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Journal Articles

Isatuximab, Bortezomib, Lenalidomide, and Dexamethasone (Isa-VRd) in Patients with Newly Diagnosed Multiple Myeloma (NDMM) Not Eligible or with No Immediate Intent for Transplant: Long-Term Efficacy and Safety in a Phase 1b Study

Enrique M Ocio, Aurore Perrot, Pierre Bories, Jesús F. San-Miguel, Lionel Karlin, Joaquin Martinez-Lopez, Song-Yau Wang, Sara Bringhen, Maria-Victoria Mateos, Paula Rodríguez-Otero, Stefania Oliva, Axel Nogai, Bruno Paiva, Yi Li, Eric Le Bras, Sandrine Macé, Ercem Kodas, Helgi Van de Velde, Philippe Moreau
Journal: Blood
Blood (2024) 144 (Supplement 1): 1976.
https://doi.org/10.1182/blood-2024-200135
Published: 2024
Journal Articles

Development and Validation of Novel Machine Learning-Based Risk Scores for Multiple Myeloma: Insights from the Harmony Alliance Big Data Platform

Adrian Mosquera Orgueira, Marta Sonia Gonzalez Perez, Mattia D'Agostino, David A. Cairns, Alessandra Larocca, Juan José Lahuerta Palacios, Ruth Wester, Uta Bertsch, Anders Waage, Elena Zamagni, Carlos Pérez Míguez, Niels W.C.J. Van De Donk, Graham Jackson, Davide Crucitti, Hans Salwender, Daniele Dall'Olio, Gastone Castellani, Manuel Piñeiro Fiel, Sara Bringhen, Sonja Zweegman, Michele Cavo, Jesus Maria Hernandez Rivas, Benedetto Bruno, Gordon Cook, Martin F Kaiser, Hartmut Goldschmidt, Pieter Sonneveld, Jesús F. San-Miguel, Mario Boccadoro, Maria- Victoria Mateos
Journal: Blood
Blood (2024) 144 (Supplement 1): 2226.
https://doi.org/10.1182/blood-2024-201448
Published: 2024
Journal Articles

Phase 3 Randomized Study of Daratumumab Monotherapy Versus Active Monitoring in Patients with High-Risk Smoldering Multiple Myeloma: Primary Results of the Aquila Study

Meletios-Athanasios Dimopoulos, Peter M. Voorhees, Fredrik Schjesvold, Yael C. Cohen, Vania Hungria, Irwindeep Sandhu, Jindriska Lindsay, Ross Ian Baker, Kenshi Suzuki, Hiroshi Kosugi, Mark-David Levin, Meral Beksac, Keith Stockerl-Goldstein, Albert Oriol, Gabor Mikala, Gonzalo Martin Garate, Koen Theunissen, Ivan Spicka, Anne K. Mylin, Sara Bringhen, Katarina Uttervall, Bartosz Michal Pula, Eva Medvedova, Andrew J. Cowan, Philippe Moreau, Maria-Victoria Mateos, Hartmut Goldschmidt, Tahamtan Ahmadi, Linlin Sha, Els Rousseau, Liang Li, Robyn M. Dennis, Robin Carson, Vincent Rajkumar
Journal: Blood
Blood (2024) 144 (Supplement 1): 773.
https://doi.org/10.1182/blood-2024-201057
Published: 2024
Journal Articles

30-Minute Infusion of Isatuximab in Newly Diagnosed Multiple Myeloma (NDMM) Patients: Results of a Phase 1b Study

Enrique M Ocio, Aurore Perrot, Philippe Moreau, Maria-Victoria Mateos, Sara Bringhen, Joaquin Martinez-Lopez, Lionel Karlin, Igor Wolfgang Blau, Song-Yau Wang, Maurizio Martelli, Corina Oprea, Yvonne Dong, Ercem Kodas, Jesus San Miguel
Journal: Blood
Blood (2023) 142 (Supplement 1): 6717.
https://doi.org/10.1182/blood-2023-175020
Published: 2023
Journal Articles

