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Journal Articles

Acute Promyelocytic Leukemia in the Molecular Age

Navin Bhatt, Michelle Becker, Juana Martinez, Hannah Levavi, Kyle Farina, Marina Kremyanskaya, Bridget Kelly Marcellino, Alan Shih, Lewis R. Silverman, Vesna Najfeld, John O. Mascarenhas, Douglas Tremblay, Jonathan Feld
Journal: Blood
Blood (2024) 144 (Supplement 1): 6131.
https://doi.org/10.1182/blood-2024-211957
Published: 2024
Journal Articles

A Novel Three-Way Translocation Involving ETV6-IL3 Drives AML with Eosinophilia

Ariel Siegel, Joseph Tripodi, Brianna Kelly, Sebastian Elghaity-Beckley, Michelle Becker, Douglas Tremblay, Jonathan Feld, Hannah Levavi, Marina Kremyanskaya, Bridget Kelly Marcellino, Christian Salib, Alla Keyzner, Amy Duffield, John O. Mascarenhas, Vesna Najfeld, Alan Shih
Journal: Blood
Blood (2024) 144 (Supplement 1): 6098.
https://doi.org/10.1182/blood-2024-203588
Published: 2024
Journal Articles

TP53 Alterations Confer Increased Risk of Leukemic Transformation and Worse Survival As Compared to High Molecular Risk Mutations in Patients with Myeloproliferative Neoplasms

Shivani Handa, Yosef Joseph Rene Amel Riazat-Kesh, Richard J Butterfield, Ganesh Sivakumar, Sangeetha Venugopal, Erin McGovern, Jonathan Feld, Douglas Tremblay, Sebastian Elghaity-Beckley, Marina Kremyanskaya, John O. Mascarenhas, Blake Langlais, Gina L. Mazza, Daniel I. Nathan, Joseph Tripodi, Vesna Najfeld, Amylou C Dueck, Raajit Rampal, Ronald Hoffman, Bridget Kelly Marcellino
Journal: Blood
Blood (2024) 144 (Supplement 1): 243.
https://doi.org/10.1182/blood-2024-206688
Published: 2024
Journal Articles

High-Resolution Chromosomal Microarrays Reveals Exon-Level Deletion in Chromosome 12q14.3 in Patients with Myeloproliferative Neoplasms

Joseph Tripodi, Shivani Handa, Christoph Schaniel, Daiva Ahire, Ronald Hoffman, Vesna Najfeld
Journal: Blood
Blood (2024) 144 (Supplement 1): 4520.
https://doi.org/10.1182/blood-2024-206440
Published: 2024
Journal Articles

Role of HMGA2 Overexpression Caused By Specific Genetic HMGA2 Aberrations in Disease Progression in Calreticulin-Mutated Myelofibrosis Patients

Christoph Schaniel, Shivani Handa, Joseph Tripodi, MD Babu Mia, Christian Salib, Jeff Vierstra, Allison J Cote, Daiva Ahire, Douglas Tremblay, Bridget Kelly Marcellino, John A Stamatoyannopoulos, Vesna Najfeld, Ronald Hoffman
Journal: Blood
Blood (2024) 144 (Supplement 1): 4512.
https://doi.org/10.1182/blood-2024-205834
Published: 2024
Journal Articles

Conventional Cytogenetic Analysis and Array CGH+SNP Identify Essential Thrombocythemia (ET)/Prefibrotic Primary Myelofibrosis (pre-PMF) Patients Who Are at Risk for Disease Progression

Joseph Tripodi, Ronald Hoffman, Douglas Tremblay, John Mascarenhas, Marina Kremyanskaya, Ian Novoselac, Vesna Najfeld
Journal: Blood
Blood (2023) 142 (Supplement 1): 1832.
https://doi.org/10.1182/blood-2023-181092
Published: 2023
Journal Articles

The Presence of Ring Chromosomes in Patients with Myeloid Neoplasms Is Predictive of a Poor Outcome

