Patients with Relapsed/Refractory Multiple Myeloma and Non-Hodgkin Lymphoma

Fredrik Schjesvold, Tomas Jelinek, Kamila Polgarova, Ludek Pour, Sung-Soo Yoon, Won Seog Kim, Alexander Fosså, Jesús F. San-Miguel, Miguel Canales, Paula Rodríguez-Otero, Albert Oriol, Javier de la Rubia, Joaquín Martínez-Lopez, Sonia González De Villambrosia, Prashant Kapoor, Ola Landgren, James Edward Hoffman, Noopur Raje, Hongfang Wang, Kunal Jhunjhunwala, Liang Zhao, Zhini Wang, Mony Morisse, Helgi Van de Velde, Nitya Nathwani
Journal: Blood
Blood (2024) 144 (Supplement 1): 1992.
https://doi.org/10.1182/blood-2024-204614
Published: 2024
Journal Articles

Reevaluating the IMWG Multiple Myeloma Complete Response Criterion in the Era of Mass Spectrometry: A Critical Analysis

Noemi Puig, Cristina Agullo, Bruno Paiva, María T Cedena, Laura Rosiñol Dachs, Teresa Contreras, Joaquín Martínez-Lopez, Albert Oriol, María-Jesús Blanchard, Rafael Rios Tamayo, Ana Maria Sureda Balari, Miguel Teodoro Hernández Garcia, Javier de la Rubia, Valentin Cabanas Perianes, Felipe De Arriba, Luis Palomera, Maria Belen Inigo Rodriguez, Veronica Gonzalez-Calle, Enrique M Ocio, Sergio Castro, Joan Bargay, Joan Bladé, Jesús F. San-Miguel, Juan-Jose Lahuerta Palacios, Maria- Victoria Mateos
Journal: Blood
Blood (2024) 144 (Supplement 1): 489.
https://doi.org/10.1182/blood-2024-210198
Published: 2024
Journal Articles

Comparative Effectiveness of Linvoseltamab Versus Current Real-World (RW) Standard-of-Care (SOC) Therapies in Triple-Class Exposed Relapsed/Refractory Multiple Myeloma (RRMM): Key Subgroups Analysis

Shaji Kumar, Sundar Jagannath, Katja C. Weisel, Laura Rosiñol Dachs, Meletios-Athanasios Dimopoulos, David S. Siegel, Jorge Monge, Xavier Leleu, Juan Du, Javier de la Rubia, Jae Hoon Lee, María-Victoria Mateos, Borja Puertas Martínez, Alessandro Gozzetti, Dominik Dytfeld, Enrique M. Ocio, Joan Bladé, Shuji Ozaki, Meral Beksac, Fernando Escalante, Madhu Nagaraj, Rafla Hassan, Paul Spin, Nicolle Bonar, Mostafa Shokoohi, Muhaimen Siddiqui, Di Wang, Kevin Hou, Jeannette Green, Olivier Humblet, Alexander Breskin, James Harnett, Wenzhen Ge, Rachel E. Sobel, Jessica J. Jalbert, Glenn S. Kroog, Karen Rodriguez Lorenc, Qiufei Ma, Christian Hampp, Brian G.M. Durie
Journal: Blood
Blood (2024) 144 (Supplement 1): 7012.
https://doi.org/10.1182/blood-2024-200679
Published: 2024
Journal Articles

An International Study of 343 Newly Diagnosed MM Patients with Acute Renal Failure Due to Cast Nephropathy: Assessment of Factors Affecting Renal Response

Heinz Ludwig, Meletios A. Dimopoulos, Meral Beksac, Frank Bridoux, Guldane Cengis-Seval, Luca Arcaini, Foteini Theodorakakou, Hermine Agis, Francesca Gay, Aristeidis Chaidos, Dario Roccatello, Daniele Derudas, Andrea Havasi, Julie Krainer, Silvia Mangiacavalli, Elise Michelon, Javier De La Rubia, Nattawat Klomjit, Tamer Shehab, Kenar Jhaveri, Nelson Leung, Efstathios Kastritis
Journal: Blood
Blood (2024) 144 (Supplement 1): 3328.
https://doi.org/10.1182/blood-2024-200038
Published: 2024
Journal Articles

