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Journal Articles

Single Cell Analysis Proves the Coexistence of NOTCH1 and TP53 Mutations within the Same Cancer Cells in Patients with Chronic Lymphocytic Leukemia

Barbara Kantorova, MSc., Jitka Malcikova, PhD, Kamila Brazdilova, MSc., Marek Borsky, MSc., Karla Plevova, PhD, Jana Smardova, Prof., Martin Trbusek, PhD, Yvona Brychtova, PhD, MD, Michael Doubek, Prof., MD, Jiri Mayer, Prof., MD, Sarka Pospisilova, Prof.
Journal: Blood
Blood (2015) 126 (23): 2913.
https://doi.org/10.1182/blood.V126.23.2913.2913
Published: 2015
Journal Articles

Prognostic Impact of NOTCH1 Hotspot Mutation in TP53 -Mutated Patients with Chronic Lymphocytic Leukemia

Barbara Kantorova, M.S., Jitka Malcikova, PhD, Veronika Navrkalova, M.S., PhD, Jana Smardova, Prof., MD PhD, Kamila Brazdilova, M.S., Karla Plevova, M.S., PhD, Eva Diviskova, M.S., Marek Borsky, M.S., Sarka Pavlova, M.S., PhD, Nikola Tom, M.S., Karol Pal, M.S., Martin Trbusek, Dr., PhD, Alexandra Oltova, Dr., Yvona Brychtova, MD PhD, Michael Doubek, Prof., MD PhD, Jiri Mayer, Prof., MD PhD, Sarka Pospisilova, Prof., Dr., PhD
Journal: Blood
Blood (2014) 124 (21): 3283.
https://doi.org/10.1182/blood.V124.21.3283.3283
Published: 2014
Journal Articles

Ofatumumab Added To Dexamethasone In Patients With Relapsed Or Refractory Chronic Lymphocytic Leukemia. Results From a Phase II Study Of The Czech Leukemia Study Group For Life

Michael Doubek, Yvona Brychtova, MD, PhD, Anna Panovska, MD, Jakub Trizuljak, MD, Ludmila Sebejova, Olga Stehlikova, MSc., Jana Chovancova, DVM, Jitka Malcikova, PhD, Jana Smardova, MD, PhD, Karla Plevova, MSc., Pavlina Volfova, MSc., Martin Trbusek, PhD, Marek Mraz, MD, PhD, Denisa Majercakova, MD, Petra Obrtlikova, MD, Josef Karban, MD, Lukas Smolej, MD, PhD, Michaela Lindtnerova, MD, Alexandra Oltova, MD, Eva Jelinkova, MSc., Sarka Pospisilova, Jiri Mayer, MD, PhD
Journal: Blood
Blood (2013) 122 (21): 2877.
https://doi.org/10.1182/blood.V122.21.2877.2877
Published: 2013
Journal Articles

SF3B1 Mutations Frequently Occur With Both ATM Mutations and TP53 Mutations In CLL Patients

Veronika Navrkalova, MSc., Jitka Malcikova, PhD, Barbara Kantorova, MSc., Ludmila Sebejova, Karla Plevova, MSc., Marek Mraz, MD, PhD, Michael Doubek, Yvona Brychtova, MD, PhD, Jana Smardova, MD, PhD, Jiri Mayer, MD, PhD, Sarka Pospisilova, Martin Trbusek, PhD
Journal: Blood
Blood (2013) 122 (21): 2868.
https://doi.org/10.1182/blood.V122.21.2868.2868
Published: 2013
Journal Articles

Defects of ATM Gene Involving Mutation Lead to Complete Elimination of ATM Function in Chronic Lymphocytic Leukemia

Veronika Navrkalova, MSc., Ludmila Sebejova, Dr., Jana Zemanova, Jana Kminkova, PharmD., Blanka Kubesova, Michael Doubek, Prof., Yvona Brychtova, M.D., Ph.D., Jana Smardova, Prof., Jiri Mayer, M.D., PhD., Prof., Sarka Pospisilova, Prof., Martin Trbusek, PhD
Journal: Blood
Blood (2012) 120 (21): 3902.
https://doi.org/10.1182/blood.V120.21.3902.3902
Published: 2012
Journal Articles

