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Journal Articles

Dnmt3a Controls Hematopoietic Stem Cells Via DNA Methylation-Independent Regulation of Telomeres

Infencia Xavier Raj, Won Kyun Koh, Jessica Harrison, Christine RC Zhang, Barbara Soares, Aishwarya Krishnan, Hassan Bjeije, Tyler M Parsons, Wentao Han, Andrew L Young, Ting Wang, Luis Batista, Grant A Challen

Blood (2024) 144 (Supplement 1): 25.

https://doi.org/10.1182/blood-2024-203958

Published: 2024

Journal Articles

In Vivo and Ex Vivo Expansion of Functional Human Repopulating Cells through JARID2 Inhibition

Wentao Han, Hassan Bjeije, Hamza Celik, Michael P. Rettig, Yanan Li, Andrew L Young, Christine RC Zhang, Infencia Xavier Raj, Saranajith Dunuwille, Grant A Challen

Blood (2024) 144 (Supplement 1): 3398.

https://doi.org/10.1182/blood-2024-211397

Published: 2024

Journal Articles

JAK2 V617F Mutant MPN Cells Support Parallel Evolution of Independent Leukemic Clones

Tyler M Parsons, Aishwarya Krishnan, Andrew L Young, Maggie Cox, Stephen Oh, Grant A Challen

Blood (2024) 144 (Supplement 1): 755.

https://doi.org/10.1182/blood-2024-203680

Published: 2024

Journal Articles

EZH2-Mediated Methylation Regulates JARID2 Protein Stability in Normal and Neoplastic Hematopoiesis

Hassan Bjeije, Wentao Han, Hamza Celik, Yanan Li, Michael P. Rettig, Andrew L Young, Saranajith Dunuwille, Nancy Issa, Wei Yang, Jeffrey A. Magee, Grant A Challen

Blood (2024) 144 (Supplement 1): 628.

https://doi.org/10.1182/blood-2024-202827

Published: 2024

Journal Articles

Loss of Microtubule Protein Stathmin-1 Impairs Autophagy in Hematopoietic Stem Cells

Luana Chiquetto Paracatu, Qian Dong, Mia G Warmka, Liana Valin, Patrick Hunt, Ashley Jones, Meg Schuetz, Mousumi Chakraborty, Zev Greenberg, Christine RC Zhang, Grant A Challen, Cliff Luke, Robert Signer, Wandy Beatty, David Kast, Stephen Sykes, Laura G. Schuettpelz

Blood (2024) 144 (Supplement 1): 4041.

https://doi.org/10.1182/blood-2024-208205

Published: 2024

Journal Articles

RSK1 Is an Exploitable Dependency in Myeloid Malignancies

Tim Kong, Angelo B. A. Laranjeira, LaYow Yu, Jared Scott Fowles, Daniel A.C. Fisher, Sherwin Ng, Wei Yang, Fan He, Maggie J Cox, Mary C. Fulbright, Stacey L. Rentschler, My-my Huynh, Gerrit Los, Sandra E. Dunn, Grant A Challen, Stephen T. Oh

Blood (2023) 142 (Supplement 1): 46.

https://doi.org/10.1182/blood-2023-182320

Published: 2023

Journal Articles

Understanding the Functional Differences between PRC2.1 and PRC2.2 in Hematopoiesis

Hassan Bjeije, Nancy Issa, Wentao Han, Yanan Li, Wei Yang, Jeffrey Magee, Grant A Challen

Blood (2023) 142 (Supplement 1): 1311.

https://doi.org/10.1182/blood-2023-184884

Published: 2023

Journal Articles

Inactivation of DNA Polymerase Theta (PolΘ) Is Synthetic Lethal in DNMT3A Mutated Myeloid Malignancies - Potential Clinical Applications

Bac Viet Le, Umeshkumar Vekariya, Monika Toma, Margaret Nieborowska-Skorska, Marie-Christine Caron, George Vassiliou, Malgorzata Gozdecka, Zayd Haydar, Gurushankar Chandramouly, Emir Hadzijusufovic, Wolfgang R. Sperr, Richard Pomerantz, Peter Valent, Jean-Yves Masson, Gaorav Gupta, Grant A Challen, Tomasz Skorski