Survival Improvement of Transplant Eligible Patients with Newly Diagnosed Multiple Myeloma in Two Consecutive Randomized Phase III Trials: Long-Term Follow up of GEM05 and GEM12 Trials

Laura Rosiñol Dachs, Albert Oriol, María-Jesús Blanchard, Javier de la Rubia, Rafael Ríos, Joan Bargay, Miguel Teodoro Hernández Garcia, Valentín Cabanas Perianes, Ana López de la Guía, Estrella Carrillo-Cruz, Anna Sureda Balari, Joaquin Martínez-López, Jose Maria Arguiñano, Esther González García, Luis Felipe Casado, Josep Maria Marti Tutusaus, Cristina Encinas, Felipe De Arriba, Luis Palomera, Antonia Sampol Mayol, Yolanda González-Montes, Jordi López-Pardo, Maialen Sirvent, Maria Belen Inigo Rodriguez, Bruno Paiva, Noemi Puig, Maria Teresa Cedena Romero, Norma C. Gutierrez, Javier De la Cruz, Maria-Victoria Mateos, Jesús F. San-Miguel, Juan-Jose Lahuerta Palacios, Joan Bladé
Journal: Blood
Blood (2024) 144 (Supplement 1): 3374.
https://doi.org/10.1182/blood-2024-205453
Published: 2024
Journal Articles

ADAMTS13 recovery in acute thrombotic thrombocytopenic purpura after caplacizumab therapy

Clinical Trials & Observations
María-Eva Mingot-Castellano, Faustino García-Candel, Jorge Martínez-Nieto, José García-Arroba, Javier de la Rubia-Comos, Inés Gómez-Seguí, María-Liz Paciello-Coronel, David Valcárcel-Ferreiras, Moraima Jiménez, Joan Cid, Miquel Lozano, José-María García-Gala, Sonia Angós-Vazquez, Miriam Vara-Pampliega, Luisa Guerra-Domínguez, Laura-Francisca Ávila-Idrobo, Ana Oliva-Hernandez, Saioa Zalba-Marcos, Inmaculada Tallón-Ruiz, Sandra Ortega-Sánchez, Rosa Goterris-Viciedo, Gemma Moreno-Jiménez, Lourdes Domínguez-Acosta, María Araiz-Ramírez, Luis Hernández-Mateos, Elena Flores-Ballesteros, Julio del Río-Garma, Cristina Pascual-Izquierdo
Journal: Blood
Blood (2024) 143 (18): 1807–1815.
https://doi.org/10.1182/blood.2023022725
Published: 2024
Includes: Supplemental data
Journal Articles

Cis-Acting Splicing-Associated Variants Can Redefine the Molecular Signature of Genes Commonly Mutated in Acute Myeloid Leukemia

Mireya Morote-Faubel, Maria Guaita-Céspedes, Beatriz Fernández-Blanco, Cristina Martínez-Valiente, Cristian García-Ruiz, Marta Santiago, Alvaro Diaz-Gonzalez, Alejandra Sanjuan-Pla, Mariam Ibáñez, Eva Barragan, Esperanza Such, Mireya Morote Faubel, Pau Montesinos, Javier De La Rubia, Alessandro Liquori, Jose Cervera
Journal: Blood
Blood (2023) 142 (Supplement 1): 2936.
https://doi.org/10.1182/blood-2023-177571
Published: 2023
Journal Articles

Enhancing Cytogenetic Diagnostics: Incorporating Optical Genome Mapping in the Laboratory Routine

Álvaro Díaz-González, Cristian García-Ruiz, Gayane Avetisyan, Gloria Llorens, José Vicente Gil, Elvira Mora, Santiago Furió, Empar Mayordomo, Carolina López-Benet, Marina Suárez-Terrón, Mireya Morote-Faubel, Marta Santiago, Samuel Romero, Marta Llop, Eva Barragán, Lourdes Cordón, Alessandro Liquori, Dolores Linares, Irene Luna, Ana Vicente, Rafael Andreu, Amparo Sempere, Leonor Senent, José Cervera, Guillermo Sanz, Javier De La Rubia, Esperanza Such
Journal: Blood
Blood (2023) 142 (Supplement 1): 5024.
https://doi.org/10.1182/blood-2023-180691
Published: 2023
Journal Articles

