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Journal Articles

Telomere Length and DNA Methylation Epitype Both Provide Independent Prognostic Information in CLL Patients; Data from the UK CLL4, Arctic and Admire Clinical Trials

Louise J. Carr, Kevin Norris, Helen Parker, Anna Nilsson-Takeuchi, Dean J. Bryant, Harindra Eranthi Amarasinghe, Latha Kadalayil, Monica Else, Tomasz Wojdacz, Andrew Pettitt, Peter Hillmen, Anna Schuh, Renata Walewska, Duncan M. Baird, David Graham Oscier, Christopher C. Oakes, Jane Gibson, Chris Pepper, Jonathan C. Strefford
Journal: Blood
Blood (2023) 142 (Supplement 1): 6514.
https://doi.org/10.1182/blood-2023-177575
Published: 2023
Journal Articles

The Proliferative History Index, Epicmit, Derived from Genome-Wide Epigenomic Profiling, Is a Key Driver of Clinical Survival in Splenic Marginal Zone Lymphoma

Helen Parker, Amatta Mirandari, Carolina Jaramillo-Oquendo, Marti Duran-Ferrer, Ben Stevens, Lara Buermann, Harindra Eranthi Amarasinghe, Jaya Thomas, Louise J. Carr, Shama Syeda, Methusha Sakthipakan, Marina Parry, Zadie Davies, Neil McIver-Brown, Aliki Xochelli, Sarah Ennis, Lydia Scarfo, Paolo Ghia, Christina H. Kalpadakis, Gerassimos Pangalis, Davide Rossi, Simon Wagner, Matthew Ahearne, Marc Seifert, Christoph Plass, Dieter Weichenhan, Eva Kimby, Lesley Ann Sutton, Richard Rosenquist, Francesco Forconi, Kostas Stamatopoulos, Marta Salido, Ana Ferrer, Catherine Thieblemont, David Graham Oscier, Renata Walewska, Matthew JJ Rose-Zerilli, Jane Gibson, Iñaki I. Martin Subero, Christopher C. Oakes, Dean J. Bryant, Jonathan C. Strefford
Journal: Blood
Blood (2023) 142 (Supplement 1): 4370.
https://doi.org/10.1182/blood-2023-174481
Published: 2023
Journal Articles

DNA Methylation-Based Classification of Hairy Cell Leukemia and Splenic B Cell Lymphoma

Kyoko Yamaguchi, Salma Abdelbaky, Evgeny Arons, Matthew Cross, Yue-Zhong Wu, Christoph Weigel, Mirela Iulia Anghelina, Helen Parker, Artur Kibler, Marta Salido, Constance Regina Baer, Manja Meggendorfer, Benjamin Durham, Omar Abdel-Wahab, Seema A Bhat, Gerard Lozanski, Kerry A Rogers, Yonghong Wang, Paul S. Meltzer, Sunil Iyengar, Sascha Dietrich, Thorsten Zenz, James S. Blachly, Aurelie Verney, Lucile Baseggio, Alexandra Traverse-Glehen, Marc Seifert, Ralf Kuppers, Richard Burack, Clive S Zent, Versha Banerji, James B. Johnston, David Graham Oscier, Renata Walewska, Kostas Stamatopoulos, Torsten Haferlach, Ana Ferrer, Catherine Thieblemont, Francesco Forconi, Robert Kreitman, Michael R. Grever, Jonathan C. Strefford, Piers Blombery, Christopher C. Oakes
Journal: Blood
Blood (2023) 142 (Supplement 1): 174.
https://doi.org/10.1182/blood-2023-189835
Published: 2023
Journal Articles

Different Prognostic Impact of Recurrent Gene Mutations in IGHV-Mutated and IGHV-Unmutated Chronic Lymphocytic Leukemia: A Retrospective, Multi-Center Cohort Study By Eric, the European Research Initiative on CLL, in Harmony

