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Journal Articles

Second Line Treatment with Bruton Tyrosine Kinase Inhibitor (BTKi) or Bcl-2 Inhibitor (Bcl-2i) in Patients with Chronic Lymphocytic Leukemia (CLL): Primary Analysis of the Czech Study Group for CLL (CSCLL)

Jana Mihalyova, Anna Panovska, Martin Simkovic, Peter Turcsanyi, Martin Spacek, Martin Brejcha, Daniel Lysak, Heidi Mocikova, Sarka Pavlova, Marika Chrapava, Jana Zuchnicka, Yvona Brychtova, Pavel Vodarek, Renata Urbanova, Tereza Likarova, Jitka Malcikova, Tereza Jurkova, Klara Lancova, Lucie Bezdekova, Tomas Papajik, Jana Baranova, Tomas Arpas, Sarka Pospisilova, Lukas Smolej, Michael Doubek
Journal: Blood
Blood (2023) 142 (Supplement 1): 6542.
https://doi.org/10.1182/blood-2023-181249
Published: 2023
Journal Articles

Low-burden TP53 mutations in CLL: clinical impact and clonal evolution within the context of different treatment options

Clinical Trials & Observations
Jitka Malcikova, Sarka Pavlova, Barbara Kunt Vonkova, Lenka Radova, Karla Plevova, Jana Kotaskova, Karol Pal, Barbara Dvorackova, Marcela Zenatova, Jakub Hynst, Eva Ondrouskova, Anna Panovska, Yvona Brychtova, Kristyna Zavacka, Boris Tichy, Nikola Tom, Jiri Mayer, Michael Doubek, Sarka Pospisilova
Journal: Blood
Blood (2021) 138 (25): 2670–2685.
https://doi.org/10.1182/blood.2020009530
Published: 2021
Includes: Supplemental data
Journal Articles

FoxO1-GAB1 axis regulates homing capacity and tonic AKT activity in chronic lymphocytic leukemia

Vaclav Seda, Eva Vojackova, Laura Ondrisova, Lenka Kostalova, Sonali Sharma, Tomas Loja, Gabriela Mladonicka Pavlasova, Daniel Zicha, Marie Kudlickova Peskova, Jan Krivanek, Kvetoslava Liskova, Leos Kren, Vladimir Benes, Katerina Musilova Litzmanova, Marek Borsky, Jan Oppelt, Jan Verner, Sarka Pospisilova, Yvona Brychtova, Anna Panovska, Zhi Tan, Shuxing Zhang, Michael Doubek, Katerina Amruz Cerna, Jiri Mayer, Marek Mraz
Journal: Blood
Blood (2021) 138 (9): 758–772.
https://doi.org/10.1182/blood.2020008101
Published: 2021
Includes: Supplemental data
Journal Articles

Rituximab Preferentially Eliminates BCR Signaling Proficient Chronic Lymphocytic Leukemia B Cells In Vivo

Gabriela Pavlasova, Marek Borsky, Katerina Musilova, Vaclav Seda, Katerina Cerna, Jitka Osickova, Eva Vojackova, Yvona Brychtova, Michael Doubek, Sarka Pospisilova, Jiri Mayer, Marek Mraz
Journal: Blood
Blood (2016) 128 (22): 2030.
https://doi.org/10.1182/blood.V128.22.2030.2030
Published: 2016
Journal Articles

Single Cell Analysis of IG Genes in CLL: Cases with Multiple IGH Rearrangements Are Constituted of Several Independent Clones Even When Indistinguishable By Flow Cytometry

Kamila Brazdilova, MSc., Karla Plevova, PhD, Hana Skuhrova Francova, MSc, Helena Kockova, MSc, Magdalena Chmelikova, MSc, Marek Borsky, MSc., Katerina Burckova, MSc, Barbara Kantorova, MSc, Boris Tichy, PhD, Hana Skabrahova, Yvona Brychtova, PhD, MD, Jiri Mayer, Prof, MD PhD, Michael Doubek, MD PhD, Sarka Pospisilova, Prof.
Journal: Blood
Blood (2015) 126 (23): 4139.
https://doi.org/10.1182/blood.V126.23.4139.4139
Published: 2015
Journal Articles

