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Martin Trbusek
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Journal Articles

miR-150 downregulation contributes to the high-grade transformation of follicular lymphoma by upregulating FOXP1 levels

Katerina Musilova, Jan Devan, Katerina Cerna, Vaclav Seda, Gabriela Pavlasova, Sonali Sharma, Jan Oppelt, Robert Pytlik, Vit Prochazka, Zuzana Prouzova, Martin Trbusek, Lenka Zlamalikova, Kvetoslava Liskova, Lenka Kruzova, Marie Jarosova, Andrea Mareckova, Christoph Kornauth, Ingrid Simonitsch-Klupp, Ana-Iris Schiefer, Olaf Merkel, Heidi Mocikova, Pavel Burda, Katerina Machova Polakova, Leos Kren, Jiri Mayer, Clive S. Zent, Marek Trneny, Andrew G. Evans, Andrea Janikova, Marek Mraz
Journal: Blood
Blood (2018) 132 (22): 2389–2400.
https://doi.org/10.1182/blood-2018-06-855502
Published: 2018
Includes: Supplemental data
Journal Articles

Ibrutinib inhibits CD20 upregulation on CLL B cells mediated by the CXCR4/SDF-1 axis

Brief Report
Gabriela Pavlasova, Marek Borsky, Vaclav Seda, Katerina Cerna, Jitka Osickova, Michael Doubek, Jiri Mayer, Raffaele Calogero, Martin Trbusek, Sarka Pospisilova, Matthew S. Davids, Thomas J. Kipps, Jennifer R. Brown, Marek Mraz
Journal: Blood
Blood (2016) 128 (12): 1609–1613.
https://doi.org/10.1182/blood-2016-04-709519
Published: 2016
Includes: Supplemental data
Journal Articles

Assessment of p53 and ATM Functionality in Chronic Lymphocytic Leukemia By Multiplex Ligation-Dependent Probe Amplification

Doreen te Raa, Perry Moerland, Alexander Leeksma, Ingrid Derks, Martin Loden, Veronika Navrkalova, Martin Trbusek, PhD, Dieuwertje Luijks, Thorsten Zenz, MD, Anna Skowronska, PhD, Tatjana Stankovic, Mels Hoogendoorn, MD PhD, Marinus H. J. van Oers, Eric Eldering, PhD, Arnon P. Kater, MD PhD
Journal: Blood
Blood (2015) 126 (23): 2918.
https://doi.org/10.1182/blood.V126.23.2918.2918
Published: 2015
Journal Articles

ATM Mutations in Major Stereotyped CLL Subsets: Enrichment in Subset #2 is Associated with Unfavourable Outcome

Veronika Navrkalova, PhD, Emma Young, Panagiotis Baliakas, Lenka Radova, Karla Plevova, PhD, Lesley-Ann Sutton, Larry Mansouri, Viktor Ljungstrom, Stavroula Ntoufa, Zadie Davis, Gunnar Juliusson, MD PhD, Karin E Smedby, MD PhD, Chrysoula Belessi, Panagiotis Panagiotidis, Frederic Davi, MD PhD, Anton W. Langerak, Paolo Ghia, MD PhD, Jonathan C Strefford, PhD, David G Oscier, Kostas Stamatopoulos, Sarka Pospisilova, Richard Rosenquist, Martin Trbusek, PhD
Journal: Blood
Blood (2015) 126 (23): 1712.
https://doi.org/10.1182/blood.V126.23.1712.1712
Published: 2015
Journal Articles

Single Cell Analysis Proves the Coexistence of NOTCH1 and TP53 Mutations within the Same Cancer Cells in Patients with Chronic Lymphocytic Leukemia

