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Journal Articles

Efficacy of a Novel BCL-XL Degrader, DT2216, in Preclinical Models of Post-Myeloproliferative Neoplasm Secondary AML

Zhe Wang, Anna Skwarska, Gowri Poigailwar, Sovira Chaudhry, Alba Rodriguez-Meira, Pinpin Sui, Emmanuel Olivier, Yannan Jia, Cassandra L. Ramage, Guangrong Zheng, Alexandra Schurer, Kira Gritsman, Eirini Papapetrou, Kapil N. Bhalla, Daohong Zhou, Adam J Mead, Raajit Rampal, Jeffrey W Tyner, Hussein A. Abbas, Naveen Pemmaraju, Qi Zhang Tatarata, Marina Konopleva
Journal: Blood
Blood (2024) 144 (Supplement 1): 2749.
https://doi.org/10.1182/blood-2024-194031
Published: 2024
Journal Articles

Non-Driver Genomic Alterations and Venous Thromboembolism in Myeloproliferative Neoplasms

Helen Ajufo, Avi Leader, Andriy Derkach, Pavlina Chrysafi, Rohan Singh, Raajit Rampal, Simon Mantha, Jeffrey I. Zwicker
Journal: Blood
Blood (2024) 144 (Supplement 1): 15.
https://doi.org/10.1182/blood-2024-205851
Published: 2024
Journal Articles

Crebbp Inhibition Potentiates JAK2 Inhibition in Post-MPN Acute Myeloid Leukemia

Kalay Bertulfo, Hannah Miller, Ryan Najac, Juan Carlos Castelan, Cindy Ma, Koen Debackere, Wenbin Xiao, Raajit Rampal, Ross L Levine, Chao Lu, Adolfo A. Ferrando, Teresa Palomero
Journal: Blood
Blood (2024) 144 (Supplement 1): 823.
https://doi.org/10.1182/blood-2024-201988
Published: 2024
Journal Articles

Nuvisertib (TP-3654), an Investigational Selective PIM1 Kinase Inhibitor, Showed Durable Clinical Response and Sustained Hematological Improvement in Relapsed/Refractory Myelofibrosis Patients

Firas El Chaer, Lindsay A.M. Rein, Junichiro Yuda, Kazuya Shimoda, Akiyoshi Takami, Michiko Ichii, James McCloskey, Joseph M. Scandura, Alessandra Iurlo, Prithviraj Bose, Tamanna Haque, Alessandro Lucchesi, Shuichi Shirane, Giulia Benevolo, Idoroenyi Amanam, Jean-Jacques Kiladjian, Pankit Vachhani, Srinivas K Tantravahi, Yasushi Onishi, Ciro Rinaldi, Marcello Rotta, Nikki Granacher, Anand Ashwin Patel, Michael Loschi, Samah Alimam, Terrence Bradley, Stanley Cheung, Vincent Ribrag, Sujan Kabir, Karen Ansaldo, Masataka Seki, Vincent Loksa, Zhonggai Li, Jason M. Foulks, Jatin Shah, Raajit Rampal
Journal: Blood
Blood (2024) 144 (Supplement 1): 655.
https://doi.org/10.1182/blood-2024-200312
Published: 2024
Journal Articles

Hematologic Improvement Experienced By Pacritinib-Treated Patients with Myelofibrosis in Real-World Clinical Settings

Michael Marrone, Lisa Morere, Abiola Oladapo, Purvi Suthar, Teena Sura, Anupama Vasudevan, Michael Vredenburg, Jia Zeng, Raajit Rampal, John O. Mascarenhas
Journal: Blood
Blood (2024) 144 (Supplement 1): 3814.
https://doi.org/10.1182/blood-2024-210826
Published: 2024
Journal Articles

Updated Results from the Phase 3 Manifest-2 Study of Pelabresib in Combination with Ruxolitinib for Janus Kinase Inhibitor-Naïve Patients with Myelofibrosis

John O. Mascarenhas, Sebastian Grosicki, Dominik Chraniuk, Elisabetta Abruzzese, Prithviraj Bose, Aaron T. Gerds, Alessandro M. Vannucchi, Francesca Palandri, Sung-Eun Lee, Vikas Gupta, Alessandro Lucchesi, Stephen Oh, Andrew T. Kuykendall, Andrea Patriarca, Alberto Alvarez-Larran, Ruben Mesa, Jean-Jacques Kiladjian, Moshe Talpaz, Morgan Harris, Sarah-Katharina Kays, Qing Li, Barbara Brown, Anna-Maria Jegg, Claire Harrison, Raajit Rampal
Journal: Blood
Blood (2024) 144 (Supplement 1): 3178.
https://doi.org/10.1182/blood-2024-193193
Published: 2024
Journal Articles

Real-Word Effectiveness of Pacritinib in Patients with Myelofibrosis Who Have Thrombocytopenia and Anemia

Raajit Rampal, Michael Marrone, Lisa Morere, Abiola Oladapo, Purvi Suthar, Teena Sura, Anupama Vasudevan, Michael Vredenburg, Jia Zeng, John O. Mascarenhas
Journal: Blood
Blood (2024) 144 (Supplement 1): 6649.
https://doi.org/10.1182/blood-2024-210274
Published: 2024
Journal Articles

