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Journal Articles

Skewing Towards Effector Memory Cells in CLL Is Associated with IGHV -Mutation Status and IFNγ and IL-4

Byeongho Jung, Anita Ng, Pui Yan Chiu, Barbara Sherry, Nicholas Chiorazzi

Blood (2023) 142 (Supplement 1): 4625.

https://doi.org/10.1182/blood-2023-190595

Published: 2023

Journal Articles

CD8+ T Cells from Patients with CLL Show Evidence of Granzyme B and Perforin Cytotoxic Capacity, Which Is Enhanced upon Exposure to Exogenous IL2 and/or IL21

Cristina Paraschivescu, Shivani Chhabra, Rukhsana Aslam, Byeongho Jung, Gerardo Ferrer, Jacqueline C. Barrientos, Joanna M. Rhodes, Jonathan E. Kolitz, Steven L Allen, Kanti R Rai, Barbara Sherry, Nicholas Chiorazzi

Blood (2022) 140 (Supplement 1): 7000–7001.

https://doi.org/10.1182/blood-2022-170023

Published: 2022

Journal Articles

Identification of Three Unique Clusters of Serum Proteins with Distinctive Functionalities in IGHV-Mutated MBL

Gonzalo Blanco, Florencia Palacios, Kamala Vanarsa, Poojitha Dugyala, Pui Yan Chiu, Steven L Allen, Yasmine Kieso, Anna Puiggros, Jacqueline C. Barrientos, Xavier Calvo, Jonathan E. Kolitz, Eva Gimeno, Joanna M. Rhodes, Ana Ferrer, Kanti R Rai, Barbara Sherry, Blanca Espinet, Chandra Mohan, Nicholas Chiorazzi

Blood (2022) 140 (Supplement 1): 9859–9861.

https://doi.org/10.1182/blood-2022-169722

Published: 2022

Journal Articles

Imbalance in T Cell Subsets Triggers the Autoimmune Toxicity of PI3K Inhibitors in CLL

Deepti Gadi, PhD, Siddha Kasar, PhD, Alec Griffith, BS, Pui Yan Chiu, Svitlana Tyekucheva, PhD, Vanessa Rai, BS, Alexander R. Vartanov, MD, Stacey M. Fernandes, BS, Yang Pan, PhD, James A Lederer, PhD, Barbara Sherry, PhD, Jennifer R. Brown, MD PhD

Blood (2019) 134 (Supplement_1): 1745.

https://doi.org/10.1182/blood-2019-122961

Published: 2019

Journal Articles

Gene Expression and Cytokine Analyses Identify Markers of Progression from CLL-like Monoclonal B-Cell Lymphocytosis to Chronic Lymphocytic Leukemia

Gonzalo Blanco, PhD, Anna Puiggros, PhD, Barbara Sherry, PhD, Lara Nonell, Eulalia Puigdecanet, Pui Yan Chiu, Yasmine Kieso, MSCR, Gerardo Ferrer, PhD, Magdalena Arnal, María Rodríguez-Rivera, Eva Gimeno, MD PhD, Eugenia Abella, Kanti R Rai, MD, Pau Abrisqueta, MD PhD, Xavier Calvo, MD PhD, Francesc Bosch, MD PhD, Ana Ferrer, MD PhD, Nicholas Chiorazzi, MD, Blanca Espinet, PhD

Blood (2019) 134 (Supplement_1): 3027.

https://doi.org/10.1182/blood-2019-122038

Published: 2019

Journal Articles

Deciphering the CXCL9-CXCL10-CXCL11/CXCR3 Axis in CLL-like Monoclonal B-Cell Lymphocytosis and Chronic Lymphocytic Leukemia: A New Target for Immune Activation?

