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Journal Articles

Dissecting the heterogeneity of IGHV-mutated CLL: An eric study.

Free
Thomas Chatzikonstantinou, Andreas Agathangelidis, Persefoni Talimtzi, Stamatia Laidou, Eva Minga, Athanasios Roussos, Maria Angelopoulou, Miguel Arguello De Tomas, Darko Antic, Fanny Baran-Marszak, Csaba Bödör, Francesc Bosch Albareda, Mark Catherwood, Sophia Chatzileontiadou, Caterina Chessa, Marta Coscia, Marta Crespo, Antonio Cuneo, Zadie Davis, Maria Dimou, Michael Doubek, Maria Efstathopoulou, Blanca Espinet, Gianluca Gaidano, Ritu Gupta, Eleftheria Hatzimichael, Yair Herishanu, Thalia Karamanli, Eliana Konstantinou, Ioannis Kotsianidis, Andreas Epameinondas Koumpis, Tamas Laszlo, Vincent Levy, Alexandros Machairas, Francesca Martini, Riccardo Moia, Samir Mouhssine, Ana Muntanola Prat, Roberta Murru, Eugenia Mpalaoura, Gerassimos Pangalis, Maria Papaioannou, Sarka Pavlova, Karla Plevova, Sarka Pospisilova, Anna Puiggros, Lata Rani, Gian Matteo Rigolin, Ilaria Romano, Davide Rossi, Angel Serna, Martin Simkovic, Lukas Smolej, Niki Stavrogianni, Kristina Tomic Vujovic, Livio Trentin, Theodoros Vassilakopoulos, Andrea Visentin, Candida Vitale, George Vrachiolias, Lydia Scarfo, Anastasia Chatzidimitriou, Paolo Ghia, Kostas Stamatopoulos
Journal: Blood
Blood (2025) 146 (Supplement 1): 2120.
https://doi.org/10.1182/blood-2025-2120
Published: 2025
Journal Articles

Survival differences of patients with treatment-naive CLL between the chemoimmunotherapy and BTKi eras: An eric study.

Free
Thomas Chatzikonstantinou, Persefoni Talimtzi, Eva Minga, Maria Angelopoulou, Miguel Arguello De Tomas, Darko Antic, Celso Arrais-Rodrigues, Francesc Bosch Albareda, Marcello Bradaschia, Alessandro Cellini, Mark Catherwood, Sophia Chatzileontiadou, Caterina Chessa, Carlos Chiattone, Rosa Collado, Marta Coscia, Marta Crespo, Antonio Cuneo, Zadie Davis, Maria Dimou, Michael Doubek, Maria Efstathopoulou, Blanca Espinet, Gianluca Gaidano, Rocio Garcia-Serra, Alessandro Gozzetti, Ritu Gupta, Eleftheria Hatzimichael, Yair Herishanu, Ozren Jaksic, Maria Kislova, Eliana Konstantinou, Sevasti Konstantinou, Maya Koren Michowitz, Ioannis Kotsianidis, Andreas Epameinondas Koumpis, Luca Laurenti, Alexandros Machairas, Francesca Martini, Riccardo Moia, Samir Mouhssine, Ana Muntanola Prat, Roberta Murru, Rocio Nieves Salgado Sanchez, Gerassimos Pangalis, Maria Papaioannou, Sarka Pavlova, Leila Perobelli, Sarka Pospisilova, Anna Puiggros, Claus Rainer, Sergio Ramos, Lata Rani, Gian Matteo Rigolin, Ilaria Romano, Davide Rossi, Rodrigo Santucci, Angel Serna, Marina Siakantaris, Talita Silveira, Paolo Sportoletti, Niki Stavrogianni, Annamaria Tomasso, Kristina Tomic Vujovic, Livio Trentin, Theodoros Vassilakopoulos, Andrea Visentin, Candida Vitale, George Vrachiolias, Munci Yagci, Seyma Yildiz, Anastasia Chatzidimitriou, Kostas Stamatopoulos, Paolo Ghia, Lydia Scarfo
Journal: Blood
Blood (2025) 146 (Supplement 1): 5664.
https://doi.org/10.1182/blood-2025-5664
Published: 2025
Journal Articles