Trial in Progress: An Open-Label Clinical Trial of RVU120 As Monotherapy and in Combination with Ruxolitinib in Patients with Intermediate or High-Risk, Primary or Secondary Myelofibrosis (POTAMI-61)

Rostislav Kuklík, Adam Falkowski, Zachary Zaroogian, Milena Mazan, Agnieszka Szymula, Gary Wilkinson, Elżbieta Adamczyk, Jerzy Woźnicki, Marta Micek, Diego Coelho, Katarzyna Wiklik, Daniel Grzywczak, Hendrik Nogai, Tomasz Rzymski, Raajit Rampal
Journal: Blood
Blood (2024) 144 (Supplement 1): 6632.
https://doi.org/10.1182/blood-2024-204897
Published: 2024
Journal Articles

A Phase 1/2 Study of Nuvisertib (TP-3654), an Investigational Selective PIM1 Kinase Inhibitor, in Combination with JAK Inhibitors Ruxolitinib or Momelotinib in Patients with Myelofibrosis

John O. Mascarenhas, Raajit Rampal, Firas El Chaer, Vikas Gupta, Kazuya Shimoda, Jean-Jacques Kiladjian, Francesco Passamonti, Prithviraj Bose, Joseph M. Scandura, Ruben Mesa, Lindsay A.M. Rein, Junichiro Yuda, David M Ross, Timothy Devos, Moshe Talpaz, Ronald Hoffman, Sujan Kabir, Zhonggai Li, Jason M. Foulks, Karen Ansaldo, Masataka Seki, Vishnu Peddagali, Jatin Shah, Claire Harrison
Journal: Blood
Blood (2024) 144 (Supplement 1): 6629.
https://doi.org/10.1182/blood-2024-200268
Published: 2024
Journal Articles

Improvement in Serum Albumin As a Measure of Improved Metabolic Profile in Pacritinib-Treated Patients: A Retrospective Analysis of Patients Treated across Three Clinical Trials

Francesca Palandri, Marta Sobas, Claire Harrison, Raajit Rampal, Sarah Buckley, Purvi Suthar, Karisse Roman-Torres, John O. Mascarenhas
Journal: Blood
Blood (2024) 144 (Supplement 1): 3191.
https://doi.org/10.1182/blood-2024-192908
Published: 2024
Journal Articles

TP53 Alterations Confer Increased Risk of Leukemic Transformation and Worse Survival As Compared to High Molecular Risk Mutations in Patients with Myeloproliferative Neoplasms

Shivani Handa, Yosef Joseph Rene Amel Riazat-Kesh, Richard J Butterfield, Ganesh Sivakumar, Sangeetha Venugopal, Erin McGovern, Jonathan Feld, Douglas Tremblay, Sebastian Elghaity-Beckley, Marina Kremyanskaya, John O. Mascarenhas, Blake Langlais, Gina L. Mazza, Daniel I. Nathan, Joseph Tripodi, Vesna Najfeld, Amylou C Dueck, Raajit Rampal, Ronald Hoffman, Bridget Kelly Marcellino
Journal: Blood
Blood (2024) 144 (Supplement 1): 243.
https://doi.org/10.1182/blood-2024-206688
Published: 2024
Journal Articles

CD38 Overexpressed Monocytes Play a Critical Role in the Fibrogenesis in Myeloproliferative Neoplasms and Can be Used As a Therapeutic Target to Ameliorate Fibrosis

Yiru Yan, Jinqin Liu, Lin Yang, Gang Huang, Xiaofan Zhu, Raajit Rampal, Zhijian Xiao, Bing Li
Journal: Blood
Blood (2024) 144 (Supplement 1): 874.
https://doi.org/10.1182/blood-2024-202529
Published: 2024
Journal Articles

Phase I Study of Ruxolitinib in Combination with Abemaciclib for Patients with Primary or Post-Polycythemia Vera/Essential Thrombocythemia Myelofibrosis

Jan Philipp Bewersdorf, Andriy Derkach, Amer M. Zeidan, Eytan M. Stein, Michael J. Mauro, Nikolai A. Podoltsev, Raajit Rampal
Journal: Blood
Blood (2024) 144 (Supplement 1): 6659.
https://doi.org/10.1182/blood-2024-194918
Published: 2024
Journal Articles

Early Anemia Response in Patients with Myelofibrosis Treated with Pacritinib in Real-Word Clinical Settings

John O. Mascarenhas, Michael Marrone, Lisa Morere, Abiola Oladapo, Purvi Suthar, Teena Sura, Anupama Vasudevan, Michael Vredenburg, Jia Zeng, Raajit Rampal
Journal: Blood
Blood (2024) 144 (Supplement 1): 6650.
https://doi.org/10.1182/blood-2024-210598
Published: 2024
Journal Articles

POIESIS: A Randomized, Double-Blind, Placebo-Controlled, Multicenter, Global Phase 3 Study of Navtemadlin As Add-on to Ruxolitinib in JAK Inhibitor-Naïve Patients with Myelofibrosis Who Have a Suboptimal Response to Ruxolitinib