Single Cell Analysis Proves the Coexistence of NOTCH1 and TP53 Mutations within the Same Cancer Cells in Patients with Chronic Lymphocytic Leukemia

Barbara Kantorova, MSc., Jitka Malcikova, PhD, Kamila Brazdilova, MSc., Marek Borsky, MSc., Karla Plevova, PhD, Jana Smardova, Prof., Martin Trbusek, PhD, Yvona Brychtova, PhD, MD, Michael Doubek, Prof., MD, Jiri Mayer, Prof., MD, Sarka Pospisilova, Prof.
Journal: Blood
Blood (2015) 126 (23): 2913.
https://doi.org/10.1182/blood.V126.23.2913.2913
Published: 2015
Journal Articles

Low-Dose FCR Is a Safe and Effective Treatment Option for Elderly/Comorbid Patients with Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma. Updated Results of Project Q-Lite By Czech CLL Study Group

Lukas Smolej, MDPhD, Yvona Brychtova, MD PhD, Michael Doubek, Prof., MD PhD, Eduard Cmunt, MDPhD, Martin Spacek, MD, PhD, David Belada, MD, Monika Motyckova, MDPhD, Irena Zygulova, MD, Dagmar Adamova, MD, Vit Prochazka, MDPhD, Martin Simkovic, MD, Katerina Klaskova, MS, Tomas Kozak, MDPhD
Journal: Blood
Blood (2014) 124 (21): 4670.
https://doi.org/10.1182/blood.V124.21.4670.4670
Published: 2014
Journal Articles

Prognostic Impact of NOTCH1 Hotspot Mutation in TP53 -Mutated Patients with Chronic Lymphocytic Leukemia

Barbara Kantorova, M.S., Jitka Malcikova, PhD, Veronika Navrkalova, M.S., PhD, Jana Smardova, Prof., MD PhD, Kamila Brazdilova, M.S., Karla Plevova, M.S., PhD, Eva Diviskova, M.S., Marek Borsky, M.S., Sarka Pavlova, M.S., PhD, Nikola Tom, M.S., Karol Pal, M.S., Martin Trbusek, Dr., PhD, Alexandra Oltova, Dr., Yvona Brychtova, MD PhD, Michael Doubek, Prof., MD PhD, Jiri Mayer, Prof., MD PhD, Sarka Pospisilova, Prof., Dr., PhD
Journal: Blood
Blood (2014) 124 (21): 3283.
https://doi.org/10.1182/blood.V124.21.3283.3283
Published: 2014
Journal Articles

SF3B1 Mutations Frequently Occur With Both ATM Mutations and TP53 Mutations In CLL Patients

Veronika Navrkalova, MSc., Jitka Malcikova, PhD, Barbara Kantorova, MSc., Ludmila Sebejova, Karla Plevova, MSc., Marek Mraz, MD, PhD, Michael Doubek, Yvona Brychtova, MD, PhD, Jana Smardova, MD, PhD, Jiri Mayer, MD, PhD, Sarka Pospisilova, Martin Trbusek, PhD
Journal: Blood
Blood (2013) 122 (21): 2868.
https://doi.org/10.1182/blood.V122.21.2868.2868
Published: 2013
Journal Articles

Ofatumumab Added To Dexamethasone In Patients With Relapsed Or Refractory Chronic Lymphocytic Leukemia. Results From a Phase II Study Of The Czech Leukemia Study Group For Life

