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Journal Articles

Survival Outcomes of Patients with Relapsed/Refractory Chronic Lymphocytic Leukemia (CLL) Treated in the Chemoimmunotherapy Vs BTK Inhibitor (BTKi) Eras: A European Research Initiative on CLL (ERIC) Study

T C, Eva Minga, Georgios Karakatsoulis, Elisa Albi, Miguel Alcoceba, David Allsup, Francesca Bacchiarri, Sotiria Besikli-Dimou, Sofia Chatzileontiadou, Rosa Collado, Zadie Davis, Maria Dimou, David Donaldson, Maria Efstathopoulou, Sara Galimberti, Andrea Galitzia, Eva Gimeno, Valerio Guarente, Eleftheria Hatzimichael, Jose-Angel Hernandez-Rivas, Gloria Iacoboni, Iliana Konstantinou, Ioannis Kotsianidis, Jana Kotaskova, Andreas Epameinondas Koumpis, Zuzana Kubova, Jorge Labrador, Luca Laurenti, Juan Marquet, Stanislava Maslejova, Carlota Mayor-Bastida, Fatima Miras, Riccardo Moia, Almudena Navarro-Bailon, Jacopo Olivieri, Maria Papaioannou, Anna Puiggros, Gian Matteo Rigolin, Mattia Schipani, Tereza Shokralla, Martin Simkovic, Antigoni Tranidou, Theodoros Vassilakopoulos, Andrea Visentin, Candida Vitale, George Vrachiolias, Renata Walewska, Lucrecia Yanez San Segundo, Jana Zuchnicka, David Graham Oscier, Alessandro Gozzetti, Panayiotis Panayiotidis, Francesc Bosch, Paolo Sportoletti, Blanca Espinet, Gerassimos Pangalis, Maria Angelopoulou, Tomas Papajik, Roberta Murru, Marta Coscia, Antonio Cuneo, Gianluca Gaidano, Niki Stavrogianni, Livio Trentin, Lukas Smolej, Mark Caterwood, Martin Spacek, Sarka Pospisilova, Michael Doubek, Anastasia Chatzidimitriou, Kostas Stamatopoulos, Paolo Ghia, Lydia Scarfo
Journal: Blood
Blood (2024) 144 (Supplement 1): 4619.
https://doi.org/10.1182/blood-2024-202046
Published: 2024
Journal Articles

Clinical Outcomes and Mutational Profile Associated with Dysmyelopoiesis in Chronic Myelomonocytic Leukemia

Xavier Calvo, David Román, Nieves Garcia Garcia-Gisbert, Concepción Fernández-Rodriguez, Marta Salido, Anna Puiggros, Blanca Espinet, Sara Garcia-Avila, Félix López Cadenas, Abora Rial-Villavecchia, Luis Colomo, Lourdes Florensa, Ana Ferrer, Leonor Arenillas
Journal: Blood
Blood (2023) 142 (Supplement 1): 3226.
https://doi.org/10.1182/blood-2023-185591
Published: 2023
Journal Articles

Patients with Chronic Lymphocytic Leukemia Carrying t(14;19) Display a Distinctive Transcriptomic Profile and Adverse Outcome, Which Might be Overcome Continuous Therapy with BTK Inhibitors. an Italian Campus CLL and Eric Study

Andrea Visentin, Enrico Gaffo, Moritz Furstenau, Jennifer A. Woyach, Panagiotis Baliakas, Kerry A Rogers, Cecelia Miller, Claudia Haferlach, Karla Plevova, David Graham Oscier, Zadie Davis, Florence Nguyen Khac, Eleonora Roncaglia, Gian Matteo Rigolin, Anastasia Athanasiadou, Fanny Baran-Marszak, Alberto Valiente, Maria Jose Terol, Pau Abrisqueta, Blanca Espinet, Anna Puiggros, Annalisa Martines, Laura Bonaldi, Francesca Romana Mauro, Lydia Scarfo, Thomas Chatzikonstantinou, Eugen Tausch, Karl Anton Kreuzer, Arnon P. Kater, Francesc Bosch, Michael Doubek, Panayiotis Panayiotidis, Olga Kalashnikova, Federica Frezzato, Monica Facco, Valeria Ruocco, Alessia Buratin, Silvia Orsi, Alessandro Cellini, Francesco Angotzi, Chiara Adele Cavarretta, Ivan Zatta, Andrea Serafin, Robin Foa, Barbara F. Eichhorst, Antonio Cuneo, Kostas Stamatopoulos, Paolo Ghia, Stefania Bortoluzzi, Livio Trentin
Journal: Blood
Blood (2023) 142 (Supplement 1): 3275.
https://doi.org/10.1182/blood-2023-174569
Published: 2023
Journal Articles

