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Journal Articles

Plitidepsin in combination with dexamethasone (ADMYRE trial) versus an external control arm of pomalidomide plus dexamethasone in patients with relapsed/refractory multiple myeloma

Free
Heinz Ludwig, Evangelos Terpos, Mario Boccadoro, Sara Martinez, Carmen Kahatt, Javier Jimenez Jimenez, Antonio Nieto, Sonia Extremera, Javier Gomez, Vicente Alfaro, Ruthanna Davi, Xiang Yin, María-Victoria Mateos
Journal: Blood
Blood (2025) 146 (Supplement 1): 7558.
https://doi.org/10.1182/blood-2025-7558
Published: 2025
Journal Articles

Circulating tumor cells (CTCs) for dynamic risk assessment of patients (Pts) with smoldering multiple myeloma (SMM)

Free
Esperanza Martin-Sanchez, Evangelos Terpos, Niels Weinhold, Albert Pérez-Montaña, Enrique Ocio, Elena Cabezudo, Joan Bargay, Artur Paiva, Rosalinda Termini, Hector Gracia, Cody Clayhold, David Žihala, Tomas Jelinek, Roman Hajek, Marc Raab, Elias K. Mai, Anna Luise Grab, Joaquin Martinez-Lopez, Irene Romera, Fernando Solano, Ianire Etxeguren, Rebeca Iglesias, Felipe de Arriba, Antonio Garcia, Heinz Ludwig, Albert Oriol, Maria Casanova Espinosa, Felipe Prosper, Aldo Roccaro, Marco Chiarini, Antonio Sacco, Adrian Alegre, Valentin Cabanas Perianes, Maialen Sirvent, Jill Corre, Francois Vergez, Herve Avet-Loiseau, María-Victoria Mateos, Noemi Puig, Jesus San-Miguel, Bruno Paiva
Journal: Blood
Blood (2025) 146 (Supplement 1): 493.
https://doi.org/10.1182/blood-2025-493
Published: 2025
Journal Articles

Randomized phase III study (ADMYRE) of plitidepsin in combination with dexamethasone vs. dexamethasone alone in relapsed/refractory multiple myeloma: Results for patients aged < 75 years

Free
María-Victoria Mateos, Evangelos Terpos, Sara Martinez, Carmen Kahatt, Javier Jimenez Jimenez, Sonia Extremera, Javier Gomez, Vicente Alfaro, Heinz Ludwig
Journal: Blood
Blood (2025) 146 (Supplement 1): 7594.
https://doi.org/10.1182/blood-2025-7594
Published: 2025
Journal Articles

Randomized comparison between isatuximab-rd versus rd induction, followed by isa-R versus R maintenance in very elderly patients with NDMM: Efficacy data on MRD after induction (AGMT-MM04 Trial)

Free
Heinz Ludwig, Thomas Melchardt, Evangelos Terpos, Jelena Bila, Martin Schreder, Sarah Bernhard, Klaus Podar, Eirini Katodrytou, Thamer Sliwa, Predrag Djurdjevic, Sosana Delimpasi, Michael Leisch, Marko Mitrovic, Maria Gavriatopoulou, Ioannis Ntanasis-Stathopoulos, Eva Maria Autzinger, August Zabernigg, Michael Fillitz, Ewald Wöll, Petra Pichler, Irene Manrique, Bruno Paiva, Richard Greil
Journal: Blood
Blood (2025) 146 (Supplement 1): 2258.
https://doi.org/10.1182/blood-2025-2258
Published: 2025
Journal Articles

Consolidation Treatment with VRD Followed By Maintenance with Lenalidomide in Multiple Myeloma Improves Overall Survival: Long-Term Follow-up of the EMN02/HOVON95 Randomized Phase 3 Trial