Mutational Analysis of TP53 Gene in Chronic Lymphocytic Leukemia: Comparison of Different Methodological Approaches

Barbara Kantorova, MSc., Jitka Malcikova, Dr., PhD., Jana Kminkova, PharmD., Veronika Navrkalova, MSc., Barbora Dvorakova, MSc., Boris Tichy, Dr., PhD., Jana Smardova, Prof., Martin Trbusek, Dr., PhD., Sim Truong, PhD., Katerina Stano-Kozubik, PhD., Nikola Tom, MSc., Karol Pal, MSc., Ludmila Sebejova, Dr., Nancy Patten, PhD., Lin Wu, PhD., Michael Doubek, M.D., PhD., Prof., Jiri Mayer, M.D., PhD., Prof., Sarka Pospisilova, Dr., PhD., Prof.
Journal: Blood
Blood (2012) 120 (21): 3911.
https://doi.org/10.1182/blood.V120.21.3911.3911
Published: 2012
Journal Articles

Monoallelic and biallelic inactivation of TP53 gene in chronic lymphocytic leukemia: selection, impact on survival, and response to DNA damage

Jitka Malcikova, Jana Smardova, Ludmila Rocnova, Boris Tichy, Petr Kuglik, Vladimira Vranova, Sona Cejkova, Miluse Svitakova, Hana Skuhrova Francova, Yvona Brychtova, Michael Doubek, Martin Brejcha, Martin Klabusay, Jiri Mayer, Sarka Pospisilova, Martin Trbusek
Journal: Blood
Blood (2009) 114 (26): 5307–5314.
https://doi.org/10.1182/blood-2009-07-234708
Published: 2009
Includes: Supplemental data
Journal Articles

P53 Inactivation and Genomic Aberrations in Relation to Imatinib Resistance in Chronic Myeloid Leukemia.

Jitka Malcikova, Jana Smardova, Daniela Zackova, Tomas Jurcek, Ludmila Rocnova, Martin Trbusek, Alexandra Oltova, Michael Doubek, Zdenek Racil, MD, PhD, Sarka Pospisilova, Jiri Mayer, MD
Journal: Blood
Blood (2009) 114 (22): 4256.
https://doi.org/10.1182/blood.V114.22.4256.4256
Published: 2009
Journal Articles

p53 Inactivation in CLL: Pattern of 110 TP53 Mutations.

Thorsten Zenz, MD, Martin Trbusek, PhD, Jana Smardova, PhD, Sonja Häbe, Tina Denzel, Jitka Malcikova, Michael Doubek, PhD, Jiri Schwarz, MD, Hartmut Dohner, MD, Stephan Stilgenbauer, MD
Journal: Blood
Blood (2007) 110 (11): 2064.
https://doi.org/10.1182/blood.V110.11.2064.2064
Published: 2007
Journal Articles

Role of p53 Gene Mutation Type in B-CLL Prognosis.

Sarka Pospisilova, PhD, Jitka Malcikova, MSc., Jiri Damborsky, PhD., Jana Smardova, PhD., Martin Trbusek, PhD., Boris Tichy, M.D., Yvona Brychtova, M.D., Michael Doubek, M.D., PhD., Jiri Vorlicek, M.D., PhD., Jiri Mayer, M.D., PhD.
Journal: Blood
Blood (2006) 108 (11): 4324.
https://doi.org/10.1182/blood.V108.11.4324.4324
Published: 2006
Journal Articles

Rituximab Sensitizes B-CLL Cells with Inactivated p53 to Fludarabine.

Martin Trbusek, Sona Cejkova, MSc, Jitka Chumchalova, Zdenek Pospisil, PhD, Jana Smardova, Petr Kuglik, Michael Doubek, MD, PhD, Yvona Brychtova, MD, Sarka Pospisilova, PhD, Jiri Mayer, MD
Journal: Blood
Blood (2006) 108 (11): 4973.
https://doi.org/10.1182/blood.V108.11.4973.4973
Published: 2006