Second Line Treatment with Bruton Tyrosine Kinase Inhibitor (BTKi) or Bcl-2 Inhibitor (Bcl-2i) in Patients with Chronic Lymphocytic Leukemia (CLL): Primary Analysis of the Czech Study Group for CLL (CSCLL)

Free
Jana Mihalyova, Anna Panovska, Martin Simkovic, Peter Turcsanyi, Martin Spacek, Martin Brejcha, Daniel Lysak, Heidi Mocikova, Sarka Pavlova, Marika Chrapava, Jana Zuchnicka, Yvona Brychtova, Pavel Vodarek, Renata Urbanova, Tereza Likarova, Jitka Malcikova, Tereza Jurkova, Klara Lancova, Lucie Bezdekova, Tomas Papajik, Jana Baranova, Tomas Arpas, Sarka Pospisilova, Lukas Smolej, Michael Doubek
Journal: Blood
Blood (2023) 142 (Supplement 1): 6542.
https://doi.org/10.1182/blood-2023-181249
Published: 2023
Journal Articles

Laboratories Can Reliably Detect Clinically Relevant Variants in the TP53 Gene below 10 % Allelic Frequency: A Multicenter Study of ERIC, the European Research Initiative on CLL

Free
Sarka Pavlova, Jitka Malcikova, Lenka Radova, Silvia Bonfiglio, Jack B. Cowland, Christian Brieghel, Mette Klarskov Andersen, Maria Karypidou, Bella V Biderman, Michael Doubek, Gregory Lazarian, Inmaculada Rapado, Matthijs Vynck, Naomi Porret, Martin Andres, Dina Rosenberg, Dvora Sahar, Carolina Martinez-Laperche, Ismael Buño Borde, Andrew Hindley, Julio Bravo Sánchez, José García-Marco, Alicia Serrano, Blanca Ferrer Lores, Concepción Fernández-Rodriguez, Beatriz Bellosillo, Stephan Stilgenbauer, Eugen Tausch, Hero Nikdin, Fiona Quinn, Emer Atkinson, Lisette Van De Corput, Cafer Yildiz, Cristina Bilbao, Yanira Florido, Christian Thiede, Caroline Schuster, Anastazja Stoj, Sylwia Czekalska, Anastasia Chatzidimitriou, Stamatia Laidou, Audrey Bidet, Charles Dussiau, Friedel Nollet, Giovanna Piras, Tereza Borosova, Terezia Kurucova, Maria Monne, Svetlana Smirnova, Evgeny Nikitin, Ivan Sloma, Marie-Helene Delfau, Laetitia Largeaud, Loic Ysebaert, Peter J. M. Valk, Amy Christian, Renata Walewska, Marta Sebastião, Maria Gomes da Silva, Piero Galieni, Mario Angelini, Davide Rossi, Valeria Spina, Sónia Matos, Vânia Martins, David Donaldson, Tomasz Stoklosa, Monika Pepek, Panagiotis Baliakas, Rafa Andreu, Irene Luna, Tiina Kahre, Ülle Murumets, Sophie Laird, Daniel Ward, Miguel Alcoceba, Ana Balanzategui, Lydia Scarfo, Francesca Gandini, Ettore Zapparoli, Adoracion Blanco, Pau Abrisqueta Costa, Ana E. Rodriguez, Maria Rocio Benito Sanchez, Frédéric Davi, Clothilde Bravetti, Paula Gameiro, Joaquin Martinez-Lopez, Barbara Tazon, Fanny Baran-Marszak, Zadie Davies, Mark Caterwood, Andrey B Sudarikov, Richard Rosenquist, Carsten Utoft Niemann, Kostas Stamatopoulos, Paolo Ghia, Sarka Pospisilova
Journal: Blood
Blood (2023) 142 (Supplement 1): 200.
https://doi.org/10.1182/blood-2023-173235
Published: 2023
Journal Articles

Low-burden TP53 mutations in CLL: clinical impact and clonal evolution within the context of different treatment options

Free
Clinical Trials & Observations
Jitka Malcikova, Sarka Pavlova, Barbara Kunt Vonkova, Lenka Radova, Karla Plevova, Jana Kotaskova, Karol Pal, Barbara Dvorackova, Marcela Zenatova, Jakub Hynst, Eva Ondrouskova, Anna Panovska, Yvona Brychtova, Kristyna Zavacka, Boris Tichy, Nikola Tom, Jiri Mayer, Michael Doubek, Sarka Pospisilova
Journal: Blood
Blood (2021) 138 (25): 2670–2685.
https://doi.org/10.1182/blood.2020009530
Published: 2021
Includes: Supplemental data
Journal Articles