Free
Pieter Sonneveld, Meletios A. Dimopoulos, Meral Beksac, Bronno van der Holt, Francesca Gay, Heinz Ludwig, Sonja Zweegman, Vladimir Maisnar, Maria Teresa Petrucci, Paolo Corradini, Francesca Patriarca, Angelo Belotti, Micol Quaresima, Mariella Grasso, Massimo Offidani, Laura Paris, Anna Marina Liberati, Markus Hansson, Heleen Visser-Wisselaar, Giulia Fumero, Renato Zambello, Paula F Ypma, Anna Pascarella, Niels Frost Andersen, Alexandra Croockewit, Mario Boccadoro, Michele Cavo
Journal: Blood
Blood (2024) 144 (Supplement 1): 674.
https://doi.org/10.1182/blood-2024-197908
Published: 2024
Journal Articles

An International Study of 343 Newly Diagnosed MM Patients with Acute Renal Failure Due to Cast Nephropathy: Assessment of Factors Affecting Renal Response

Free
Heinz Ludwig, Meletios A. Dimopoulos, Meral Beksac, Frank Bridoux, Guldane Cengis-Seval, Luca Arcaini, Foteini Theodorakakou, Hermine Agis, Francesca Gay, Aristeidis Chaidos, Dario Roccatello, Daniele Derudas, Andrea Havasi, Julie Krainer, Silvia Mangiacavalli, Elise Michelon, Javier De La Rubia, Nattawat Klomjit, Tamer Shehab, Kenar Jhaveri, Nelson Leung, Efstathios Kastritis
Journal: Blood
Blood (2024) 144 (Supplement 1): 3328.
https://doi.org/10.1182/blood-2024-200038
Published: 2024
Journal Articles

Allogeneic (Allo-SCT) Versus Autologous Stem-Cell Transplantation (Auto-SCT) after Relapse to First Line Auto-SCT in Multiple Myeloma: A Meta-Analysis with Predominantly Individual Patient Data

Free
Heinz Ludwig, Takashi Ikeda, Cesar O. Freytes, Koji Kawamura, Yoshiko Atsuta, Hiroyuki Takamatsu, David H. Vesole, Hari Parameswaran, Axel Hinke
Journal: Blood
Blood (2023) 142 (Supplement 1): 7100.
https://doi.org/10.1182/blood-2023-179105
Published: 2023
Journal Articles

Randomized Comparison between Krd and Ktd Induction, Followed By K Maintenance or Control in Transplant Non-Eligible Patients with NDMM: Efficacy and Qol Data (AGMT-MM02 Trial)

Free
Heinz Ludwig, Thomas Melchardt, Siegfried Sormann, Niklas Zojer, Johannes Andel, Bernd L. Hartmann, Christoph Tinchon, Eberhard Gunsilius, Klaus Podar, Alexander Egle, Wolfgang Willenbacher, Ewald Wöll, Martin Schreder, Reinhard Ruckser, Boris Bozic, Maria-Theresa Krauth, Andreas Petzer, Clemens A. Schmitt, Sigrid Machherndl-Spandl, Hermine Agis, Michael Fillitz, Song-Yau Wang, Stefan Knop, Sarah Kainz, Bruno Paiva, Richard Greil
Journal: Blood
Blood (2022) 140 (Supplement 1): 10185–10188.
https://doi.org/10.1182/blood-2022-162336
Published: 2022
Journal Articles

CTPS1 Is a Novel Therapeutic Target in Multiple Myeloma That Synergizes with Inhibition of ATR, CHEK1 or WEE1

Free
Christina Pfeiffer, Alexander Michael Grandits, Hélène Asnagli, Anja Schneller, Julia Huber, Niklas Zojer, Martin Schreder, Andrew Parker, Arnold Bolomsky, Philip Beer, Heinz Ludwig
Journal: Blood
Blood (2022) 140 (Supplement 1): 7088–7089.
https://doi.org/10.1182/blood-2022-160333
Published: 2022
Journal Articles

OCEAN (OP-103): Melflufen/Dexamethasone Compared Wth Pomalidomide/Dexamethasone in Patients with Relapsed/Refractory Multiple Myeloma - Subgroup Analysis in Patients Refractory to Prior Alkylators

