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Journal Articles

The Hyperbolic NAMPT Inhibitor RPT1G Synergizes with BCL-2 Family Inhibitors and Helps Overcome Venetoclax Resistance in Acute Myeloid Leukemia Cells

Gregory Crimmins, Min Wu, Francis Roushar, Claudia F. Ramos Aguilar, Mehdi Gharghabi, Banumathi Cole, Rosa Lapalombella, Dennise A. De Jesús-Díaz
Journal: Blood
Blood (2024) 144 (Supplement 1): 4134.
https://doi.org/10.1182/blood-2024-197972
Published: 2024
Journal Articles

Genome-Wide CRISPR/Cas9 Knockout Screen Reveals Novel LP-168 (Rocbrutinib) Combinations Targeting BCL-2 Protein Members for Chronic Lymphocytic Leukemia

Britten K. Gordon, Ethan C. Whipp, Lianbo Yu, Samon Benrashid, Andrew D. Mitchell, Alexander He, Jazmin Urrutia, Shrilekha Misra, Alexander R. Marr, Tzung-Huei Lai, Naina Karnati, Shanmugapriya Thangavadivel, Kerry A. Rogers, Seema A. Bhat, Nicole R. Grieselhuber, Yi Chen, Fenlai Tan, Stephen P. Anthony, Yu Chen, Deepa Sampath, Rosa Lapalombella, Jennifer A. Woyach
Journal: Blood
Blood (2024) 144 (Supplement 1): 3587.
https://doi.org/10.1182/blood-2024-203522
Published: 2024
Journal Articles

Targeting Inflammation in Tet2 Mutant Clonal Hematopoiesis Via Inhibition of Brd4 Demonstrates Activity in Both Murine and Human Models

Alexander R. Marr, Madeline Halpin, Dominique L. Corbin, Britten K. Gordon, Samon Benrashid, Ethan C. Whipp, Jean Truxall, Olivia Cahn, Bethany L. Mundy-Bosse, Julia Cooper, Marina Beltrami Moreira, James S. Blachly, Uma Borate, Jennifer A. Woyach, Rosa Lapalombella, Nicole R. Grieselhuber
Journal: Blood
Blood (2024) 144 (Supplement 1): 2661.
https://doi.org/10.1182/blood-2024-203526
Published: 2024
Journal Articles

Temporally Controlled MYC Overexpression in Chronic Lymphocytic Leukemia Accelerates Progression and Promotes Large B Cell Lymphoma Transformation

Ethan C. Whipp, Krithik Tella, Aidan Macaskill, Steven Sher, Casey Cempre, Jean Truxall, Mehdi Gharghabi, Fang Hao, Alexander R. Marr, Madeline Halpin, Pearlly S. Yan, Jennifer A. Woyach, Rosa Lapalombella
Journal: Blood
Blood (2024) 144 (Supplement 1): 2978.
https://doi.org/10.1182/blood-2024-210328
Published: 2024
Journal Articles

Targeting Covalent and Non-Covalent Btki-Resistant CLL Using the Dual Irreversible/Reversible 4 th Generation BTK Inhibitor LP-168

Britten Gordon, Elizabeth Muhowski, Janani Ravikrishnan, Samon Benrashid, Andrew Mitchell, Alexander He, Shrilekha Misra, Tzung-Huei Lai, Shanmugapriya Thangavadivel, Alexander Marr, Lianbo Yu, Brandi Walker, Elizabeth Perry, Kerry A Rogers, Adam S Kittai, Seema A Bhat, John C. Byrd, Deepa Sampath, Rosa Lapalombella, Weiguo Han, Neil E. Kay, Yi Chen, Fenlai Tan, Stephen P. Anthony, Yu Chen, Jennifer A. Woyach
Journal: Blood
Blood (2023) 142 (Supplement 1): 416.
https://doi.org/10.1182/blood-2023-178259
Published: 2023
Journal Articles

Brd4 Inhibition Abrogates Inflammation and Self-Renewal in a Murine Model of Tet2 Mutated Clonal Hematopoiesis

Alexander Marr, Madeline Halpin, Dominique Corbin, Britten Gordon, Samon Benrashid, Ethan C. Whipp, Mehdi Gharghabi, Jean Truxall, Olivia Cahn, Kristin L Koenig, Karilyn T. Larkin, Jennifer A. Woyach, Rosa Lapalombella, Nicole R. Grieselhuber
Journal: Blood
Blood (2023) 142 (Supplement 1): 4070.
https://doi.org/10.1182/blood-2023-179237
Published: 2023
Journal Articles

Cooperative Somatic Alterations in XPO1 and TNFAIP3 (A20) Promote Immune Modulation and Tissue Infiltration in Primary Mediastinal B Cell Lymphoma

Ethan C. Whipp, Janek S. Walker, Mehdi Gharghabi, Casey Cempre, Brandi Walker, Rosa Lapalombella
Journal: Blood
Blood (2023) 142 (Supplement 1): 2995.
https://doi.org/10.1182/blood-2023-189886
Published: 2023
Journal Articles

