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Journal Articles

Venetoclax As a Combination Partner with NAMPT Inhibitor Rpt-1G for T-ALL

John R. Sanchez, II, Daisy Y. Diaz Rohena, Charmelle D. Williams, Valerio Ciaurro, Min Wu, Francis Roushar, Dennise A. De Jesús-Díaz, Gregory Crimmins, Vinay Puduvalli, Francisco Vega, Palaniraja Thandapani, Deepa Sampath
Journal: Blood
Blood (2024) 144 (Supplement 1): 5900.
https://doi.org/10.1182/blood-2024-208190
Published: 2024
Journal Articles

The Hyperbolic NAMPT Inhibitor RPT1G Synergizes with BCL-2 Family Inhibitors and Helps Overcome Venetoclax Resistance in Acute Myeloid Leukemia Cells

Gregory Crimmins, Min Wu, Francis Roushar, Claudia F. Ramos Aguilar, Mehdi Gharghabi, Banumathi Cole, Rosa Lapalombella, Dennise A. De Jesús-Díaz
Journal: Blood
Blood (2024) 144 (Supplement 1): 4134.
https://doi.org/10.1182/blood-2024-197972
Published: 2024
Journal Articles

Pharmacological Inhibition of TMPRSS6 Decreases Hemoglobin Concentration and Red Blood Cell (RBC) Hemolysis in a Mouse Model of Sickle Cell Disease

Silvia Giannini, Earl Fields, Jr., Jesse Bueno, Christopher Chambliss, Min Wu, David R Archer
Journal: Blood
Blood (2024) 144 (Supplement 1): 3863.
https://doi.org/10.1182/blood-2024-204708
Published: 2024
Journal Articles

Inhibition of Glycine Transporter 1 Reduces Phototoxicity in a Mouse Model of Erythropoietic Protoporphyria (EPP)

Yi Xiang, Min Wu, Yue Chen, Scott A Reisman, Srikanth Venkatraman, Hua Yang, Brian MacDonald
Journal: Blood
Blood (2024) 144 (Supplement 1): 2460.
https://doi.org/10.1182/blood-2024-208017
Published: 2024
Journal Articles

The Endocannabinoid N-Arachidonoyl Dopamine Induces Leukemia Cell Pyroptosis to Overcome the Venetoclax Resistance

Min Wu, Lingyun Tang, Bo Jiao, Ping Liu, Junmin Li, Ruibao Ren
Journal: Blood
Blood (2024) 144 (Supplement 1): 2206.
https://doi.org/10.1182/blood-2024-202040
Published: 2024
Journal Articles

High Remission Rates in Relapsed/Refractory Acute Myeloid Leukemia with QHRD107 (CDK9 Inhibitor), Venetoclax, and Azacitidine Combination Therapy (107VA regimen) : Preliminary Results of a Phase 2a Study

Min Wu, Yunxiang Zhang, Wen Wu, Zheng Ge, Ligen Liu, Chunyan Ji, Weiying Gu, Chunling Wang, Yanli Zhang, Wei Yang, Fuling Zhou, Zhengping Yu, Min Ji, Banghe Ding, Shudong Wang, Lijun Wei, Hengwen Song, Yan Zhou, Bomin Yin, Zhichao Shao, Mengdan Sun, Qi Jiang, Junjie Lu, Junmin Li
Journal: Blood
Blood (2024) 144 (Supplement 1): 2882.
https://doi.org/10.1182/blood-2024-199412
Published: 2024
Journal Articles

Anti-Hemojuvelin Monoclonal Antibody Reverses Anemia and Exerts Disease-Modifying Effects in a Mouse Model of Inflammatory Bowel Disease

Julia Xu, Brian MacDonald, Min Wu
Journal: Blood
Blood (2024) 144 (Supplement 1): 3849.
https://doi.org/10.1182/blood-2024-205343
Published: 2024
Journal Articles

Anti-Hemojuvelin Monoclonal Antibody Alleviated Anemia Induced By Ruxolitinib Treatment in Mice

Julia Xu, Brian MacDonald, John Quisel, Min Wu
Journal: Blood
Blood (2024) 144 (Supplement 1): 1752.
https://doi.org/10.1182/blood-2024-207686
Published: 2024
Journal Articles

Combination of Decitabine and Etoposide Is Highly Effective in Treating p53-Mutated MDS/AML Via Activating Notch Signaling

Jiexian Ma, Shunrong Sun, Min Wu, Xinyu Zuo, Mixue Xie, Xiaoqin Wang, Xiu-Jin Ye, Shuhong Shen, Yanhui Xie
Journal: Blood
Blood (2023) 142 (Supplement 1): 4131.
https://doi.org/10.1182/blood-2023-184355
Published: 2023
Journal Articles

RPT1G: A 1 st -in-Class Small Molecule NAMPT Inhibitor As a Novel Therapeutic for Acute Lymphocytic Leukemia

Gregory Crimmins, Yushma Bhurruth-Alcor, Timothy Jarvela, Min Wu, Caroline M. Robb, James Digel, Parisa Moghaddam-Taaheri, Dennise A. De Jesús-Díaz
Journal: Blood
Blood (2023) 142 (Supplement 1): 419.
https://doi.org/10.1182/blood-2023-189691
Published: 2023
Journal Articles