Pankit Vachhani, Raajit Rampal, Terrence Bradley, Claire Harrison, Tania Jain, Andrew T. Kuykendall, Francesca Palandri, John O. Mascarenhas, Haifa Kathrin Al-Ali, Francesco Passamonti, Anna Nekhymchuk, Hilarie Foss, Wayne Rothbaum, Srdan Verstovsek, Florian Heidel
Journal: Blood
Blood (2024) 144 (Supplement 1): 1808.2.
https://doi.org/10.1182/blood-2024-200966
Published: 2024
Journal Articles

A Multicenter, Open-Label, Phase 1 Clinical Trial of AJ1-11095 Administered As Oral Monotherapy in Patients with Primary Myelofibrosis (PMF), Post-Polycythemia Vera Myelofibrosis (PPV-MF), or Post-Essential Thrombocythemia Myelofibrosis (PET-MF) Who Have Been Failed By a Type I JAK2 Inhibitor (JAK2i)

John O. Mascarenhas, Uma Borate, Prithviraj Bose, John C. Byrd, Jacqueline S. Garcia, Michael R. Grunwald, Gabriela S. Hobbs, Ronald Hoffman, Andrew T. Kuykendall, Ruben A. Mesa, Stephen Oh, Raajit Rampal, Abdulraheem Yacoub, David P. Steensma
Journal: Blood
Blood (2024) 144 (Supplement 1): 3147.1.
https://doi.org/10.1182/blood-2024-193905
Published: 2024
Journal Articles

A Phase 1 Study of Avapritinib in Combination with Decitabine in Patients with Systemic Mastocytosis with an Associated Hematologic Neoplasm

Andrew T. Kuykendall, Somedeb Ball, Jason Gotlib, Cecilia Y. Arana Yi, Tsewang Tashi, Raajit Rampal, Daniel J DeAngelo, Virginia O. Volpe, Kristen M. Pettit, Gerard Hoehn, Sasa Dimitrijevic, Rami S. Komrokji, Eric Padron
Journal: Blood
Blood (2024) 144 (Supplement 1): 4569.2.
https://doi.org/10.1182/blood-2024-211148
Published: 2024
Journal Articles

Outcomes of Patients with IDH1/2 Mutated Accelerated/Blast-Phase Myeloproliferative Neoplasms in the Era of IDH Inhibitors

Leah A Goldberg, James J. Yoon, Hannah Johnston, Marta Beata Davidson, Alexa Siddon, Rory M. Shallis, Evan C. Chen, Madelyn Burkart, Timothy S. Oh, Sunil G. Iyer, Ellen Madarang, Chandrasekar Muthiah, Joshua Kassner, Raajit Rampal, Guru Subramanian Guru Murthy, Terrence Bradley, Yasmin Abaza, Jacqueline S. Garcia, Vikas Gupta, Kristen M. Pettit, Olatoyosi Odenike, John F. Cursio, Anand Ashwin Patel
Journal: Blood
Blood (2024) 144 (Supplement 1): 1787.
https://doi.org/10.1182/blood-2024-197898
Published: 2024
Journal Articles

Cytokine Modulation Correlates Strongly with Symptom Improvement in Patients with Myelofibrosis Treated with Nuvisertib (TP-3654), an Investigational Selective PIM1 Kinase Inhibitor

Lindsay A.M. Rein, Firas El Chaer, Junichiro Yuda, Kazuya Shimoda, Raajit Rampal, Joseph M. Scandura, Akiyoshi Takami, James McCloskey, Michiko Ichii, Shuichi Shirane, Alessandra Iurlo, Prithviraj Bose, Alessandro Lucchesi, Giulia Benevolo, Idoroenyi Amanam, Pankit Vachhani, Srinivas K Tantravahi, Marcello Rotta, Yasushi Onishi, Jean-Jacques Kiladjian, Ciro Rinaldi, Nikki Granacher, Terrence Bradley, Anand Ashwin Patel, Michael Loschi, Samah Alimam, Stanley Cheung, Vincent Ribrag, Sujan Kabir, Masataka Seki, Karen Ansaldo, Guia Guffanti, Jinny Lee, Steven L. Warner, Jason M. Foulks, Ruben Mesa
Journal: Blood
Blood (2024) 144 (Supplement 1): 3179.
https://doi.org/10.1182/blood-2024-200999
Published: 2024
Journal Articles

HMGA1 Chromatin Regulators Disrupt 3D Genome Architecture and Chromatin Looping to Repress MHC II Genes and Drive Immune Evasion during MPN Progression

Linda Resar, Joseph Kim, Audrey-Ann Supreme, Hyunsung Woo, Bailey West, Mariah C. Antopia, Zanshe Thompson, Karen Reddy, Jung-Hyun Kim, Leslie Cope, Raajit Rampal, Richard Koche, Alison R. Moliterno, Jerry L. Spivak
Journal: Blood
Blood (2024) 144 (Supplement 1): 756.
https://doi.org/10.1182/blood-2024-211336
Published: 2024