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Journal Articles

JAK2 V617F Mutant MPN Cells Support Parallel Evolution of Independent Leukemic Clones

Tyler M Parsons, Aishwarya Krishnan, Andrew L Young, Maggie Cox, Stephen Oh, Grant A Challen
Journal: Blood
Blood (2024) 144 (Supplement 1): 755.
https://doi.org/10.1182/blood-2024-203680
Published: 2024
Journal Articles

Monocyte-Driven Aberrant Inflammation in Myeloproliferative Neoplasms Is Regulated By Galectin-1

Fan He, Shuyang Lin, Tim Kong, Daniel Fisher, Alexander Kim, Molly Brakhane, Christopher Letson, Yanbo Yu, Noelle Champagne, Mary Fulbright, Varun Ramesh, Angelo Laranjeira, Maggie Cox, Katrina Ashworth, Stephen Sykes, Jorge Di Paola, Stephen Oh
Journal: Blood
Blood (2024) 144 (Supplement 1): 875.
https://doi.org/10.1182/blood-2024-211520
Published: 2024
Journal Articles

JAK2-V617F Expression Results in a Cell-Intrinsic Expansion of Megakaryocyte Progenitors with Evidence of Myc Pathway Activation in Both Mature and Precursor Megakaryocytes By Single Cell RNA Sequencing

Joshua Siner, Jun Xia, Juo-Chin Yao, Kartik Singhal, Daniel Fisher, Lilian Antunes Heck, Malachi Griffith, Stephen Oh, Jorge Di Paola, Daniel C. Link
Journal: Blood
Blood (2024) 144 (Supplement 1): 6567.
https://doi.org/10.1182/blood-2024-211373
Published: 2024
Journal Articles

A Multicenter, Open-Label, Phase 1 Clinical Trial of AJ1-11095 Administered As Oral Monotherapy in Patients with Primary Myelofibrosis (PMF), Post-Polycythemia Vera Myelofibrosis (PPV-MF), or Post-Essential Thrombocythemia Myelofibrosis (PET-MF) Who Have Been Failed By a Type I JAK2 Inhibitor (JAK2i)

John O. Mascarenhas, Uma Borate, Prithviraj Bose, John C. Byrd, Jacqueline S. Garcia, Michael R. Grunwald, Gabriela S. Hobbs, Ronald Hoffman, Andrew T. Kuykendall, Ruben A. Mesa, Stephen Oh, Raajit Rampal, Abdulraheem Yacoub, David P. Steensma
Journal: Blood
Blood (2024) 144 (Supplement 1): 3147.1.
https://doi.org/10.1182/blood-2024-193905
Published: 2024
Journal Articles

Updated Results from the Phase 3 Manifest-2 Study of Pelabresib in Combination with Ruxolitinib for Janus Kinase Inhibitor-Naïve Patients with Myelofibrosis

John O. Mascarenhas, Sebastian Grosicki, Dominik Chraniuk, Elisabetta Abruzzese, Prithviraj Bose, Aaron T. Gerds, Alessandro M. Vannucchi, Francesca Palandri, Sung-Eun Lee, Vikas Gupta, Alessandro Lucchesi, Stephen Oh, Andrew T. Kuykendall, Andrea Patriarca, Alberto Alvarez-Larran, Ruben Mesa, Jean-Jacques Kiladjian, Moshe Talpaz, Morgan Harris, Sarah-Katharina Kays, Qing Li, Barbara Brown, Anna-Maria Jegg, Claire Harrison, Raajit Rampal
Journal: Blood
Blood (2024) 144 (Supplement 1): 3178.
https://doi.org/10.1182/blood-2024-193193
Published: 2024
Journal Articles

Construction of a Myeloid Gene Signature Revealing Novel Therapeutic Targets for Myeloid Malignancies

Fan He, Shuyang Lin, Bei Gao, Varun Ramesh, Alexander Kim, Tim Kong, Noelle Champagne, Mary Fulbright, Daniel Fisher, Christopher Letson, Molly Brakhane, Yanbo Yu, Marco Sardiello, Stephen Sykes, Jorge Di Paola, Stephen Oh
Journal: Blood
Blood (2024) 144 (Supplement 1): 6161.
https://doi.org/10.1182/blood-2024-212168
Published: 2024
Journal Articles

Updated Efficacy and Safety Results of Patients Receiving Selected 100mg Bezuclastinib Dose and Participating in the Open-Label Extension of Summit: A Randomized, Double-Blind, Placebo Controlled Phase 2 Clinical Trial of Bezuclastinib in Adult Patients with Nonadvanced Systemic Mastocytosis