Casein kinase 1 is a therapeutic target in chronic lymphocytic leukemia

Free
Pavlina Janovska, Jan Verner, Jiri Kohoutek, Lenka Bryjova, Michaela Gregorova, Marta Dzimkova, Hana Skabrahova, Tomasz Radaszkiewicz, Petra Ovesna, Olga Vondalova Blanarova, Tereza Nemcova, Zuzana Hoferova, Katerina Vasickova, Lucie Smyckova, Alexander Egle, Sarka Pavlova, Lucie Poppova, Karla Plevova, Sarka Pospisilova, Vitezslav Bryja
Journal: Blood
Blood (2018) 131 (11): 1206–1218.
https://doi.org/10.1182/blood-2017-05-786947
Published: 2018
Includes: Supplemental data
Journal Articles

Low-Burden TP53 Mutations Occur in Chronic Phase of Myeloproliferative Neoplasms Regardless of Hydroxyurea Administration, Disease Type, and JAK2 Status

Free
Blanka Kubesova, MSc, Sarka Pavlova, PhD, Jitka Malcikova, PhD, Jitka Kabathova, MSc, Lenka Radova, PhD, Nikola Tom, MSc, Boris Tichy, PhD, Karla Plevova, PhD, Barbara Kantorova, PhD, Kristyna Fiedorova, MSc, Jarmila Kissova, PhD, Bettina Gisslinger, Heinz Gisslinger, Jiri Mayer, MD, Robert Kralovics, Sarka Pospisilova, Michael Doubek
Journal: Blood
Blood (2016) 128 (22): 4284.
https://doi.org/10.1182/blood.V128.22.4284.4284
Published: 2016
Journal Articles

Prognostic Impact of NOTCH1 Hotspot Mutation in TP53 -Mutated Patients with Chronic Lymphocytic Leukemia

Free
Barbara Kantorova, M.S., Jitka Malcikova, PhD, Veronika Navrkalova, M.S., PhD, Jana Smardova, Prof., MD PhD, Kamila Brazdilova, M.S., Karla Plevova, M.S., PhD, Eva Diviskova, M.S., Marek Borsky, M.S., Sarka Pavlova, M.S., PhD, Nikola Tom, M.S., Karol Pal, M.S., Martin Trbusek, Dr., PhD, Alexandra Oltova, Dr., Yvona Brychtova, MD PhD, Michael Doubek, Prof., MD PhD, Jiri Mayer, Prof., MD PhD, Sarka Pospisilova, Prof., Dr., PhD
Journal: Blood
Blood (2014) 124 (21): 3283.
https://doi.org/10.1182/blood.V124.21.3283.3283
Published: 2014
Journal Articles

Clonal Evolution and Therapy Related Selection Of TP53 Mutations In Chronic Lymphocytic Leukemia Patients

Free
Karla Plevova, MSc., Jitka Malcikova, Dr., PhD., Martin Trbusek, Dr., PhD, Sarka Pavlova, MSc., PhD., Ludmila Sebejova, Dr., Boris Tichy, Dr., PhD., Michael Doubek, Prof., Yvona Brychtova, MD, PhD, Jiri Mayer, Prof., Sarka Pospisilova, Prof.
Journal: Blood
Blood (2013) 122 (21): 4126.
https://doi.org/10.1182/blood.V122.21.4126.4126
Published: 2013
Journal Articles

Microrna-34a As a Marker for Fludarabine Resistance and Impairment of p53-Pathway in Chronic Lymphocytic Leukemia

Free
Marek Mraz, MD, PhD, Katerina Cerna, Veronika Mayerova, Katerina Musilova, Karla Plevova, Sarka Pavlova, PhD, Boris Tichy, Dr., PhD., Michael Doubek, M.D., PhD., Prof., Yvona Brychtova, M.D., Ph.D., Jitka Malcikova, Dr, PhD, Jiri Mayer, M.D., PhD., Prof., Martin Trbusek, PhD, Sarka Pospisilova, Dr, PhD
Journal: Blood
Blood (2012) 120 (21): 3883.
https://doi.org/10.1182/blood.V120.21.3883.3883
Published: 2012
Journal Articles

Inhibition of Chk1 Kinase Sensitizes Leukemia and Lymphoma Cell Lines with TP53 M utations to Chemotherapy.