Analysis of Peripheral Blood and Bone Marrow Residual Disease Dynamics during Intensive Treatment and Maintenance in Patients with Multiple Myeloma Included in the GEM12MENOS65 and GEM14MAIN Clinical Trials

Noemi Puig, Cristina Agullo, Teresa Contreras, Bruno Paiva, María T Cedena, Laura Rosiñol, Ramon Garcia-Sanz, Joaquin Martinez-Lopez, Albert Oriol Rocafiguera, María-Jesús Blanchard, Rafael Ríos, Anna Maria Sureda Balari, Miguel Teodoro Hernández Garcia, Javier De La Rubia, Felipe De Arriba, Luis Palomera, Valentín Cabañas, Maria Belen Inigo Rodriguez, José Juan Pérez, Sergio Castro, Bargay Joan, Joan Bladé, Juan Jose Lahuerta Palacios, Jesús San Miguel, Maria Victoria Mateos
Journal: Blood
Blood (2023) 142 (Supplement 1): 3324.
https://doi.org/10.1182/blood-2023-184837
Published: 2023
Journal Articles

Caplacizumab Frontline Added to Therapeutic Plasma Exchange and Immunosuppression Prevents Unfavorable Outcomes in Immune-Mediated TTP: An International Real-World Study of the TTP-IWG (The Capla 500 Project)

PAUL Coppo, Michaël Bubenheim, Ygal Benhamou, Linus A. Voelker, Paul T. Brinkkoetter, Lucas Kühne, Paul N. Knoebl, Maria Eva Mingot, Maria Cristina Pascual Izquierdo, Javier De La Rubia, Julio Del Rio Garma, Shruti Chaturvedi, Camila Masias, Marshall Mazepa, X. Long Zheng, Gyorgy Sinkovits, Marienn Reti, Christopher J. Patriquin, Katerina Pavenski, Tiago Boechat, Joao Farias, Eduardo Flavio Oliveira Ribeiro, Michaela Larissa Lobo de Andrade, Agnès Veyradier, Bérangère Joly, Sr., Raïda Bouzid, Kazuya Sakai, Masanori Matsumoto, Ilaria Mancini, Pasquale Agosti, Flora Peyvandi, Matthew James Stubbs, Amjad Hmaid, Sobia Sharif, Tina Dutt, Spero Cataland, Bernhard Lammle, Marie Scully
Journal: Blood
Blood (2023) 142 (Supplement 1): 2636.
https://doi.org/10.1182/blood-2023-179316
Published: 2023
Journal Articles

Caplacizumab Treatment in Elderly Patients with iTTP: Updated Experience from the Spanish TTP Registry

Inés Gómez Seguí, Clara Sopeña Pell-Ilderton, Joan Cid, Miquel Lozano, Maria Eva Mingot Castellano, Maria Cristina Pascual Izquierdo, Luz Maria Gonzalez del Castillo, Julia Maria Vidan Estevez, Faustino Garcia-Candel, Moraima Jiménez Balarezo, David Valcarcel, Clara Cuellar Perez-Avila, Maria Aranzazu Aguirre Arrizabalaga, Laura Francisca Avila Idrovo, Maria Gemma Moreno Jimenez, Ana Yurena Oliva Hernandez, Jose Maria Garcia Gala, Jorge Martínez Nieto, Rosa Goterris, Marta Fernández Docampo, Javier De La Rubia
Journal: Blood
Blood (2023) 142 (Supplement 1): 5429.
https://doi.org/10.1182/blood-2023-180970
Published: 2023
Journal Articles

Clinical Characteristics, Treatment Approach and Long-Term Outcomes of 678 Patients with Symptomatic Waldenstrom's Macroglobulinemia: Comprehensive Insights from a Spanish Registry of IgM Gammapathies

Elham Askari, David F. Moreno, Fernando Escalante, Amalia Domingo-González, Angela Heredia, Arancha Bermúdez, Miguel Canales, Mario Arnao Herraiz, Maria Magdalena Alcala Peña, Ana Saus Carreres, Pablo Ríos Rull, María Casanova, Mercedes Gironella, Paz Ribas Garcia, Javier De La Rubia, Belén Navarro, María-Jesús Blanchard, Cristina Motlló, Ricarda García Sánchez, Francisco Taboada Alameda, Antonio Garcia, Eugenio Abella, Miguel Angel Alvarez Rivas, Joan Bargay, Laura Abril Sabater, Amanda Lopez Picado, Carlos Fernández de Larrea, Ramon Garcia-Sanz
Journal: Blood
Blood (2023) 142 (Supplement 1): 4406.
https://doi.org/10.1182/blood-2023-189581
Published: 2023
Journal Articles