Daniel I. Nathan, Ronald Hoffman, Daiva Ahire, John Mascarenhas, Lewis R. Silverman, Vesna Najfeld, Jonathan Feld
Journal: Blood
Blood (2023) 142 (Supplement 1): 2940.
https://doi.org/10.1182/blood-2023-179585
Published: 2023
Journal Articles

Array CGH + SNP in ALL Enhances Detection of Complex Cytogenetic Profiles and Suggests That PRSS1 Loss May Play a Role in Leukemogenesis

Hannah Levavi, Daiva Ahire, Yosef Joseph Rene Amel Riazat-Kesh, Tianxiang Sheng, Dahniel L Sastow, Jonathan Feld, Douglas Tremblay, Marina Kremyanskaya, John Mascarenhas, Vesna Najfeld, Michal Bar-Natan
Journal: Blood
Blood (2023) 142 (Supplement 1): 6062.
https://doi.org/10.1182/blood-2023-185332
Published: 2023
Journal Articles

A randomized phase 3 trial of interferon-α vs hydroxyurea in polycythemia vera and essential thrombocythemia

Clinical Trials & Observations
John Mascarenhas, Heidi E. Kosiorek, Josef T. Prchal, Alessandro Rambaldi, Dmitriy Berenzon, Abdulraheem Yacoub, Claire N. Harrison, Mary Frances McMullin, Alessandro M. Vannucchi, Joanne Ewing, Casey L. O'Connell, Jean-Jacques Kiladjian, Adam J. Mead, Elliott F. Winton, David S. Leibowitz, Valerio De Stefano, Murat O. Arcasoy, Craig M. Kessler, Rosalind Catchatourian, Damiano Rondelli, Richard T. Silver, Andrea Bacigalupo, Arnon Nagler, Marina Kremyanskaya, Max F. Levine, Juan E. Arango Ossa, Erin McGovern, Lonette Sandy, Mohamad E. Salama, Vesna Najfeld, Joseph Tripodi, Noushin Farnoud, Alexander V. Penson, Rona Singer Weinberg, Leah Price, Judith D. Goldberg, Tiziano Barbui, Roberto Marchioli, Gianni Tognoni, Raajit K. Rampal, Ruben A. Mesa, Amylou C. Dueck, Ronald Hoffman
Journal: Blood
Blood (2022) 139 (19): 2931–2941.
https://doi.org/10.1182/blood.2021012743
Published: 2022
Includes: Supplemental data
Journal Articles

Treatment of Myelofibrosis Patients with the TGF-β 1/3 Inhibitor AVID200 (MPN-RC 118) Induces a Profound Effect on Platelet Production

John Mascarenhas, Heidi E. Kosiorek, Rupali Bhave, Jeanne M. Palmer, Andrew T. Kuykendall, Ruben A. Mesa, Raajit Rampal, Aaron T. Gerds, Abdulraheem Yacoub, Kristen M. Pettit, Moshe Talpaz, Rami S. Komrokji, Marina Kremyanskaya, Agapito Gonzalez, Frank Fabris, Lonette Sandy, Kathryn Johnson, Mikaela Doughtery, Erin McGovern, Juan Arango Ossa, Dylan Domenico, Noushin Farnoud, Anna Rita Migliaccio, Mohamed E Salama, Rona Singer Weinberg, Amy Kong, Vesna Najfeld, Carolyn Mead-Harvey, Amylou C. Dueck, Lilian Varricchio, Ronald Hoffman
Journal: Blood
Blood (2021) 138 (Supplement 1): 142.
https://doi.org/10.1182/blood-2021-148995
Published: 2021
Journal Articles

Exon-Level Genomic Abnormalities Are Frequent in Cytogenetically Normal Patients with Philadelphia-Chromosome Negative Myeloproliferative Neoplasms (MPNs)

Joseph Tripodi, Douglas Tremblay, MD, Ronald Hoffman, MD, Umut Ozbek, PhD, John Mascarenhas, MD, Marina Kremyanskaya, Vesna Najfeld, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1687.
https://doi.org/10.1182/blood-2019-128948
Published: 2019
Journal Articles