Michael Doubek, Yvona Brychtova, MD, PhD, Anna Panovska, MD, Jakub Trizuljak, MD, Ludmila Sebejova, Olga Stehlikova, MSc., Jana Chovancova, DVM, Jitka Malcikova, PhD, Jana Smardova, MD, PhD, Karla Plevova, MSc., Pavlina Volfova, MSc., Martin Trbusek, PhD, Marek Mraz, MD, PhD, Denisa Majercakova, MD, Petra Obrtlikova, MD, Josef Karban, MD, Lukas Smolej, MD, PhD, Michaela Lindtnerova, MD, Alexandra Oltova, MD, Eva Jelinkova, MSc., Sarka Pospisilova, Jiri Mayer, MD, PhD
Journal: Blood
Blood (2013) 122 (21): 2877.
https://doi.org/10.1182/blood.V122.21.2877.2877
Published: 2013
Journal Articles

Clonal Evolution and Therapy Related Selection Of TP53 Mutations In Chronic Lymphocytic Leukemia Patients

Karla Plevova, MSc., Jitka Malcikova, Dr., PhD., Martin Trbusek, Dr., PhD, Sarka Pavlova, MSc., PhD., Ludmila Sebejova, Dr., Boris Tichy, Dr., PhD., Michael Doubek, Prof., Yvona Brychtova, MD, PhD, Jiri Mayer, Prof., Sarka Pospisilova, Prof.
Journal: Blood
Blood (2013) 122 (21): 4126.
https://doi.org/10.1182/blood.V122.21.4126.4126
Published: 2013
Journal Articles

The Fate of Chronic Lymphocytic Leukemia Patients After Failure of Fludarabine, Cyclophosphamide, and Rituximab Regimen

Anna Panovska, MD, Daniel Lysák, MD, Lukas Smolej, M.D., Ph.D., Yvona Brychtova, M.D., Ph.D., Martin Simkovic, MD, Monika Motyckova, M.D., Michaela Lindtnerova, MD, Martin Trbusek, PhD, Jitka Malcikova, Dr, PhD, Sarka Pospisilova, Prof., Jiri Mayer, M.D., PhD., Prof., Michael Doubek, M.D., PhD., Prof.
Journal: Blood
Blood (2012) 120 (21): 4603.
https://doi.org/10.1182/blood.V120.21.4603.4603
Published: 2012
Journal Articles

Microrna-34a As a Marker for Fludarabine Resistance and Impairment of p53-Pathway in Chronic Lymphocytic Leukemia

Marek Mraz, MD, PhD, Katerina Cerna, Veronika Mayerova, Katerina Musilova, Karla Plevova, Sarka Pavlova, PhD, Boris Tichy, Dr., PhD., Michael Doubek, M.D., PhD., Prof., Yvona Brychtova, M.D., Ph.D., Jitka Malcikova, Dr, PhD, Jiri Mayer, M.D., PhD., Prof., Martin Trbusek, PhD, Sarka Pospisilova, Dr, PhD
Journal: Blood
Blood (2012) 120 (21): 3883.
https://doi.org/10.1182/blood.V120.21.3883.3883
Published: 2012
Journal Articles

Sequence Variations in miRNA Genes Are Common and May Affect Their Expression in Patients with Chronic Lymphocytic Leukemia

Jana Kminkova, PharmD., Marek Mraz, MD, PhD, Veronika Navrkalova, MSc., Boris Tichy, Dr., PhD., Jitka Malcikova, Dr., PhD., Karla Plevova, Vladimir Benes, Tobias Rausch, PhD, Yvona Brychtova, M.D., Ph.D., Michael Doubek, M.D., PhD., Prof., Jiri Mayer, M.D., PhD., Prof., Sarka Pospisilova, Dr., PhD, Prof.
Journal: Blood
Blood (2012) 120 (21): 3895.
https://doi.org/10.1182/blood.V120.21.3895.3895
Published: 2012
Journal Articles

Defects of ATM Gene Involving Mutation Lead to Complete Elimination of ATM Function in Chronic Lymphocytic Leukemia