Assessment of Dysgranulopoiesis By Optical Cytology Compared to Distribution of Monocyte Subsets By Flow Cytometry in Peripheral Blood for Predicting the Diagnosis of CMML

David Roman-Bravo, Leonor Arenillas, Aylin Vasquez, Lourdes Florensa, Beatriz Costan, Rosa Navarro, Martina Karasiewicz, Sara Garcia-Avila, Felix Lopez-Cadenas, Marta Salido, Anna Puiggros, Blanca Espinet, Ana Ferrer, Xavier Calvo
Journal: Blood
Blood (2022) 140 (Supplement 1): 12347–12348.
https://doi.org/10.1182/blood-2022-166229
Published: 2022
Journal Articles

Pilot Inter-Laboratory Comparison Study of Optical Genome Mapping Analysis for Cytogenomic Characterization of Hematological Malignancies: A Spanish Multicentric Study

Anna Puiggros, Mar Mallo, Marta Salido, Ana Gómez-García, Adela Cisneros, Rocío García-Serra, Celia González-Gil, Gayane Avetisyan, María Rodríguez-Rivera, Alvaro Diaz-Gonzalez, Isabel Granada, Esperanza Such, Eulàlia Genescà, Rosa Collado, Manuel Ramírez-Orellana, Francesc Solé, Blanca Espinet
Journal: Blood
Blood (2022) 140 (Supplement 1): 4981–4983.
https://doi.org/10.1182/blood-2022-166293
Published: 2022
Journal Articles

Identification of Three Unique Clusters of Serum Proteins with Distinctive Functionalities in IGHV-Mutated MBL

Gonzalo Blanco, Florencia Palacios, Kamala Vanarsa, Poojitha Dugyala, Pui Yan Chiu, Steven L Allen, Yasmine Kieso, Anna Puiggros, Jacqueline C. Barrientos, Xavier Calvo, Jonathan E. Kolitz, Eva Gimeno, Joanna M. Rhodes, Ana Ferrer, Kanti R Rai, Barbara Sherry, Blanca Espinet, Chandra Mohan, Nicholas Chiorazzi
Journal: Blood
Blood (2022) 140 (Supplement 1): 9859–9861.
https://doi.org/10.1182/blood-2022-169722
Published: 2022
Journal Articles

Real-World Evidence on Therapeutic Strategies and Treatment-Sequencing in Patients with Chronic Lymphocytic Leukemia: An International Study of Eric, the European Research Initiative on CLL

Thomas Chatzikonstantinou, Lydia Scarfo, Christos Demosthenous, Jana Kotaskova, Gloria Iacoboni, Evangelia Minga, Dimitra Chammou, Georgios Karakatsoulis, Elisa Albi, Miguel Alcoceba, Shaimaa El-Ashwah, Francesca Bacchiarri, Mehreen Ali Khan, Thérèse Aurran, Anne Calleja, Ramona Cassin, Sofia Chatzileontiadou, Amy Christian, Rainer Claus, Rosa Collado, Marcos Daniel De Deus Santos, Zadie Davis, Maria Dimou, David Donaldson, Gimena Dos Santos, Barbara Dreta, Maria Efstathopoulou, Alicia Enrico, Alberto Fresa, Sara Galimberti, Rocío García-Serra, Isabel González-Gascón Y Marín, Alessandro Gozzetti, Valerio Guarente, Sean Harrop, Eleftheria Hatzimichael, Yair Herishanu, Luca Inchiappa, Michalis Iskas, Ozren Jaksic, Susanne R. Janssen, Elzbieta Kalicinska, Volkan Karakus, Arnon P. Kater, Bonnie Kho, Iliana Konstantinou, Thomas Longval, Maya Koren-Michowitz, Ioannis Kotsianidis, Robert J. Kreitman, Uttam Kumar Nath, Jorge Labrador, Deepesh Lad, Kamel Laribi, Ilana Levy, Alberto Lopez-Garcia, Juan Marquet Palomanes, Stanislava Maslejova, Carlota Mayor-Bastida, Fatiha Merabet, Biljana Mihaljevic, Ivana Milosevic, Fatima Miras, Riccardo Moia, Marta Morawska, Almudena Navarro-Bailón, David Oscier, Jacopo Olivieri, Tomáš Papajík, Maria Papaioannou, Cheyenne Pierie, Anna Puiggros, Gianluigi Reda, Gian Matteo Rigolin, Rosa Ruchlemer, Luana Schiattone, Omur Gokmen Sevindik, Yandong Shen, Martin Šimkovič, Svetlana Smirnova, Dina Sameh Soliman, Martin Špaček, Annett Schiwitza, Tamar Tadmor, Liat Tourjeman, Eric Tse, Andrea Visentin, Kristina Tomic, Michel Van Gelder, Theodoros P. Vassilakopoulos, Candida Vitale, George Vrachiolias, Vojin Vukovic, Zhenshu Xu, Lucrecia Yáñez, Munci Yagci, Mohamed A Yassin, Jana Zuchnicka, Maria K. Angelopoulou, Darko Antic, Bella V. Biderman, Mark Catherwood, Marta Coscia, Antonio Cuneo, Fatih Demirkan, Blanca Espinet, Gianluca Gaidano, Romain Guièze, Olga Kalashnikova, Luca Laurenti, Stephen Mulligan, Roberta Murru, Eugene A. Nikitin, Panayiotis Panayiotidis, Gerasimos Pangalis, Irina Panovska, Viola Maria Popov, Šárka Pospíšilová, Lukas Smolej, Paolo Sportoletti, Niki Stavroyianni, Constantine S. Tam, Livio Trentin, Marek Trněný, Francesc Bosch Albareda, Michael Doubek, Anastasia Chatzidimitriou, Paolo Ghia, Kostas Stamatopoulos
Journal: Blood
Blood (2021) 138 (Supplement 1): 2635.
https://doi.org/10.1182/blood-2021-148738
Published: 2021
Journal Articles