Barbara Kantorova, MSc., Jitka Malcikova, PhD, Kamila Brazdilova, MSc., Marek Borsky, MSc., Karla Plevova, PhD, Jana Smardova, Prof., Martin Trbusek, PhD, Yvona Brychtova, PhD, MD, Michael Doubek, Prof., MD, Jiri Mayer, Prof., MD, Sarka Pospisilova, Prof.
Journal: Blood
Blood (2015) 126 (23): 2913.
https://doi.org/10.1182/blood.V126.23.2913.2913
Published: 2015
Journal Articles

Prognostic Impact of NOTCH1 Hotspot Mutation in TP53 -Mutated Patients with Chronic Lymphocytic Leukemia

Barbara Kantorova, M.S., Jitka Malcikova, PhD, Veronika Navrkalova, M.S., PhD, Jana Smardova, Prof., MD PhD, Kamila Brazdilova, M.S., Karla Plevova, M.S., PhD, Eva Diviskova, M.S., Marek Borsky, M.S., Sarka Pavlova, M.S., PhD, Nikola Tom, M.S., Karol Pal, M.S., Martin Trbusek, Dr., PhD, Alexandra Oltova, Dr., Yvona Brychtova, MD PhD, Michael Doubek, Prof., MD PhD, Jiri Mayer, Prof., MD PhD, Sarka Pospisilova, Prof., Dr., PhD
Journal: Blood
Blood (2014) 124 (21): 3283.
https://doi.org/10.1182/blood.V124.21.3283.3283
Published: 2014
Journal Articles

SF3B1 Mutations Frequently Occur With Both ATM Mutations and TP53 Mutations In CLL Patients

Veronika Navrkalova, MSc., Jitka Malcikova, PhD, Barbara Kantorova, MSc., Ludmila Sebejova, Karla Plevova, MSc., Marek Mraz, MD, PhD, Michael Doubek, Yvona Brychtova, MD, PhD, Jana Smardova, MD, PhD, Jiri Mayer, MD, PhD, Sarka Pospisilova, Martin Trbusek, PhD
Journal: Blood
Blood (2013) 122 (21): 2868.
https://doi.org/10.1182/blood.V122.21.2868.2868
Published: 2013
Journal Articles

Ofatumumab Added To Dexamethasone In Patients With Relapsed Or Refractory Chronic Lymphocytic Leukemia. Results From a Phase II Study Of The Czech Leukemia Study Group For Life

Michael Doubek, Yvona Brychtova, MD, PhD, Anna Panovska, MD, Jakub Trizuljak, MD, Ludmila Sebejova, Olga Stehlikova, MSc., Jana Chovancova, DVM, Jitka Malcikova, PhD, Jana Smardova, MD, PhD, Karla Plevova, MSc., Pavlina Volfova, MSc., Martin Trbusek, PhD, Marek Mraz, MD, PhD, Denisa Majercakova, MD, Petra Obrtlikova, MD, Josef Karban, MD, Lukas Smolej, MD, PhD, Michaela Lindtnerova, MD, Alexandra Oltova, MD, Eva Jelinkova, MSc., Sarka Pospisilova, Jiri Mayer, MD, PhD
Journal: Blood
Blood (2013) 122 (21): 2877.
https://doi.org/10.1182/blood.V122.21.2877.2877
Published: 2013
Journal Articles

Clonal Evolution and Therapy Related Selection Of TP53 Mutations In Chronic Lymphocytic Leukemia Patients

Karla Plevova, MSc., Jitka Malcikova, Dr., PhD., Martin Trbusek, Dr., PhD, Sarka Pavlova, MSc., PhD., Ludmila Sebejova, Dr., Boris Tichy, Dr., PhD., Michael Doubek, Prof., Yvona Brychtova, MD, PhD, Jiri Mayer, Prof., Sarka Pospisilova, Prof.
Journal: Blood
Blood (2013) 122 (21): 4126.
https://doi.org/10.1182/blood.V122.21.4126.4126
Published: 2013
Journal Articles

Inhibition of Chk1 Kinase Sensitizes Leukemia and Lymphoma Cell Lines with TP53 M utations to Chemotherapy.