PRMT5 supports multiple oncogenic pathways in mantle cell lymphoma

Shelby L. Sloan, Fiona Brown, Mackenzie Long, Christoph Weigel, Shirsha Koirala, Ji-Hyun Chung, Betsy Pray, Lynda Villagomez, Claire Hinterschied, Anuvrat Sircar, JoBeth Helmig-Mason, Alexander Prouty, Eric Brooks, Youssef Youssef, Walter Hanel, Samir Parekh, Wing Keung Chan, Zhengming Chen, Rosa Lapalombella, Lalit Sehgal, Kris Vaddi, Peggy Scherle, Selina Chen-Kiang, Maurizio Di Liberto, Olivier Elemento, Cem Meydan, Jonathan Foox, Daniel Butler, Christopher E. Mason, Robert A. Baiocchi, Lapo Alinari
Journal: Blood
Blood (2023) 142 (10): 887–902.
https://doi.org/10.1182/blood.2022019419
Published: 2023
Includes: Supplemental data
Journal Articles

LP-118, a Selective Bcl-2 Inhibitor with Tuned Bcl-Xl Activity, Causes Myeloid Differentiation and Cell Death in Acute Myeloid Leukemia (AML)

Kristin L Koenig, Colin Brame, Steven Sher, Larry Beaver, Casey B. Cempre, Katie Williams, Matthew Purcell, Bonnie Harrington, Yi Chen, Felai Tan, Stephen P. Anthony, Yu Chen, Yue Shen, John C. Byrd, Rosa Lapalombella
Journal: Blood
Blood (2022) 140 (Supplement 1): 9068–9069.
https://doi.org/10.1182/blood-2022-170578
Published: 2022
Journal Articles

Genome-Wide CRISPR/Cas9 Knockout Screen Reveals Novel Gilteritinib Combinations Targeting Oxidative Phosphorylation and De-Novo Purine Biosynthesis Pathways for FLT3-ITD + Acute Myeloid Leukemia

Steven Sher, Pu Zhang, Lindsey Brinton, Mehdi Gharghabi, Katie Williams, Matthew Cannon, Janek S. Walker, Daniel Canfield, Larry Beaver, Casey B. Cempre, Hannah Phillips, Xuyong Chen, Pearlly S. Yan, Amy M. Lehman, Peggy Scherle, Min Wang, Kris Vaddi, Robert A. Baiocchi, Ruoning Wang, Deepa Sampath, Lapo Alinari, James S. Blachly, Rosa Lapalombella
Journal: Blood
Blood (2022) 140 (Supplement 1): 681–682.
https://doi.org/10.1182/blood-2022-165573
Published: 2022
Journal Articles

Constitutive PRMT5 Expression Drives Spontaneous Lymphoblastic Lymphoma In Vivo

Lynda Villagomez, Porsha Smith, Fengting Yan, Victor Chen, Shelby Sloan, John T. Patton, Mackenzie Long, Fiona Brown, Elshafa H. Ahmed, Natarajan Muthusamy, Vincenzo Coppola, Anjali Mishra, Kris Vaddi, Peggy Scherle, Rosa Lapalombella, Lapo Alinari, Robert A. Baiocchi
Journal: Blood
Blood (2022) 140 (Supplement 1): 6381–6382.
https://doi.org/10.1182/blood-2022-168160
Published: 2022
Journal Articles

The Multi-CDK Inhibitor Dinaciclib Shows Synergistic Activity with the BET Inhibitor PLX51107 and Reverses BET Resistance through Inhibition of Canonical Wnt Signaling in Acute Myeloid Leukemia (AML)

Alexander Marr, Soumendrakrishna Karmahapatra, Dominique Corbin, Yerdanos Asemelash, Steven Sher, Shaneice Renee Mitchell, Bonnie K Harrington, Shelley Orwick, Larry Beaver, Ronni Wasmuth, Virginia Goettl, Alice S. Mims, Karilyn T. Larkin, Sumithira Vasu, Meixiao Long, James S. Blachly, Ramiro Garzon, John C. Byrd, Rosa Lapalombella, Nicole Grieselhuber
Journal: Blood
Blood (2022) 140 (Supplement 1): 3075–3076.
https://doi.org/10.1182/blood-2022-160277
Published: 2022
Journal Articles

Dysregulation of PRMT5 in Chronic Lymphocytic Leukemia Supports Transformation to Diffuse Large B-Cell Lymphoma

Ethan Whipp, Zachary A Hing, Janek S. Walker, Steven Sher, Casey B. Cempre, Fiona Brown, Claudio Agostinelli, Stefano A Pileri, Katie Williams, Larry Beaver, Alexander Pan, Charles T. Gregory, Pearlly S. Yan, Peggy Scherle, Min Wang, Kris Vaddi, Selina Chen-Kiang, Jennifer A. Woyach, James S. Blachly, Lapo Alinari, Yiping Yang, Robert A. Baiocchi, Bradley W Blaser, Rosa Lapalombella
Journal: Blood
Blood (2022) 140 (Supplement 1): 8746–8747.
https://doi.org/10.1182/blood-2022-169949
Published: 2022
Journal Articles

