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Xavier Leleu
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Journal Articles

Efficacy and safety of teclistamab in patients with relapsed/refractory multiple myeloma after BCMA-targeting therapies

Clinical Trials & Observations
Cyrille Touzeau, Amrita Y. Krishnan, Philippe Moreau, Aurore Perrot, Saad Z. Usmani, Salomon Manier, Michele Cavo, Carmen Martinez Chamorro, Ajay K. Nooka, Thomas G. Martin, Lionel Karlin, Xavier Leleu, Nizar J. Bahlis, Britta Besemer, Lixia Pei, Sarah Stein, Shun Xin Wang Lin, Danielle Trancucci, Raluca I. Verona, Suzette Girgis, Xin Miao, Clarissa M. Uhlar, Katherine Chastain, Alfred L. Garfall
Journal: Blood
Blood (2024) 144 (23): 2375–2388.
https://doi.org/10.1182/blood.2023023616
Published: 2024
Includes: Supplemental data
Journal Articles

Health-Related Quality of Life in Transplant-Eligible Patients with Newly Diagnosed Multiple Myeloma: Data from the Perseus Trial of Subcutaneous Daratumumab Combined with Bortezomib, Lenalidomide, and Dexamethasone (D-VRd)

Pieter Sonneveld, Meletios A. Dimopoulos, Mario Boccadoro, Hang Quach, Phoebe Joy Ho, Meral Beksac, Cyrille Hulin, Elisabetta Antonioli, Xavier Leleu, Silvia Mangiacavalli, Aurore Perrot, Michele Cavo, Angelo Belotti, Annemiek Broijl, Francesca Gay, Roberto Mina, Inger S. Nijhof, Niels W.C.J. van de Donk, Eirini Katodritou, Fredrik Schjesvold, Anna Sureda Balari, Laura Rosiñol Dachs, Michel Delforge, Wilfried Roeloffzen, Christoph Driessen, Annette Vangsted, Hermann Einsele, Andrew Spencer, Roman Hajek, Artur Jurczyszyn, Sarah Lonergan, Yanfang Liu, Jianping Wang, Emilie M.J. van Brummelen, Veronique Vanquickelberghe, Anna Sitthi-Amorn, Carla J. de Boer, Robin Carson, Eva G. Katz, Katharine S. Gries, Jiaqi Song, Kai Fai Ho, Paula Rodríguez-Otero, Joan Bladé, Philippe Moreau
Journal: Blood
Blood (2024) 144 (Supplement 1): 2000.
https://doi.org/10.1182/blood-2024-201630
Published: 2024
Journal Articles

Cross-Cohort Correlative Analysis of Clinically High-Risk Patients (pts) Treated with Idecabtagene Vicleucel (ide-cel) in KarMMa-2: Association between Progression-Free Survival (PFS) and Tumor Burden and Immune Status at Apheresis

Debashree Basudhar, Dante Descalzi-Montoya, Hao Tang, Minshi Wang, Fan Wu, P. Leif Bergsagel, Xavier Leleu, Daniela Hosseyni, Maria Chaudhry, Nathan Martin, Ethan G. Thompson
Journal: Blood
Blood (2024) 144 (Supplement 1): 3382.
https://doi.org/10.1182/blood-2024-198740
Published: 2024
Journal Articles

Idecabtagene Vicleucel (Ide-cel) in Patients (Pts) with Newly Diagnosed Multiple Myeloma (NDMM) with an Inadequate Response to Front-Line Autologous Stem Cell Transplantation (ASCT): KarMMa-2 Cohort 2c Extended Follow-up

Barry Paul, Madhav V. Dhodapkar, Melissa Alsina, Jesús G. Berdeja, Shambavi Richard, Ravi Vij, Xavier Leleu, Daniel N. Egan, P. Leif Bergsagel, Ran Reshef, Saad Z. Usmani, Anna Truppel-Hartmann, Debashree Basudhar, Ethan G. Thompson, Fan Wu, Laurie Eliason, Soyun Park, Sinhan Tran, Maria Chaudhry, David S. Siegel, Krina K. Patel
Journal: Blood
Blood (2024) 144 (Supplement 1): 3388.
https://doi.org/10.1182/blood-2024-200829
Published: 2024
Journal Articles