Larry Mansouri, Birna Thorvaldsdottir, Lesley-Ann Sutton, Manja Meggendorfer, Ferran Nadeu, Christian Brieghel, Helen Parker, Stamatia Laidou, Riccardo Moia, Davide Rossi, Mark Catherwood, Jana Kotaskova, Julio Delgado, Ana E Rodríguez-Vicente, Rocio Benito, Gian Matteo Rigolin, Silvia Bonfiglio, Lydia Scarfo, Mattias Mattsson, Zadie Davis, Ajay Gogia, Lata Rani, Panagiotis Baliakas, Cecilia Jylhä, Aron Skaftason, Inmaculada Rapado, Fatima Miras, Joaquin Martinez-Lopez, Javier de la Serna, Jesús M Hernández Rivas, Patrick Thornton, Maria Jose Larrayoz, María José Calasanz, Zoltán Mátrai, Csaba Bodor, Karin E. Smedby, Blanca Espinet, Anna Puiggros, Ritu Gupta, Lars Bullinger, Francesc Bosch, Bárbara Tazón, Fanny Baran-Marszak, David Oscier, Florence Nguyen-Khac, Thorsten Zenz, María José Terol, Antonio Cuneo, María Hernández-Sánchez, Sarka Pospisilova, Ken I Mills, Gianluca Gaidano, Carsten Utoft Niemann, Elías Campo, Jonathan C Strefford, Paolo Ghia, Kostas Stamatopoulos, Richard Rosenquist
Journal: Blood
Blood (2021) 138 (Supplement 1): 2617.
https://doi.org/10.1182/blood-2021-150648
Published: 2021
Journal Articles

High Surface IgM Levels Associate with Shorter Response Duration and Bypass of the BTK Blockade during Ibrutinib Therapy in CLL Patients

Giorgia Chiodin, David Dutton, MD, Enrica Antonia Martino, MD, Samantha Drennan, PhD, Ian Tracy, PhD, Laura Ondrisova, Isla Henderson, Annalisa D'Avola, PhD, Christina Pitsillidou, Marek Mraz, MD, Peter Johnson, MDFRCP, Andrew Duncombe, MD, Graham Packham, PhD, Andrew J Steele, PhD, Helen Parker, PhD, Silvia Bonfiglio, Lydia Scarfo, MD, Lesley-Ann Sutton, Paolo Ghia, MD PhD, Matthew John Jerome Rose-Zerilli, PhD, Jonathan C Strefford, PhD, Freda K. Stevenson, DPhil, Francesco Forconi, MD DM, PhD FRCPath
Journal: Blood
Blood (2019) 134 (Supplement_1): 1752.
https://doi.org/10.1182/blood-2019-128899
Published: 2019
Journal Articles

Prognostic Impact of Germ-Line FCGR2A (H131R), FCGR3A (F158V), and FCGR2B (I232T) Single Nucleotide Polymorphisms in Lymphoma Patients Treated with Obinutuzumab or Rituximab in Combination with Chemotherapy: Results from the Phase III GALLIUM and GOYA Clinical Trials

Jonathan C Strefford, Malgorzata Nowicka, Chantal Hargreaves, Chisako Iriyama, Kate V Latham, Rosalind Ganderton, Helen Parker, Kathleen N Potter, Andrea Knapp, Farheen Mir, Matthew JJ Rose-Zerilli, Cathy Burton, Wolfgang Hiddemann, Wolfram Klapper, MD, Laurie H Sehn, MD MPH, Umberto Vitolo, Maurizio Martelli, Marek Trněný, Andrew Davies, Mark C Cragg, Mikkel Z Oestergaard
Journal: Blood
Blood (2018) 132 (Supplement 1): 4109.
https://doi.org/10.1182/blood-2018-99-116750
Published: 2018
Journal Articles

The Contribution of Gene Mutations to Long-Term Clinical Outcomes: Data from the Randomised UK LRF CLL4 Trial