Free
Fredrik Schjesvold, Heinz Ludwig, María-Victoria Mateos, Haifaa Abdulhaq, Stefan Norin, Marcus Thuresson, Nicolaas A. Bakker, Paul G. Richardson, Pieter Sonneveld
Journal: Blood
Blood (2022) 140 (Supplement 1): 12607–12609.
https://doi.org/10.1182/blood-2022-160159
Published: 2022
Journal Articles

Real-World Effectiveness of Bortezomib Plus Dexamethasone in Patients with t(11;14) Positive Multiple Myeloma

Free
Nnadozie Emechebe, Shaji Kumar, Hartmut Goldschmidt, Maria-Victoria Mateos, Juan Du, Kihyun Kim, Giampaolo Merlini, Meletios A. Dimopoulos, Heinz Ludwig, Hiroshi Handa, Carlos Fernandez de Larrea, Donna E. Reece, Wenming Chen, Noopur S. Raje, Sudeep Karve, Emma Arriola, Jeremy A. Ross, Brian G.M. Durie
Journal: Blood
Blood (2021) 138 (Supplement 1): 4725.
https://doi.org/10.1182/blood-2021-149270
Published: 2021
Journal Articles

Composition of the Immune Environment at Baseline Correlates with Time to Response and Treatment Outcome in Newly Diagnosed Transplant-Ineligible Multiple Myeloma (MM) Patients Randomized to Krd or Ktd Followed By Carfilzomib Maintenance or Observation (AGMT_MM 02 Study)

Free
Irene Manrique, Richard Greil, Johannes Andel, Siegfried Sormann, Bernd L. Hartmann, Klaus Podar, Alexander Egle, Andreas Petzer, Niklas Zojer, Eberhard Gunsilius, Reinhard Ruckser, Boris Bozic, Clemens A. Schmitt, Sigrid Machherndl-Spandl, Hermine Agis, Martin Schreder, Song-Yau Wang, Wolfgang Willenbacher, Maria-Theresa Krauth, Christoph Tinchon, Michael Fillitz, Thomas Melchardt, Stefan Knop, Bruno Paiva, Heinz Ludwig
Journal: Blood
Blood (2021) 138 (Supplement 1): 1669.
https://doi.org/10.1182/blood-2021-150311
Published: 2021
Journal Articles

Effectiveness and Safety of Ixazomib-Based Therapy in Relapsed/Refractory Multiple Myeloma (RRMM) Patients (Pts) Treated Outside the Clinical Trial Setting Via an Early Access Program (EAP) in Europe: Second Interim Analysis of the 'Use Via Early Access to Ixazomib' (UVEA-IXA) Study

Free
Heinz Ludwig, MD, Evangelos Terpos, MD PhD, María-Victoria Mateos, MD PhD, Mario Boccadoro, Bhuvan Kishore, Karthik Ramasamy, Sylvie Fernandez, Fabio Ferri, Nawal Bent-Ennakhil, Athanasios Zomas, François Gavini, Roman Hajek, MD
Journal: Blood
Blood (2020) 136 (Supplement 1): 42–44.
https://doi.org/10.1182/blood-2020-136519
Published: 2020
Journal Articles

Consolidation Treatment with VRD Followed By Maintenance Therapy Versus Maintenance Alone in Newly Diagnosed, Transplant-Eligible Patients with Multiple Myeloma (MM): A Randomized Phase 3 Trial of the European Myeloma Network (EMN02/HO95)

Free
Pieter Sonneveld, MD PhD, Meral Beksac, MD, Bronno Van Der Holt, PhD, Meletios A Dimopoulos, Angelo Michele Carella, MD, Heinz Ludwig, MD, Sonja Zweegman, MD PhD, Thilo Zander, MD, Ruth Wester, MD, Roman Hajek, MD, Lucia Pantani, MD PhD, Luca Dozza, MSc, Francesca Gay, MD, Anna Maria Cafro, Luca De Rosa, Francesca Fioritoni, MD, Ulf-Henrik Mellqvist, MD PhD, Rossella Troia, PharmD, Niels Frost Andersen, MD PhD, Ka Lung Wu, MD PhD, Christoph Driessen, MD, Susana Carvalho, MD, Alexandra J. Croockewit, MD PhD, Fredrik Schjesvold, MDPhD, Massimo Offidani, Michele Cavo, Mario Boccadoro
Journal: Blood
Blood (2020) 136 (Supplement 1): 46–48.
https://doi.org/10.1182/blood-2020-139337
Published: 2020
Journal Articles