High-Risk Multiple Myeloma in Benefit (IFM 2020-05) Phase 3 Randomized Study of Isatuximab (Isa) Plus Lenalidomide and Dexamethasone (Rd) with Bortezomib Versus Isard in Patients with Newly Diagnosed Transplant Ineligible Multiple Myeloma (NDMM TI)

Jill Corre, Jérôme Lambert, Arthur Bobin, Salomon Manier, Aurore Perrot, Lionel Karlin, Murielle Roussel, Noemie Bigot, Omar Benbrahim, Olivier Thierry Allangba, Philippe Rey, Veronique Dorvaux, Marguerite Vignon, Virginie Roland, Reda Garidi, Jean-Noel Bastie, Marie-Lorraine Chrétien, Sophie Godet, Lydia Montes, Brieuc Cherel, Thomas Chalopin, Borhane Slama, Kamel Laribi, Claire Dingremont, Christophe Roul, Valentine Richez, Clara Mariette, Sophie Rigaudeau, Claire Calmettes, Mamoun Dib, Mourad Tiab, Laure Vincent, Jacques Delaunay, Jean Pierre Marolleau, Pascal Godmer, Laurent Frenzel, Ronan Le Calloch, Emilie Chalayer, Helene Gardeney, Margaret Macro, Bruno Royer, Olivier Decaux, Bertrand Arnulf, Karim Belhadj Merzoug, Cyrille Touzeau, Mohamad Mohty, Aurelie Gontier, Amine Kasmi, Philippe Moreau, Thierry Facon, Herve Avet Loiseau, Cyrille Hulin, Xavier Leleu
Journal: Blood
Blood (2024) 144 (Supplement 1): 4756.
https://doi.org/10.1182/blood-2024-210345
Published: 2024
Journal Articles

The Combination of Isatuximab with Pomalidomide and Dexamethasone in Second Line Relapse and Refractory Multiple Myeloma

Arthur Bobin, Ennebet Soufyane, Stephanie Guidez, Aurelia Chacon, Helene Gardeney, Caroline Basle, Elodie Dindinaud, Soukaina Douma, Christophe Roul, Anne Corby, Carine Motard, Gaelle Olivier, Guillaume Denis, Camille Vinson, Cecile Tomowiak, Cecile Gruchet, Niels Moya, Pauline Mocquot, Berangere Dessane, Annick Boscagli, Aurore Perrot, Xavier Leleu
Journal: Blood
Blood (2024) 144 (Supplement 1): 7041.
https://doi.org/10.1182/blood-2024-210687
Published: 2024
Journal Articles

Comparative Effectiveness of Linvoseltamab Versus Current Real-World Standard of Care Therapies in Triple-Class Exposed Relapsed/Refractory Multiple Myeloma Treated at IMWG Sites

Shaji Kumar, Sundar Jagannath, Katja C. Weisel, Laura Rosiñol Dachs, Meletios-Athanasios Dimopoulos, David S. Siegel, Jorge Monge, Xavier Leleu, Juan Du, Javier de la Rubia, Jae Hoon Lee, María-Victoria Mateos, Alessandro Gozzetti, Dominik Dytfeld, Enrique M. Ocio, Joan Bladé, Shuji Ozaki, Madhu Nagaraj, Rafla Hassan, Jeannette Green, Glenn S. Kroog, Karen Rodriguez Lorenc, Christian Hampp, Qiufei Ma, Brian G.M. Durie
Journal: Blood
Blood (2024) 144 (Supplement 1): 7039.
https://doi.org/10.1182/blood-2024-210376
Published: 2024
Journal Articles

Health Related Quality of Life (HRQoL) in Relapsed/Refractory Multiple Myeloma (RRMM): A Systematic Literature Review (SLR) and Meta-Analysis