Significance of Abnormalities of PPM1D in Myeloproliferative Neoplasms

Bridget Marcellino, MD PhD, Joseph Tripodi, Michal Bar-Natan, MD, Harry Fruchtman, Noushin Farnoud, PhD, Min Lu, PhD, Heidi E. Kosiorek, MS, Amylou C. Dueck, PhD, Raajit K. Rampal, MD PhD, John Mascarenhas, MD, Vesna Najfeld, PhD, Ronald Hoffman, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 4207.
https://doi.org/10.1182/blood-2019-129565
Published: 2019
Journal Articles

Dual Driver Mutant BCR-ABL1-Negative Myeloid Neoplasms: Multicenter Clinicopathologic and Genomic Analysis

Zachary D. Epstein-Peterson, MD, Joseph Tripodi, Maria E Arcila, MD, Filiz Sen, MD, Vesna Najfeld, PhD, John Mascarenhas, MD, Ronald Hoffman, MD, Rajit K. Rampal, MD, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 4173.
https://doi.org/10.1182/blood-2019-125379
Published: 2019
Journal Articles

Pegylated interferon alfa-2a for polycythemia vera or essential thrombocythemia resistant or intolerant to hydroxyurea

Clinical Trials & Observations
Abdulraheem Yacoub, John Mascarenhas, Heidi Kosiorek, Josef T. Prchal, Dmitry Berenzon, Maria R. Baer, Ellen Ritchie, Richard T. Silver, Craig Kessler, Elliott Winton, Maria Chiara Finazzi, Alessandro Rambaldi, Alessandro M. Vannucchi, David Leibowitz, Damiano Rondelli, Murat O. Arcasoy, Rosalind Catchatourian, Joseph Vadakara, Vittorio Rosti, Elizabeth Hexner, Marina Kremyanskaya, Lonette Sandy, Joseph Tripodi, Vesna Najfeld, Noushin Farnoud, Elli Papaemmanuil, Mohamed Salama, Rona Singer-Weinberg, Raajit Rampal, Judith D. Goldberg, Tiziano Barbui, Ruben Mesa, Amylou C. Dueck, Ronald Hoffman
Journal: Blood
Blood (2019) 134 (18): 1498–1509.
https://doi.org/10.1182/blood.2019000428
Published: 2019
Includes: Supplemental data
Journal Articles

Oral idasanutlin in patients with polycythemia vera

Clinical Trials & Observations
John Mascarenhas, Min Lu, Heidi Kosiorek, Elizabeth Virtgaym, Lijuan Xia, Lonette Sandy, Ruben Mesa, Bruce Petersen, Noushin Farnoud, Vesna Najfeld, Raajit Rampal, Amylou Dueck, Ronald Hoffman
Journal: Blood
Blood (2019) 134 (6): 525–533.
https://doi.org/10.1182/blood.2018893545
Published: 2019
Includes: Supplemental data
Journal Articles

Impact on MPN Symptoms and Quality of Life of Front Line Pegylated Interferon Alpha-2a Vs. Hydroxyurea in High Risk Polycythemia Vera and Essential Thrombocythemia: Results of Myeloproliferative Disorders Research Consortium (MPD-RC) 112 Global Phase III Trial

Ruben A. Mesa, MD FACP, Heidi E. Kosiorek, MS, John Mascarenhas, MD, Josef T. Prchal, MD, Alessandro Rambaldi, MD, Dmitriy Berenzon, MD, Abdulraheem Yacoub, MD, Claire N. Harrison, MD DM, FRCP, PRCPath, Mary Frances McMullin, MD, Alessandro M. Vannucchi, MD, Joanne Ewing, PhD BMBS, BSc, FRPATH,, Casey L. O'Connell, MD, Jean-Jacques Kiladjian, MD PhD, Adam J. Mead, MD PhD, Elliott F. Winton, MD, David S. Leibowitz, MD, Valerio De Stefano, MD, Murat O. Arcasoy, MD, Craig M. Kessler, Rosalind Catchatourian, MD, Damiano Rondelli, MD, Richard T. Silver, MD, Andrea Bacigalupo, MD, Arnon Nagler, MD, Marina Kremyanskaya, MD PhD, Lonette Sandy, Mohamed E. Salama, MD, Vesna Najfeld, PhD, Joseph Tripodi, Rona Singer Weinberg, PhD, Raajit K. Rampal, MD PhD, Ronald Hoffman, MD, Amylou C. Dueck, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 3032.
https://doi.org/10.1182/blood-2018-99-111929
Published: 2018
Journal Articles