Longitudinal Immunogenomic Profiling of Tumor and Immune Cells for Minimally-Invasive Monitoring of Smoldering Multiple Myeloma (SMM): The Immunocell Study

Free
Rosalinda Termini, Evangelos Terpos, MDPhD, Albert Pérez, MD, Tomas Jelinek, Nikoletta-Aikaterini Kokkali, Joan Bargay, MD, Fernando Solano Ramos, MD PhD, Sara Rodríguez, PhD, Cristina Pérez Ruiz, Catarina Maia, Antonio Sacco, RN, Marco Chiarini, MSc, Viviana Giustini, MSc, Jill Corre, PharmD, PhD, Francois Vergez, DVM, PhD, Marc S. Raab, MD, Niels Weinhold, PhD, Aitziber Lopez Lopez, Sonia Garate, Diego Alignani, PhD, Sarvide Sarai, Remco Loos, Antoni Garcia-Guiñon, MD, Maialen Sirvent, José Enrique de la Puerta, Rebeca Iglesias, Maria Casanova, MD, Maria Elena Cabezudo, Valentin Cabañas, MD, Enrique M. Ocio, MDPhD, Joaquin Martinez-Lopez, MD, Javier de la Rubia, Artur Paiva, Helena Vitoria, Catarina Geraldes, MD PhD, Roman Hajek, MD, Heinz Ludwig, MD, Hartmut Goldschmidt, MD, Herve Avet-Loiseau, Aldo M. Roccaro, MDPhD, Jesús F. San-Miguel, Bruno Paiva, PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 1–2.
https://doi.org/10.1182/blood-2020-136251
Published: 2020
Journal Articles

Upfront Autologous Hematopoietic Stem-Cell Transplantation Improves Overall Survival in Comparison with Bortezomib-Based Intensification Therapy in Newly Diagnosed Multiple Myeloma: Long-Term Follow-up Analysis of the Randomized Phase 3 EMN02/HO95 Study

Free
Michele Cavo, Francesca Gay, MD, Meral Beksac, MD, Meletios A Dimopoulos, Lucia Pantani, MD PhD, Maria Teresa Petrucci, Luca Dozza, MSc, Bronno Van Der Holt, PhD, Sonja Zweegman, MDPhD, Elena Zamagni, Giuseppe A. Palumbo, MD PhD, Francesca Patriarca, Monica Galli, Vladimir Maisnar, MD PhD MBA, Markus Hansson, MD, Angelo Belotti, Ludek Pour, MD, Paula F Ypma, MD PhD, Mariella Grasso, Sandra Croockewit, MD, Massimo Offidani, Renato Zambello, Anna Marina Liberati, MD, Niels Frost Andersen, MD PhD, Annemiek Broyl, MD PhD, Rossella Troia, PharmD, Pellegrino Musto, Heinz Ludwig, MD, Anna Maria Morelli, MD, Roman Hajek, MD, Christoph Driessen, MD, Anders Waage, MD PhD, Peter Gimsing, DO, PhD, Ulf-Henrik Mellqvist, MD PhD, Thilo Zander, MD, Mario Boccadoro, Pieter Sonneveld, MD PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 37–38.
https://doi.org/10.1182/blood-2020-137575
Published: 2020
Journal Articles

Quality of Life in Newly Diagnosed Patients with Multiple Myeloma Randomized to Either Krd or Ktd Induction Therapy Followed By Carfilzomib Maintenance or Control (AGMT MM 02 trial)