Rahul Banerjee, Ken Hasegawa, Taha Itani, Monique Giordana, Enrique Granados, Margrit B Rosado, Rebecca J Chan, Ana Kostic, Steve Kanters, Michael J Zoratti, Xavier Leleu
Journal: Blood
Blood (2024) 144 (Supplement 1): 4721.
https://doi.org/10.1182/blood-2024-203741
Published: 2024
Journal Articles

Comparative Effectiveness of Linvoseltamab Versus Current Real-World (RW) Standard-of-Care (SOC) Therapies in Triple-Class Exposed Relapsed/Refractory Multiple Myeloma (RRMM): Key Subgroups Analysis

Shaji Kumar, Sundar Jagannath, Katja C. Weisel, Laura Rosiñol Dachs, Meletios-Athanasios Dimopoulos, David S. Siegel, Jorge Monge, Xavier Leleu, Juan Du, Javier de la Rubia, Jae Hoon Lee, María-Victoria Mateos, Borja Puertas Martínez, Alessandro Gozzetti, Dominik Dytfeld, Enrique M. Ocio, Joan Bladé, Shuji Ozaki, Meral Beksac, Fernando Escalante, Madhu Nagaraj, Rafla Hassan, Paul Spin, Nicolle Bonar, Mostafa Shokoohi, Muhaimen Siddiqui, Di Wang, Kevin Hou, Jeannette Green, Olivier Humblet, Alexander Breskin, James Harnett, Wenzhen Ge, Rachel E. Sobel, Jessica J. Jalbert, Glenn S. Kroog, Karen Rodriguez Lorenc, Qiufei Ma, Christian Hampp, Brian G.M. Durie
Journal: Blood
Blood (2024) 144 (Supplement 1): 7012.
https://doi.org/10.1182/blood-2024-200679
Published: 2024
Journal Articles

The IFM2017-03 Phase 3 Trial: A Dexamethasone Sparing-Regimen with Daratumumab and Lenalidomide for Frail Patients with Newly-Diagnosed Multiple Myeloma

Salomon Manier, Jérome Lambert, Cyrille Hulin, Kamel Laribi, Carla Araujo, Gian Matteo Pica, Cyrille Touzeau, Pascal Godmer, Bohrane Slama, Lionel Karlin, Frederique Orsini Piocelle, Mamoun Dib, Magaret Macro, Laurence Sanhes, Lydia Montes, Abderrazak El Yamani, Mourad Tiab, Reza Tabrizi, Laurent Garderet, Bruno Royer, Benoit Bareau, Aurore Perrot, Jean Yves Mary, Jill Corre, Herve Avet Loiseau, Philippe Moreau, Xavier Leleu, Thierry Facon
Journal: Blood
Blood (2024) 144 (Supplement 1): 774.
https://doi.org/10.1182/blood-2024-203045
Published: 2024
Journal Articles

Isatuximab, Bortezomib, Lenalidomide, and Dexamethasone (Isa-VRd) in Patients with Newly Diagnosed Multiple Myeloma (NDMM): Analyses of Minimal Residual Disease (MRD) Negativity Dynamics in the Phase 3 Imroz Study

Robert Z. Orlowski, Meletios-Athanasios Dimopoulos, Xavier Leleu, Zhuogang Liu, Tadao Ishida, Roman Hajek, Ivan Špička, Joanna Romejko-Jarosinska, Vladimir I. Vorobyev, Britta Besemer, Sevgi Beşışık, Pawel Robak, Hartmut Goldschmidt, Thomas Martin, Mohamad Mohty, Sandrine Macé, Ercem Kodas, Christina Tekle, Andrea Shafer, Philippe Moreau
Journal: Blood
Blood (2024) 144 (Supplement 1): 770.
https://doi.org/10.1182/blood-2024-203818
Published: 2024
Journal Articles

