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Journal Articles

Real-World Clinical Outcomes of Daratumumab-Based Regimens in Chinese Patients with Multiple Myeloma By Cytogenetic Risk: A Subgroup Analysis of the MMY4032 Study

Luqun Wang, Wei Yang, Ting Niu, Yafei Wang, Rong Fu, Yuping Zhong, Kaiyang Ding, Kai Sun, Baijun Fang, Hong Liu, Wenbin Qian, Hui Liu, Yanhui Li, Yishen Yang, Jianmin Zhuo, Xi Chen, Canchan Cui, Jin Lu
Journal: Blood
Blood (2024) 144 (Supplement 1): 7874.
https://doi.org/10.1182/blood-2024-201134
Published: 2024
Journal Articles

Safety and Efficacy of Rocbrutinib in Patients with Relapsed/Refractory Marginal Zone Lymphoma

Yuqin Song, Qingqing Cai, Keshu Zhou, Ming Jiang, Zhengming Jin, Lei Zhang, Xiuhua Sun, Haiyan Yang, Lanfang Li, Kaiyang Ding, Junyuan Qi, Hongmei Jing, Wei Yang, Min Zhou, Jun Ma, Zhigang Peng, Wei Xu, Hui Zhou, Li Yu, Yuankai Shi, Guohui Cui, Zheng Wang, Nawei Liu, Yejiang Lou, Yue Shen, Yi Chen, Fenlai Tan, Jun Zhu
Journal: Blood
Blood (2024) 144 (Supplement 1): 1635.
https://doi.org/10.1182/blood-2024-194572
Published: 2024
Journal Articles

In-Class Transition (iCT) of Proteasome Inhibitor-Based Therapy Prolongs Progression-Free Survival in High-Risk Myeloma Patients: A Real-World Chinese Cohort Study

Rong Fu, Hong Yu, Aijun Liu, Rui Hou, Zunmin Zhu, Junling Zhuang, Li Bao, Zhenling Li, Lihong Liu, Luoming Hua, Yanping Ma, Da Gao, ARong Jin, Xiaohui Suo, Wei Yang, Yuansong Bai, Deqiang Zheng, Wenming Chen
Journal: Blood
Blood (2024) 144 (Supplement 1): 7846.
https://doi.org/10.1182/blood-2024-209471
Published: 2024
Journal Articles

Age-Related Changes in Hematopoietic Stem Cell Proteostasis Promote the Emergence of Clonal Hematopoiesis and Leukemia in Older Adults

Fanny Jiahua J. Zhou, Helen C. Wang, Michelle K. Le, Wei Yang, Mary Jean Sunshine, Jeffrey A. Magee, Robert Signer
Journal: Blood
Blood (2024) 144 (Supplement 1): 4047.
https://doi.org/10.1182/blood-2024-202652
Published: 2024
Journal Articles

A Novel JAK2 Inhibitor OB756 in Treatment of Janus Kinase Inhibitor-Naive Patients with Myelofibrosis: A Phase 1/2, Open-Label, Multicenter Study

Yile Zhou, Jian Huang, Bingbing Wen, Hu Zhou, Wei Yang, Lianlian Fan, Tiejun Gong, Sujun Gao, Zongjiu Jiao, Qingchi Liu, Lidong Zhao, Guocai Wu, Cuicui Wu, Jun Wang, Jin Zhang, Jiaping Fu, Zengmei Sheng, Zunmin Zhu, Jian Lu, Yi Zhang, Jie Jin
Journal: Blood
Blood (2024) 144 (Supplement 1): 1808.
https://doi.org/10.1182/blood-2024-212216
Published: 2024
Journal Articles

First in-Class JAK2 Inhibitor OB756 Therapy for Patients with Polycythemia Vera : A Phase 2, Open-Label, Multicenter Study

Jian Huang, Bingbing Wen, Tiejun Gong, Hu Zhou, Lihong Shou, Qingchi Liu, Feng Zhang, Cuicui WU, Wei Yang, Lidong Zhao, Lili Chen, Jian Lu, Yile Zhou, Yi Zhang, Jie Jin
Journal: Blood
Blood (2024) 144 (Supplement 1): 3180.
https://doi.org/10.1182/blood-2024-210330
Published: 2024
Journal Articles

Phase 1 Study of TT-01488, a Novel, Non-Covalent, Reversible BTK Inhibitor, in Patients with Relapsed or Refractory B-Cell Malignancies

Yufu Li, Wei Xu, Caixia Li, Pengcheng He, Wei Yang, Xiangmin Tong, Ying Wang, Hongchan Zhang, Caixia Sun, Zejuan Sheng, Jean Fan, Jianyong Li
Journal: Blood
Blood (2024) 144 (Supplement 1): 3036.
https://doi.org/10.1182/blood-2024-202976
Published: 2024
Journal Articles

Rocbrutinib, a New-Generation BTK Inhibitor, Demonstrates Safety and Efficacy in Relapsed/Refractory Non-GCB Diffuse Large B Cell Lymphoma

Yuqin Song, Qingqing Cai, Keshu Zhou, Ming Jiang, Zhengming Jin, Lei Zhang, Xiuhua Sun, Haiyan Yang, Lanfang Li, Kaiyang Ding, Junyuan Qi, Hongmei Jing, Wei Yang, Min Zhou, Jun Ma, Zhigang Peng, Wei Xu, Hui Zhou, Li Yu, Yuankai Shi, Guohui Cui, Zheng Wang, Nawei Liu, Yejiang Lou, Yue Shen, Yi Chen, Fenlai Tan, Jun Zhu
Journal: Blood
Blood (2024) 144 (Supplement 1): 3119.
https://doi.org/10.1182/blood-2024-194561
Published: 2024
Journal Articles

Subgroup Analyses of Phase 2 Study: Evaluating the Efficacy of Fully Human BCMA-Targeting CAR T Cells (Zevorcabtagene Autoleucel) in Patients with Relapsed/Refractory Multiple Myeloma

Wenming Chen, Chengcheng Fu, Baijun Fang, Aibin Liang, Zhongjun Xia, Yanjuan He, Jin Lu, Hui Liu, Ming Hou, Zhen Cai, Wei Yang, Siguo Hao, Songfu Jiang, Hongmei Jing, Jing Liu, Xin Du, Rong Fu, Heng Mei, Zunmin Zhu, Yanli Yang, Hong Liu, Xingxing Meng, Nishanthan Rajakumaraswamy, Wei Zheng, Huamao Wang, Zonghai Li
Journal: Blood
Blood (2024) 144 (Supplement 1): 4762.
https://doi.org/10.1182/blood-2024-204620
Published: 2024
Journal Articles

SG301, a Novel Anti-CD38 Monoclonal Antibody, in Patients with Relapsed/Refractory Multiple Myeloma: A First-in-Human, Multicentre, Phase 1 Trial

Ying Tian, Keshu Zhou, Quande Lin, Wenbin Qian, Wei Yang, Li Bao, Guolin Yuan, Xiaojing Yan, Liangming Ma, Xin Zhou, Lihong Liu, Fangbing Zhu, Xuelan Zuo, Xin Du, Xu Ji, Xuzhao Zhang, Jing Shen, Hai Zhou, Na Li, Wenming Chen
Journal: Blood
Blood (2024) 144 (Supplement 1): 4746.
https://doi.org/10.1182/blood-2024-199381
Published: 2024
Journal Articles

Fetal Differentiation Programs Afford a Protective Barrier to NUP98 Fusion-Driven AML That Dissipates Shortly after Birth

Jihye Yoon, Elisabeth Denby, Wei Yang, Emily B. Casey, Riddhi M. Patel, Yanan Li, J. Michael White, Luis Batista, Jeffrey A. Magee
Journal: Blood
Blood (2024) 144 (Supplement 1): 630.
https://doi.org/10.1182/blood-2024-194913
Published: 2024
Journal Articles

EZH2-Mediated Methylation Regulates JARID2 Protein Stability in Normal and Neoplastic Hematopoiesis

Hassan Bjeije, Wentao Han, Hamza Celik, Yanan Li, Michael P. Rettig, Andrew L Young, Saranajith Dunuwille, Nancy Issa, Wei Yang, Jeffrey A. Magee, Grant A Challen
Journal: Blood
Blood (2024) 144 (Supplement 1): 628.
https://doi.org/10.1182/blood-2024-202827
Published: 2024
Journal Articles

Loss of BCLAF1 Impairs AML Pathogenesis

Neetij Krishnan, Stephanie Crowley, Lynn S. White, Wei Yang, Jeffrey A. Magee, Jeffrey J. Bednarski
Journal: Blood
Blood (2024) 144 (Supplement 1): 1335.
https://doi.org/10.1182/blood-2024-203794
Published: 2024
Journal Articles

LY4152199, a First-in-Class BAFF-RxCD3 Bispecific Antibody for the Treatment of B Cell Malignancies

Wei Yang, Colleen Burns, Kevin Lindquist, Julie Dobkin, Hee Rae Shin, Cindy Nguyen, Xiaodong Huang, Whitney Helms, Nicholas Arce, Yvonne Mak, Audrey Au, Abraham Abouzeid, Marta Witek, Ching Ching Leow, Xueqian Gong, Mohan Srinivasan, Joshua I. Park, Kyla Driscoll, Andrew Hass, Rikke Holmgaard, Omar Duramad, Kristin Bedard
Journal: Blood
Blood (2024) 144 (Supplement 1): 2785.
https://doi.org/10.1182/blood-2024-200316
Published: 2024
Journal Articles

High Remission Rates in Relapsed/Refractory Acute Myeloid Leukemia with QHRD107 (CDK9 Inhibitor), Venetoclax, and Azacitidine Combination Therapy (107VA regimen) : Preliminary Results of a Phase 2a Study

Min Wu, Yunxiang Zhang, Wen Wu, Zheng Ge, Ligen Liu, Chunyan Ji, Weiying Gu, Chunling Wang, Yanli Zhang, Wei Yang, Fuling Zhou, Zhengping Yu, Min Ji, Banghe Ding, Shudong Wang, Lijun Wei, Hengwen Song, Yan Zhou, Bomin Yin, Zhichao Shao, Mengdan Sun, Qi Jiang, Junjie Lu, Junmin Li
Journal: Blood
Blood (2024) 144 (Supplement 1): 2882.
https://doi.org/10.1182/blood-2024-199412
Published: 2024
Journal Articles

Preliminary Results of Patients with Myelofibrosis (MF) from a Phase I Trial of Jab-8263, a Potent BET Inhibitor

Junyuan Qi, Bo Jiang, Wei Yang, Xudong Wei, Hongmei Jing, Yongping Song, Andrea Wang-Gillam, Yuli Ding, Chao Bi, Ting Zhang
Journal: Blood
Blood (2024) 144 (Supplement 1): 4567.
https://doi.org/10.1182/blood-2024-209977
Published: 2024
Journal Articles

Phase 1/2 Studies of DZD8586, a Non-Covalent BBB Penetrant LYN/BTK Dual Inhibitor, in BTK Inhibitor Resistant Chronic Lymphocytic Leukemia (CLL) and Other B-Cell Non-Hodgkin Lymphoma (B-NHL)

Yuqin Song, Keshu Zhou, Hongmei Jing, Geoffrey Chong, Jianqiu Wu, Wei Liu, Zengjun Li, Ming Jiang, Mei Lan, Kaiyang Ding, Guohui CUI, Tingyu Wang, Xutao Guo, Sujun Gao, Constantine S. Tam, Haiyan Yang, Fang Zhu, Wei Yang, Jian-Qing Mi, Liping Su, Ke Fang, Ziyi Liu, Lindsey Roeker, Chan Y. Cheah, Jianyong Li, Lu-Gui Qiu
Journal: Blood
Blood (2024) 144 (Supplement 1): 3248.
https://doi.org/10.1182/blood-2024-197877
Published: 2024
Journal Articles

A predictive model for therapy failure in patients with chronic myeloid leukemia receiving tyrosine kinase inhibitor therapy

Clinical Trials & Observations
Xiaoshuai Zhang, Bingcheng Liu, Jian Huang, Yanli Zhang, Na Xu, Robert Peter Gale, Weiming Li, Xiaoli Liu, Huanling Zhu, Ling Pan, Yunfan Yang, Hai Lin, Xin Du, Rong Liang, Chunyan Chen, Xiaodong Wang, Guohui Li, Zhuogang Liu, Yanqing Zhang, Zhenfang Liu, Jianda Hu, Chunshui Liu, Fei Li, Wei Yang, Li Meng, Yanqiu Han, Li’e Lin, Zhenyu Zhao, Chuanqing Tu, Caifeng Zheng, Yanliang Bai, Zeping Zhou, Suning Chen, Huiying Qiu, Lijie Yang, Xiuli Sun, Hui Sun, Li Zhou, Zelin Liu, Danyu Wang, Jianxin Guo, Liping Pang, Qingshu Zeng, Xiaohui Suo, Weihua Zhang, Yuanjun Zheng, Xiaojun Huang, Qian Jiang
Journal: Blood
Blood (2024) 144 (18): 1951–1961.
https://doi.org/10.1182/blood.2024024761
Published: 2024
Includes: Supplemental data
Journal Articles

A Novel Dual Covalent and Non-Covalent Next Generation Inhibitor of Bruton's Tyrosine Kinase LP-168 in Patients with Relapsed/Refractory B Cell Non-Hodgkin Lymphoma: Safety and Efficacy Results from a Phase 1 Study

Yuqin Song, Qingqing Cai, Ming Jiang, Keshu Zhou, Lei Zhang, Xiuhua Sun, Zhengming Jin, Lanfang Li, Hongmei Jing, Zhigang Peng, Haiyan Yang, Junyuan Qi, Hui Zhou, Wei Yang, Min Zhou, Chunyan Ji, Wei Xu, Kaiyang Ding, Li Yu, Zheng Wang, Nawei Liu, Yejiang Lou, Yue Shen, Yi Chen, Fenlai Tan, Jun Zhu
Journal: Blood
Blood (2023) 142 (Supplement 1): 4400.
https://doi.org/10.1182/blood-2023-180485
Published: 2023
Journal Articles

Safety and Efficacy Results from the Phase I Study of a Novel Dual Covalent and Non-Covalent Next Generation Inhibitor of Bruton's Tyrosine Kinase LP-168 in Patients with Relapsed/Refractory Mantle Cell Lymphoma

Yuqin Song, Qingqing Cai, Ming Jiang, Keshu Zhou, Lei Zhang, Xiuhua Sun, Zhengming Jin, Lanfang Li, Hongmei Jing, Zhigang Peng, Haiyan Yang, Junyuan Qi, Hui Zhou, Wei Yang, Min Zhou, Chunyan Ji, Wei Xu, Kaiyang Ding, Li Yu, Zheng Wang, Nawei Liu, Yejiang Lou, Yue Shen, Yi Chen, Fenlai Tan, Jun Zhu
Journal: Blood
Blood (2023) 142 (Supplement 1): 3033.
https://doi.org/10.1182/blood-2023-180694
Published: 2023