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Journal Articles

RAS/RAF landscape in monoclonal plasma cell conditions

Brief Report
Anais Schavgoulidze, Jill Corre, Mehmet Kemal Samur, Celine Mazzotti, Luka Pavageau, Aurore Perrot, Titouan Cazaubiel, Xavier Leleu, Margaret Macro, Karim Belhadj, Murielle Roussel, Sabine Brechignac, Lydia Montes, Denis Caillot, Laurent Frenzel, Philippe Rey, Jean-Marc Schiano de Colella, Thomas Chalopin, Caroline Jacquet, Valentine Richez, Frederique Orsini-Piocelle, Jean Fontan, Salomon Manier, Ludovic Martinet, Adam Sciambi, Mohamad Mohty, Herve Avet-Loiseau
Journal: Blood
Blood (2024) 144 (2): 201–205.
https://doi.org/10.1182/blood.2023022295
Published: 2024
Includes: Supplemental data
Journal Articles

Isatuximab Plus Pomalidomide and Dexamethasone in Patients with Relapsed and/or Refractory Multiple Myeloma (RRMM) in Real-Life Context in France: IMAGE Subgroup Analysis Based on Prior Lines of Therapy and Refractory Status in Anti-CD38-Naïve Population

Xavier Leleu, Jean Fontan, Aurore Perrot, Lionel Karlin, Cyrille Touzeau, Samantha Schulmann, Salomon Manier, Karim Belhadj Merzoug, Adrien Trebouet, Patricia Zunic, Jean Marc Schiano De Colella, Christina Tekle, Marianne Gaucher, Olivier Decaux
Journal: Blood
Blood (2023) 142 (Supplement 1): 7419.
https://doi.org/10.1182/blood-2023-179532
Published: 2023
Journal Articles

Multicenter Open Label Phase 2 Study of Quadruplet-Based Regimen Iskpd (isatuximab plus pomalidomide and dexamethasone with carfilzomib) in Early Relapsed or Refractory Multiple Myeloma - IFM2018-03

Arthur Bobin, Jerome Lambert, Stéfanie Ragot, Aurore Perrot, Salomon Manier, Lionel Karlin, Denis Caillot, Lotfi Benboubker, Thomas Chalopin, Carla Araujo, Jean Fontan, Thorsten Braun, Clara Mariette, Elodie Scherman, Olivier Decaux, jean Sebastien Blade, Faiza Keddar, Christophe Roul, Mamoun Dib, Jill Corre, Frederique Orsini Piocelle, Laure Vincent, Cyrille Touzeau, Philippe Moreau, Herve Avet Loiseau, Xavier Leleu
Journal: Blood
Blood (2023) 142 (Supplement 1): 6742.
https://doi.org/10.1182/blood-2023-185792
Published: 2023
Journal Articles

Biallelic deletion of 1p32 defines ultra-high-risk myeloma, but monoallelic del(1p32) remains a strong prognostic factor

CME Clinical Trials & Observations
Anaïs Schavgoulidze, Alexis Talbot, Aurore Perrot, Titouan Cazaubiel, Xavier Leleu, Salomon Manier, Laure Buisson, Sabrina Mahéo, Laura Do Souto Ferreira, Luka Pavageau, Cyrille Hulin, Jean-Pierre Marolleau, Laurent Voillat, Karim Belhadj, Marion Divoux, Borhane Slama, Sabine Brechignac, Margaret Macro, Anne-Marie Stoppa, Laurence Sanhes, Frédérique Orsini-Piocelle, Jean Fontan, Marie-Lorraine Chretien, Hélène Demarquette, Mohamad Mohty, Hervé Avet-Loiseau, Jill Corre
Journal: Blood
Blood (2023) 141 (11): 1308–1315.
https://doi.org/10.1182/blood.2022017863
Published: 2023
Includes: Supplemental data
Journal Articles

Multicenter Open Label Phase 2 Study of Isatuximab Plus Pomalidomide and Dexamethasone with Carfilzomib in Relapsed or Refractory Multiple Myeloma. Iskpd - IFM2018-03

Arthur Bobin, Jerome Lambert, Stéphanie Ragot, Aurore Perrot, Salomon Manier, Lionel Karlin, Denis Caillot, Cyrille Hulin, Lotfi Benboubker, Carla Araujo, Jean Fontan, Thorsten Braun, Clara Mariette, Elodie Scherman, Olivier Decaux, jean Sebastien Blade, Faida Keddar, Christophe Roul, Mamoun Dib, Jill Corre, Frederique Orsini, Laure Vincent, Mohamad Mohty, Cyrille Touzeau, Philippe Moreau, Herve Avet Loiseau, Xavier Leleu
Journal: Blood
Blood (2022) 140 (Supplement 1): 4452–4453.
https://doi.org/10.1182/blood-2022-166870
Published: 2022
Journal Articles