PP2A is a therapeutically targetable driver of cell fate decisions via a c-Myc/p21 axis in human and murine acute myeloid leukemia

Swagata Goswami, Rajeswaran Mani, Jessica Nunes, Chi-Ling Chiang, Kevan Zapolnik, Eileen Hu, Frank Frissora, Xiaokui Mo, Logan A. Walker, Pearlly Yan, Ralf Bundschuh, Larry Beaver, Raymond Devine, Yo-Ting Tsai, Ann Ventura, Zhiliang Xie, Min Chen, Rosa Lapalombella, Alison Walker, Alice Mims, Karilyn Larkin, Nicole Grieselhuber, Chad Bennett, Mitch Phelps, Erin Hertlein, Gregory Behbehani, Sumithira Vasu, John C. Byrd, Natarajan Muthusamy
Journal: Blood
Blood (2022) 139 (9): 1340–1358.
https://doi.org/10.1182/blood.2020010344
Published: 2022
Includes: Supplemental data
Journal Articles

PRMT5 Inhibition Promotes FOXO1 Tumor Suppressor Activity to Drive a Pro-Apoptotic Program That Creates Vulnerability to Combination Treatment with Venetoclax in Mantle Cell Lymphoma

Fiona Brown, Inah Hwang, Shelby Sloan, Claire Hinterschied, JoBeth Helmig-Mason, Mackenzie Long, Youssef Youssef, Wing Keung Chan, Alexander Prouty, Ji Hyun Chung, Yang Zhang, Kris Vaddi, Selina Chen-Kiang, Maurizio Di Liberto, Olivier Elemento, Lalit Sehgal, Lapo Alinari, Peggy Scherle, Rosa Lapalombella, Jihye Paik, Robert Baiocchi
Journal: Blood
Blood (2021) 138 (Supplement 1): 681.
https://doi.org/10.1182/blood-2021-153733
Published: 2021
Journal Articles

VIP152 Is a Novel CDK9 Inhibitor with Efficacy in Chronic Lymphocytic Leukemia

Steven Sher, Larry Beaver, Katie Williams, Shelley Orwick, Brandi R. Walker, Charles Thomas Gregory, Matthew Purcell, Alexander Pan, Pearlly S. Yan, Amy J. Johnson, Melanie M. Frigault, Joy M. Greer, Ahmed Hamdy, Raquel Izumi, Stuart Hwang, James S. Blachly, John C. Byrd, Rosa Lapalombella
Journal: Blood
Blood (2021) 138 (Supplement 1): 270.
https://doi.org/10.1182/blood-2021-153812
Published: 2021
Journal Articles

PRMT5 Inhibition Modulates E2F1 and P53 to Restore Cell Cycle Regulation and Drive DNA Damage Response in Ibrutinib-Resistant Mantle Cell Lymphoma

Shelby Sloan, Fiona Brown, Mackenzie Long, JoBeth Helmig-Mason, Stacey Beck, Ji Hyun Chung, Walter Hanel, Eric Brooks, Haley Klimazewski, Cem Meydan, Jonathan Foox, Daniel Butler, John C. Byrd, Rosa Lapalombella, Maurizio Di Liberto, Christopher Mason, Selina Chen-Kiang, Kris Vaddi, Peggy Scherle, Robert Baiocchi, Lapo Alinari
Journal: Blood
Blood (2021) 138 (Supplement 1): 787.
https://doi.org/10.1182/blood-2021-153992
Published: 2021
Journal Articles

Simultaneous Disruption of XPO1 and A20 in Murine B Cells Influences Both B and T Cell Repertoire

Janek S. Walker, Casey B. Cempre, Jordan N. Skinner, Brandi R. Walker, John C. Byrd, Rosa Lapalombella
Journal: Blood
Blood (2021) 138 (Supplement 1): 1542.
https://doi.org/10.1182/blood-2021-152777
Published: 2021
Journal Articles

Identification of Novel Synthetic Lethal Partners of NAMPT Inhibitor By CRISPR-Cas9 Screens in Acute Myeloid Leukemia

Pu Zhang, Lindsey Brinton, PhD, James S. Blachly, MD, John C. Byrd, MD, Rosa Lapalombella, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2072.
https://doi.org/10.1182/blood-2019-129036
Published: 2019
Journal Articles

PRMT5 Inhibition Drives Therapeutic Vulnerability to BCL-2 Inhibition with Venetoclax and Provides Rationale for Combination Therapy in Mantle Cell Lymphoma

Fiona Brown, BS, Yang Zhang, PhD, Claire Hinterschied, Alexander Prouty, BS, Shelby Sloan, BS, JoBeth Helmig-Mason, Msc, Ji Hyun Chung, PhD, Kris Vaddi, PhD, Selina Chen-Kiang, PhD, Maurizio Di Liberto, PhD, Lapo Alinari, MD PhD, Peggy Scherle, PhD, Rosa Lapalombella, PhD, Jihye Paik, PhD, Robert A Baiocchi, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 302.
https://doi.org/10.1182/blood-2019-130797
Published: 2019