Free
Heinz Ludwig, MD, Thomas Melchardt, MD PhD, Johannes Andel, MD, Eberhard Gunsilius, MD, Siegfried Sormann, MD, Axel Hinke, PhD, Bernd L. Hartmann, MD, Klaus Podar, MDPhD, Wolfgang Willenbacher, MD PhD, Alexander Egle, MD, Andreas Petzer, MD, Niklas Zojer, MD, Ewald Wöll, MD, Reinhard Ruckser, MD, Boris Bozic, MD, Clemens A. Schmitt, MD, Sigrid Machherndl-Spandl, MD, Maria-Theresa Krauth, MD, Martin Schreder, MD, Hermine Agis, MD, Christoph Tinchon, MD, Michael Fillitz, MD, Richard Greil, MD
Journal: Blood
Blood (2020) 136 (Supplement 1): 27–29.
https://doi.org/10.1182/blood-2020-140701
Published: 2020
Journal Articles

Immunophenotyping of Baseline Bone Marrow Reveals a Specific Pattern of Immune Cells Associated with Greater Depth and Sustained Response in Newly Diagnosed Patients Randomized to Krd or Ktd Followed By Carfilzomib Maintenance or Control (AGMT MM 02 Study)

Free
Irene Manrique, PhD, Richard Greil, MD, Johannes Andel, MD, Siegfried Sormann, MD, Bernd L. Hartmann, MD, Klaus Podar, MDPhD, Alexander Egle, MD, Andreas Petzer, MD, Niklas Zojer, MD, Reinhard Ruckser, MD, Boris Bozic, MD, Clemens A. Schmitt, MD, Sigrid Machherndl-Spandl, MD, Hermine Agis, MD, Martin Schreder, MD, Maria-Theresa Krauth, MD, Christoph Tinchon, MD, Michael Fillitz, MD, Thomas Melchardt, MD PhD, Bruno Paiva, PhD, Heinz Ludwig, MD
Journal: Blood
Blood (2020) 136 (Supplement 1): 29–30.
https://doi.org/10.1182/blood-2020-140918
Published: 2020
Journal Articles

Carfilzomib-Revlimid-Dexamethasone Vs. Carfilzomib-Thalidomide-Dexamethasone Weekly (After 2 Twice Weekly Cycles) Followed By Carfilzomib Maintenance Vs. Control in Transplant Non-Eligible Patients with Newly Diagnosed Multiple Myeloma (NDMM) - Interim Efficacy Analysis of Combined Data (AGMT MM-02)

Free
Heinz Ludwig, MD, Siegfried Sormann, Niklas Zojer, Johannes Andel, Bernd L. Hartmann, Christoph Tinchon, MD, Eberhard Gunsilius, MD, Klaus Podar, MD PhD, Alexander Egle, MD, Wolfgang Willenbacher, MD PhD, Ewald Wöll, MD, Reinhard Ruckser, MD, Boris Bozic, MD, Maria-Theresa Krauth, MD, Andreas Petzer, MD, Clemens A. Schmitt, MD, Sigrid Machherndl-Spandl, MD, Hermine Agis, MD, Bruno Paiva, PhD, Richard Greil, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 696.
https://doi.org/10.1182/blood-2019-127954
Published: 2019
Journal Articles

Outcomes of Patients with t(11;14) Multiple Myeloma: An International Myeloma Working Group Multicenter Study

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Shaji K. Kumar, MD, Jin Lu, MDProf, Yang Terry Liu, PhD, Max Bittrich, MD, Juan Du, MD, Hartmut Goldschmidt, MD, Charalampia Kyriakou, MD PhD, Donna E Reece, MD, Kihyun Kim, MD PhD, Maria-Victoria Mateos, Veronica Gonzalez De La Calle, MD PhD, Wenming Chen, MD, Heinz Ludwig, MD, Giampaolo Merlini, MD, Silvia Mangiacavalli, Meletios A. Dimopoulos, MD, Eftathios Kastritis, Chang-Ki Min, MD PhD, Graca Esteves, Andrew J. Yee, MD, Noopur S. Raje, MD, Emily Rosta, Anja Haltner, Chris Cameron, Brian G.M. Durie, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3066.
https://doi.org/10.1182/blood-2019-126867
Published: 2019