Carfilzomib-Lenalidomide-Dexamethasone (KRd) Vs. Lenalidomide-Dexamethasone (Rd) in Newly Diagnosed Fit or Intermediate-Fit Multiple Myeloma Patients Not Eligible for Autologous Stem-Cell Transplantation (Phase III EMN20 Trial): Analysis of Sustained Undetectable Minimal Residual Disease (MRD)

Sara Bringhen, Elisabetta Antonioli, Barbara Gamberi, Benedetto Bruno, Daniele Derudas, Patrizia Tosi, Francesca Fazio, Rita Mazza, Sonia Ronconi, Paolo Corradini, Flavia Lotti, Claudia Cellini, Antonietta Pia Falcone, Piero Galieni, Roberto Ria, Angelo Belotti, Donato Mannina, Anna Maria Cafro, Clotilde Cangialosi, Iolanda Donatella Vincelli, Alessandra Lombardo, Alessandra Larocca, Mario Boccadoro, Mattia D'Agostino
Journal: Blood
Blood (2023) 142 (Supplement 1): 205.
https://doi.org/10.1182/blood-2023-177673
Published: 2023
Journal Articles

Impact of Daratumumab on Hematopoietic Stem Cell Mobilization with G-CSF and on-Demand Plerixafor in Newly-Diagnosed Multiple Myeloma Patients

Roberto Mina, Bruno Garibaldi, Giuseppe Bertuglia, Andrea Casson, Barbara Sarina, Francesca Gay, Silvio Mercadante, Jacopo Mariotti, Mattia D'Agostino, Daniela Taurino, Stefania Oliva, Alessandra Larocca, Daniele Mannina, Chiara De Philippis, Giulia Benevolo, Tiziana Francisci, Marco Lorenzi, Benedetto Bruno, Armando Santoro, Sara Bringhen, Stefania Bramanti
Journal: Blood
Blood (2023) 142 (Supplement 1): 6633.
https://doi.org/10.1182/blood-2023-180082
Published: 2023
Journal Articles

Bortezomib-Melphalan-Prednisone (VMP) Vs. Lenalidomide-Dexamethasone (Rd) in Transplant-Ineligible Real-Life Multiple Myeloma Patients: Updated Results of the Randomized Phase IV Real MM Trial

Sara Bringhen, Mattia D'Agostino, Nicola Giuliani, Irene Attucci, Renato Zambello, Sonia Ronconi, Iolanda Donatella Vincelli, Alessandro Allegra, Giovanna Leonardi, Giuseppe Rossi, Francesco Cattel, Andrea Capra, Piero Galieni, Alessandra Lombardo, Francesca Bonello, Patrizia Tosi, Maide Maria Cavalli, Elisa Sciorsi, Donato Mannina, Roberto Ria, Francesca Patriarca, Michele Cavo, Silvia Mangiacavalli, Giulia Benevolo, Andrea Evangelista, Mario Boccadoro, Benedetto Bruno, Alessandra Larocca
Journal: Blood
Blood (2022) 140 (Supplement 1): 1814–1816.
https://doi.org/10.1182/blood-2022-162178
Published: 2022
Journal Articles

Dose/schedule-adjusted Rd-R vs continuous Rd for elderly, intermediate-fit patients with newly diagnosed multiple myeloma

Clinical Trials & Observations
Alessandra Larocca, Francesca Bonello, Gianluca Gaidano, Mattia D’Agostino, Massimo Offidani, Nicola Cascavilla, Andrea Capra, Giulia Benevolo, Patrizia Tosi, Monica Galli, Roberto Marasca, Nicola Giuliani, Annalisa Bernardini, Elisabetta Antonioli, Delia Rota-Scalabrini, Claudia Cellini, Alessandra Pompa, Federico Monaco, Francesca Patriarca, Tommaso Caravita di Toritto, Paolo Corradini, Paola Tacchetti, Mario Boccadoro, Sara Bringhen
Journal: Blood
Blood (2021) 137 (22): 3027–3036.
https://doi.org/10.1182/blood.2020009507
Published: 2021
Includes: Supplemental data
Journal Articles

