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Journal Articles

The Proteostasis Network Is a Therapeutic Target in Acute Myeloid Leukemia

Kentson Lam, Yoon Joon Kim, Carlo M. Ong, Andrea Z. Liu, Fanny Jiahua Jiahua Zhou, Bernadette A. Chua, Silvia Vicenzi, Pierce W. Ford, Jie-Hua Zhou, Eric Bennett, Leslie A Crews, Edward D. Ball, Robert Signer

Blood (2024) 144 (Supplement 1): 2767.

https://doi.org/10.1182/blood-2024-204380

Published: 2024

Journal Articles

Dynamic Changes in Proteostasis Network Activity Influence Hematopoietic Stem Cell Ontogeny and Human Umbilical Cord Blood Fitness

Helena Yu, Robert Signer

Blood (2024) 144 (Supplement 1): 2658.

https://doi.org/10.1182/blood-2024-203968

Published: 2024

Journal Articles

Loss of Microtubule Protein Stathmin-1 Impairs Autophagy in Hematopoietic Stem Cells

Luana Chiquetto Paracatu, Qian Dong, Mia G Warmka, Liana Valin, Patrick Hunt, Ashley Jones, Meg Schuetz, Mousumi Chakraborty, Zev Greenberg, Christine RC Zhang, Grant A Challen, Cliff Luke, Robert Signer, Wandy Beatty, David Kast, Stephen Sykes, Laura G. Schuettpelz

Blood (2024) 144 (Supplement 1): 4041.

https://doi.org/10.1182/blood-2024-208205

Published: 2024

Journal Articles

Age-Related Changes in Hematopoietic Stem Cell Proteostasis Promote the Emergence of Clonal Hematopoiesis and Leukemia in Older Adults

Fanny Jiahua J. Zhou, Helen C. Wang, Michelle K. Le, Wei Yang, Mary Jean Sunshine, Jeffrey A. Magee, Robert Signer

Blood (2024) 144 (Supplement 1): 4047.

https://doi.org/10.1182/blood-2024-202652

Published: 2024

Journal Articles

Disrupting Autophagy Sensitizes Human Acute Myeloid Leukemia Cells to Proteasome Inhibition By Disrupting Protein Homeostasis

Kentson Lam, Yoon Joon Kim, Carlo M. Ong, Andrea Liu, Bernadette Chua, Jie-Hua Zhou, Edward D. Ball, Robert Signer

Blood (2023) 142 (Supplement 1): 2805.

https://doi.org/10.1182/blood-2023-182149

Published: 2023

Journal Articles

TGFβ1 Secretion in Megakaryocytes Is Autophagy-Dependent and Its Inhibition Ameliorates Myelofibrosis in Mice

Isabelle C. Becker, Maria N. Barrachina, Virginia Camacho, Harvey G. Roweth, Julia Tilburg, Bernadette Chua, Zoltan Nagy, Maximilian Englert, Kellie R. Machlus, Robert Signer, Bernhard Nieswandt, Joseph E. Italiano

Blood (2023) 142 (Supplement 1): 744.

https://doi.org/10.1182/blood-2023-174409

Published: 2023

Journal Articles

Protein Homeostasis Is Dynamically Regulated throughout Hematopoietic Stem Cell Ontogeny

Robert Signer, Helena Yu

Blood (2022) 140 (Supplement 1): 2861.

https://doi.org/10.1182/blood-2022-167839

Published: 2022

Journal Articles

A Stress Response Pathway That Enhances Hematopoietic Stem Cell Longevity Promotes Acute Myeloid Leukemia Growth and Progression

Yoon Joon Kim, Kentson Lam, Fanny Zhou, Carlo M Ong, Jeffrey A. Magee, Robert Signer

Blood (2022) 140 (Supplement 1): 5872.

https://doi.org/10.1182/blood-2022-170243

Published: 2022

Journal Articles

Hematopoietic Stem Cells Depend upon Aggrephagy to Maintain Protein Homeostasis and Self-Renewal Activity

Bernadette Anne Chua, Connor J Lennan, Mary Jean Sunshine, Ashu Chawla, Lorena H San Jose, Daniela Dreifke, Eric J Bennett, Robert Signer

Blood (2022) 140 (Supplement 1): 5723.

https://doi.org/10.1182/blood-2022-163857

Published: 2022

Journal Articles

Proteostasis and Myeloid Stem Cell Production

Robert Signer, PhD

Blood (2019) 134 (Supplement_1): SCI-42.

https://doi.org/10.1182/blood-2019-121085

Published: 2019

Journal Articles

Mitochondria Coordinate Intracellular Metabolism and Epigenetic Gene Regulation during Erythropoiesis

Xin Liu, PhD, Yuannyu Zhang, PhD, Min Ni, PhD, Hui Cao, M.S., Robert Signer, PhD, Dan Li, B.S., Zhimin Gu, PhD, Zeping Hu, PhD, Navdeep Chandel, Ralph DeBerardinis, MD PhD, Feng Zhou, PhD, Zhen Shao, PhD, Jian Xu, PhD

Blood (2016) 128 (22): 1038.

https://doi.org/10.1182/blood.V128.22.1038.1038

Published: 2016

Journal Articles

Quantitative Proteomic and Transcriptomic Analysis Reveals Post-Transcriptional Regulation of Mitochondrial Biogenesis during Erythropoiesis

Xin Liu, PhD, Yuannyu Zhang, PhD, Feng Zhou, PhD, Zhen Shao, PhD, Robert Signer, PhD, Hui Cao, M.S., Zeping Hu, PhD, Ralph DeBerardinis, MD PhD, Jian Xu, PhD

Blood (2015) 126 (23): 47.

https://doi.org/10.1182/blood.V126.23.47.47

Published: 2015

NARROW

The Proteostasis Network Is a Therapeutic Target in Acute Myeloid Leukemia

Dynamic Changes in Proteostasis Network Activity Influence Hematopoietic Stem Cell Ontogeny and Human Umbilical Cord Blood Fitness

Loss of Microtubule Protein Stathmin-1 Impairs Autophagy in Hematopoietic Stem Cells

Age-Related Changes in Hematopoietic Stem Cell Proteostasis Promote the Emergence of Clonal Hematopoiesis and Leukemia in Older Adults

Disrupting Autophagy Sensitizes Human Acute Myeloid Leukemia Cells to Proteasome Inhibition By Disrupting Protein Homeostasis

TGFβ1 Secretion in Megakaryocytes Is Autophagy-Dependent and Its Inhibition Ameliorates Myelofibrosis in Mice

Protein Homeostasis Is Dynamically Regulated throughout Hematopoietic Stem Cell Ontogeny

A Stress Response Pathway That Enhances Hematopoietic Stem Cell Longevity Promotes Acute Myeloid Leukemia Growth and Progression

Hematopoietic Stem Cells Depend upon Aggrephagy to Maintain Protein Homeostasis and Self-Renewal Activity

Proteostasis and Myeloid Stem Cell Production

Mitochondria Coordinate Intracellular Metabolism and Epigenetic Gene Regulation during Erythropoiesis

Quantitative Proteomic and Transcriptomic Analysis Reveals Post-Transcriptional Regulation of Mitochondrial Biogenesis during Erythropoiesis

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American Society of Hematology

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ASH Publications

American Society of Hematology

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