Jana Zemanova, Ludmila Sebejova, Dr., Ondrej Hylse, Kamil Paruch, Ph.D., Sarka Pavlova, Jiri Mayer, M.D., PhD., Prof., Sarka Pospisilova, Dr., PhD, Prof., Martin Trbusek, Dr., PhD.
Journal: Blood
Blood (2012) 120 (21): 2460.
https://doi.org/10.1182/blood.V120.21.2460.2460
Published: 2012
Journal Articles

The Fate of Chronic Lymphocytic Leukemia Patients After Failure of Fludarabine, Cyclophosphamide, and Rituximab Regimen

Anna Panovska, MD, Daniel Lysák, MD, Lukas Smolej, M.D., Ph.D., Yvona Brychtova, M.D., Ph.D., Martin Simkovic, MD, Monika Motyckova, M.D., Michaela Lindtnerova, MD, Martin Trbusek, PhD, Jitka Malcikova, Dr, PhD, Sarka Pospisilova, Prof., Jiri Mayer, M.D., PhD., Prof., Michael Doubek, M.D., PhD., Prof.
Journal: Blood
Blood (2012) 120 (21): 4603.
https://doi.org/10.1182/blood.V120.21.4603.4603
Published: 2012
Journal Articles

Microrna-34a As a Marker for Fludarabine Resistance and Impairment of p53-Pathway in Chronic Lymphocytic Leukemia

Marek Mraz, MD, PhD, Katerina Cerna, Veronika Mayerova, Katerina Musilova, Karla Plevova, Sarka Pavlova, PhD, Boris Tichy, Dr., PhD., Michael Doubek, M.D., PhD., Prof., Yvona Brychtova, M.D., Ph.D., Jitka Malcikova, Dr, PhD, Jiri Mayer, M.D., PhD., Prof., Martin Trbusek, PhD, Sarka Pospisilova, Dr, PhD
Journal: Blood
Blood (2012) 120 (21): 3883.
https://doi.org/10.1182/blood.V120.21.3883.3883
Published: 2012
Journal Articles

Defects of ATM Gene Involving Mutation Lead to Complete Elimination of ATM Function in Chronic Lymphocytic Leukemia

Veronika Navrkalova, MSc., Ludmila Sebejova, Dr., Jana Zemanova, Jana Kminkova, PharmD., Blanka Kubesova, Michael Doubek, Prof., Yvona Brychtova, M.D., Ph.D., Jana Smardova, Prof., Jiri Mayer, M.D., PhD., Prof., Sarka Pospisilova, Prof., Martin Trbusek, PhD
Journal: Blood
Blood (2012) 120 (21): 3902.
https://doi.org/10.1182/blood.V120.21.3902.3902
Published: 2012
Journal Articles

Mutational Analysis of TP53 Gene in Chronic Lymphocytic Leukemia: Comparison of Different Methodological Approaches

Barbara Kantorova, MSc., Jitka Malcikova, Dr., PhD., Jana Kminkova, PharmD., Veronika Navrkalova, MSc., Barbora Dvorakova, MSc., Boris Tichy, Dr., PhD., Jana Smardova, Prof., Martin Trbusek, Dr., PhD., Sim Truong, PhD., Katerina Stano-Kozubik, PhD., Nikola Tom, MSc., Karol Pal, MSc., Ludmila Sebejova, Dr., Nancy Patten, PhD., Lin Wu, PhD., Michael Doubek, M.D., PhD., Prof., Jiri Mayer, M.D., PhD., Prof., Sarka Pospisilova, Dr., PhD., Prof.
Journal: Blood
Blood (2012) 120 (21): 3911.
https://doi.org/10.1182/blood.V120.21.3911.3911
Published: 2012
Journal Articles

MicroRNA-650 expression is influenced by immunoglobulin gene rearrangement and affects the biology of chronic lymphocytic leukemia

Brief Report
Marek Mraz, Dasa Dolezalova, Karla Plevova, Katerina Stano Kozubik, Veronika Mayerova, Katerina Cerna, Katerina Musilova, Boris Tichy, Sarka Pavlova, Marek Borsky, Jan Verner, Michael Doubek, Yvona Brychtova, Martin Trbusek, Ales Hampl, Jiri Mayer, Sarka Pospisilova
Journal: Blood
Blood (2012) 119 (9): 2110–2113.
https://doi.org/10.1182/blood-2011-11-394874
Published: 2012
Includes: Supplemental data
Journal Articles

The Regulation, Targets and Clinical Relevance of Microrna Mir-650 in Chronic Lymphocytic Leukemia (CLL),

Marek Mraz, MD, Karla Plevova, Dasa Dolezalova, Katerina Stano-Kozubik, Veronika Mayerova, Katerina Cerna, Katerina Musilova, Sarka Pavlova, Dr., Boris Tichy, Dr., Jana Lochmanova, Michael Doubek, MD, PhD, Yvona Brychtova, MD, Martin Trbusek, PhD, Ales Hampl, Jiri Mayer, Sarka Pospisilova, Dr, PhD
Journal: Blood
Blood (2011) 118 (21): 3874.
https://doi.org/10.1182/blood.V118.21.3874.3874
Published: 2011
Journal Articles

Mutational Analysis of Mir-29 Family Members in Chronic Lymphocytic Leukemia

Jana Lochmanova, PharmD, Marek Mraz, MD, Veronika Navrkalova, Barbora Dvorakova, Boris Tichy, Dr, Karla Plevova, Ludmila Sebejova, Dr, Jitka Malcikova, Dr, Sarka Pavlova, PhD, Vladimir Benes, Tobias Rausch, Dr, Yvona Brychtova, MD, Michael Doubek, MD, PhD, Martin Trbusek, PhD, Jiri Mayer, Sarka Pospisilova, Dr
Journal: Blood
Blood (2011) 118 (21): 1770.
https://doi.org/10.1182/blood.V118.21.1770.1770
Published: 2011
Journal Articles

Monoallelic and biallelic inactivation of TP53 gene in chronic lymphocytic leukemia: selection, impact on survival, and response to DNA damage

Jitka Malcikova, Jana Smardova, Ludmila Rocnova, Boris Tichy, Petr Kuglik, Vladimira Vranova, Sona Cejkova, Miluse Svitakova, Hana Skuhrova Francova, Yvona Brychtova, Michael Doubek, Martin Brejcha, Martin Klabusay, Jiri Mayer, Sarka Pospisilova, Martin Trbusek
Journal: Blood
Blood (2009) 114 (26): 5307–5314.
https://doi.org/10.1182/blood-2009-07-234708
Published: 2009
Includes: Supplemental data
Journal Articles

Detail Characterization of 22q11 Deletion and Mir-650 Role in CLL Patients.

Marek Mraz, MD, MSC., Karla Malinova, Sarka Pavlova, Boris Tichy, Katerina Stano Kozubik, Jitka Malcikova, Marek Borsky, Jan Verner, Michael Doubek, Yvona Brychtova, Martin Trbusek, Jiri Mayer, MD, Sarka Pospisilova
Journal: Blood
Blood (2009) 114 (22): 1231.
https://doi.org/10.1182/blood.V114.22.1231.1231
Published: 2009
Journal Articles

P53 Inactivation and Genomic Aberrations in Relation to Imatinib Resistance in Chronic Myeloid Leukemia.

Jitka Malcikova, Jana Smardova, Daniela Zackova, Tomas Jurcek, Ludmila Rocnova, Martin Trbusek, Alexandra Oltova, Michael Doubek, Zdenek Racil, MD, PhD, Sarka Pospisilova, Jiri Mayer, MD
Journal: Blood
Blood (2009) 114 (22): 4256.
https://doi.org/10.1182/blood.V114.22.4256.4256
Published: 2009