Gonzalo Blanco, PhD, Anna Puiggros, PhD, Barbara Sherry, PhD, Lara Nonell, Xavier Calvo, MD PhD, Eulalia Puigdecanet, Pui Yan Chiu, Yasmine Kieso, MSCR, Gerardo Ferrer, PhD, Magdalena Arnal, María Rodríguez-Rivera, Eva Gimeno, MD PhD, Eugenia Abella, Kanti R Rai, MD, Pau Abrisqueta, MD PhD, Francesc Bosch, MD PhD, Ana Ferrer, MD PhD, Nicholas Chiorazzi, MD, Blanca Espinet, PhD

Blood (2019) 134 (Supplement_1): 3029.

https://doi.org/10.1182/blood-2019-122061

Published: 2019

Journal Articles

Extended Survival in CLL Patients Who Discontinued Idelalisib Because of Colitis Correlates with Higher Th17 Levels in Blood and Colon Tissue

Rukhsana Aslam, MD, Jacqueline C Barrientos, MD MS, Gerardo Ferrer, PhD, Pui Yan Chiu, Kanti R Rai, MD, Nicholas Chiorazzi, MD, Barbara Sherry, PhD

Blood (2018) 132 (Supplement 1): 1848.

https://doi.org/10.1182/blood-2018-99-116910

Published: 2018

Journal Articles

Ibrutinib Treatment Reduces Myeloid Derived Suppressor Cell Numbers and Function in Chronic Lymphocytic Leukemia

Gerardo Ferrer, PhD, Byeongho Jung, BS, Aslam Rukhsana, MD, Pui Yan Chiu, Andrea Nicola Mazzarello, PhD, Florenca Palacios, PhD, Shih-Shih Chen, PhD, Xiao J. Yan, MDPhD, Jacqueline C. Barrientos, MD MS, Jan A. Burger, MD PhD, Jonathan E. Kolitz, MD, Steven L. Allen, MD, Kanti R Rai, MD, Barbara Sherry, PhD, Nicholas Chiorazzi, MD

Blood (2018) 132 (Supplement 1): 239.

https://doi.org/10.1182/blood-2018-99-114799

Published: 2018

Journal Articles

Activated CLL B Cells Variably Modulate microRNA-155 Levels in Naïve CD4 + T Cells, and the Direction and Magnitude of microRNA-155 Change Correlates with Th17 Levels and Clinical Course

Byeongho Jung, BS, Gerardo Ferrer, PhD, Pui Yan Chiu, Rukhsana Aslam, MD, Florencia Palacios, PhD, Barbara Sherry, PhD, Nicholas Chiorazzi, MD

Blood (2018) 132 (Supplement 1): 4402.

https://doi.org/10.1182/blood-2018-99-116505

Published: 2018

Journal Articles

B-Cell Mediated Humoral Responses Are Impaired in Sepsis Survivors

Minakshi Rana, PhD, Barbara Sherry, PhD, Betty Diamond, MD

Blood (2018) 132 (Supplement 1): 1123.

https://doi.org/10.1182/blood-2018-99-117760

Published: 2018

Journal Articles

CLL Intraclonal Fractions Defined By Time Since Cell Birth/Division Promote a Leukemia-Supportive, Immune-Tolerant Microenvironment By Distinct Mechanisms

Shih-Shih Chen, PhD, Xiao J. Yan, MD PhD, Thomas M. Herndon, MD, Clare C. Sun, MD, Priyadarshini Ravichandran, Michael Ibrahim, Barbara Sherry, PhD, Adrian Wiestner, MD, Kanti R Rai, MD, Nicholas Chiorazzi, MD

Blood (2018) 132 (Supplement 1): 1836.

https://doi.org/10.1182/blood-2018-99-119843

Published: 2018

Journal Articles

Ibrutinib Disrupts IL-4R - IL-4 Axis By Inhibiting IL-4R Signaling and Reversing Th2/Th1 Polarization through Diminished CLECL1 in CLL B Cells

Shih-Shih Chen, PhD, Priyadarshini Ravichandran, Gerardo Ferrer, PhD, Andrea Nicola Mazzarello, PhD, Florencia Palacios, PhD, Michael Ibrahim, Yasmine Kieso, Jacqueline C. Barrientos, MD, Edward Clark, PhD, Barbara Sherry, PhD, Jan A. Burger, MD PhD, Kanti Rai, MD, Nicholas Chiorazzi, MD

Blood (2017) 130 (Supplement 1): 387.

https://doi.org/10.1182/blood.V130.Suppl_1.387.387

Published: 2017

Journal Articles

Myeloid-Derived Suppressor Cell Subtypes Are Responsible for the Th2 Phenotype of T Cells in CLL

Gerardo Ferrer, PhD, Brendan Franca, BS, Pui Yan Chiu, Stefano Vergani, PhD, Andrea Nicola Mazzarello, PhD, Florenca Palacios, PhD, Shihshih Chen, PhD, Davide Bagnara, PhD, Sophia Yancopoulos, Yun Liu, MS, Aliki Xochelli, MD, Xiao J. Yan, MDPhD, Jonathan E. Kolitz, MD, Steven L. Allen, MD, Jacqueline C. Barrientos, MD, Kostas Stamatopoulos, Kanti Rai, MD, Barbara Sherry, PhD, Nicholas Chiorazzi, MD

Blood (2017) 130 (Supplement 1): 4294.

https://doi.org/10.1182/blood.V130.Suppl_1.4294.4294

Published: 2017

Journal Articles

In CLL, Myeloid-Derived Suppressor Cells and Their Monocytic and Granulocytic Varieties Differ in T-Cell Subset Association and Polarization Induction

Gerardo Ferrer, PhD, Brendan Franca, Pui Yan Chiu, MSc, Stefano Vergani, MS, Andrea Nicola Mazzarello, PhD, Florencia Palacios, PhD, Davide Bagnara, PhD, Shih-Shih Chen, PhD, Sophia Yancopoulos, PhD, Yun Liu, MS, Aliki Xochelli, MD PhD, Xiao-Jie Yan, MD PhD, Jacqueline C. Barrientos, MD, Jonathan E. Kolitz, MD, Steven L. Allen, MD, Kostas Stamatopoulos, MD PhD, Kanti R. Rai, MD, Barbara Sherry, PhD, Nicholas Chiorazzi, MD

Blood (2016) 128 (22): 4350.

https://doi.org/10.1182/blood.V128.22.4350.4350

Published: 2016

Journal Articles

In Vivo Evidence That Ibrutininb Deregulates Chemokine Receptor CXCR4 Surface Membrane Expression and Signaling, Along with Inhibiting B Cell Antigen Receptor Signaling, As Causes for Defective Homing and Impaired Retention of CLL Cells in Tissues

Shih-Shih Chen, PhD, Betty Y. Chang, Stella Chang, Timothy Tong, Yong-Rui Zou, Barbara Sherry, PhD, Joseph J. Buggy, PhD, Jan A. Burger, MD PhD, Kanti R. Rai, MD, Nicholas Chiorazzi, MD

Blood (2014) 124 (21): 1948.

https://doi.org/10.1182/blood.V124.21.1948.1948

Published: 2014

Journal Articles

CLL Sera Drive Maturation of Normal Monocytes to M2-like Macrophages By Direct and Indirect Mechanisms

Sonia Marsilio, PhD, Barbara Sherry, PhD, Xiao J. Yan, MD PhD, Jacqueline C. Barrientos, MD, Steven L. Allen, MD, Jonathan E. Kolitz, MD, Kanti R. Rai, MD, Nicholas Chiorazzi, MD

Blood (2014) 124 (21): 1970.

https://doi.org/10.1182/blood.V124.21.1970.1970

Published: 2014

Journal Articles

Chronic Lymphocytic Leukemia Patients Exhibit Expanded Functional Granulocyte-like Myeloid Derived Suppressor Cells

Gerardo Ferrer, PhD, Rita Simone, PhD, Sonia Marsilio, PhD, Stefano Vergani, Andrea Nicola Mazzarello, PhD, Shih-Shih Chen, PhD, Xiao Jie Yan, PhD, Barbara Sherry, PhD, Jaqueline C. Barrientos, MD, Jonathan E. Kolitz, MD, Steven L. Allen, MD, Kanti R. Rai, MD, Nicholas Chiorazzi, MD

Blood (2014) 124 (21): 3279.

https://doi.org/10.1182/blood.V124.21.3279.3279

Published: 2014

Journal Articles

Identification of outcome-correlated cytokine clusters in chronic lymphocytic leukemia

Xiao-Jie Yan, Igor Dozmorov, Wentian Li, Sophia Yancopoulos, Cristina Sison, Michael Centola, Preetesh Jain, Steven L. Allen, Jonathan E. Kolitz, Kanti R. Rai, Nicholas Chiorazzi, Barbara Sherry

Blood (2011) 118 (19): 5201–5210.

https://doi.org/10.1182/blood-2011-03-342436

Published: 2011

Includes: Supplemental data

Journal Articles

Elevated IL-17 Producing Cells (Th17 and Non-Th17) In Different CLL Microenvironments: Correlation with Overall Survival, Prognostic Relevance and Phenotypic Heterogenity