Bortezomib and high-dose melphalan conditioning regimen in frontline multiple myeloma: an IFM randomized phase 3 study

Clinical Trials & Observations
Murielle Roussel, Valérie Lauwers-Cances, Margaret Macro, Xavier Leleu, Bruno Royer, Cyrille Hulin, Lionel Karlin, Aurore Perrot, Cyrille Touzeau, Marie-Lorraine Chrétien, Sophie Rigaudeau, Mamoun Dib, Emmanuelle Nicolas-Virelizier, Martine Escoffre-Barbe, Karim Belhadj, Clara Mariette, Anne-Marie Stoppa, Carla Araujo, Chantal Doyen, Jean Fontan, Brigitte Kolb, Laurent Garderet, Sabine Brechignac, Jean-Valère Malfuson, Arnaud Jaccard, Pascal Lenain, Cécile Borel, Benjamin Hebraud, Omar Benbrahim, Véronique Dorvaux, Salomon Manier, Karine Augeul-Meunier, Marie-Christiane Vekemans, Edouard Randriamalala, Driss Chaoui, Jo Caers, Carine Chaleteix, Lofti Benboubker, Laure Vincent, Sylvie Glaisner, Patricia Zunic, Borhane Slama, Jean-Richard Eveillard, Catherine Humbrecht-Kraut, Véronique Morel, Philippe Mineur, Jean-Claude Eisenmann, Hélène Demarquette, Valentine Richez, Marguerite Vignon, Denis Caillot, Thierry Facon, Philippe Moreau, Anne-Laurène Colin, Pascale Olivier, Soraya Wuilleme, Hervé Avet-Loiseau, Jill Corre, Michel Attal
Journal: Blood
Blood (2022) 139 (18): 2747–2757.
https://doi.org/10.1182/blood.2021014635
Published: 2022
Includes: Supplemental data
Journal Articles

Primary plasma cell leukemias displaying t(11;14) have specific genomic, transcriptional, and clinical features

Brief Report
Titouan Cazaubiel, Xavier Leleu, Aurore Perrot, Salomon Manier, Laure Buisson, Sabrina Maheo, Laura Do Souto Ferreira, Romain Lannes, Luka Pavageau, Cyrille Hulin, Jean-Pierre Marolleau, Laurent Voillat, Karim Belhadj, Marion Divoux, Borhane Slama, Sabine Brechignac, Margaret Macro, Anne-Marie Stoppa, Laurence Sanhes, Frédérique Orsini-Piocelle, Jean Fontan, Marie-Lorraine Chretien, Hélène Demarquette, Mohamad Mohty, Anais Schavgoulidze, Herve Avet-Loiseau, Jill Corre
Journal: Blood
Blood (2022) 139 (17): 2666–2672.
https://doi.org/10.1182/blood.2021014968
Published: 2022
Includes: Supplemental data
Journal Articles

Epidemiological landscape of young patients with multiple myeloma diagnosed before 40 years of age: the French experience

Clinical Trials & Observations
Alexis Caulier, Murielle Roussel, Pierre Morel, Naelle Lombion, Benoît Branco, Jean Galtier, Cyrille Hulin, Aurore Perrot, Valentine Richez, Anne-Victoire Michaud, Cyrille Touzeau, Chantal Doyen, Clara Mariette, Denis Caillot, Stéphanie Harel, Pascal Lenain, Sarah Ivanoff, Jean Fontan, Anne-Marie Stoppa, Salomon Manier, Laurent Garderet, Xavier Leleu, Jean-Pierre Marolleau, Bertrand Arnulf, Hervé Avet-Loiseau, Bruno Royer
Journal: Blood
Blood (2021) 138 (25): 2686–2695.
https://doi.org/10.1182/blood.2021011285
Published: 2021
Includes: Supplemental data
Journal Articles

RD Vs. VRD: What Is the First-Line, Real-Life Management of Multiple Myeloma Patients Ineligible for Stem Cell Auto Transplantation in the Emmy Cohort?