Comparative Effectiveness of Ciltacabtagene Autoleucel from the Cartitude-4 Trial Vs Real-World Physician's Choice of Therapy from the Flatiron Registry in Lenalidomide-Refractory Multiple Myeloma - an Updated Overall Survival Analysis

Cyrille Touzeau, Brea Lipe, Abdullah Mohammad Khan, Binod Dhakal, Sandhya Nair, Jianming He, João Mendes, Seina Lee, Carolina Lonardi, Ana Slaughter, Nikoletta Lendvai, Jordan M. Schecter, Diana Chen, Man Zhao, Tzu-min Yeh, Xavier Leleu, Noemi Puig, Dominik Dytfeld, Elena Zamagni, Katja C. Weisel, Lionel Karlin, Michel Delforge, Paolo Corradini, Roberto Mina, Wilfried Roeloffzen, Surbhi Sidana
Journal: Blood
Blood (2024) 144 (Supplement 1): 7089.
https://doi.org/10.1182/blood-2024-205383
Published: 2024
Journal Articles

Comparative Efficacy of Ciltacabtagene Autoleucel Versus Isatuximab, Carfilzomib and Dexamethasone in the Treatment of Patients with Lenalidomide-Refractory Multiple Myeloma with 1-3 Prior Lines of Therapy Using a Matching-Adjusted Indirect Comparison

Roberto Mina, Paolo Corradini, Michele Cavo, Jesús F. San-Miguel, Leyla O. Shune, Abdullah Mohammad Khan, Surbhi Sidana, Xavier Leleu, Salomon Manier, Brea Lipe, Katja C. Weisel, Suzy van Sanden, Joris Diels, João Mendes, Seina Lee, Sandra Van Hoorenbeeck, Adrián Pons, Ana Slaughter, Nina Benachour, Carolina Lonardi, Arnab Ghosh, Nitin Patel, Erika Florendo, Joaquín Martínez-Lopez
Journal: Blood
Blood (2024) 144 (Supplement 1): 7088.
https://doi.org/10.1182/blood-2024-205189
Published: 2024
Journal Articles

Sipavibart (AZD-3152), a COVID-19 Pre-Exposure Prophylaxis in Myeloma Treated with BCMA/CD3 Bispecific Antibodies

Helene Gardeney, Arthur Bobin, Jean-Marc Gombert, Andre Herbelin, Cecile Tomowiak, Elodie Dindinaud, Caroline Basle, Laly Nsiala, Laura Cailly, Mathilde Vonfeld, Aurelia Chacon, Aurelien Pichon, Thomas Lombard, Isabelle Princet, Nicolas Leveque, Xavier Leleu, Thomas Systchenko
Journal: Blood
Blood (2024) 144 (Supplement 1): 7222.
https://doi.org/10.1182/blood-2024-208428
Published: 2024
Journal Articles

NK Cells and KIR+ / NKG2A+ Innate like CD8+ T Lymphocytes Features in the Bone Marrow of Multiple Myeloma Patients

Helene Gardeney, Emma Narbeburu, Alice Barbarin, Niels Moya, Arthur Bobin, Anthony Levy, Cecile Gruchet, Xavier Leleu, Andre Herbelin, Jean-Marc Gombert
Journal: Blood
Blood (2024) 144 (Supplement 1): 6865.
https://doi.org/10.1182/blood-2024-208578
Published: 2024
Journal Articles

RAS/RAF landscape in monoclonal plasma cell conditions

Brief Report
Anais Schavgoulidze, Jill Corre, Mehmet Kemal Samur, Celine Mazzotti, Luka Pavageau, Aurore Perrot, Titouan Cazaubiel, Xavier Leleu, Margaret Macro, Karim Belhadj, Murielle Roussel, Sabine Brechignac, Lydia Montes, Denis Caillot, Laurent Frenzel, Philippe Rey, Jean-Marc Schiano de Colella, Thomas Chalopin, Caroline Jacquet, Valentine Richez, Frederique Orsini-Piocelle, Jean Fontan, Salomon Manier, Ludovic Martinet, Adam Sciambi, Mohamad Mohty, Herve Avet-Loiseau
Journal: Blood
Blood (2024) 144 (2): 201–205.
https://doi.org/10.1182/blood.2023022295
Published: 2024
Includes: Supplemental data
Journal Articles

