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Journal Articles

KT-253, a Highly Potent and Selective MDM2 Protein Degrader, Eliminates Malignant Myelofibrosis Stem/Progenitor Cells

Min Lu, Lijuan Xia, Yogesh Chutake, Joyoti Dey, Ronald Hoffman

Blood (2024) 144 (Supplement 1): 3588.

https://doi.org/10.1182/blood-2024-210354

Published: 2024

Journal Articles

Selinexor Depletes Ruxolitinib Refractory Myelofibrosis Hematopoietic Stem Cells By Inducing Apoptosis and Blunting the Pro-Inflammatory Milieu

Min Lu, MD Babu Mia, Lijuan Xia, Andrea Ellero, Christopher J. Walker, Ronald Hoffman

Blood (2024) 144 (Supplement 1): 1377.

https://doi.org/10.1182/blood-2024-205114

Published: 2024

Journal Articles

Use of Combination Therapies Including the XPO1 Inhibitor Selinexor in Is a Potential Effective Therapeutic Strategy to Treat Myelofibrosis Patients

Min Lu, Lijuan Xia, Ronald Hoffman

Blood (2023) 142 (Supplement 1): 1792.

https://doi.org/10.1182/blood-2023-186674

Published: 2023

Journal Articles

CXCL8/CXCR2 signaling mediates bone marrow fibrosis and is a therapeutic target in myelofibrosis

Blood (2023) 141 (20): 2508–2519.

https://doi.org/10.1182/blood.2022015418

Published: 2023

Includes: Supplemental data

Journal Articles

Co-Cultivation of MF CD34+ Cells with Microenvironmental Cells Has a Profound Effect on MF Hematopoiesis and Responses to Drug Therapy

Min Lu, Christoph Schaniel, Jeff Vierstra, Lijuan Xia, Ronald Hoffman

Blood (2022) 140 (Supplement 1): 8625–8626.

https://doi.org/10.1182/blood-2022-170704

Published: 2022

Journal Articles

Pharmacological Disruption of the Interplay between HDM2-p53 and NFκB Depletes Myelofibrosis Progenitor/Stem Cells and Dampens the Accompanying Inflammatory Milieu

Min Lu, Lijuan Xia, Ronald Hoffman

Blood (2022) 140 (Supplement 1): 3069–3070.

https://doi.org/10.1182/blood-2022-169781

Published: 2022

Journal Articles

A Novel Combination of Drugs Which Target Both the Intrinsic and Extrinsic Apoptotic Pathways to Eliminate Myelofibrosis CD34+ Cells

Min Lu, PhD, Lijuan Xia, Ronald Hoffman, MD

Blood (2019) 134 (Supplement_1): 4201.

https://doi.org/10.1182/blood-2019-129017

Published: 2019

Journal Articles

Oral idasanutlin in patients with polycythemia vera

John Mascarenhas, Min Lu, Heidi Kosiorek, Elizabeth Virtgaym, Lijuan Xia, Lonette Sandy, Ruben Mesa, Bruce Petersen, Noushin Farnoud, Vesna Najfeld, Raajit Rampal, Amylou Dueck, Ronald Hoffman

Blood (2019) 134 (6): 525–533.

https://doi.org/10.1182/blood.2018893545

Published: 2019

Includes: Supplemental data

Journal Articles

Enriched Populations of Human Megakaryocytic Cells Affect the Behavior of Myelofibrosis CD34+ Cells As Well As Cells Belonging to the MF Supportive Microenvironment

Min Lu, PhD MD, Lijuan Xia, Mohamed E. Salama, MD, Ronald Hoffman, MD

Blood (2018) 132 (Supplement 1): 3057.

https://doi.org/10.1182/blood-2018-99-117062

Published: 2018

Journal Articles

Combination Treatment with an MDM2 Antagonist and a BET Inhibitor Targets Both Myelofibrosis Hematopoietic Stem/ Progenitor Cells and Their Tumor Promoting Microenvironment

Min Lu, PhDMD, Lijuan Xia, Mohamed E. Salama, MD, Ronald Hoffman, MD

Blood (2017) 130 (Supplement 1): 4225.

https://doi.org/10.1182/blood.V130.Suppl_1.4225.4225

Published: 2017

Journal Articles

Open Label Phase I Study of Single Agent Oral RG7388 (idasanutlin) in Patients with Polycythemia Vera and Essential Thrombocythemia

John Mascarenhas, MD, Min Lu, PhDMD, Elizabeth Virtgaym, Heidi Kosiorek, MS, Marina Stal, Lonette Sandy, Alicia Orellana, MD MPH, Lijuan Xia, Marina Kremyanskaya, MD PhD, Bruce Petersen, MD, Amylou Dueck, PhD, Ronald Hoffman, MD

Blood (2017) 130 (Supplement 1): 254.

https://doi.org/10.1182/blood.V130.Suppl_1.254.254

Published: 2017

Journal Articles

Splenic Micro Environmental Cells from Patients with Myelofibrosis Elaborate a Cascade of Cytokines and Serve As a Niche for Malignant Hematopoiesis

Min Lu, PhD MD, Lijuan Xia, Mohamed E Salama, MD, Ronald Hoffman, MD

Blood (2016) 128 (22): 953.

https://doi.org/10.1182/blood.V128.22.953.953

Published: 2016

Journal Articles

Lipocalin produced by myelofibrosis cells affects the fate of both hematopoietic and marrow microenvironmental cells

Min Lu, Lijuan Xia, Yen-Chun Liu, Tsivia Hochman, Laetizia Bizzari, Daniel Aruch, Jane Lew, Rona Weinberg, Judith D. Goldberg, Ronald Hoffman

Blood (2015) 126 (8): 972–982.

https://doi.org/10.1182/blood-2014-12-618595

Published: 2015

Includes: Supplemental data

Journal Articles

The Effects of Lipocalin (LCN2) on Hematopoiesis in Primary Myelofibrosis

Min Lu, PhD MD, Lijuan Xia, Yen-Chun Liu, Tsivia Hochman, Rona Singer Weinberg, PhD, Judith D Goldberg, Ronald Hoffman

Blood (2014) 124 (21): 1878.

https://doi.org/10.1182/blood.V124.21.1878.1878

Published: 2014

Journal Articles

The orally bioavailable MDM2 antagonist RG7112 and pegylated interferon α 2a target JAK2V617F -positive progenitor and stem cells

Min Lu, Lijuan Xia, Yan Li, Xiaoli Wang, Ronald Hoffman

Blood (2014) 124 (5): 771–779.

https://doi.org/10.1182/blood-2013-11-536854

Published: 2014

Includes: Supplemental data

Journal Articles

Neutophil Gelatinase –Associated Lipocalin (LCN2) Affects Primary Melofibrosis Hematopoietic Progenitor Cells As Well As Microenvironmental Cells

Min Lu, PhD, Lijuan Xia, Rona Singer Weinberg, PhD, Ronald Hoffman, MD

Blood (2013) 122 (21): 2839.

https://doi.org/10.1182/blood.V122.21.2839.2839

Published: 2013

Journal Articles

Interferon α Has Varied Effects On CD34 + Cells From Patients With Polycythemia Vera

Min Lu, PhD, Seungyeul Yoo, Lijuan Xia, Xiaoli Wang, Yan Li, Jun Zhu, Ronald Hoffman, MD

Blood (2013) 122 (21): 2840.

https://doi.org/10.1182/blood.V122.21.2840.2840

Published: 2013

Journal Articles

Arsenic Trioxide Plus ABT-737 Is Synergistic to Induce Apoptosis in AML Cells by Repression of Mcl-1 Protein and Inactivation of Bcl-2 Protein

Lijuan Xia, Rui Wang, Hao Qian, Janice Gabrilove, MD, Samuel Waxman, MD, Yongkui Jing, PhD

Blood (2008) 112 (11): 2653.

https://doi.org/10.1182/blood.V112.11.2653.2653

Published: 2008

Journal Articles

Myeloperoxidase Is Required for the Combined Apoptotic Effects of Arsenic Trioxide with Ascorbic Acid or Epigallocatechin-3-Gallate in Myeloid Leukemia Cells.