Blood (2023) 142 (Supplement 1): 580.

https://doi.org/10.1182/blood-2023-174333

Published: 2023

Journal Articles

Stathmin-1 Regulates Hematopoietic Stem Cell Mitochondrial and Cellular Function

Luana Chiquetto Paracatu, Qian Dong, Mia G Warmka, Liana Valin, Mousumi Chakraborty, Zev Greenberg, Nate Roundy, Christine RC Zhang, Grant A Challen, Cliff Luke, Wandy Beatty, Stephen M Sykes, Laura G. Schuettpelz

Blood (2023) 142 (Supplement 1): 4045.

https://doi.org/10.1182/blood-2023-189443

Published: 2023

Journal Articles

The Tetraspanin CD53 Promotes the Clonal Advantage of Dnmt3a-Deficient Hematopoietic Stem Cells

Mia G Warmka, Luana Chiquetto Paracatu, Mousumi Chakraborty, Qian Dong, Nate Roundy, Grant A Challen, Laura G. Schuettpelz

Blood (2023) 142 (Supplement 1): 5602.

https://doi.org/10.1182/blood-2023-180980

Published: 2023

Journal Articles

Leukemic Driver Clones Can Arise Independently and Outcompete MPN Cells in Post-MPN Secondary AML

Tyler M Parsons, Andrew L Young, Daniel A.C. Fisher, Maggie J Cox, Stephen T. Oh, Grant A Challen

Blood (2023) 142 (Supplement 1): 1784.

https://doi.org/10.1182/blood-2023-186610

Published: 2023

Journal Articles

Methods to Elucidate Hematopoietic Clonal Organization in Bone Marrow

Andrew L Young, Hannah C Davis, Maggie J Cox, Tyler M Parsons, Samantha C Burkart, Stephen T. Oh, Grant A Challen

Blood (2023) 142 (Supplement 1): 5595.

https://doi.org/10.1182/blood-2023-179367

Published: 2023

Journal Articles

Using a Humanized Animal Model to Determine the Minimum JAK2 V617F Mutant Allele Burden Required to Generate MPN Pathologies

Tyler M. Parsons, Aishwarya Krishnan, Wentao Han, Andrew L Young, Grant A Challen

Blood (2022) 140 (Supplement 1): 6744–6745.

https://doi.org/10.1182/blood-2022-165335

Published: 2022

Journal Articles

Spatial Organization of Hematopoietic Clones in the Bone Marrow of a Patient with Polycythemia Vera

Andrew L Young, Hannah C Davis, David H Spencer, Timothy J Ley, Stephen T Oh, Matthew J Walter, Grant A Challen

Blood (2022) 140 (Supplement 1): 2910–2911.

https://doi.org/10.1182/blood-2022-167351

Published: 2022

Journal Articles

DNMT3A Mutations Enhance T-ALL Survival, Which Is Reversed By JAK/STAT Inhibition

Wangisa M.B. Dunuwille, William Casey Wilson, Nancy Issa, Won Kyun Koh, Wentao Han, Grant A Challen

Blood (2022) 140 (Supplement 1): 8756–8757.

https://doi.org/10.1182/blood-2022-167136

Published: 2022

Journal Articles

The PRC2 Co-Factor JARID2 Regulates Hematopoiesis through Non-Canonical Mechanisms

Hassan Bjeije, Infencia Xavier Raj, Hamza Celik, Nancy Issa, Wentao Han, Jason Arand, Grant A Challen

Blood (2022) 140 (Supplement 1): 8578–8579.

https://doi.org/10.1182/blood-2022-164743

Published: 2022

Journal Articles

Dnmt3a Loss-of-Function Enhances DNA Repair in Proliferative HSCs Under Inflammatory Stress

Christine R Zhang, Jason Arand, Wentao Han, Infencia Xavier Raj, Saranajith Dunuwille, Grant A Challen