Different Prognostic Impact of Recurrent Gene Mutations in IGHV-Mutated and IGHV-Unmutated Chronic Lymphocytic Leukemia: A Retrospective, Multi-Center Cohort Study By Eric, the European Research Initiative on CLL, in Harmony

Larry Mansouri, Birna Thorvaldsdottir, Lesley-Ann Sutton, Manja Meggendorfer, Ferran Nadeu, Christian Brieghel, Helen Parker, Stamatia Laidou, Riccardo Moia, Davide Rossi, Mark Catherwood, Jana Kotaskova, Julio Delgado, Ana E Rodríguez-Vicente, Rocio Benito, Gian Matteo Rigolin, Silvia Bonfiglio, Lydia Scarfo, Mattias Mattsson, Zadie Davis, Ajay Gogia, Lata Rani, Panagiotis Baliakas, Cecilia Jylhä, Aron Skaftason, Inmaculada Rapado, Fatima Miras, Joaquin Martinez-Lopez, Javier de la Serna, Jesús M Hernández Rivas, Patrick Thornton, Maria Jose Larrayoz, María José Calasanz, Zoltán Mátrai, Csaba Bodor, Karin E. Smedby, Blanca Espinet, Anna Puiggros, Ritu Gupta, Lars Bullinger, Francesc Bosch, Bárbara Tazón, Fanny Baran-Marszak, David Oscier, Florence Nguyen-Khac, Thorsten Zenz, María José Terol, Antonio Cuneo, María Hernández-Sánchez, Sarka Pospisilova, Ken I Mills, Gianluca Gaidano, Carsten Utoft Niemann, Elías Campo, Jonathan C Strefford, Paolo Ghia, Kostas Stamatopoulos, Richard Rosenquist
Journal: Blood
Blood (2021) 138 (Supplement 1): 2617.
https://doi.org/10.1182/blood-2021-150648
Published: 2021
Journal Articles

Serum Proteomic Analyses Suggest That the HMGB1 and Other Inflammatory Pathways Are Operational in MBL and Are Less in Overt CLL

Florencia Palacios, Gonzalo Blanco, Kamala Vanarsa, Poojitha Dugyala, Steven L Allen, Yasmine Kieso, Anna Puiggros, Jacqueline Barrientos, Xavier Calvo, Jonathan E Kolitz, Eva Gimeno, Joanna M Rhodes, ANA Ferrer, Kanti R Rai, Blanca Espinet, Chandra Mohan, Nicholas Chiorazzi
Journal: Blood
Blood (2021) 138 (Supplement 1): 2625.
https://doi.org/10.1182/blood-2021-152514
Published: 2021
Journal Articles

NOTCH1 Mutation in CLL Enhances Cell Cycle G1/S Transition through Specific Cyclin Overexpression: Preclinical Ground for CDK4/6 Targeted Inhibition

Salvador Carrillo-Tornel, Tzu Hua Chen-Liang, María Zurdo, Anna Puiggros, Andrea Gómez-Llonín, María-Dolores García-Malo, Ernesto J Cuenca, Francisco José Ortuño, Ana M Hurtado López, Blanca Espinet, Andres Jerez
Journal: Blood
Blood (2021) 138 (Supplement 1): 1544.
https://doi.org/10.1182/blood-2021-152931
Published: 2021
Journal Articles