Lijuan Xia, BS, Min Lu, Ph.D., Duo Chen, Ph.D., Samuel Waxman, M.D., Yongkui Jing, PhD

Blood (2007) 110 (11): 3474.

https://doi.org/10.1182/blood.V110.11.3474.3474

Published: 2007

Journal Articles

Induction of Both CCAAT/Enhancer Binding Protein β and ε Are Required for All Trans Retinoic Acid-Induced Granulocytic Differentiation of Myeloid Leukemia Cells.

Min Lu, Ph.D., Lijuan Xia, B.S., Alan D. Friedman, M.D., Samuel Waxman, M.D., Yongkui Jing, PhD

Blood (2007) 110 (11): 3459.

https://doi.org/10.1182/blood.V110.11.3459.3459

Published: 2007

NARROW

KT-253, a Highly Potent and Selective MDM2 Protein Degrader, Eliminates Malignant Myelofibrosis Stem/Progenitor Cells

Selinexor Depletes Ruxolitinib Refractory Myelofibrosis Hematopoietic Stem Cells By Inducing Apoptosis and Blunting the Pro-Inflammatory Milieu

Use of Combination Therapies Including the XPO1 Inhibitor Selinexor in Is a Potential Effective Therapeutic Strategy to Treat Myelofibrosis Patients

CXCL8/CXCR2 signaling mediates bone marrow fibrosis and is a therapeutic target in myelofibrosis

Co-Cultivation of MF CD34+ Cells with Microenvironmental Cells Has a Profound Effect on MF Hematopoiesis and Responses to Drug Therapy

Pharmacological Disruption of the Interplay between HDM2-p53 and NFκB Depletes Myelofibrosis Progenitor/Stem Cells and Dampens the Accompanying Inflammatory Milieu

A Novel Combination of Drugs Which Target Both the Intrinsic and Extrinsic Apoptotic Pathways to Eliminate Myelofibrosis CD34+ Cells

Oral idasanutlin in patients with polycythemia vera

Enriched Populations of Human Megakaryocytic Cells Affect the Behavior of Myelofibrosis CD34+ Cells As Well As Cells Belonging to the MF Supportive Microenvironment

Combination Treatment with an MDM2 Antagonist and a BET Inhibitor Targets Both Myelofibrosis Hematopoietic Stem/ Progenitor Cells and Their Tumor Promoting Microenvironment

Open Label Phase I Study of Single Agent Oral RG7388 (idasanutlin) in Patients with Polycythemia Vera and Essential Thrombocythemia

Splenic Micro Environmental Cells from Patients with Myelofibrosis Elaborate a Cascade of Cytokines and Serve As a Niche for Malignant Hematopoiesis

Lipocalin produced by myelofibrosis cells affects the fate of both hematopoietic and marrow microenvironmental cells

The Effects of Lipocalin (LCN2) on Hematopoiesis in Primary Myelofibrosis

The orally bioavailable MDM2 antagonist RG7112 and pegylated interferon α 2a target JAK2V617F -positive progenitor and stem cells

Neutophil Gelatinase –Associated Lipocalin (LCN2) Affects Primary Melofibrosis Hematopoietic Progenitor Cells As Well As Microenvironmental Cells

Interferon α Has Varied Effects On CD34 + Cells From Patients With Polycythemia Vera

Arsenic Trioxide Plus ABT-737 Is Synergistic to Induce Apoptosis in AML Cells by Repression of Mcl-1 Protein and Inactivation of Bcl-2 Protein

Myeloperoxidase Is Required for the Combined Apoptotic Effects of Arsenic Trioxide with Ascorbic Acid or Epigallocatechin-3-Gallate in Myeloid Leukemia Cells.

Induction of Both CCAAT/Enhancer Binding Protein β and ε Are Required for All Trans Retinoic Acid-Induced Granulocytic Differentiation of Myeloid Leukemia Cells.

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American Society of Hematology

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American Society of Hematology

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