Lindsay A.M. Rein, Daniel J. DeAngelo, Brian Modena, Stephen Oh, Bulai Livideanu Cridtina, Celalettin Ustun, Nathan Boggs, Michael Manning, Anthony M. Hunter, Cem Akin, Arnold Kirshenbaum, Ingunn Dybedal, Cecilia Y. Arana Yi, Richard Herrscher, Mariana Castells, Frederick Lansigan, Tracy I. George, Jay Patel, Lei Sun, Nisha Shah, Jenna Zhang, Amanda Pilla, Priya Singh, Marcus Carden, Frank Siebenhaar, Prithviraj Bose
Journal: Blood
Blood (2024) 144 (Supplement 1): 4556.
https://doi.org/10.1182/blood-2024-194551
Published: 2024
Journal Articles

Altered Calcium Signaling Via STIM1 Drives Aberrant Megakaryopoiesis and Myelofibrosis

Molly Brakhane, Vittorio Abbonante, Angelo Laranjeira, Christian Andrea Di Buduo, Brooke Sadler, Katrina Ashworth, Tim Kong, Fan He, Mary Fulbright, Dong Chen, Regina Clemens, Elena Pegoraro, Michele P. Lambert, Kandace Gollomp, Jorge Di Paola, Alessandra Balduini, Stephen Oh
Journal: Blood
Blood (2024) 144 (Supplement 1): 1169.
https://doi.org/10.1182/blood-2024-210283
Published: 2024
Journal Articles

Phase 1/2 Study of the Activin Receptor-like Kinase-2 Inhibitor Zilurgisertib (INCB000928, LIMBER-104) As Monotherapy or with Ruxolitinib in Patients with Anemia Due to Myelofibrosis

Sanjay Mohan, Stephen Oh, Jean-Jacques Kiladjian, Masahiro Takeuchi, Jason Gotlib, Ellen K. Ritchie, Taizo Shimomura, Paola Guglielmelli, Anthony M. Hunter, Francesca Palandri, Francoise Boyer, Alessandro Rambaldi, Takehiko Mori, Tomoki Ito, Betty Lamothe, Yan-Ou Yang, Yi Cui, Francis Seguy, Amanda McBride, Prithviraj Bose
Journal: Blood
Blood (2023) 142 (Supplement 1): 624.
https://doi.org/10.1182/blood-2023-179291
Published: 2023
Journal Articles

Deep and Durable Cytogenetic and Molecular Responses with Pemigatinib in Myeloid/Lymphoid Neoplasms with Fibroblast Growth Factor Receptor 1 Rearrangement: The Fight-203 Study

Andreas Reiter, Jean-Jacques Kiladjian, Jay L. Patel, William Shomali, Alessandro Rambaldi, Srdan Verstovsek, Stephen Oh, Kensuke Usuki, Claire N Harrison, Ellen K. Ritchie, Luke P. Akard, Juan Carlos Hernandez Boluda, Françoise Huguet, Natalia Oliveira, Huiling Zhen, Tracy I. George, Philomena Colucci, Aidan Gilmartin, Jason Gotlib, Alessandro M. Vannucchi
Journal: Blood
Blood (2023) 142 (Supplement 1): 4551.
https://doi.org/10.1182/blood-2023-180945
Published: 2023
Journal Articles

A Real-World Evaluation of Risk Factors for Disease Progression in Patients with Polycythemia Vera (PV) Enrolled in REVEAL

Michael R. Grunwald, Jeffrey I. Zwicker, Aaron T. Gerds, John M. Burke, Zhenyi Xue, Erin L. Crowgey, Justine Carl, Patricia Feldman, Evan M. Braunstein, Stephen Oh
Journal: Blood
Blood (2023) 142 (Supplement 1): 385.
https://doi.org/10.1182/blood-2023-180215
Published: 2023
Journal Articles

A Real-World Evaluation of the Association between Elevated Blood Counts and Thrombotic Events in Polycythemia Vera (Analysis of Data from the REVEAL Study)

Aaron T. Gerds, Ruben A. Mesa, John M. Burke, Michael R. Grunwald, Brady Lee Stein, Robyn Scherber, Jingbo Yu, J.E. Hamer-Maansson, Stephen Oh
Journal: Blood
Blood (2021) 138 (Supplement 1): 239.
https://doi.org/10.1182/blood-2021-148509
Published: 2021
Journal Articles

Subgroup Analysis from a Phase 2 Study of the Efficacy and Safety of Parsaclisib, a Selective PI3Kδ Inhibitor, in Combination with Ruxolitinib in Patients with Myelofibrosis (MF)

Abdulraheem Yacoub, Uma Borate, Raajit Rampal, Haris Ali, Eunice S. Wang, Aaron T. Gerds, Gabriela Hobbs, Marina Kremyanskaya, Elliott Winton, Casey O'Connell, Swati Goel, Stephen Oh, Gary J. Schiller, Albert Assad, Sue Erickson-Viitanen, Feng Zhou, Naval Daver
Journal: Blood
Blood (2021) 138 (Supplement 1): 3647.
https://doi.org/10.1182/blood-2021-148668
Published: 2021
Journal Articles

