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Florian Heidel
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Journal Articles

Time of CAR-T Failure Is a Strong Predictor of Outcome for Bispecific Antibody Therapy in Relapsed/Refractory Large B-Cell Lymphoma

Evgenii Shumilov, Rebecca Wurm-Kuczera, Vladan Vucinic, Maximilian Seib, Udo Holtick, Paolo Mazzeo, Julia Katharina Scholz, Hristo Boyadzhiev, Thomas Melchardt, Alexander Hölscher, Christian R Schultze-Florey, Giuliano Filippini Velazquez, Anna Ossami Saidy, Vadim Lesan, Ulf Schnetzke, Andrea Kerkhoff, Ulrike Bacher, Susanne Ghandili, Enver Aydilek, Niklas Gebauer, Thomas Weber, Gerald Wulf, Bertram Glass, Lorenz Thurner, Florian Heidel, Christoph Schmid, Andreas Viardot, Mathias Hänel, Sascha Dietrich, Thomas Pabst, Francis A. Ayuk, Bastian von Tresckow, Björn Chapuy, Christiane Pott, Fabian Mueller, Georg Lenz
Journal: Blood
Blood (2024) 144 (Supplement 1): 114.
https://doi.org/10.1182/blood-2024-198883
Published: 2024
Journal Articles

Revised ELN Criteria in Polycythemia Vera Identify an Increased Risk Phenotype for Thrombotic Events Beyond Conventional Risk Stratification. a Multicenter Cooperative Study

Francesca Palandri, Elena Maria Elli, Giulia Benevolo, Alessandra Dedola, Roberto Latagliata, Erika Morsia, Mario Tiribelli, Francesco Cavazzini, Alessia Tieghi, Mirko Farina, Alessandra D'Addio, Elisabetta Abruzzese, Fabrizio Cavalca, Rikard Mullai, Antonio Cuneo, Bruno Martino, Florian Heidel, Elena Rossi, Massimo Breccia, Valerio De Stefano, Filippo Branzanti
Journal: Blood
Blood (2024) 144 (Supplement 1): 242.
https://doi.org/10.1182/blood-2024-200528
Published: 2024
Journal Articles

Cytopenias and Failure to Use Innovative Therapy Are Main Drivers of Worse Outcome after Discontinuation of Ruxolitinib in Myelofibrosis

Francesca Palandri, Massimo Breccia, Erika Morsia, Giulia Benevolo, Mario Tiribelli, Eloise Beggiato, Mirko Farina, Bruno Martino, Giovanni Caocci, Novella Pugliese, Alessia Tieghi, Monica Crugnola, Gianni Binotto, Francesco Cavazzini, Elisabetta Abruzzese, Alessandro Isidori, Alessandra Dedola, Emilia Scalzulli, Alessia Moioli, Veronica Guglielmana, Santino Caserta, Andrea Duminuco, Roberto Massimo Lemoli, Daniela Cilloni, Monica Bocchia, Fabrizio Pane, Florian Heidel, Elena Maria Elli, Massimiliano Bonifacio, Giuseppe Alberto Palumbo, Filippo Branzanti
Journal: Blood
Blood (2024) 144 (Supplement 1): 6664.
https://doi.org/10.1182/blood-2024-199961
Published: 2024
Journal Articles

POIESIS: A Randomized, Double-Blind, Placebo-Controlled, Multicenter, Global Phase 3 Study of Navtemadlin As Add-on to Ruxolitinib in JAK Inhibitor-Naïve Patients with Myelofibrosis Who Have a Suboptimal Response to Ruxolitinib

Pankit Vachhani, Raajit Rampal, Terrence Bradley, Claire Harrison, Tania Jain, Andrew T. Kuykendall, Francesca Palandri, John O. Mascarenhas, Haifa Kathrin Al-Ali, Francesco Passamonti, Anna Nekhymchuk, Hilarie Foss, Wayne Rothbaum, Srdan Verstovsek, Florian Heidel
Journal: Blood
Blood (2024) 144 (Supplement 1): 1808.2.
https://doi.org/10.1182/blood-2024-200966
Published: 2024
Journal Articles

The Prognostic Impact of Myelodysplasia-Related Gene Mutations in Acute Myeloid Leukemia with FLT3 -ITD Mutations

Rabea Mecklenbrauck, Angela Villaverde Ramiro, Eric Sträng, Razif Gabdoulline, Javier Martínez Elicegui, Marta Sobas, Lisa Pleyer, Maria Teresa Voso, Axel Benner, Alberto Hernández Sánchez, Jesse M. Tettero, Laura Tur, Klaus H Metzeler, