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Aishwarya Krishnan
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Journal Articles

Dnmt3a Controls Hematopoietic Stem Cells Via DNA Methylation-Independent Regulation of Telomeres

Infencia Xavier Raj, Won Kyun Koh, Jessica Harrison, Christine RC Zhang, Barbara Soares, Aishwarya Krishnan, Hassan Bjeije, Tyler M Parsons, Wentao Han, Andrew L Young, Ting Wang, Luis Batista, Grant A Challen
Journal: Blood
Blood (2024) 144 (Supplement 1): 25.
https://doi.org/10.1182/blood-2024-203958
Published: 2024
Journal Articles

JAK2 V617F Mutant MPN Cells Support Parallel Evolution of Independent Leukemic Clones

Tyler M Parsons, Aishwarya Krishnan, Andrew L Young, Maggie Cox, Stephen Oh, Grant A Challen
Journal: Blood
Blood (2024) 144 (Supplement 1): 755.
https://doi.org/10.1182/blood-2024-203680
Published: 2024
Journal Articles

CXCL8/CXCR2 signaling mediates bone marrow fibrosis and is a therapeutic target in myelofibrosis

Andrew J. Dunbar, Dongjoo Kim, Min Lu, Mirko Farina, Robert L. Bowman, Julie L. Yang, Young Park, Abdul Karzai, Wenbin Xiao, Zach Zaroogian, Kavi O’Connor, Shoron Mowla, Francesca Gobbo, Paola Verachi, Fabrizio Martelli, Giuseppe Sarli, Lijuan Xia, Nada Elmansy, Maria Kleppe, Zhuo Chen, Yang Xiao, Erin McGovern, Jenna Snyder, Aishwarya Krishnan, Corrine Hill, Keith Cordner, Anouar Zouak, Mohamed E. Salama, Jayden Yohai, Eric Tucker, Jonathan Chen, Jing Zhou, Timothy McConnell, Anna R. Migliaccio, Richard Koche, Raajit Rampal, Rong Fan, Ross L. Levine, Ronald Hoffman
Journal: Blood
Blood (2023) 141 (20): 2508–2519.
https://doi.org/10.1182/blood.2022015418
Published: 2023
Includes: Supplemental data
Journal Articles

Using a Humanized Animal Model to Determine the Minimum JAK2 V617F Mutant Allele Burden Required to Generate MPN Pathologies

Tyler M. Parsons, Aishwarya Krishnan, Wentao Han, Andrew L Young, Grant A Challen
Journal: Blood
Blood (2022) 140 (Supplement 1): 6744–6745.
https://doi.org/10.1182/blood-2022-165335
Published: 2022
Journal Articles

Mutational Profile of Children with Myeloproliferative Neoplasms

Kayleigh Rutherford, Noushin Farnoud, Aishwarya Krishnan, Raajit K Rampal, Ross L. Levine, Nicole Kucine
Journal: Blood
Blood (2022) 140 (Supplement 1): 3991–3992.
https://doi.org/10.1182/blood-2022-164732
Published: 2022
Journal Articles

BMP2/SMAD pathway activation in JAK2/p53-mutant megakaryocyte/erythroid progenitors promotes leukemic transformation

Bing Li, Wenbin An, Hua Wang, Timour Baslan, Shoron Mowla, Aishwarya Krishnan, Wenbin Xiao, Richard P. Koche, Ying Liu, Sheng F. Cai, Zhijian Xiao, Andriy Derkach, Ilaria Iacobucci, Charles G. Mullighan, Kristian Helin, Scott W. Lowe, Ross L. Levine, Raajit K. Rampal
Journal: Blood
Blood (2022) 139 (25): 3630–3646.
https://doi.org/10.1182/blood.2021014465
Published: 2022
Includes: Supplemental data
Journal Articles

The BMP/SMAD Pathway Is a Key Mediator of Leukemic Transformation of TP53-Mutant Post-MPN AML

Bing Li, Wenbin An, Hua Wang, Aishwarya Krishnan, Shoron Mowla, Timour Baslan, Richard Koche, Wenbin Xiao, Scott Lowe, Ross L. Levine, Raajit Rampal
Journal: Blood
Blood (2021) 138 (Supplement 1): 626.
https://doi.org/10.1182/blood-2021-152036
Published: 2021
Journal Articles

LSD1 Inhibitor CPI-482 Shows Efficacy and Prolongs Survival in Mouse Models of AML and Post-MPN AML in the Context of Constitutive JAK-STAT Pathway Activation

Raajit K. Rampal, MD PhD, John P. McGrath, PhD, Aishwarya Krishnan, BS, Bing Li, MD, Wenbin Xiao, MD PhD, David Nikom, Jing Wang, PhD, Ross L. Levine, MD, Patrick Trojer, PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 50–51.
https://doi.org/10.1182/blood-2020-140186
Published: 2020
Journal Articles

Increased Interleukin-8 (IL8)-CXCR2 Signaling Promotes Progression of Bone Marrow Fibrosis in Myeloproliferative Neoplasms

Andrew Dunbar, MD, Min Lu, PhDMD, Mirko Farina, MD, Young Park, BS, Julie Yang, PhD, Dongjoo Kim, PhD, Abdul Karzai, BS, Mohamed E Salama, MD, Jenna Snyder, BS, Aishwarya Krishnan, BS, Richard P. Koche, PhD, Rong Fan, PhD, Ross L. Levine, MD, Ronald Hoffman, MD
Journal: Blood
Blood (2020) 136 (Supplement 1): 6–7.
https://doi.org/10.1182/blood-2020-138843
Published: 2020
Journal Articles

Identifying Cytokine Biomarkers of Response to Pegylated-Interferon Therapy in Polycythemia Vera and Essential Thrombocythemia: Correlative Analysis from the MPN-RC 111/112 Trials

Andrew Dunbar, MD, Heidi E. Kosiorek, MS, Aishwarya Krishnan, Erin McGovern, BA, Young Park, BS, Minal A Patel, MPH, Rona Singer Weinberg, PhD, Abdulraheem Yacoub, MD, Amylou C. Dueck, PhD, John Mascarenhas, MD, Ross L. Levine, MD, Ronald Hoffman, MD, Raajit K. Rampal, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1661.
https://doi.org/10.1182/blood-2019-129571
Published: 2019
Journal Articles

Evaluation of Tagraxofusp (SL-401) Alone and in Combination with Ruxolitinib for the Treatment of Myeloproliferative Neoplasms

Aishwarya Krishnan, Maria Pagane, Mikhail Roshal, MD PhD, Erin McGovern, BA, Zoe Stone-Molloy, Janice Chen, PhD, Christopher Brooks, PhD, Ross L. Levine, MD, Raajit K. Rampal, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2967.
https://doi.org/10.1182/blood-2019-129397
Published: 2019
Journal Articles

PRMT5 Inhibition Modulates E2F1 Methylation and Gene Regulatory Networks Leading to Therapeutic Efficacy in JAK2VF Mutant MPN

Friederike Pastore, MD, Neha Bhagwat, PhDBS, Aishwarya Krishnan, Alessandro Pastore, Bing Li, MD, Robert L Bowman, PhD, Wenbin Xiao, MD PhD, Aaron D Viny, MDMS, Abdul Karzai, Anouar Zouak, Young C Park, Keith Cordner, Stephanie Braunstein, Alexander Grego, Jaanvi Mehta, Benjamin H Durham, MD, Richard P. Koche, PhD, Jesper Maag, Peggy Scherle, PhD, Kris Vaddi, PhD, Ross L. Levine, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 473.
https://doi.org/10.1182/blood-2019-127122
Published: 2019
Journal Articles

Transcriptome Profiling of Pediatric Myeloproliferative Neoplasms Demonstrates Dysregulation of Platelet-Relevant Genes and Enrichment of Inflammatory and JAK2 Mediated Complement Pathways

Nicole Kucine, MD, Amanda R. Leonti, MS, Aishwarya Krishnan, Rhonda E. Ries, MA, Ross L. Levine, MD, Soheil Meshinchi, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 4203.
https://doi.org/10.1182/blood-2019-125103
Published: 2019
Journal Articles

Evaluation of Combination Tagraxofusp (SL-401) and Hypomethylating Agent (HMA) Therapy for the Treatment of Chronic Myelomonocytic Leukemia (CMML)

Aishwarya Krishnan, Bing Li, MD, Maria Pagane, Erin McGovern, BA, Zoe Stone-Molloy, Janice Chen, PhD, Christopher Brooks, PhD, Ross L. Levine, MD, Raajit K. Rampal, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 1809.
https://doi.org/10.1182/blood-2018-99-120035
Published: 2018