Preetesh Jain, MBBS, MD, DM, Mohammad Javadan, PhD, Franziska Feger, Pui Chiu, Stella Stefanova, Rajendra N Damle, PhD, Steven L. Allen, MD, Jonathan E Kolitz, MD, Kanti R Rai, MD, Nicholas Chiorazzi, Barbara Sherry

Blood (2010) 116 (21): 2442.

https://doi.org/10.1182/blood.V116.21.2442.2442

Published: 2010

Journal Articles

Identification of Distinct Cytokine and Chemokine Clusters That Correlate with Outcome In B-Cell Chronic Lymphocytic Leukemia: Implications for Disease Pathogenesis

Xiao-Jie Yan, M.D., Ph.D., Wentian Li, Sophie Yancopoulos, PhD, Igor Dozmorov, MD, PhD, Michael Centola, MD, Steven L. Allen, MD, Kanti R Rai, MD, Nicholas Chiorazzi, M.D., Barbara Sherry, PhD

Blood (2010) 116 (21): 1368.

https://doi.org/10.1182/blood.V116.21.1368.1368

Published: 2010

NARROW

Skewing Towards Effector Memory Cells in CLL Is Associated with IGHV -Mutation Status and IFNγ and IL-4

CD8+ T Cells from Patients with CLL Show Evidence of Granzyme B and Perforin Cytotoxic Capacity, Which Is Enhanced upon Exposure to Exogenous IL2 and/or IL21

Identification of Three Unique Clusters of Serum Proteins with Distinctive Functionalities in IGHV-Mutated MBL

Imbalance in T Cell Subsets Triggers the Autoimmune Toxicity of PI3K Inhibitors in CLL

Gene Expression and Cytokine Analyses Identify Markers of Progression from CLL-like Monoclonal B-Cell Lymphocytosis to Chronic Lymphocytic Leukemia

Deciphering the CXCL9-CXCL10-CXCL11/CXCR3 Axis in CLL-like Monoclonal B-Cell Lymphocytosis and Chronic Lymphocytic Leukemia: A New Target for Immune Activation?

Extended Survival in CLL Patients Who Discontinued Idelalisib Because of Colitis Correlates with Higher Th17 Levels in Blood and Colon Tissue

Ibrutinib Treatment Reduces Myeloid Derived Suppressor Cell Numbers and Function in Chronic Lymphocytic Leukemia

Activated CLL B Cells Variably Modulate microRNA-155 Levels in Naïve CD4 + T Cells, and the Direction and Magnitude of microRNA-155 Change Correlates with Th17 Levels and Clinical Course

B-Cell Mediated Humoral Responses Are Impaired in Sepsis Survivors

CLL Intraclonal Fractions Defined By Time Since Cell Birth/Division Promote a Leukemia-Supportive, Immune-Tolerant Microenvironment By Distinct Mechanisms

Ibrutinib Disrupts IL-4R - IL-4 Axis By Inhibiting IL-4R Signaling and Reversing Th2/Th1 Polarization through Diminished CLECL1 in CLL B Cells

Myeloid-Derived Suppressor Cell Subtypes Are Responsible for the Th2 Phenotype of T Cells in CLL

In CLL, Myeloid-Derived Suppressor Cells and Their Monocytic and Granulocytic Varieties Differ in T-Cell Subset Association and Polarization Induction

In Vivo Evidence That Ibrutininb Deregulates Chemokine Receptor CXCR4 Surface Membrane Expression and Signaling, Along with Inhibiting B Cell Antigen Receptor Signaling, As Causes for Defective Homing and Impaired Retention of CLL Cells in Tissues

CLL Sera Drive Maturation of Normal Monocytes to M2-like Macrophages By Direct and Indirect Mechanisms

Chronic Lymphocytic Leukemia Patients Exhibit Expanded Functional Granulocyte-like Myeloid Derived Suppressor Cells

Identification of outcome-correlated cytokine clusters in chronic lymphocytic leukemia

Elevated IL-17 Producing Cells (Th17 and Non-Th17) In Different CLL Microenvironments: Correlation with Overall Survival, Prognostic Relevance and Phenotypic Heterogenity

Identification of Distinct Cytokine and Chemokine Clusters That Correlate with Outcome In B-Cell Chronic Lymphocytic Leukemia: Implications for Disease Pathogenesis

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American Society of Hematology

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American Society of Hematology

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