Effect of Caplacizumab in the Recovery of ADAMTS13 Level in Patients with Autoimmune Thrombotic Thrombocytopenic Purpura. Analysis from the Spanish Registry (REPTT)

Maria Eva Mingot, Cristina Izquierdo Pascual, Faustino Garcia-Candel, Jorge Martínez Nieto, José García-Arroba Peinado, Javier De La Rubia, Ines Gomez Segui, Maria Liz Pacielo Coronel, David Valcárcel, Moraima Jiménez Balarezo, Joan Cid, Miquel Lozano, Jose Maria Garcia Gala, Sonia Angos Vazquez, Míriam Vara, Luisa Guerra, Francisca Avila Idrobo, ANA Yurena Oliva Hernandez, Saoia Zalba, Inmaculada Tallon Ruiz, Sandra Ortega Sánchez, Rosa Goterris, Maria Moreno Jimenez, Lourdes Dominguez Acosta, Maria Arraiz Ramirez, Luis Hernández, Elena Flores Ballesteros, Julio Del Rio Garma
Journal: Blood
Blood (2023) 142 (Supplement 1): 5394.
https://doi.org/10.1182/blood-2023-182876
Published: 2023
Journal Articles

Isolated and Dynamic Peripheral Blood Residual Disease Status Characterized By Mass Spectrometry Predicts Outcome in Patients with High Risk Smoldering Multiple Myeloma Treated in the GEM-CESAR Trial

Noemi Puig, Cristina Agullo, Teresa Contreras, Bruno Paiva, Maria Teresa Cedena Romero, José Juan Pérez, Irene Aires, Joaquin Martinez-Lopez, Paula Rodriguez Otero, Veronica Gonzalez-Calle, Marta Sonia Gonzalez Perez, Norma C. Gutierrez, Albert Oriol Rocafiguera, Rafael Ríos, Laura Rosiñol, Miguel Angel Alvarez Rivas, Maria Jose Calasanz, Bargay Joan, Ramon Garcia-Sanz, Ana Pilar Gonzalez, Adrián Alegre, Fernando Escalante, Rafael Martínez, Javier De La Rubia, Ana Isabel Teruel, Felipe De Arriba, Luis Palomera, Sergio Castro, Miguel Teodoro Hernández Garcia, Javier López, Aránzazu García Mateo, Enrique M Ocio, Joan Bladé, Juan Jose Lahuerta Palacios, Jesús San Miguel, Maria Victoria Mateos
Journal: Blood
Blood (2023) 142 (Supplement 1): 645.
https://doi.org/10.1182/blood-2023-182964
Published: 2023
Journal Articles

Alnuctamab (ALNUC; BMS-986349; CC-93269), a 2+1 B-Cell Maturation Antigen (BCMA) × CD3 T-Cell Engager (TCE), Administered Subcutaneously (SC) in Patients (Pts) with Relapsed/Refractory Multiple Myeloma (RRMM): Updated Results from a Phase 1 First-in-Human Clinical Study

Noffar Bar, Maria Victoria Mateos, Paz Ribas, Markus Hansson, Laura Paris, Craig C. Hofmeister, Paula Rodriguez Otero, Maria Aranzazu Bermúdez, Thomas Martin, Armando Santoro, Andrew J. Yee, Maria Creignou, Cristina Encinas Rodriguez, Claudio Cerchione, Javier De La Rubia, Albert Oriol, Heidi Waibel, Britta Besemer, Ethan Thompson, Brian Kiesel, Jinjie Chen, Alexander Chung, Isaac W. Boss, Allison Gaudy, Shaoyi Li, Kevin Hsu, Colin Godwin, Michael R. Burgess, Jesús San-Miguel, Luciano Costa
Journal: Blood
Blood (2023) 142 (Supplement 1): 2011.
https://doi.org/10.1182/blood-2023-180013
Published: 2023