Examining the Treatment Patterns and Blood Counts Among Patients with Polycythemia Vera Treated with Hydroxyurea in the United States: An Analysis from the Reveal Study

Michael Richard Grunwald, MD, Ivy Altomare, MD, John M. Burke, MD, Aaron T. Gerds, MDMS, Mark A. Walshauser, MD, Michael R. Savona, MD, David J Kuter, MD DPhil, Brady Lee Stein, MD MHS, Stephen Oh, MD PhD, Philomena Colucci, DO, MS, Ahmad B. Naim, MD, Dilan Chamikara Paranagama, PhD, Ruben A Mesa, MD
Journal: Blood
Blood (2017) 130 (Supplement 1): 1633.
https://doi.org/10.1182/blood.V130.Suppl_1.1633.1633
Published: 2017
Journal Articles

Mass Cytometry Analysis Reveals Cellular Loci of Cytokine Overproduction in Myelofibrosis with Differential Sensitivity to Ruxolitinib

Daniel A.C. Fisher, PhD, Cathrine Miner, Elizabeth Engle, PhD, Taylor B. Collins, Hengrui Hu, Olga Malkova, Stephen Oh, MD PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 4209.
https://doi.org/10.1182/blood.V130.Suppl_1.4209.4209
Published: 2017
Journal Articles

Dynamic Changes in Clonal Clearance with Decitabine Therapy in AML and MDS Patients

John S. Welch, MD PhD, Allegra Petti, PhD, Christopher A. Miller, PhD, Daniel C. Link, MD, Matthew J. Walter, MD, Catrina C. Fronick, Robert S. Fulton, PhD, Lukas D. Wartman, MD, Geoffrey L. Uy, MD, Armin Ghobadi, MD, Michael Tomasson, Iskra Pusic, MD, Rizwan Romee, MD, Todd A Fehniger, MD PhD, Keith Stockerl-Goldstein, Ravi Vij, MBBS, Stephen Oh, MDPhD, Camille N. Abboud, MD FACP, Amanda F. Cashen, MD, Mark A. Schroeder, MD, Meagan A. Jacoby, MD PhD, Peter Westervelt, MD PhD, John F Dipersio, MD PhD, Richard K Wilson, PhD, Timothy J. Ley, MD
Journal: Blood
Blood (2015) 126 (23): 689.
https://doi.org/10.1182/blood.V126.23.689.689
Published: 2015
Journal Articles

NF Kappa B Signaling Hyperactivation in Myelofibrosis and Secondary Acute Myeloid Leukemia

Daniel A.C. Fisher, PhD, Elizabeth K. Engle, PhD, Olga Malkova, PhD, Mary C. Fulbright, Amy Zhou, MD, Stephen Oh, MDPhD
Journal: Blood
Blood (2015) 126 (23): 602.
https://doi.org/10.1182/blood.V126.23.602.602
Published: 2015
Journal Articles

A Phase 2 Study to Evaluate the Efficacy and Safety of Simtuzumab in Adult Subjects with Primary, Post Polycythemia Vera (PV) or Post Essential Thrombocythemia (ET) Myelofibrosis

Srdan Verstovsek, MD, Michael R. Savona, MD, Ruben A. Mesa, Stephen Oh, MDPhD, Hua Dong, PhD, Dung Thai, Jason Gotlib, MD
Journal: Blood
Blood (2015) 126 (23): 2810.
https://doi.org/10.1182/blood.V126.23.2810.2810
Published: 2015
Journal Articles

RNAi Screening of the Tyrosine Kinome Identifies Therapeutic Targets in Leukemia Patients

Jeffrey W Tyner, PhD, Marc Loriaux, MD, PhD, Stephanie G Willis, Bill Chang, MD, PhD, Vincent T Bicocca, Stephen Oh, MD, PhD, Iris H.I.M. Hollink, MD, Stefanie Segers, Monique L. den Boer, C. M Zwaan, MD, PhD, Jason R. Gotlib, Michael W.N. Deininger, MD, Brian J. Druker
Journal: Blood
Blood (2008) 112 (11): 758.
https://doi.org/10.1182/blood.V112.11.758.758
Published: 2008
Journal Articles

Small-Molecule Inhibitor Screen Rapidly Identifies Key Signaling Pathways in Leukemogenesis

Jeffrey W Tyner, PhD, Heidi Erickson, Stephen Oh, MD, PhD, Jason R. Gotlib, Michael W.N. Deininger, MD, Brian J. Druker, Marc Loriaux, MD, PhD
Journal: Blood
Blood (2008) 112 (11): 2519.
https://doi.org/10.1182/blood.V112.11.2519.2519
Published: 2008