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Alexander Egle
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Journal Articles

Real-World Comparison of Outcomes of Patients Treated with HMA Monotherapy Versus HMA-Ven - Insights from 1634 Patients Included within the Austrian Myeloid Registry of the AGMT Study Group

Lisa Pleyer, Patrick Klammer, Manuel Drost, Hubert Angermann, Felix Keil, Verena Petzer, Sonja Heibl, Jennifer Moritz, Michael Girschikofsky, Margarete Stampfl-Mattersberger, Angelika Pichler, Bernd L. Hartmann, Gregor Aschauer, Clemens Schmitt, Sonia Vallet, Szilvia Boros, Petra Pichler, Andrea Hammerl-Steiner, Felix Renneberg, Susanne Schnabel, Dilyan Majjiga, Thomas Melchardt, Alexander Egle, Michael Leisch, Richard Greil
Journal: Blood
Blood (2024) 144 (Supplement 1): 3793.
https://doi.org/10.1182/blood-2024-207230
Published: 2024
Journal Articles

Validation of Recent Response Criteria (ELN-22, IWG-23 and PB-CR) in 1634 MDS/CMML/AML Patients Treated with HMA or HMA-Ven Using CPH Models and a CPH Deep Neural Network - Can or Should Response Criteria be Harmonized for Similarly Treated Patients?

Lisa Pleyer, Marc Vaisband, Patrick Klammer, Manuel Drost, Hubert Angermann, Felix Keil, Verena Petzer, Sonja Heibl, Jennifer Moritz, Michael Girschikofsky, Margarete Stampfl-Mattersberger, Angelika Pichler, Bernd L. Hartmann, Gregor Aschauer, Clemens Schmitt, Sonia Vallet, Szilvia Boros, Petra Pichler, Andrea Hammerl-Steiner, Felix Renneberg, Dilyan Majjiga, Gudrun Russ, Alexander Egle, Michael Leisch, Thomas Melchardt, Nadja Zaborsky, Viktoria Faber, Jan Philipp Bewersdorf, Amer M. Zeidan, Jan Hasenauer, Richard Greil
Journal: Blood
Blood (2024) 144 (Supplement 1): 7511.
https://doi.org/10.1182/blood-2024-208073
Published: 2024
Journal Articles

Randomized Comparison between Krd and Ktd Induction, Followed By K Maintenance or Control in Transplant Non-Eligible Patients with NDMM: Efficacy and Qol Data (AGMT-MM02 Trial)

Heinz Ludwig, Thomas Melchardt, Siegfried Sormann, Niklas Zojer, Johannes Andel, Bernd L. Hartmann, Christoph Tinchon, Eberhard Gunsilius, Klaus Podar, Alexander Egle, Wolfgang Willenbacher, Ewald Wöll, Martin Schreder, Reinhard Ruckser, Boris Bozic, Maria-Theresa Krauth, Andreas Petzer, Clemens A. Schmitt, Sigrid Machherndl-Spandl, Hermine Agis, Michael Fillitz, Song-Yau Wang, Stefan Knop, Sarah Kainz, Bruno Paiva, Richard Greil
Journal: Blood
Blood (2022) 140 (Supplement 1): 10185–10188.
https://doi.org/10.1182/blood-2022-162336
Published: 2022
Journal Articles

The EQ-5D-5L Predicts Treatment Outcomes and Provides Added Value to the R-IPSS in Patients with MDS, CMML or AML Treated within the Austrian Azacitidine Registry - a Prospective Cohort Study By the AGMT Study Group

Lisa Pleyer, Sonja Heibl, Christoph Tinchon, Sonja Vallet, Branka Petricevic, Michael Leisch, Alexander Egle, Thomas Melchardt, Gudrun Piringer, Dominik Wolf, Richard Beswick, Manuel Drost, Julian Larcher-Senn, Thomas Grochtdreis, Richard Greil, Reinhard Stauder
Journal: Blood
Blood (2021) 138 (Supplement 1): 64.
https://doi.org/10.1182/blood-2021-145281
Published: 2021
Journal Articles

Peripheral Blood Complete Remission Provides Added Value to the Classical Definition of Morphologic Complete Remission - a Prospective Cohort Study of 1441 Patients with MDS, CMML and AML Treated within the Austrian Azacitidine Registry