Dose-Adjusted Intensive Chemotherapy Is Safe and Tolerable in Older Patients with Ph-Negative Acute Lymphoblastic Leukemia

Anne S. Renteria, MD, Sangeetha Venugopal, MD, Bridget Marcellino, MD PhD, Alla Keyzner, MD, Marina Kremyanskaya, MD PhD, Vesna Najfeld, PhD, John Mascarenhas, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 5158.
https://doi.org/10.1182/blood-2018-99-115634
Published: 2018
Journal Articles

Myeloproliferative Neoplasm (MPN) Blastic Transformation Occurs at the Level of Hematopoietic Stem Cells

Xiaoli Wang, PhD, Cing Siang Hu, Joseph Tripodi, Vesna Najfeld, PhD, Bruce Petersen, MD, Raajit K. Rampal, MD PhD, Noushin Farnoud, Christopher Famulare, MS, John Mascarenhas, MD, Ronald Hoffman, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 101.
https://doi.org/10.1182/blood-2018-99-117348
Published: 2018
Journal Articles

Results of the Myeloproliferative Neoplasms - Research Consortium (MPN-RC) 112 Randomized Trial of Pegylated Interferon Alfa-2a (PEG) Versus Hydroxyurea (HU) Therapy for the Treatment of High Risk Polycythemia Vera (PV) and High Risk Essential Thrombocythemia (ET)

John Mascarenhas, MD, Heidi E. Kosiorek, MS, Josef T. Prchal, MD, Alessandro Rambaldi, MD, Dmitriy Berenzon, MD, Abdulraheem Yacoub, MD, Claire N. Harrison, MD DM, FRCP, PRCPath, Mary Frances McMullin, MD, Alessandro M. Vannucchi, MD, Joanne Ewing, PhD BMBS, BSc, FRPATH,, Casey L. O'Connell, MD, Jean-Jacques Kiladjian, MD PhD, Adam J. Mead, MD PhD, Elliott F. Winton, MD, David S. Leibowitz, MD, Valerio De Stefano, MD, Murat O. Arcasoy, MD, Craig M. Kessler, Rosalind Catchatourian, MD, Damiano Rondelli, MD, Richard T. Silver, MD, Andrea Bacigalupo, MD, Arnon Nagler, MD, Marina Kremyanskaya, MD PhD, Lonette Sandy, Mohamed E. Salama, MD, Vesna Najfeld, PhD, Joseph Tripodi, Rona Singer Weinberg, PhD, Leah Price, Judith D Goldberg, ScD, Raajit K. Rampal, MD PhD, Ruben A. Mesa, MD FACP, Amylou C. Dueck, PhD, Ronald Hoffman, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 577.
https://doi.org/10.1182/blood-2018-99-111946
Published: 2018
Journal Articles

Efficacy of Combined Ruxolitinib and Decitabine in Patients with Accelerated and Blast-Phase Myeloproliferative Neoplasms: Results of a Phase II Study (MPN-RC 109 trial)

Raajit K. Rampal, MD PhD, John Mascarenhas, MD, Heidi E. Kosiorek, MS, Rupali Bhave, MD, Elizabeth O. Hexner, MD MS, Eunice S. Wang, MD, Aaron T. Gerds, MD MS, Mark L Heaney, MD PhD, Camille N Abboud, MD, Marina Kremyanskaya, MD PhD, Dmitriy Berenzon, MD, Olatoyosi Odenike, MD, Elizabeth Virtgaym, Lonette Sandy, Rona Singer Weinberg, PhD, Vesna Najfeld, PhD, Mohamed E. Salama, MD, Ross L. Levine, MD, Ruben A. Mesa, MD FACP, Amylou C. Dueck, PhD, Ronald Hoffman, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 3027.
https://doi.org/10.1182/blood-2018-99-111935
Published: 2018