Olivier Decaux, Aurore Perrot, Laurent Frenzel, Bruno Royer, Carla Araujo, Karim Belhadj, Philippe Moreau, Denis Caillot, Xavier Leleu, Agathe Farge, Anne Vekhoff, Samantha Schulmann, Jean Fontan, Frederique Orsini, Laurence Sanhes, Valentine Richez, Arnaud Jaccard, Ronan Garlantezec, Nathalie Texier, Raphael Germain, Catherine Boccaccio, Cyrille Hulin
Journal: Blood
Blood (2021) 138 (Supplement 1): 3766.
https://doi.org/10.1182/blood-2021-149480
Published: 2021
Journal Articles

del(17p) without TP53 mutation confers a poor prognosis in intensively treated newly diagnosed patients with multiple myeloma

Clinical Trials & Observations Brief Report
Jill Corre, Aurore Perrot, Denis Caillot, Karim Belhadj, Cyrille Hulin, Xavier Leleu, Mohamad Mohty, Thierry Facon, Laure Buisson, Laura Do Souto, Romain Lannes, Stephanie Dufrechou, Naïs Prade, Frederique Orsini-Piocelle, Laurent Voillat, Arnaud Jaccard, Lionel Karlin, Margaret Macro, Sabine Brechignac, Mamoun Dib, Laurence Sanhes, Jean Fontan, Lauriane Clement-Filliatre, Jean-Pierre Marolleau, Stephane Minvielle, Philippe Moreau, Hervé Avet-Loiseau
Journal: Blood
Blood (2021) 137 (9): 1192–1195.
https://doi.org/10.1182/blood.2020008346
Published: 2021
Includes: Supplemental data
Journal Articles

Four-Year Interim Analysis of Miroir, a French Multicenter, Non-Interventional Study of Pomalidomide in Relapsed/Refractory Multiple Myeloma

Olivier Decaux, Margaret Macro, Sophie Gourgou, Florence Lachenal, Caroline Bureau Lenoir, Bertrand Arnulf, Denis Caillot, MD, Anne-Marie Stoppa, Laure Vincent, Arnaud Jaccard, MD PhD, Philippe Moreau, MD, Aurore Perrot, MD PhD, Mohamad Mohty, MD PhD, Lionel Karlin, MD, Cécile Fohrer, Jean-Richard Eveillard, Jean Fontan, MD, Xavier Leleu, MD PhD, Cyrille Hulin, MD, Choquet Sylvain
Journal: Blood
Blood (2019) 134 (Supplement_1): 1836.
https://doi.org/10.1182/blood-2019-124484
Published: 2019
Journal Articles

A National, Multicenter, Non-Interventional Study of Pomalidomide in Relapsed/Refractory Multiple Myeloma: Updated Results from the Miroir Study

Cyrille Hulin, Margaret Macro, Sophie Gourgou, Florence Lachenal, Caroline Bureau Lenoir, Bertrand Arnulf, Denis Caillot, Anne Marie Stoppa, Laure Vincent, Arnaud Jaccard, MD PhD, Philippe Moreau, Aurore Perrot, Mohamad Mohty, MD PhD, Lionel Karlin, MD, Cécile Fohrer, Jean-Richard Eveillard, Choquet Sylvain, MD, Jean Fontan, MD, Xavier Leleu, MD PhD, Olivier Decaux, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 3238.
https://doi.org/10.1182/blood-2018-99-111892
Published: 2018
Journal Articles

Light Chain Escape in Multiple Myeloma

Thomas Dejoie, MD, Guillemette Fouquet, Cyrille Hulin, Murielle Roussel, Benjamin Hebraud, Lionel Karlin, MD, Brigitte Kolb, MD, Carla Araujo, MD, Nathalie Meuleman, PhD MD, Mourad Tiab, MD, Jean Valère Malfuson, MD, Pascal Bourquard, MD, Pascal Lenain, MD, Arnaud Jaccard, MD PhD, Karim Belhadj, Gérard Lepeu, MD, Marie Lorraine Chretien, MD, Denis Caillot, Jean Fontan, MD, Philippe Rodon, MD, Anna Schmitt, Laurent Voillat, MD, Sophie Cereja, MD, Brigitte Pegourie, MD, Frederique Kuhnowski, MD, Sophie Rigaudeau, MD, Olivier Decaux, MD, Catherine Humbrecht-Kraut, MD, Jamilé Frayfer, MD, Laurent Garderet, Damien Roos-Weil, MD, Jean Claude Eisenmann, MD, Veronique Dorvaux, MD, Eric G. Voog, MD, Claire Mathiot, MD, Jean-Paul Fermand, MD, Thierry Facon, Hervé Avet-Loiseau, MD PhD, Jean Luc Harousseau, MD, Philippe Moreau, Michel Attal, MD PhD, Xavier Leleu, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 1881.
https://doi.org/10.1182/blood-2018-99-112396
Published: 2018
Journal Articles