Stuart Blakemore, PhD, Ruth Clifford, Pavlos Antoniou, Helen Parker, PhD, Pauline Robbe, MSc, Marta Larrayoz, PhD, Zadie Davis, Latha Kadalyayil, Andrew Collins, Jade Forster, PhD, Monica Else, Andrew J Steele, PhD, Jacqueline Chan, PhD, Graham Speight, PhD, Mark Cragg, PhD, Matthew John Jerome Rose-Zerilli, PhD, Daniel Catovsky, MD FRCP, David Oscier, MD PhD, Anna Schuh, MD PhD, Jonathan C Strefford, PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 259.
https://doi.org/10.1182/blood.V130.Suppl_1.259.259
Published: 2017
Journal Articles

Clinical Importance of DNA Methylation Signatures in Chronic Lymphocytic Leukaemia Patients Treated with Chemo-Immunotherapy

Harindra Amarasinghe, PhD, Tomasz K Wojdacz, PhD MSc, Matthew John Jerome Rose-Zerilli, PhD, Alice Beattie, Jade Forster, PhD, Latha Kadalayil, Stuart Blakemore, PhD, Helen Parker, PhD, Marta Larrayoz, PhD, Ruth Clifford, Zadie Davis, Monica Else, Dena Cohen, Andrew J Steele, PhD, Richard Rosenquist, MD PhD, Andrew Collins, Andrew Pettitt, FRCPath, PhD, Peter Hillmen, MBChB, PhD, Pauline Robbe, MSc, Christopher Plass, Anna Schuh, MD PhD, Daniel Catovsky, MD FRCP, David Oscier, MD PhD, Christopher C. Oakes, PhD, Jonathan C Strefford, PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 56.
https://doi.org/10.1182/blood.V130.Suppl_1.56.56
Published: 2017
Journal Articles

Tailored Approaches for Refined Prognostication in Chronic Lymphocytic Leukemia Patients with Mutated Versus Unmutated Immunoglobulin Receptors

Panagiotis Baliakas, Theodoros Moysiadis, Anastasia Hadzidimitriou, Aliki Xochelli, MD PhD, Mattias Mattsson, Lesley-Ann Sutton, Eva Minga, Lydia Scarfo, Davide Rossi, Zadie Davis, Andreas Agathangelidis, Neus Villamor, Helen Parker, Jana Kotaskova, Evangelia Stalika, Karla Plevova, Larry Mansouri, Diego Cortese, Alba Navaro Lopez, Julio Delgado, Marta Larrayoz, Emma Young, Achilles Anagnostopoulos, Karin E Smedby, Gunnar Juliusson, Mark Catherwood, Jonathan C Strefford, Niki Stavroyianni, MD, Chrysoula Belessi, Sarka Pospisilova, David Oscier, Gianluca Gaidano, MD, Elias Campo, Paolo Ghia, Richard Rosenquist, Kostas Stamatopoulos, on behalf of ERIC
Journal: Blood
Blood (2016) 128 (22): 3199.
https://doi.org/10.1182/blood.V128.22.3199.3199
Published: 2016
Journal Articles

Genomic Disruption of the Histone Methyltransferase SETD2 in Chronic Lymphocytic Leukemia