Isatuximab as monotherapy and combined with dexamethasone in patients with relapsed/refractory multiple myeloma

Clinical Trials & Observations
Meletios Dimopoulos, Sara Bringhen, Pekka Anttila, Marcelo Capra, Michele Cavo, Craig Cole, Cristina Gasparetto, Vania Hungria, Matthew Jenner, Vladimir Vorobyev, Eduardo Yanez Ruiz, Jian Y. Yin, Rao Saleem, Maeva Hellet, Sandrine Macé, Bruno Paiva, Ravi Vij
Journal: Blood
Blood (2021) 137 (9): 1154–1165.
https://doi.org/10.1182/blood.2020008209
Published: 2021
Includes: Supplemental data
Journal Articles

Efficacy and Safety of Ixazomib Induction and Maintenance in Newly Diagnosed Multiple Myeloma Patients According to the IMWG Frailty Score: A Post-Hoc Analysis of the EMN10-Unito Trial

Roberto Mina, MD, Alessandra Larocca, Massimo Offidani, Vanessa Innao, Claudia Cellini, Monica Galli, Giusy Cetani, Mariella Grasso, Giovannino Ciccone, Andrea Capra, Sara Aquino, Claudia Priola, Gloria Margiotta Casaluci, Giovanni De Sabbata, Stelvio Ballanti, Michele Cavo, Mario Boccadoro, Sara Bringhen, MD
Journal: Blood
Blood (2020) 136 (Supplement 1): 44–45.
https://doi.org/10.1182/blood-2020-136292
Published: 2020
Journal Articles

First Results of Iberdomide (IBER; CC-220) in Combination with Dexamethasone (DEX) and Daratumumab (DARA) or Bortezomib (BORT) in Patients with Relapsed/Refractory Multiple Myeloma (RRMM)

Niels W.C.J. van de Donk, MD PhD, Rakesh Popat, Jeremy Larsen, Monique C. Minnema, Sundar Jagannath, MD, Albert Oriol, Jeffrey Zonder, Paul G. Richardson, MD, Paula Rodriguez-Otero, MD PhD, Ashraf Z. Badros, MD, Edward Stadtmauer, Sara Bringhen, MD, Erica Campagnaro, MD, David S. Siegel, MD PhD, Barbara Gamberi, Mercedes Gironella Mesa, Pieter Sonneveld, MD PhD, Tuong Vi Nguyen, Antonia Di Micco, April Sorrell, Min Chen, Michael Amatangelo, Elisabeth Kueenburg, Sagar Lonial, MD FACP
Journal: Blood
Blood (2020) 136 (Supplement 1): 16–17.
https://doi.org/10.1182/blood-2020-137743
Published: 2020
Journal Articles

A New Risk Stratification Model (R2-ISS) in Newly Diagnosed Multiple Myeloma: Analysis of Mature Data from 7077 Patients Collected By European Myeloma Network within Harmony Big Data Platform

Mattia D'Agostino, MD, Juan-José Lahuerta, MD PhD, Ruth Wester, MD, Anders Waage, MD PhD, Uta Bertsch, Elena Zamagni, Maria-Victoria Mateos, MD PhD, Alessandra Larocca, Daniele Dall'Olio, Niels W. C. J. van de Donk, David Cairns, MSc, PhD, Serena Rocchi, Hans Salwender, MD, Joan Blade Creixenti, Bronno van der Holt, PhD, Castellani Gastone, Giovannino Ciccone, Andrea Capra, Jan Dürig, MD, Sara Bringhen, MD, Sonja Zweegman, MDPhD, Michele Cavo, Hartmut Goldschmidt, MD, Gordon Cook, MB ChB, PhD, Jesus Maria Hernández-Rivas, MD PhD, Jesus F. San-Miguel, MD PhD, Mario Boccadoro, Pieter Sonneveld, MD PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 34–37.
https://doi.org/10.1182/blood-2020-137021
Published: 2020
Journal Articles