Notch1 mutation in B Chronic Lymphocytic Lymphocytes Induces Proliferation through Cell Cycle G1/S Phase-Specific Cyclin Overexpression

Ana M Hurtado López, Tzu Hua Chen-Liang, María Zurdo, Anna Puiggros, PhD, Andrea Gómez-Llonín, B.Sc., María-Dolores García-Malo, MD, Francisco José Ortuño, Vicente Vicente Garcia, MD PhD, Blanca Espinet, PhD, Andres Jerez
Journal: Blood
Blood (2019) 134 (Supplement_1): 851.
https://doi.org/10.1182/blood-2019-127960
Published: 2019
Journal Articles

Clinical Interest of LMO2 Testing in Aggressive Large B-Cell Lymphomas

Luis Colomo, Ivonne Vazquez, Natalia Papaleo, Marta Salido, Anna Puiggros, Blanca Espinet, Maria Rodriguez-Rivera, Ramon Diez-Feijoo, Blanca Sanchez-Gonzalez, Antonio Salar, Ana Ferrer, Leonor Arenillas, Marcio Andrade Campos, MD PhD, Xavier Calvo
Journal: Blood
Blood (2019) 134 (Supplement_1): 2899.
https://doi.org/10.1182/blood-2019-125717
Published: 2019
Journal Articles

Gene Expression and Cytokine Analyses Identify Markers of Progression from CLL-like Monoclonal B-Cell Lymphocytosis to Chronic Lymphocytic Leukemia

Gonzalo Blanco, PhD, Anna Puiggros, PhD, Barbara Sherry, PhD, Lara Nonell, Eulalia Puigdecanet, Pui Yan Chiu, Yasmine Kieso, MSCR, Gerardo Ferrer, PhD, Magdalena Arnal, María Rodríguez-Rivera, Eva Gimeno, MD PhD, Eugenia Abella, Kanti R Rai, MD, Pau Abrisqueta, MD PhD, Xavier Calvo, MD PhD, Francesc Bosch, MD PhD, Ana Ferrer, MD PhD, Nicholas Chiorazzi, MD, Blanca Espinet, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3027.
https://doi.org/10.1182/blood-2019-122038
Published: 2019
Journal Articles

Deciphering the CXCL9-CXCL10-CXCL11/CXCR3 Axis in CLL-like Monoclonal B-Cell Lymphocytosis and Chronic Lymphocytic Leukemia: A New Target for Immune Activation?

Gonzalo Blanco, PhD, Anna Puiggros, PhD, Barbara Sherry, PhD, Lara Nonell, Xavier Calvo, MD PhD, Eulalia Puigdecanet, Pui Yan Chiu, Yasmine Kieso, MSCR, Gerardo Ferrer, PhD, Magdalena Arnal, María Rodríguez-Rivera, Eva Gimeno, MD PhD, Eugenia Abella, Kanti R Rai, MD, Pau Abrisqueta, MD PhD, Francesc Bosch, MD PhD, Ana Ferrer, MD PhD, Nicholas Chiorazzi, MD, Blanca Espinet, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3029.
https://doi.org/10.1182/blood-2019-122061
Published: 2019
Journal Articles

Reduced Expression of the CD94/NKG2C NK Cell Receptor in Chronic Lymphocytic Leukemia (CLL) and CLL-like Monoclonal B-Cell Lymphocytosis (MBL)

Anna Puiggros, PhD, Gonzalo Blanco, PhD, Aura Muntasell, María Rodríguez-Rivera, Lara Nonell, Eulalia Puigdecanet, Magdalena Arnal, Xavier Calvo, MD PhD, Eva Gimeno, MD PhD, Eugenia Abella, Pau Abrisqueta, MD PhD, Francesc Bosch, MD PhD, José Yélamos, Ana Ferrer, MD PhD, Miguel Lopez-Botet, Blanca Espinet, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 5457.
https://doi.org/10.1182/blood-2019-128055
Published: 2019
Journal Articles

High Diagnostic Utility of Flow Cytometry Based Peripheral Blood Monocyte Subset Analysis, CD56 and CD2 Expression in Chronic Myelomonocytic Leukemia (CMML)