Blood (2022) 140 (Supplement 1): 983–984.

https://doi.org/10.1182/blood-2022-167238

Published: 2022

Journal Articles

The Role of Stathmin-1 in the Regulation of Hematopoietic Stem Cells

Luana Chiquetto Paracatu, Qian Dong, Zev J. Greenberg, Liana Valin, Nate Roundy, Christine R Zhang, Grant A Challen, Cliff Luke, Stephen M. Sykes, Laura G. Schuettpelz

Blood (2022) 140 (Supplement 1): 5734–5735.

https://doi.org/10.1182/blood-2022-166665

Published: 2022

Journal Articles

DUSP6 Mediates Resistance to JAK2 Inhibition and Drives Myeloproliferative Neoplasm Disease Progression

Tim Kong, Angelo BA Laranjeira, Kangning Yang, Daniel AC Fisher, LaYow Yu, Anthony Z Wang, Marianna B. Ruzinova, Jared S. Fowles, Maggie J. Allen, Hamza Celik, Grant A. Challen, Sidong Huang, Stephen T. Oh

Blood (2021) 138 (Supplement 1): 55.

https://doi.org/10.1182/blood-2021-147455

Published: 2021

Journal Articles

The Histone Demethylase KDM6B Is a Genetic Dependency of NOTCH1-Driven T-ALL

Nancy Issa, Hamza Celik, Hassan Bjeije, Wangisa M.B. Dunuwille, Won Kyun Koh, Tyler Parsons, Christine R Zhang, Wentao Han, Grant A. Challen

Blood (2021) 138 (Supplement 1): 782.

https://doi.org/10.1182/blood-2021-150790

Published: 2021

NARROW

Dnmt3a Controls Hematopoietic Stem Cells Via DNA Methylation-Independent Regulation of Telomeres

In Vivo and Ex Vivo Expansion of Functional Human Repopulating Cells through JARID2 Inhibition

JAK2 V617F Mutant MPN Cells Support Parallel Evolution of Independent Leukemic Clones

EZH2-Mediated Methylation Regulates JARID2 Protein Stability in Normal and Neoplastic Hematopoiesis

Loss of Microtubule Protein Stathmin-1 Impairs Autophagy in Hematopoietic Stem Cells

RSK1 Is an Exploitable Dependency in Myeloid Malignancies

Understanding the Functional Differences between PRC2.1 and PRC2.2 in Hematopoiesis

Inactivation of DNA Polymerase Theta (PolΘ) Is Synthetic Lethal in DNMT3A Mutated Myeloid Malignancies - Potential Clinical Applications

Stathmin-1 Regulates Hematopoietic Stem Cell Mitochondrial and Cellular Function

The Tetraspanin CD53 Promotes the Clonal Advantage of Dnmt3a-Deficient Hematopoietic Stem Cells

Leukemic Driver Clones Can Arise Independently and Outcompete MPN Cells in Post-MPN Secondary AML

Methods to Elucidate Hematopoietic Clonal Organization in Bone Marrow

Using a Humanized Animal Model to Determine the Minimum JAK2 V617F Mutant Allele Burden Required to Generate MPN Pathologies

Spatial Organization of Hematopoietic Clones in the Bone Marrow of a Patient with Polycythemia Vera

DNMT3A Mutations Enhance T-ALL Survival, Which Is Reversed By JAK/STAT Inhibition

The PRC2 Co-Factor JARID2 Regulates Hematopoiesis through Non-Canonical Mechanisms

Dnmt3a Loss-of-Function Enhances DNA Repair in Proliferative HSCs Under Inflammatory Stress

The Role of Stathmin-1 in the Regulation of Hematopoietic Stem Cells

DUSP6 Mediates Resistance to JAK2 Inhibition and Drives Myeloproliferative Neoplasm Disease Progression

The Histone Demethylase KDM6B Is a Genetic Dependency of NOTCH1-Driven T-ALL

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American Society of Hematology

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ASH Publications

American Society of Hematology

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