Ixazomib-Based Induction Followed By Single-Agent Ixazomib Maintenance in Transplant Ineligible, Newly Diagnosed Multiple Myeloma Patients: Updated Results of the EMN10-Unito Trial

Roberto Mina, MD, Alessandra Larocca, Paolo Corradini, Nicola Cascavilla, Anna Marina Liberati, Norbert Pescosta, Francesca Fazio, Giovannino Ciccone, Andrea Capra, Francesca Patriarca, Annalisa Bernardini, Delia Rota Scalabrini, Michele Cea, Renato Zambello, Anna Baraldi, Angelo Belotti, Mario Boccadoro, Sara Bringhen, MD
Journal: Blood
Blood (2020) 136 (Supplement 1): 27–28.
https://doi.org/10.1182/blood-2020-134671
Published: 2020
Journal Articles

Progression-Free Survival (PFS) Benefit Demonstrated and Quality of Life (QoL) Maintained across Age and Frailty Subgroups with the Oral Proteasome Inhibitor (PI) Ixazomib Vs Placebo As Post-Induction Maintenance Therapy in Non-Transplant Newly Diagnosed Multiple Myeloma (NDMM) Patients (Pts): Analysis of the TOURMALINE-MM4 Phase 3 Trial

Sara Bringhen, MD, Luděk Pour, MD, Reuben Benjamin, MBBS, FRCPath, PhD, Sebastian Grosicki, MD PhD, Chang-Ki Min, MD PhD, Danielle Leao Cordeiro De Farias, MDMSc,MBA, Alexander Vorog, MD, Richard J Labotka, MD, Bingxia Wang, PhD, Dasha Cherepanov, Lauren E. Cain, MHS, ScM, PhD, Sudhakar Manne, S. Vincent Rajkumar, MD, Meletios A. Dimopoulos, MD
Journal: Blood
Blood (2020) 136 (Supplement 1): 30–31.
https://doi.org/10.1182/blood-2020-136293
Published: 2020
Journal Articles

Risk of Early Severe Infections in Newly Diagnosed Multiple Myeloma Patients Treated with Novel Agents: A Pooled Analysis

Francesca Bonello, Mattia D'Agostino, MD, Massimo Offidani, Maria Teresa Petrucci, Anna Marina Liberati, Francesca Patriarca, Andrea Capra, Giulia Benevolo, Gianluca Gaidano, Gregorio Barilà, Monica Galli, Elena Ponticelli, Nicola Cascavilla, Emanuele Angelucci, Stelvio Ballanti, Giuseppe Pietrantuono, Stefano Pulini, Daniele Derudas, Paolo de Fabritiis, Paolo Corradini, Concetta Conticello, Michele Cavo, Pieter Sonneveld, MD PhD, Mario Boccadoro, Sara Bringhen, MD
Journal: Blood
Blood (2020) 136 (Supplement 1): 11–12.
https://doi.org/10.1182/blood-2020-136302
Published: 2020
Journal Articles

Isatuximab Short-Duration Fixed-Volume Infusion Plus Bortezomib (V) Lenalidomide (R) and Dexamethasone(d) Combined Therapy for Newly Diagnosed Multiple Myeloma (NDMM): Results from a Phase 1b Feasibility/Safety Study

Enrique M. Ocio, MDPhD, Aurore Perrot, Pierre Bories, MD, Jesus F. San-Miguel, MD PhD, Igor W Blau, MD PhD, Lionel Karlin, MD, Joaquin Martinez-Lopez, MD PhD, Wolfram Pönisch, MD, Sara Bringhen, MD, Fabio Ciceri, MD, María-Victoria Mateos, MD PhD, Paula Rodriguez-Otero, Nadia Le Roux, Yvonne Dong, Thomas Fitzmaurice, PhD, Corina Oprea, MD, Philippe Moreau, MD
Journal: Blood
Blood (2020) 136 (Supplement 1): 15–16.
https://doi.org/10.1182/blood-2020-136569
Published: 2020
Journal Articles