Lisa Pleyer, Michael Pfeilstocker, Reinhard Stauder, Sonja Heibl, Heinz Sill, Michael Girschikofsky, Margarete Stampfl-Mattesberger, Christoph Tinchon, Bernd Hartmann, Andreas Petzer, Branka Petricevic, Clemens A. Schmitt, Sonja Vallet, Klaus Geissler, Wolfgang R. Sperr, Michael Leisch, Alexander Egle, Thomas Melchardt, Gudrun Piringer, Armin Zebisch, Sigrid Machherndl-Spandl, Dominik Wolf, Felix Keil, Hubert Angermann, Manuel Drost, Julian Larcher-Senn, Richard Greil
Journal: Blood
Blood (2021) 138 (Supplement 1): 3387.
https://doi.org/10.1182/blood-2021-145401
Published: 2021
Journal Articles

Composition of the Immune Environment at Baseline Correlates with Time to Response and Treatment Outcome in Newly Diagnosed Transplant-Ineligible Multiple Myeloma (MM) Patients Randomized to Krd or Ktd Followed By Carfilzomib Maintenance or Observation (AGMT_MM 02 Study)

Irene Manrique, Richard Greil, Johannes Andel, Siegfried Sormann, Bernd L. Hartmann, Klaus Podar, Alexander Egle, Andreas Petzer, Niklas Zojer, Eberhard Gunsilius, Reinhard Ruckser, Boris Bozic, Clemens A. Schmitt, Sigrid Machherndl-Spandl, Hermine Agis, Martin Schreder, Song-Yau Wang, Wolfgang Willenbacher, Maria-Theresa Krauth, Christoph Tinchon, Michael Fillitz, Thomas Melchardt, Stefan Knop, Bruno Paiva, Heinz Ludwig
Journal: Blood
Blood (2021) 138 (Supplement 1): 1669.
https://doi.org/10.1182/blood-2021-150311
Published: 2021
Journal Articles

Lack of Bmf Facilitates the Selection of Highly Responsive B-Cell Receptor Clones in Chronic Lymphocytic Leukemia

Nicole Maeding, Daniela Asslaber, Nadja Zaborsky, Andreas Villunger, Richard Greil, Alexander Egle
Journal: Blood
Blood (2021) 138 (Supplement 1): 1543.
https://doi.org/10.1182/blood-2021-152216
Published: 2021
Journal Articles

Clinical Presentation of Patients with Adult Late-Onset Telomere Biology Disorders - Results from the Aachen Telomeropathy Registry

Fabian Beier, Mareike Tometten, Martin Kirschner, Insa Halfmeyer, Margherita Vieri, Kim Kricheldorf, Angela Maurer, Alexander Roeth, Uwe Platzbecker, Markus P. Radsak, Philippe Schafhausen, Selim Corbacioglu, Britta Hoechsmann, C. Matthias Wilk, Claas Hinze, Jörg Chromik, Alexander Egle, Michael Heuser, Michael Kreuter, Ingo Kurth, Steffen Koschmieder, Jens Panse, Robert Meyer, Susanne Isfort, Tim H Brummendorf
Journal: Blood
Blood (2021) 138 (Supplement 1): 1130.
https://doi.org/10.1182/blood-2021-153630
Published: 2021
Journal Articles

Immunophenotyping of Baseline Bone Marrow Reveals a Specific Pattern of Immune Cells Associated with Greater Depth and Sustained Response in Newly Diagnosed Patients Randomized to Krd or Ktd Followed By Carfilzomib Maintenance or Control (AGMT MM 02 Study)

Irene Manrique, PhD, Richard Greil, MD, Johannes Andel, MD, Siegfried Sormann, MD, Bernd L. Hartmann, MD, Klaus Podar, MDPhD, Alexander Egle, MD, Andreas Petzer, MD, Niklas Zojer, MD, Reinhard Ruckser, MD, Boris Bozic, MD, Clemens A. Schmitt, MD, Sigrid Machherndl-Spandl, MD, Hermine Agis, MD, Martin Schreder, MD, Maria-Theresa Krauth, MD, Christoph Tinchon, MD, Michael Fillitz, MD, Thomas Melchardt, MD PhD, Bruno Paiva, PhD, Heinz Ludwig, MD
Journal: Blood
Blood (2020) 136 (Supplement 1): 29–30.
https://doi.org/10.1182/blood-2020-140918
Published: 2020
Journal Articles