Free
Jana Zemanova, Ludmila Sebejova, Dr., Ondrej Hylse, Kamil Paruch, Ph.D., Sarka Pavlova, Jiri Mayer, M.D., PhD., Prof., Sarka Pospisilova, Dr., PhD, Prof., Martin Trbusek, Dr., PhD.
Journal: Blood
Blood (2012) 120 (21): 2460.
https://doi.org/10.1182/blood.V120.21.2460.2460
Published: 2012
Journal Articles

MicroRNA-650 expression is influenced by immunoglobulin gene rearrangement and affects the biology of chronic lymphocytic leukemia

Free
Brief Report
Marek Mraz, Dasa Dolezalova, Karla Plevova, Katerina Stano Kozubik, Veronika Mayerova, Katerina Cerna, Katerina Musilova, Boris Tichy, Sarka Pavlova, Marek Borsky, Jan Verner, Michael Doubek, Yvona Brychtova, Martin Trbusek, Ales Hampl, Jiri Mayer, Sarka Pospisilova
Journal: Blood
Blood (2012) 119 (9): 2110–2113.
https://doi.org/10.1182/blood-2011-11-394874
Published: 2012
Includes: Supplemental data
Journal Articles

The Regulation, Targets and Clinical Relevance of Microrna Mir-650 in Chronic Lymphocytic Leukemia (CLL),

Free
Marek Mraz, MD, Karla Plevova, Dasa Dolezalova, Katerina Stano-Kozubik, Veronika Mayerova, Katerina Cerna, Katerina Musilova, Sarka Pavlova, Dr., Boris Tichy, Dr., Jana Lochmanova, Michael Doubek, MD, PhD, Yvona Brychtova, MD, Martin Trbusek, PhD, Ales Hampl, Jiri Mayer, Sarka Pospisilova, Dr, PhD
Journal: Blood
Blood (2011) 118 (21): 3874.
https://doi.org/10.1182/blood.V118.21.3874.3874
Published: 2011
Journal Articles

Mutational Analysis of Mir-29 Family Members in Chronic Lymphocytic Leukemia

Free
Jana Lochmanova, PharmD, Marek Mraz, MD, Veronika Navrkalova, Barbora Dvorakova, Boris Tichy, Dr, Karla Plevova, Ludmila Sebejova, Dr, Jitka Malcikova, Dr, Sarka Pavlova, PhD, Vladimir Benes, Tobias Rausch, Dr, Yvona Brychtova, MD, Michael Doubek, MD, PhD, Martin Trbusek, PhD, Jiri Mayer, Sarka Pospisilova, Dr
Journal: Blood
Blood (2011) 118 (21): 1770.
https://doi.org/10.1182/blood.V118.21.1770.1770
Published: 2011
Journal Articles

Clonal Evolution of Malignant Populations In Potentially Biclonal Chronic Lymphocytic Leukemia Patients

Free
Karla Plevova, Hana Skuhrova Francova, Boris Tichy, Dr, Jitka Malcikova, Dr., Sarka Pavlova, Dr., Ondrej Horky, Olga Stehlikova, Michael Doubek, MD, PhD, Yvona Brychtova, MD, Jiri Mayer, MD, PhD, Sarka Pospisilova, Dr, PhD
Journal: Blood
Blood (2010) 116 (21): 2412.
https://doi.org/10.1182/blood.V116.21.2412.2412
Published: 2010
Journal Articles

Detail Characterization of 22q11 Deletion and Mir-650 Role in CLL Patients.

Free
Marek Mraz, MD, MSC., Karla Malinova, Sarka Pavlova, Boris Tichy, Katerina Stano Kozubik, Jitka Malcikova, Marek Borsky, Jan Verner, Michael Doubek, Yvona Brychtova, Martin Trbusek, Jiri Mayer, MD, Sarka Pospisilova
Journal: Blood
Blood (2009) 114 (22): 1231.
https://doi.org/10.1182/blood.V114.22.1231.1231
Published: 2009