Efficacy of Isatuximab with Pomalidomide and Dexamethasone in Elderly Patients with Relapsed/Refractory Multiple Myeloma: Icaria-MM Subgroup Analysis

Fredrik H. Schjesvold, MD PhD, Paul G. Richardson, MD, Michel Attal, MD PhD, Thierry Facon, MD, Adrián Alegre, MD, Andrew Spencer, DM, Artur Jurczyszyn, MD, Kazutaka Sunami, MD PhD, Laurent Frenzel, MD PhD, Chang-Ki Min, MD PhD, Solenn Le-Guennec, Frank Campana, MD, Helgi van de Velde, MD PhD, Samira Bensfia, MD, Sara Bringhen
Journal: Blood
Blood (2019) 134 (Supplement_1): 1893.
https://doi.org/10.1182/blood-2019-128010
Published: 2019
Journal Articles

Updated Progression-Free Survival (PFS) and Overall Survival (OS) with Melflufen and Dexamethasone in Patients with Relapsed/Refractory Multiple Myeloma (RRMM): Results from the Phase 2 Study O-12-M1

Sara Bringhen, Peter M. Voorhees, MD, Torben Plesner, MD DSc, Ulf-Henrik Mellqvist, MD PhD, Brandi Reeves, MD, Pieter Sonneveld, Catriona Byrne, RN, Eva Nordström, MSc, Johan Harmenberg, MD PhD, Jakob Obermüller, MSc, Paul G. Richardson, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1839.
https://doi.org/10.1182/blood-2019-124828
Published: 2019
Journal Articles

The MP0250-CP201 Mirror Study: A Phase 2 Study Update of MP0250 Plus Bortezomib and Dexamethasone in Relapse/Refractory Multiple Myeloma (RRMM) Patients Previously Exposed to Proteasome Inhibitors and Immunomodulatory Drugs

Norbert Grząśko, MD PhD, Stefan Knop, Hartmut Goldschmidt, MD, Marc S Raab, MD PhD, Jan Dürig, Sara Bringhen, Mattia D'Agostino, MD, Barbara Gamberi, Elena Rivolti, MD, Angelo Vacca, MD PhD, Roberto Ria, MD, Artur Jurczyszyn, MD, Jorge Castellano Acosta, MD, Doris Lang, Guy Lemaillet, PhD, Bansod Sudhir, MD, Monika Szarejko, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1899.
https://doi.org/10.1182/blood-2019-129827
Published: 2019
Journal Articles

Efficacy and Safety of Ixazomib-Dexamethasone, Ixazomib-Cyclophosphamide-Dexamethasone, Ixazomib-Thalidomide-Dexamethasone and Ixazomib-Bendamustine-Dexamethasone for Elderly Newly Diagnosed Multiple Myeloma (NDMM) Patients: Analysis of the Phase II Randomized Unito-EMN10 Study

Alessandra Larocca, Paolo Corradini, Roberto Mina, Nicola Cascavilla, Anna Marina Liberati, Norbert Pescosta, Maria Teresa Petrucci, Giovannino Ciccone, Andrea Capra, Francesca Patriarca, Delia Rota Scalabrini, Vanessa Innao, Marco Poggiu, Michele Cea, Renato Zambello, Anna Baraldi, Angelo Belotti, Claudia Cellini, Monica Galli, Mariella Grasso, Sara Aquino, Gloria Margiotta Casaluci, Giovanni De Sabbata, Stelvio Ballanti, Massimo Offidani, Katia Mancuso, Mario Boccadoro, Sara Bringhen
Journal: Blood
Blood (2019) 134 (Supplement_1): 3195.
https://doi.org/10.1182/blood-2019-124388
Published: 2019