Xavier Calvo, MD PhD, Ivonne Parraga, Fellow, Nieves Garcia-Gisbert, MSc, Lourdes Florensa, MD PhD, Sara Montesdeoca, MD, Concepción Fernández, Marta Salido, PhD, Anna Puiggros, PhD, Blanca Espinet, PhD, Beatriz Bellosillo, PhD, Lluís Colomo, MD PhD, David Roman, MD, Marcio Andrade Campos, MD PhD, Brayan Merchan, MD MSc, Ana Ferrer, MD PhD, Leonor Arenillas, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 5437.
https://doi.org/10.1182/blood-2019-130499
Published: 2019
Journal Articles

Chromosome Banding Analysis Versus Genomic Microarrays: A Comparison of Methods for Genomic Complexity Risk Stratification in Chronic Lymphocytic Leukemia Patients with Complex Karyotype

Silvia Ramos Campoy, Anna Puiggros, PhD, Silvia Bea, PhD, Sandrine Bougeon, Maria Jose Larrayoz, PhD, Guillem Clot, Dolors Costa, MD, Gian Matteo Rigolin, MD, Margarita Ortega, Laura Blanco, Rosa Collado, MD, Rocio N Salgado, PhD, María-Dolores García-Malo, MD, Andrea Campeny, Alberto Valiente, Ferran Nadeu, BSc, MSc, Julio Delgado, Tycho Baumann, Idoya Ancín, Marco Antonio Moro García, Eva Gimeno, MD PhD, Carol Moreno, MD PhD, Francesc Bosch, MD PhD, Ana Ferrer, MD PhD, Gonzalo Blanco, PhD, Maria Jose Calasanz, PhD BSc, Antonio Cuneo, MD, Claudia Haferlach, MD, Jacqueline Schoumans, PhD, Blanca Espinet, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 4287.
https://doi.org/10.1182/blood-2019-126557
Published: 2019
Journal Articles

Oligomonocytic Chronic Myelomonocytic Leukemia (O-CMML) and Chronic Myelomonocytic Leukemia (CMML) Show Similar Clinical, Morphological, Immunophenotypic and Molecular Features

Xavier Calvo, MD PhD, Nieves Garcia-Gisbert, MSc, Ivonne Parraga, Fellow, Lourdes Florensa, MD PhD, Sara Montesdeoca, MD, Concepción Fernández, Marta Salido, PhD, Anna Puiggros, PhD, Blanca Espinet, PhD, Beatriz Bellosillo, PhD, Lluís Colomo, MD PhD, David Roman, MD, Marcio Andrade, MD PhD, Brayan Merchan, MD MSc, Ana Ferrer, MD PhD, Leonor Arenillas, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 4266.
https://doi.org/10.1182/blood-2019-130445
Published: 2019
Journal Articles

Cytogenetic complexity in chronic lymphocytic leukemia: definitions, associations, and clinical impact

Panagiotis Baliakas, Sabine Jeromin, Michalis Iskas, Anna Puiggros, Karla Plevova, Florence Nguyen-Khac, Zadie Davis, Gian Matteo Rigolin, Andrea Visentin, Aliki Xochelli, Julio Delgado, Fanny Baran-Marszak, Evangelia Stalika, Pau Abrisqueta, Kristina Durechova, George Papaioannou, Virginie Eclache, Maria Dimou, Theodoros Iliakis, Rosa Collado, Michael Doubek, M. Jose Calasanz, Neus Ruiz-Xiville, Carolina Moreno, Marie Jarosova, Alexander C. Leeksma, Panayiotis Panayiotidis, Helena Podgornik, Florence Cymbalista, Achilles Anagnostopoulos, Livio Trentin, Niki Stavroyianni, Fred Davi, Paolo Ghia, Arnon P. Kater, Antonio Cuneo, Sarka Pospisilova, Blanca Espinet, Anastasia Athanasiadou, David Oscier, Claudia Haferlach, Kostas Stamatopoulos
Journal: Blood
Blood (2019) 133 (11): 1205–1216.
https://doi.org/10.1182/blood-2018-09-873083
Published: 2019
Includes: Supplemental data
Journal Articles

Design of a NGS Platform for the Integrated Analysis of Genetic Mutations, Copy Number Alteration and Somatic Hypermutation of IGHV in CLL

Miguel Alcoceba, PhD, Maria Garcia-Alvarez, B.Sc., Anna Puiggros, PhD, Luis Espinosa-Hevia, PhD, Andrea Gómez-Llonín, B.Sc., Almudena Navarro, MD, Jose Maria Bastida, MD PhD, Norma C. Gutierrez, MD PhD, Jose A. Garcia-Marco, MD PhD, Blanca Espinet, PhD, Ramón García-Sanz, MD PhD, Marcos González, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 1851.
https://doi.org/10.1182/blood-2018-99-114995
Published: 2018