Phase II Single-Arm "Window-of-Opportunity" Study of a Combination of Obinutuzumab and Venetoclax in Early Relapsed or Refractory Diffuse Large B-Cell Lymphoma (DLBCL) - First Results of the AGMT NHL15B Study

Ulrich Jaeger, MD, Alexander Egle, MD, Ingrid Simonitsch-Klupp, MD, Sonja Heibl, MD, Peter Neumeister, MD, Ella Willenbacher, MD, Florian Erlsbacher, Julian Larcher-Senn, Michael A. Fridrik, MD, Richard Greil, MD
Journal: Blood
Blood (2020) 136 (Supplement 1): 26.
https://doi.org/10.1182/blood-2020-136953
Published: 2020
Journal Articles

The Integrin Adaptor Kindlin-3 Is Important for Development and Retention of Marginal Zone B Cells

Andrea Härzschel, Peter William Krenn, Elisabeth Bayer, Simone Tangermann, Geoffroy Andrieux, Elif Karabatak, Eva Szenes, Danielle-Justine Danner, Ursula Denk, Raphael Ruppert, Alexander Egle, MD, Richard Greil, MD, Lukas Kenner, MD, Melanie Boerries, MD PhD, Tanja Nicole Hartmann, PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 46–47.
https://doi.org/10.1182/blood-2020-136905
Published: 2020
Journal Articles

Quality of Life in Newly Diagnosed Patients with Multiple Myeloma Randomized to Either Krd or Ktd Induction Therapy Followed By Carfilzomib Maintenance or Control (AGMT MM 02 trial)

Heinz Ludwig, MD, Thomas Melchardt, MD PhD, Johannes Andel, MD, Eberhard Gunsilius, MD, Siegfried Sormann, MD, Axel Hinke, PhD, Bernd L. Hartmann, MD, Klaus Podar, MDPhD, Wolfgang Willenbacher, MD PhD, Alexander Egle, MD, Andreas Petzer, MD, Niklas Zojer, MD, Ewald Wöll, MD, Reinhard Ruckser, MD, Boris Bozic, MD, Clemens A. Schmitt, MD, Sigrid Machherndl-Spandl, MD, Maria-Theresa Krauth, MD, Martin Schreder, MD, Hermine Agis, MD, Christoph Tinchon, MD, Michael Fillitz, MD, Richard Greil, MD
Journal: Blood
Blood (2020) 136 (Supplement 1): 27–29.
https://doi.org/10.1182/blood-2020-140701
Published: 2020
Journal Articles

B-cell–specific IRF4 deletion accelerates chronic lymphocytic leukemia development by enhanced tumor immune evasion

Daniela Asslaber, Yuan Qi, Nicole Maeding, Markus Steiner, Ursula Denk, Jan Philip Höpner, Tanja Nicole Hartmann, Nadja Zaborsky, Richard Greil, Alexander Egle
Journal: Blood
Blood (2019) 134 (20): 1717–1729.
https://doi.org/10.1182/blood.2019000973
Published: 2019
Includes: Supplemental data
Journal Articles

Carfilzomib-Revlimid-Dexamethasone Vs. Carfilzomib-Thalidomide-Dexamethasone Weekly (After 2 Twice Weekly Cycles) Followed By Carfilzomib Maintenance Vs. Control in Transplant Non-Eligible Patients with Newly Diagnosed Multiple Myeloma (NDMM) - Interim Efficacy Analysis of Combined Data (AGMT MM-02)

Heinz Ludwig, MD, Siegfried Sormann, Niklas Zojer, Johannes Andel, Bernd L. Hartmann, Christoph Tinchon, MD, Eberhard Gunsilius, MD, Klaus Podar, MD PhD, Alexander Egle, MD, Wolfgang Willenbacher, MD PhD, Ewald Wöll, MD, Reinhard Ruckser, MD, Boris Bozic, MD, Maria-Theresa Krauth, MD, Andreas Petzer, MD, Clemens A. Schmitt, MD, Sigrid Machherndl-Spandl, MD, Hermine Agis, MD, Bruno Paiva, PhD, Richard Greil, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 696.
https://doi.org/10.1182/blood-2019-127954
Published: 2019
Journal Articles

BCR-Induced VLA-4 Activation in the TCL1 Transgenic Mouse Model for Chronic Lymphocytic Leukemia