DISC-0974, an Anti-Hemojuvelin Antibody, Reduces Hepcidin and Mobilizes Iron in Healthy Volunteers

Natasha Novikov, Akshay Buch, Hua Yang, Sarah Tuller, Michelle Andruk, Katherine Chan, Min Wu, Richard Rodriguez, Rajiv Panwar, Haley Howell, Brian MacDonald, Will Savage
Journal: Blood
Blood (2022) 140 (Supplement 1): 5339–5340.
https://doi.org/10.1182/blood-2022-167870
Published: 2022
Journal Articles

DISC-0974, an Anti-Hemojuvelin (HJV) Monoclonal Antibody, Reduced Hepcidin and Improved Anemia in a Rat Model of Chronic Kidney Disease

Min Wu, Kathryn Wang, Brian MacDonald
Journal: Blood
Blood (2022) 140 (Supplement 1): 8153–8154.
https://doi.org/10.1182/blood-2022-169552
Published: 2022
Journal Articles

Bitopertin, a Selective Glycine Transporter 1 Inhibitor, Reduced Protoporphyrin IX (PPIX) Level and Improved Liver Fibrosis in a Mouse Model of Erythropoietic Protoporphyria (EPP)

Min Wu, Sarah Ducamp, Yi Xiang, Juan Putra, Mark D. Fleming, Brian MacDonald, Paul J Schmidt
Journal: Blood
Blood (2022) 140 (Supplement 1): 8192–8193.
https://doi.org/10.1182/blood-2022-168924
Published: 2022
Journal Articles

Preclinical Pharmacokinetics and Pharmacodynamics of DISC-0998, a Humanized Anti-Hemojuvelin (HJV) Monoclonal Antibody to Suppress the Production of Hepcidin

Yue Chen, Will Savage, Rajiv Panwar, Richard Rodriguez, Min Wu, John Quisel, Hua Yang
Journal: Blood
Blood (2022) 140 (Supplement 1): 8184–8185.
https://doi.org/10.1182/blood-2022-168985
Published: 2022
Journal Articles

Targeting Bfl-1 via acute CDK9 inhibition overcomes intrinsic BH3-mimetic resistance in lymphomas

Scott Boiko, Theresa Proia, Maryann San Martin, Gareth P. Gregory, Michelle Min Wu, Neeraj Aryal, Maureen Hattersley, Wenlin Shao, Jamal C. Saeh, Stephen E. Fawell, Ricky W. Johnstone, Lisa Drew, Justin Cidado
Journal: Blood
Blood (2021) 137 (21): 2947–2957.
https://doi.org/10.1182/blood.2020008528
Published: 2021
Includes: Supplemental data
Journal Articles

Improved clinical symptoms and mortality among patients with severe or critical COVID-19 after convalescent plasma transfusion

Clinical Trials & Observations
Xinyi Xia, Kening Li, Lingxiang Wu, Zhihua Wang, Mengyan Zhu, Bin Huang, Jie Li, Ziyu Wang, Wei Wu, Min Wu, Wanlin Li, Lu Li, Yun Cai, Bakwatanisa Bosco, Aifang Zhong, Xiong Liu, Tangfeng Lv, Zhenhua Gan, Guang Chen, Yunhu Pan, Caidong Liu, Kai Zhang, Xiaoli Xu, Changjun Wang, Qianghu Wang
Journal: Blood
Blood (2020) 136 (6): 755–759.
https://doi.org/10.1182/blood.2020007079
Published: 2020
Includes: Supplemental data
Journal Articles

DOCK2 Expression Affects Leukemogenesis and Disease Progression in a Murine Model of FLT3/ITD Acute Myeloid Leukemia

Min Wu, PhD, Li Li, MD PhD, Donald Small, MD PhD, Amy S. Duffield, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2534.
https://doi.org/10.1182/blood-2019-129157
Published: 2019
Journal Articles

Akt2 Mediates Glucocorticoid Resistance in Acute Lymphoblastic Leukemia through FoxO3a/Bim Axis and Serves As a Direct Target for Resistance Reversal

Mixue Xie, Yanhui Xie, PhD, Apeng Yang, MD, Jiexian Ma, MD, Min Wu, Youxin Jin, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 3955.
https://doi.org/10.1182/blood-2018-99-110496
Published: 2018
Journal Articles

DOCK2 Knockdown Mitigates Disease Progression in Murine Models Harboring a FLT3/ITD Mutation

Min Wu, PhD, Li Li, MD PhD, Bao Nguyen, MS, Donald Small, MD PhD, Amy S. Duffield, MD PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 1216.
https://doi.org/10.1182/blood.V130.Suppl_1.1216.1216
Published: 2017
Journal Articles

FLT3/ITD Cooperates with Rac1/DOCK2 to Modulate the Sensitivity of Leukemic Cells to Chemotherapeutic Agents Via Regulation of DNA Repair Pathways

Min Wu, PhD, Li Li, PhD, Max Hamaker, BA, Donald Small, MD PhD, Amy S. Duffield, MD PhD
Journal: Blood
Blood (2016) 128 (22): 2732.
https://doi.org/10.1182/blood.V128.22.2732.2732
Published: 2016