Bortezomib and High-Dose Melphalan Vs. High-Dose Melphalan As Conditioning Regimen before Autologous Stem Cell Transplantation in De Novo Multiple Myeloma Patients: A Phase 3 Study of the Intergroupe Francophone Du Myelome (IFM 2014-02)

Murielle Roussel, Benjamin Hebraud, MD, Valerie Lauwers-Cances, MD, Margaret Macro, MD, Xavier Leleu, MD PhD, Cyrille Hulin, MD, Lionel Karlin, MD, Bruno Royer, MD, Aurore Perrot, MD, Philippe Moreau, MDPhD, Denis Caillot, MD, Sophie Rigaudeau, MD, Mamoun Dib, MD, Emmanuelle Nicolas-Virelizier, MD, Martine Escoffre-Barbe, MD, Karim Belhadj, MD, Brigitte Pegourie, MD, Anne-Marie Stoppa, MD, Carla Araujo, MD, Chantal Doyen, MD, Jean Fontan, MD, Brigitte Kolb, MD, Laurent Garderet, MD PhD, Sabine Brechignac, MD, Jean Valere Malfuson, MD, Veronique Dorvaux, MD, Pascal Lenain, MD, Omar Benbrahim, MD, Arnaud Jaccard, Cecile Borel, MD, Herve Avet Loiseau, MD PhD, Michel Attal, MD PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 398.
https://doi.org/10.1182/blood.V130.Suppl_1.398.398
Published: 2017
Journal Articles

Miroir: A National, Multicenter, Non-Interventional Study of Patients with Relapsed and/or Refractory Multiple Myeloma (RRMM) Treated with Pomalidomide (POM) in France

Cyrille Hulin, MD, Margaret Macro, MD, Sophie Gourgou, Bertrand Arnulf, MD PhD, Florence Lachenal, Caroline Lenoir, Anne-Marie Stoppa, MD, Marie Lorraine Chretien, Laure Vincent, Aurore Perrot, MD, Philippe Moreau, MDPhD, Lionel Karlin, MD, Cécile Fohrer, Jean-Richard Eveilard, Jean Fontan, MD, Olivier Decaux
Journal: Blood
Blood (2017) 130 (Supplement 1): 1848.
https://doi.org/10.1182/blood.V130.Suppl_1.1848.1848
Published: 2017
Journal Articles

Serum free light chains, not urine specimens, should be used to evaluate response in light-chain multiple myeloma

CME
Thomas Dejoie, Jill Corre, Helene Caillon, Cyrille Hulin, Aurore Perrot, Denis Caillot, Eileen Boyle, Marie-Lorraine Chretien, Jean Fontan, Karim Belhadj, Sabine Brechignac, Olivier Decaux, Laurent Voillat, Philippe Rodon, Olivier Fitoussi, Carla Araujo, Lotfi Benboubker, Charlotte Fontan, Mourad Tiab, Pascal Godmer, Odile Luycx, Olivier Allangba, Jean-Michel Pignon, Jean-Gabriel Fuzibet, Laurence Legros, Anne Marie Stoppa, Mamoun Dib, Brigitte Pegourie, Frederique Orsini-Piocelle, Lionel Karlin, Bertrand Arnulf, Murielle Roussel, Laurent Garderet, Mohamad Mohty, Nathalie Meuleman, Chantal Doyen, Pascal Lenain, Margaret Macro, Xavier Leleu, Thierry Facon, Philippe Moreau, Michel Attal, Herve Avet-Loiseau
Journal: Blood
Blood (2016) 128 (25): 2941–2948.
https://doi.org/10.1182/blood-2016-07-726778
Published: 2016
Journal Articles

IFM2012-03

Xavier Leleu, Guillemette Fouquet, Lionel Karlin, MD, Brigitte Kolb, Mourad Tiab, Carla Araujo, Nathalie Meuleman, MD PhD, Jv Malfuson, Pascal Bourquard, MD, Pascal Lenain, Murielle Roussel, MD, Arnaud Jaccard, MD PhD, Marie-Odile Petillon, MD, Karim Belhadj-Merzoug, Gerard Lepeu, Marie-Lorraine Chretien, Jean Fontan, Philippe Rodon, MD, Anna Schmitt, MD, Fritz Offner, Laurent Voillat, Sophie Cereja, Frederique Kuhnowski, Sophie Rigaudeau, Olivier Decaux, MD PhD, Catherine Humbrecht-Kraut, Jamile Frayfer, MD, Olivier Fitoussi, MD, Damien Roos Weil, Jean Claude Eisenmann, MD, Veronique Dorvaux, Eric G. Voog, MD, Cyrille Hulin, Michel Attal, Philippe Moreau, Thierry Facon, MD
Journal: Blood
Blood (2016) 128 (22): 2128.
https://doi.org/10.1182/blood.V128.22.2128.2128
Published: 2016
Journal Articles