Veronika Navrkalova, MSc., Ludmila Sebejova, Dr., Jana Zemanova, Jana Kminkova, PharmD., Blanka Kubesova, Michael Doubek, Prof., Yvona Brychtova, M.D., Ph.D., Jana Smardova, Prof., Jiri Mayer, M.D., PhD., Prof., Sarka Pospisilova, Prof., Martin Trbusek, PhD
Journal: Blood
Blood (2012) 120 (21): 3902.
https://doi.org/10.1182/blood.V120.21.3902.3902
Published: 2012
Journal Articles

MicroRNA-650 expression is influenced by immunoglobulin gene rearrangement and affects the biology of chronic lymphocytic leukemia

Brief Report
Marek Mraz, Dasa Dolezalova, Karla Plevova, Katerina Stano Kozubik, Veronika Mayerova, Katerina Cerna, Katerina Musilova, Boris Tichy, Sarka Pavlova, Marek Borsky, Jan Verner, Michael Doubek, Yvona Brychtova, Martin Trbusek, Ales Hampl, Jiri Mayer, Sarka Pospisilova
Journal: Blood
Blood (2012) 119 (9): 2110–2113.
https://doi.org/10.1182/blood-2011-11-394874
Published: 2012
Includes: Supplemental data
Journal Articles

The Regulation, Targets and Clinical Relevance of Microrna Mir-650 in Chronic Lymphocytic Leukemia (CLL),

Marek Mraz, MD, Karla Plevova, Dasa Dolezalova, Katerina Stano-Kozubik, Veronika Mayerova, Katerina Cerna, Katerina Musilova, Sarka Pavlova, Dr., Boris Tichy, Dr., Jana Lochmanova, Michael Doubek, MD, PhD, Yvona Brychtova, MD, Martin Trbusek, PhD, Ales Hampl, Jiri Mayer, Sarka Pospisilova, Dr, PhD
Journal: Blood
Blood (2011) 118 (21): 3874.
https://doi.org/10.1182/blood.V118.21.3874.3874
Published: 2011
Journal Articles

Thrombosis in MPN with Thrombocythemia Is Associated with Higher Platelet Count At the Time of the Event: Data From the Czech Registry of Patients Treated with Anagrelide,

Jiri Schwarz, MD, PhD, Miroslav Penka, MD, PhD, Petra Ovesna, PhD, Olga Cerna, MD, Yvona Brychtova, MD, Petr Dulicek, MD, PhD
Journal: Blood
Blood (2011) 118 (21): 3857.
https://doi.org/10.1182/blood.V118.21.3857.3857
Published: 2011
Journal Articles

Mutational Analysis of Mir-29 Family Members in Chronic Lymphocytic Leukemia

Jana Lochmanova, PharmD, Marek Mraz, MD, Veronika Navrkalova, Barbora Dvorakova, Boris Tichy, Dr, Karla Plevova, Ludmila Sebejova, Dr, Jitka Malcikova, Dr, Sarka Pavlova, PhD, Vladimir Benes, Tobias Rausch, Dr, Yvona Brychtova, MD, Michael Doubek, MD, PhD, Martin Trbusek, PhD, Jiri Mayer, Sarka Pospisilova, Dr
Journal: Blood
Blood (2011) 118 (21): 1770.
https://doi.org/10.1182/blood.V118.21.1770.1770
Published: 2011
Journal Articles

Rituximab In Combination with High-Dose Dexamethasone: An Effective Treatment Option for Patients with Relapsed/Refractory Chronic Lymphocytic Leukemia

Michael Doubek, MD, PhD, Martin Simkovic, MD, Anna Panovska, MD, Monika Hrudkova, MD, David Belada, MD, PhD, Yvona Brychtova, MD, Jiri Mayer, MD, PhD, Lukas Smolej, M.D., Ph.D.
Journal: Blood
Blood (2010) 116 (21): 4629.
https://doi.org/10.1182/blood.V116.21.4629.4629
Published: 2010