Daratumumab, carfilzomib, lenalidomide, and dexamethasone with tandem transplant for high-risk newly diagnosed myeloma

Clinical Trials & Observations
Cyrille Touzeau, Aurore Perrot, Cyrille Hulin, Salomon Manier, Margaret Macro, Marie-Lorraine Chretien, Lionel Karlin, Martine Escoffre, Caroline Jacquet, Mourad Tiab, Xavier Leleu, Herve Avet-Loiseau, Alexandra Jobert, Lucie Planche, Jill Corre, Philippe Moreau
Journal: Blood
Blood (2024) 143 (20): 2029–2036.
https://doi.org/10.1182/blood.2023023597
Published: 2024
Includes: Supplemental data
Journal Articles

How I treat multiple myeloma in geriatric patients

Thierry Facon, Xavier Leleu, Salomon Manier
Journal: Blood
Blood (2024) 143 (3): 224–232.
https://doi.org/10.1182/blood.2022017635
Published: 2024
Journal Articles

Phase 3 Randomized Study of Daratumumab (DARA) + Bortezomib, Lenalidomide, and Dexamethasone (VRd) Versus Vrd Alone in Patients (Pts) with Newly Diagnosed Multiple Myeloma (NDMM) Who Are Eligible for Autologous Stem Cell Transplantation (ASCT): Primary Results of the Perseus Trial

Pieter Sonneveld, Meletios A. Dimopoulos, Mario Boccadoro, Hang Quach, P. Joy Ho, Meral Beksac, Cyrille Hulin, Elisabetta Antonioli, Xavier Leleu, Silvia Mangiacavalli, Aurore Perrot, Michele Cavo, Angelo Belotti, Annemiek Broijl, Francesca Gay, Roberto Mina, Inger S. Nijhof, Niels W.C.J van de Donk, Eirini Katodritou, Fredrik Schjesvold, Anna Sureda Balari, Laura Rosiñol, Michel Delforge, Wilfried Roeloffzen, Tobias Silzle, Annette Vangsted, Hermann Einsele, Andrew Spencer, Roman Hajek, Artur Jurczyszyn, Sarah Lonergan, Tahamtan Ahmadi, Yanfang Liu, Jianping Wang, Diego Vieyra, Emilie M.J. van Brummelen, Veronique Vanquickelberghe, Anna Sitthi-Amorn, Carla J. de Boer, Robin Carson, Paula Rodríguez Otero, Joan Bladé, Philippe Moreau
Journal: Blood
Blood (2023) 142 (Supplement 2): LBA-1.
https://doi.org/10.1182/blood-2023-191911
Published: 2023
Journal Articles

French Early Nationwide Idecabtagene Vicleucel (Ide-Cel) Chimeric Antigen Receptor (CAR) T-Cell Therapy Experience in Patients with Relapsed/Refractory Multiple Myeloma (FENIX): Update of the IFM Study from the Descar-T Registry

Sarah Cayla, Benoit Ferment, Noemie Bigot, Denis Caillot, Ingrid Lafon, Lionel Karlin, Anne Lazareth, Cyrille Touzeau, Xavier Leleu, Niels Moya, Stephanie Harel, Aurore Perrot, Pierre Bories, Laure Vincent, Sylvain Lamure, Mohamad Mohty, Florent Malard, Salomon Manier, Ibrahim Yakoub-Agha, Anne-Marie Stoppa, Gabriel Brisou, Olivier Decaux, Roch Houot, Steven Le Gouill, Jerome Lambert, Thierry Facon, Herve Avet Loiseau, Philippe Moreau, Bertrand Arnulf
Journal: Blood
Blood (2023) 142 (Supplement 1): 2139.
https://doi.org/10.1182/blood-2023-188655
Published: 2023