Eva Szenes, Andrea Härzschel, Erika Tissino, PhD, Pischeli Justine, Julia Gutjahr, Sandra Pennisi, Jan Höpner, Alexander Egle, MD, Nadja Zaborsky, Marie Follo, Sarah Decker, PhD, Christine Dierks, Alexandre Chigaev, Antonella Zucchetto, Valter Gattei, MD, Richard Greil, MD, Tanja Nicole Hartmann, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1730.
https://doi.org/10.1182/blood-2019-125634
Published: 2019
Journal Articles

Expanding on Current Definitions of Hematologic Improvement in MDS, CMML and AML: Landmark Analyses of 1301 Patients Treated with Azacitidine in the Austrian Registry of Hypomethylating Agents By the AGMT-Study Group

Lisa Pleyer, Michael Pfeilstocker, MD, Reinhard Stauder, MD MSc, Sonja Heibl, MD, Heinz Sill, MD, Michael Girschikofsky, MD, Margarete Stampfl-Mattersberger, MD, Christoph Tinchon, MD, Andreas Petzer, MD, Clemens A. Schmitt, MD, Sonia Vallet, MD, Inga Mandac, MD, Klaus Geissler, MD, Wolfgang R. Sperr, MD, Michael Leisch, MD, Alexander Egle, MD, Thomas Melchardt, MD PhD, Julia Fusinato, BSc, Gudrun Piringer, MD MSc, Armin Zebisch, MD, Sigrid Machherndl-Spandl, MD, Dominik Wolf, MD, Felix Keil, MD, Richard Greil, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3821.
https://doi.org/10.1182/blood-2019-128153
Published: 2019
Journal Articles

Deletion of the p53 Target Gene PUMA Prevents Bone Marrow Failure in a Dyskeratosis Congenita Mouse Model

Miriam Erlacher, MD PhD, Christian Molnar, Julia Miriam Weiss, Sheila Bohler, Doris Steinemann, PhD, Gudrun Göhring, MD, Andreas Villunger, Verena Labi, Charlotte Niemeyer, MD, Alexander Egle, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 648.
https://doi.org/10.1182/blood-2018-99-116349
Published: 2018
Journal Articles

Long-Term Efficacy and Safety of Ropeginterferon Alfa-2b in Patients with Polycythemia Vera — Final Phase I/II Peginvera Study Results

Heinz Gisslinger, Veronika Buxhofer-Ausch, MD, Josef Thaler, MD, Ernst Forjan, MD, Ella Willenbacher, MD, Dominik Wolf, MD, Robert Kralovics, PhD, Bettina Gisslinger, Margarete Stampfl-Mattersberger, Alexander Egle, MD, Thomas Melchardt, MD, Sonja Burgstaller, MD, Martin Schalling, MSc, Maria-Theresa Krauth, MD, Richard Greil, MD, Pavla Kadlecova, Michael Zoerer, Victoria Empson, MSc, Barbara Grohmann-Izay, MD MSc, Christoph Klade, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 3030.
https://doi.org/10.1182/blood-2018-99-118584
Published: 2018
Journal Articles

Microenvironment-induced CD44v6 promotes early disease progression in chronic lymphocytic leukemia

Julia C. Gutjahr, Eva Szenes, Lisa Tschech, Daniela Asslaber, Michaela Schlederer, Simone Roos, Xiaobing Yu, Tamara Girbl, Christina Sternberg, Alexander Egle, Fritz Aberger, Ronen Alon, Lukas Kenner, Richard Greil, Veronique Orian-Rousseau, Tanja N. Hartmann
Journal: Blood
Blood (2018) 131 (12): 1337–1349.
https://doi.org/10.1182/blood-2017-08-802462
Published: 2018
Includes: Supplemental data
Journal Articles

Casein kinase 1 is a therapeutic target in chronic lymphocytic leukemia

Pavlina Janovska, Jan Verner, Jiri Kohoutek, Lenka Bryjova, Michaela Gregorova, Marta Dzimkova, Hana Skabrahova, Tomasz Radaszkiewicz, Petra Ovesna, Olga Vondalova Blanarova, Tereza Nemcova, Zuzana Hoferova, Katerina Vasickova, Lucie Smyckova, Alexander Egle, Sarka Pavlova, Lucie Poppova, Karla Plevova, Sarka Pospisilova, Vitezslav Bryja
Journal: Blood
Blood (2018) 131 (11): 1206–1218.
https://doi.org/10.1182/blood-2017-05-786947
Published: 2018
Includes: Supplemental data