Matthew John Jerome Rose-Zerilli, PhD, Helen Parker, Marta Larrayoz, PhD, Ruth Clifford, Stuart Blakemore, Jennifer Edelmann, MD, Jane Gibson, Jun Wang, Viktor Ljungstrom, Tracy Chaplin, Ali Roghanian, Zadie Davis, Anton Parker, BSc, Eugen Tausch, MD, Stavroula Ntoufa, Sara Ramos, Pauline Robbe, MSc, Andrew J Steele, PhD, Graham Packham, PhD, Ana E. Rodriguez, Lee Brown, Feargal McNicholl, Francesco Forconi, MD DM, PhD FRCPath, Andrew R Pettitt, MRCP PhD, Peter Hillmen, Martin J.S. Dyer, Prof., Mark S Cragg, PhD, Bryan D Young, BSc, PhD, Claude Chelala, Richard Rosenquist, Kostas Stamatopoulos, MD, Stephan Stilgenbauer, Samantha Knight, Anna Schuh, MD PhD, David Oscier, Jonathan C Strefford, PhD
Journal: Blood
Blood (2015) 126 (23): 365.
https://doi.org/10.1182/blood.V126.23.365.365
Published: 2015
Journal Articles

Deep-Sequencing Reveals the Molecular Landscape of Splenic Marginal Zone Lymphoma: Biological and Clinical Implications

Matthew JJ Rose-Zerilli, PhD, Marina Parry, Viktor Ljungstrom, Jane Gibson, Jun Wang, Renata Walewska, Helen Parker, PhD, Anton Parker, Zadie Davis, Anne Catherine Gardiner, Neil McIver-Brown, Christina H. Kalpadakis, MD, Aliki Xochelli, Achilles Anagnostopoulos, Claudia Fazi, PhD, David Gonzalez de Castro, PhD, Claire Dearden, MD, Guy Pratt, Richard Rosenquist, MD PhD, Margaret Ashton-Keys, Francesco Forconi, Andrew Collins, PhD, Paolo Ghia, MD PhD, Estella Matutes, MD PhD, Gerassimos A Pangalis, Kostas Stamatopoulos, David G Oscier, MD, Jonathan C Strefford, PhD
Journal: Blood
Blood (2014) 124 (21): 76.
https://doi.org/10.1182/blood.V124.21.76.76
Published: 2014
Journal Articles

Tracking Subclonal Mutations in IGHV-Mutated CLL with Progressive Disease

Matthew JJ Rose-Zerilli, PhD, Gibson Jane, PhD, Jun Wang, PhD, William J Tapper, PhD, Helen Parker, PhD, Anton Parker, Zadie Davis, Anne Catherine Gardiner, Jade Forster, Andrew J Steele, PhD, Renata Walewska, Helen McCarthy, Andrew Collins, PhD, David G Oscier, MD, Jonathan C Strefford, PhD
Journal: Blood
Blood (2014) 124 (21): 1962.
https://doi.org/10.1182/blood.V124.21.1962.1962
Published: 2014
Journal Articles

Mutations In XPO1, POT1, BIRC3 and FBXW7 collectively Predict Poor Outcome At Diagnosis In CLL and MBL Independent From The SF3B1 and NOTCH1 Status

Nils Winkelmann, MD, Mathew J Rose-Zerilli, PhD, Jade Forster, Mathew Parry, PhD, Anton Parker, BSc, Anne Gardiner, Zadie Davies, BSC, Andrew J Steele, PhD, Helen Parker, PhD, Andrew Collins, PhD, Nick C.P. Cross, PhD, David Oscier, MD, Jonathan C Strefford
Journal: Blood
Blood (2013) 122 (21): 4138.
https://doi.org/10.1182/blood.V122.21.4138.4138
Published: 2013
Journal Articles

The clinical significance of NOTCH1 and SF3B1 mutations in the UK LRF CLL4 trial

CME Clinical Trials & Observations
David G. Oscier, Matthew J. J. Rose-Zerilli, Nils Winkelmann, David Gonzalez de Castro, Belen Gomez, Jade Forster, Helen Parker, Anton Parker, Anne Gardiner, Andrew Collins, Monica Else, Nicholas C. P. Cross, Daniel Catovsky, Jonathan C. Strefford
Journal: Blood
Blood (2013) 121 (3): 468–475.
https://doi.org/10.1182/blood-2012-05-429282
Published: 2013
Includes: Supplemental data
Journal Articles

