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James S. Blachly
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Journal Articles

Transcriptomically Defined Acute Myeloid Leukemia, Myelodysplasia-Related (AML-MR) Phenotype Governs Mutation-Based Disease Group Assignment

Lorenz Oelschläger, Deedra Nicolet, Krzysztof Mrózek, Daniel Schnell, Najla Alotaibi, Christopher J. Walker, Alice Mims, James S. Blachly, Bayard L Powell, Jonathan E Kolitz, Eunice S. Wang, Andrew J. Carroll, Lynn van Rosmalen, Bettina Nadorp, Nathan Salomonis, H. Leighton Grimes, Maarten Fornerod, Ann-Kathrin Eisfeld
Journal: Blood
Blood (2024) 144 (Supplement 1): 641.
https://doi.org/10.1182/blood-2024-210423
Published: 2024
Journal Articles

Updated Results and Longer Follow-up from the AUGMENT-101 Phase 2 Study of Revumenib in All Patients with Relapsed or Refractory (R/R) KMT2Ar Acute Leukemia

Ibrahim Aldoss, Ghayas C. Issa, James S. Blachly, Michael J. Thirman, Gabriel N Mannis, Martha L. Arellano, John F. DiPersio, Elie Traer, C. Michel Zwaan, Neerav Shukla, Branko Cuglievan, Carolyn S. Grove, Matthew Greenwood, Christine M. McMahon, Alexander E. Perl, Richard M. Stone, Cristina Papayannidis, David S. Dickens, Maël Heiblig, Andrius Žučenka, Pau Montesinos, Ioannis Mantzaris, Tibor Kovacsovics, Paul J. Shami, Li Yu, Rebecca G. Bagley, Nicole McNeer, Eytan M. Stein
Journal: Blood
Blood (2024) 144 (Supplement 1): 211.
https://doi.org/10.1182/blood-2024-194384
Published: 2024
Journal Articles

Targeting Inflammation in Tet2 Mutant Clonal Hematopoiesis Via Inhibition of Brd4 Demonstrates Activity in Both Murine and Human Models

Alexander R. Marr, Madeline Halpin, Dominique L. Corbin, Britten K. Gordon, Samon Benrashid, Ethan C. Whipp, Jean Truxall, Olivia Cahn, Bethany L. Mundy-Bosse, Julia Cooper, Marina Beltrami Moreira, James S. Blachly, Uma Borate, Jennifer A. Woyach, Rosa Lapalombella, Nicole R. Grieselhuber
Journal: Blood
Blood (2024) 144 (Supplement 1): 2661.
https://doi.org/10.1182/blood-2024-203526
Published: 2024
Journal Articles

Comparison of Two Myeloablative Total-Body Irradiation (MAC-TBI) Regimens: 1200 Cgy Vs 800 Cgy of TBI for Allogeneic Stem Cell Transplantation in Adults with Hematological Malignancies

Gabriela Sanchez-Petitto, Ying Huang, Evandro Bezerra, Jonathan E. Brammer, Hannah Choe, Nathan Denlinger, Polina Shindiapina, Sam Penza, Sarah A Wall, Gregory K Behbehani, James S. Blachly, Bradley Wayne Blaser, Uma Borate, Ann-Kathrin Eisfeld, Nicole R. Grieselhuber, Kristin L Koenig, Karilyn T. Larkin, Meixiao Long, Alice Mims, Andrew Srisuwananukorn, Ayman Saad, Sumithira Vasu, Marcos de Lima
Journal: Blood
Blood (2024) 144 (Supplement 1): 7303.
https://doi.org/10.1182/blood-2024-194146
Published: 2024
Journal Articles

GATA2 -Mutated AML: Clinical Outcomes and Spectrum of Infections in Patients Undergoing or Not Allogeneic Stem Cell Transplantation

Gabriela Sanchez-Petitto, Zeinab El Boghdadly, Deedra Nicolet, Julia Cooper, Ann-Kathrin Eisfeld, Victoria Klein, Michael C Walker, Krzysztof Mrózek, Evandro Bezerra, Jonathan E. Brammer, Nathan Denlinger, Polina Shindiapina, Sam Penza, Sarah A. Wall, Gregory K Behbehani, James S. Blachly, Bradley Wayne Blaser, Uma Borate, Nicole R. Grieselhuber, Kristin L Koenig, Karilyn T. Larkin, Meixiao Long, Alice Mims, Andrew Srisuwananukorn, Sumithira Vasu, Marcos de Lima
Journal: Blood
Blood (2024) 144 (Supplement 1): 7309.
https://doi.org/10.1182/blood-2024-202650
Published: 2024
Journal Articles

A Phase II Study of the Menin Inhibitor Revumenib in Leukemia Associated with Upregulation of HOX Genes: Trial in Progress

Ghayas C. Issa, Kuo-Kai Chin, James S. Blachly, Aziz Farhat, Lianchun Xiao, Jing Ning, Branko Cuglievan, Neerav Shukla, Koji Sasaki, Sanam Loghavi, Sheng Cai, Hagop M. Kantarjian, Eytan M. Stein
Journal: Blood
Blood (2024) 144 (Supplement 1): 5995.
https://doi.org/10.1182/blood-2024-203466
Published: 2024
Journal Articles

Real World Outcomes of Patients (Pts) with Acute Myeloid Leukemia, Myelodysplasia-Related (AML-MR) or Therapy-Related AML (t-AML) Receiving Venetoclax-Based Therapies

Kelly Pugh, Michael C Walker, Deedra Nicolet, Victoria Klein, Krzysztof Mrózek, Gregory K Behbehani, James S. Blachly, Uma Borate, Nicole R. Grieselhuber, Kristin L Koenig, Karilyn T. Larkin, Meixiao Long, Andrew Srisuwananukorn, Ann-Kathrin Eisfeld, Alice Mims
Journal: Blood
Blood (2024) 144 (Supplement 1): 7929.
https://doi.org/10.1182/blood-2024-210135
Published: 2024
Journal Articles

A Phase I Study to Evaluate the Safety and Tolerability of Gemtuzumab Ozogamicin and Midostaurin When Used in Combination with Standard Cytarabine and Daunorubicin Induction for Newly Diagnosed FLT3-Mutated Acute Myeloid Leukemia

Uma Borate, Kaitlyn M. Dvorak-Kornaus, Qiuhong Zhao, Roland B. Walter, Rachel J. Cook, Jennifer N. Saultz, Ronan T. Swords, Nicole R. Grieselhuber, Alice Mims, Karilyn T. Larkin, Kieran D Sahasrabudhe, James S. Blachly, Gregory K Behbehani, Ann-Kathrin Eisfeld, Meixiao Long, Andrew Srisuwananukorn, Kristin L Koenig
Journal: Blood
Blood (2024) 144 (Supplement 1): 4286.
https://doi.org/10.1182/blood-2024-210605
Published: 2024
Journal Articles

Real-World Experience of Venetoclax Target Dosing with Concomitant Posaconazole in Adult Patients with Acute Myeloid Leukemia

Tracelyn Freeman, Alma Habib, Ying Huang, Pooja Kumar, Allyson Waller, Megan Fleming, Kelsey McMillan, Natalia Hartzler, Gregory K Behbehani, James S. Blachly, Bradley Wayne Blaser, Uma Borate, Ann-Kathrin Eisfeld, Nicole R. Grieselhuber, Karilyn T. Larkin, Shinae Lee, Meixiao Long, Alice Mims, Andrew Srisuwananukorn, Kieran D Sahasrabudhe, Kristin L Koenig
Journal: Blood
Blood (2024) 144 (Supplement 1): 2432.
https://doi.org/10.1182/blood-2024-203704
Published: 2024
Journal Articles

A Rapid Diagnostic Assay to Detect a DNA Methylation Signature of Menin Inhibitor Response in Acute Myeloid Leukemia

Salma B. Abdelbaky, Matthew R Avenarius, Yi Seok Chang, Susan Long, Kyoko Yamaguchi, Yue-Zhong Wu, Cecelia Miller, Ann-Kathrin Eisfeld, James S. Blachly, Dan Jones, Christopher C. Oakes
Journal: Blood
Blood (2024) 144 (Supplement 1): 2922.
https://doi.org/10.1182/blood-2024-210498
Published: 2024
Journal Articles

BRAF -Mutated Acute Myeloid Leukemia (AML) Represents a Prognostically Poor Subgroup Enriched for Myelodysplasia-Related Subtypes and Distinct from Other RAS Pathway Mutant AML

Darren Lee, Yazan Abu-Shihab, Deedra Nicolet, Krzysztof Mrózek, Mark Routbort, Keyur P. Patel, Christopher J. Walker, Jill Buss, Andrew Stiff, Andrea Laganson, Courtney D. DiNardo, Naval Daver, Gautam Borthakur, Tapan M. Kadia, Farhad Ravandi, Andrew J. Carroll, Jonathan E Kolitz, Bayard L Powell, William Blum, Maria R. Baer, Guido Marcucci, Geoffrey L. Uy, Wendy Stock, Richard M. Stone, L. Jeffrey Medeiros, Jeffrey W. Tyner, Robert L. Bowman, John C. Byrd, James S. Blachly, Sanam Loghavi, Ann-Kathrin Eisfeld, Linde A. Miles
Journal: Blood
Blood (2024) 144 (Supplement 1): 2921.
https://doi.org/10.1182/blood-2024-210110
Published: 2024
Journal Articles

Revumenib Monotherapy in Patients with Relapsed/Refractory KMT2Ar Acute Leukemia: Topline Efficacy and Safety Results from the Pivotal Augment-101 Phase 2 Study

Ibrahim Aldoss, Ghayas C. Issa, Michael Thirman, John DiPersio, Martha Arellano, James S. Blachly, Gabriel N. Mannis, Alexander Perl, David S. Dickens, Christine M. McMahon, Elie Traer, C. Michel Zwaan, Carolyn Grove, Richard Stone, Paul J. Shami, Ioannis Mantzaris, Matthew Greenwood, Neerav Shukla, Branko Cuglievan, Yu Gu, Rebecca G. Bagley, Kate Madigan, Soujanya Sunkaraneni, Huy Van Nguyen, Nicole McNeer, Eytan M. Stein
Journal: Blood
Blood (2023) 142 (Supplement 2): LBA-5.
https://doi.org/10.1182/blood-2023-192042
Published: 2023
Journal Articles

Wilms' Tumor 1 Functions As a Tumor Suppressor to Suppress FLT3-STAT Signaling and Epigenetic Remodeling in Acute Myeloid Leukemia (CALGB 8461, 9665 and 20202; Alliance)

Daelynn Buelow, Xining Yang, Deedra Nicolet, Krzysztof Mrózek, Kathrin Krowiorz, Raj Bhayadia, Jack Stromatt, Anna Denny, Christoph Wiegel, Colin Corbett, Salma Abdelbaky, Yonger Xue, Yizhou Dong, Jeremy Hui, Arshia Shad, Sharon Gao, Si Wei Wu, Marion van den Bosch, Liam MacPhee, Leo Escano, James S. Blachly, Jonathan E Kolitz, William Blum, Maria R. Baer, Jan-Henning Klusmann, Ann-Kathrin Eisfeld, Arefeh Rouhi, Sharyn D. Baker, Florian Kuchenbauer, Christopher C. Oakes
Journal: Blood
Blood (2023) 142 (Supplement 1): 4126.
https://doi.org/10.1182/blood-2023-188892
Published: 2023
Journal Articles

Safety and Tolerability of AZD0466 As Monotherapy for Patients with Advanced Hematologic Malignancies. Results from a Phase I/II Trial

Shukaib Arslan, Giovanni Marconi, Giovanni Martinelli, Shaun Fleming, Antonio Curti, Shira N. Dinner, James S Blachly, Matteo Giovanni Della Porta, Ashish Bajel, Tim Sauer, Martina Crysandt, Arnaud Pigneux, Lars Fransecky, Claudia D Baldus, Marina Y. Konopleva, Yotvat Marmor, Shringi Sharma, Nairouz Elgeioushi, Patricia Cheung, Emily Rowe, Ekaterina Jahn, Ting Yu, Jamal Saeh, Raoul Tibes, Fathima Zumla Cader, Nitin Jain
Journal: Blood
Blood (2023) 142 (Supplement 1): 5907.
https://doi.org/10.1182/blood-2023-179168
Published: 2023
Journal Articles

Single-Cell RNA-Seq Analysis Reveals Distinct Tumor and Immunosuppressive T Cell Phenotypes in CLL Patients Treated with Ibrutinib

Shanmugapriya Thangavadivel, Shrilekha Misra, Samon Benrashid, Britten Gordon, Alexander He, Tzung-Huei Lai, Kerry A Rogers, Seema A Bhat, Adam S Kittai, John C. Byrd, James S. Blachly, Jennifer A. Woyach, Bradley Wayne Blaser
Journal: Blood
Blood (2023) 142 (Supplement 1): 3262.
https://doi.org/10.1182/blood-2023-186604
Published: 2023
Journal Articles

DNA Methylation-Based Classification of Hairy Cell Leukemia and Splenic B Cell Lymphoma

Kyoko Yamaguchi, Salma Abdelbaky, Evgeny Arons, Matthew Cross, Yue-Zhong Wu, Christoph Weigel, Mirela Iulia Anghelina, Helen Parker, Artur Kibler, Marta Salido, Constance Regina Baer, Manja Meggendorfer, Benjamin Durham, Omar Abdel-Wahab, Seema A Bhat, Gerard Lozanski, Kerry A Rogers, Yonghong Wang, Paul S. Meltzer, Sunil Iyengar, Sascha Dietrich, Thorsten Zenz, James S. Blachly, Aurelie Verney, Lucile Baseggio, Alexandra Traverse-Glehen, Marc Seifert, Ralf Kuppers, Richard Burack, Clive S Zent, Versha Banerji, James B. Johnston, David Graham Oscier, Renata Walewska, Kostas Stamatopoulos, Torsten Haferlach, Ana Ferrer, Catherine Thieblemont, Francesco Forconi, Robert Kreitman, Michael R. Grever, Jonathan C. Strefford, Piers Blombery, Christopher C. Oakes
Journal: Blood
Blood (2023) 142 (Supplement 1): 174.
https://doi.org/10.1182/blood-2023-189835
Published: 2023
Journal Articles

MS-553 Therapy Inhibits BCR Signaling and Increases Survival Dependence on BCL-2 in BTK-Inhibitor Resistant CLL

Jyotsana Singh, John R. Sanchez II, Chaomei Liu, Bailey Slawin, Nitin Jain, William G. Wierda, Kai Zhang, Michael Niesman, James S. Blachly, Jennifer A. Woyach, Deepa Sampath
Journal: Blood
Blood (2023) 142 (Supplement 1): 2283.
https://doi.org/10.1182/blood-2023-189378
Published: 2023
Journal Articles

Revumenib Monotherapy in Patients with Relapsed/Refractory KMT2Ar Acute Leukemias: Efficacy and Safety Results from the Augment-101 Phase 1/2 Study

Ibrahim Aldoss, Ghayas C. Issa, Michael J Thirman, John DiPersio, Martha Arellano, James S. Blachly, Gabriel Mannis, Alexander Perl, David Dickens, Christine M. McMahon, Elie Traer, C. Michel Zwaan, Carolyn Grove, Richard Stone, Paul J Shami, Ioannis Mantzaris, Matthew Greenwood, Neerav Shukla, Branko Cuglievan, Yu Gu, Rebecca G Bagley, Kate Madigan, Soujanya Sunkaraneni, Huy Van Nguyen, Nicole McNeer, Eytan M. Stein
Journal: Blood
Blood (2023) 142 (Supplement 1): 2907.
https://doi.org/10.1182/blood-2023-189762
Published: 2023
Journal Articles

The PKC-β Inhibitor MS-553 Displays Preclinical Efficacy in BTK Inhibitor Resistant Chronic Lymphocytic Leukemia

Britten Gordon, Elizabeth Muhowski, Janani Ravikrishnan, Shanmugapriya Thangavadivel, Samon Benrashid, Alexander He, Shrilekha Misra, Tzung-Huei Lai, Alexander Marr, Lianbo Yu, Brandi Walker, Elizabeth Perry, Nicole R. Grieselhuber, Kerry A Rogers, James S. Blachly, Adam S Kittai, Seema A Bhat, John C. Byrd, Michael Niesman, Kai Zhang, Deepa Sampath, Jennifer A. Woyach
Journal: Blood
Blood (2023) 142 (Supplement 1): 2260.
https://doi.org/10.1182/blood-2023-182024
Published: 2023
Journal Articles

BRAF -Mutated Acute Myeloid Leukemia (AML) Represents a Distinct, Prognostically Poor Subgroup Enriched in Myelodysplasia-Related (MR-)AML

Yazan Abu-Shihab, Deedra Nicolet, Krzysztof Mrózek, Mark Routbort, Keyur P. Patel, Christopher J. Walker, Jill Buss, Andrew Stiff, Andrea Laganson, Courtney D. DiNardo, Naval Daver, Tapan M. Kadia, Gautam Borthakur, Farhad Ravandi, Andrew J Carroll, Jonathan E Kolitz, Bayard L Powell, William Blum, Maria R. Baer, Guido Marcucci, Geoffrey L Uy, Wendy Stock, Richard M Stone, L. Jeffrey Medeiros, Robert L. Bowman, John C. Byrd, James S. Blachly, Linde A. Miles, Ann-Kathrin Eisfeld, Sanam Loghavi
Journal: Blood
Blood (2023) 142 (Supplement 1): 1575.
https://doi.org/10.1182/blood-2023-185135
Published: 2023