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Gregory Crimmins
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Journal Articles

RPT1G, a novel hyperbolic NAMPT inhibitor, is highly effective against B-cell non-Hodgkin's lymphoma with germinal center origin

Free
Michael Schelle, Min Wu, Francis Roushar, Timothy Jarvela, Caroline Robb, Banumathi Cole, Dennise De Jesús-Díaz, Gregory Crimmins
Journal: Blood
Blood (2025) 146 (Supplement 1): 5080.
https://doi.org/10.1182/blood-2025-5080
Published: 2025
Journal Articles

First-in-human randomized placebo-controlled Phase 1 study of RPT1G, a novel hyperbolic NAMPT inhibitor for use in acute leukemias: Safety, pharmacokinetics, and pharmacodynamics in healthy volunteers

Free
Gregory Crimmins, Thomas Polasek, Caroline Robb, Srikanth Pendyala, Michael Schelle, Timothy Jarvela, Banumathi Cole, Min Wu, Kelechi Joe-Nweke, Dennise De Jesús-Díaz
Journal: Blood
Blood (2025) 146 (Supplement 1): 5044.
https://doi.org/10.1182/blood-2025-5044
Published: 2025
Journal Articles

Phase 1, open-label, multi-center trial of RPT1G in patients with Relapsed/Refractory Acute Myeloid Leukemia and high-risk Myelodysplastic Syndromes/neoplasms

Free
Dennise De Jesús-Díaz, Aaron Goldberg, Esteban Abella, Michael Schelle, Gregory Crimmins
Journal: Blood
Blood (2025) 146 (Supplement 1): 5208.
https://doi.org/10.1182/blood-2025-5208
Published: 2025
Journal Articles

The Hyperbolic NAMPT Inhibitor RPT1G Synergizes with BCL-2 Family Inhibitors and Helps Overcome Venetoclax Resistance in Acute Myeloid Leukemia Cells

Free
Gregory Crimmins, Min Wu, Francis Roushar, Claudia F. Ramos Aguilar, Mehdi Gharghabi, Banumathi Cole, Rosa Lapalombella, Dennise A. De Jesús-Díaz
Journal: Blood
Blood (2024) 144 (Supplement 1): 4134.
https://doi.org/10.1182/blood-2024-197972
Published: 2024
Journal Articles

Venetoclax As a Combination Partner with NAMPT Inhibitor Rpt-1G for T-ALL

Free
John R. Sanchez, II, Daisy Y. Diaz Rohena, Charmelle D. Williams, Valerio Ciaurro, Min Wu, Francis Roushar, Dennise A. De Jesús-Díaz, Gregory Crimmins, Vinay Puduvalli, Francisco Vega, Palaniraja Thandapani, Deepa Sampath
Journal: Blood
Blood (2024) 144 (Supplement 1): 5900.
https://doi.org/10.1182/blood-2024-208190
Published: 2024
Journal Articles

RPT1G: A 1 st -in-Class Small Molecule NAMPT Inhibitor As a Novel Therapeutic for Acute Lymphocytic Leukemia

Free
Gregory Crimmins, Yushma Bhurruth-Alcor, Timothy Jarvela, Min Wu, Caroline M. Robb, James Digel, Parisa Moghaddam-Taaheri, Dennise A. De Jesús-Díaz
Journal: Blood
Blood (2023) 142 (Supplement 1): 419.
https://doi.org/10.1182/blood-2023-189691
Published: 2023