VTD is superior to VCD prior to intensive therapy in multiple myeloma: results of the prospective IFM2013-04 trial

Clinical Trials & Observations
Philippe Moreau, Cyrille Hulin, Margaret Macro, Denis Caillot, Carine Chaleteix, Murielle Roussel, Laurent Garderet, Bruno Royer, Sabine Brechignac, Mourad Tiab, Mathieu Puyade, Martine Escoffre, Anne-Marie Stoppa, Thierry Facon, Brigitte Pegourie, Driss Chaoui, Arnaud Jaccard, Borhane Slama, Gerald Marit, Karim Laribi, Pascal Godmer, Odile Luycx, Jean-Claude Eisenmann, Olivier Allangba, Mamoun Dib, Carla Araujo, Jean Fontan, Karim Belhadj, Marc Wetterwald, Véronique Dorvaux, Jean-Paul Fermand, Philippe Rodon, Brigitte Kolb, Sylvie Glaisner, Jean-Valere Malfuson, Pascal Lenain, Laetitia Biron, Lucie Planche, Helene Caillon, Herve Avet-Loiseau, Thomas Dejoie, Michel Attal
Journal: Blood
Blood (2016) 127 (21): 2569–2574.
https://doi.org/10.1182/blood-2016-01-693580
Published: 2016
Journal Articles

Understanding the role of hyperdiploidy in myeloma prognosis: which trisomies really matter?

Marie-Lorraine Chretien, Jill Corre, Valerie Lauwers-Cances, Florence Magrangeas, Alice Cleynen, Edwige Yon, Cyrille Hulin, Xavier Leleu, Frederique Orsini-Piocelle, Jean-Sebastien Blade, Claudine Sohn, Lionel Karlin, Xavier Delbrel, Benjamin Hebraud, Murielle Roussel, Gerald Marit, Laurent Garderet, Mohamad Mohty, Philippe Rodon, Laurent Voillat, Bruno Royer, Arnaud Jaccard, Karim Belhadj, Jean Fontan, Denis Caillot, Anne-Marie Stoppa, Michel Attal, Thierry Facon, Philippe Moreau, Stephane Minvielle, Hervé Avet-Loiseau
Journal: Blood
Blood (2015) 126 (25): 2713–2719.
https://doi.org/10.1182/blood-2015-06-650242
Published: 2015
Includes: Supplemental data
Journal Articles

Bortezomib, Thalidomide and Dexamethasone (VTD) Is Superior to Bortezomib, Cyclophosphamide and Dexamethasone (VCD) Prior to Autologous Stem Cell Transplantation for Patients with De Novo Multiple Myeloma. Results of the Prospective IFM 2013-04 Trial

Philippe Moreau, Cyrille Hulin, Margaret MACRO, MD, Denis Caillot, Carine Chaleteix, Murielle Roussel, Laurent Garderet, MD, Bruno Royer, MD, Sabine Brechignac, MD, Mourad Tiab, MD, Mathieu Puyade, MD, Martine Escoffre, Anne-Marie Stoppa, MD, Thierry Facon, Brigitte Pégourie, Driss Chaoui, MD, Arnaud Jaccard, MD PhD, Borhane Slama, Gerald Marit, Kamel Laribi, Pascal Godmer, MD, Odile Luycx, Jean Claude Eisenmann, MD, Olivier Allangha, Sylvie Glaisner, Mamoun Dib, Carla Araujo, Jean Fontan, Karim Belhadj, MD, Marc Wetterwald, MD PhD, Veronique Dorvaux, Jean-Paul Fermand, Philippe Rodon, MD, Brigitte Kolb, Pascal Lenain, MD, Lucie Planche, Laetitia Biron, Helene Caillon, Herve Avet-Loiseau, Thomas Dejoie, Michel Attal
Journal: Blood
Blood (2015) 126 (23): 393.
https://doi.org/10.1182/blood.V126.23.393.393
Published: 2015