The Correlation Between Deletion Architecture, ATM Mutational Status and BIRC3 Disruption in 11q-Deleted CLL

Matthew JJ Rose-Zerilli, PhD, Jade Forster, Helen Parker, PhD, Anton Parker, Ana E Rodríguez, Tracy Chaplin, Anne Gardiner, Andrew Collins, PhD, Bryan D Young, PhD, Tatjana Stankovic, MD., PhD, David Oscier, MD, Jonathan C. Strefford, BSc, PhD
Journal: Blood
Blood (2012) 120 (21): 658.
https://doi.org/10.1182/blood.V120.21.658.658
Published: 2012
Journal Articles

Genomic characterization implicates iAMP21 as a likely primary genetic event in childhood B-cell precursor acute lymphoblastic leukemia

Vikki Rand, Helen Parker, Lisa J. Russell, Claire Schwab, Hannah Ensor, Julie Irving, Lisa Jones, Dino Masic, Lynne Minto, Heather Morrison, Sarra Ryan, Hazel Robinson, Paul Sinclair, Anthony V. Moorman, Jonathan C. Strefford, Christine J. Harrison
Journal: Blood
Blood (2011) 117 (25): 6848–6855.
https://doi.org/10.1182/blood-2011-01-329961
Published: 2011
Includes: Supplemental data
Journal Articles

Sequential SNP6.0 Microarray Analysis In Rai Stage 0 CLL Patients with Either Stable or Progressive Identifies Genomic Evolution In Both Cohorts

Matthew JJ Rose-Zerilli, PhD, Miqdad Rajibali, BSc, Helen Parker, PhD, Anton Parker, BSc, Anne Catherine Gardiner, BSc, Zadie Davis, PhD, Sarah Mold, BSc, Sharron Glide, BSc, Tracy Chaplin, Bryan D Young, BSc, PhD, David Graham Oscier, Jonathan C. Strefford, BSc, PhD
Journal: Blood
Blood (2010) 116 (21): 1696.
https://doi.org/10.1182/blood.V116.21.1696.1696
Published: 2010
Journal Articles

Deletion Size Influences Clinical Outcome In Patients with Chronic Lymphocytic Leukemia; 13q Deletion Anatomy, Cooperating Lesions and Cancer Pathogenesis

Helen Parker, PhD, Matthew JJ Rose-Zerilli, PhD, Anton Parker, BSc, Tracy Chaplin, Anne Catherine Gardiner, BSc, Mike Griffiths, Andrew Collins, PhD, Bryan D Young, BSc, PhD, David Graham Oscier, Jonathan C. Strefford, BSc, PhD
Journal: Blood
Blood (2010) 116 (21): 757.
https://doi.org/10.1182/blood.V116.21.757.757
Published: 2010
Journal Articles

13q Deletion Size Predicts Disease Progression and Response to Treatment in Patients with Chronic Lymphocytic Leukaemia.

Jonathan C Strefford, PhD, Helen Parker, PhD, Anton Parker, BSc, Hazel Robinson, PhD, Tracy Chaplin, MSc, Xiao-He Chen, PhD, David Bunyan, PhD, Anne Gardiner, BSc, Bryan D Young, PhD, David Graham Oscier, MD
Journal: Blood
Blood (2009) 114 (22): 671.
https://doi.org/10.1182/blood.V114.22.671.671
Published: 2009
Journal Articles

What Is the Initiating Mechanism of iAMP21 in Childhood B Cell Precursor ALL?.

Vikki Rand, Helen Parker, Lisa J Russell, Julie Irving, Lisa Jones, Dino Masic, Lynne Minto, Heather Morrison, Hazel Robinson, Claire Schwab, Paul Sinclair, Anthony V Moorman, Jonathan C Strefford, Christine J Harrison
Journal: Blood
Blood (2009) 114 (22): 581.
https://doi.org/10.1182/blood.V114.22.581.581
Published: 2009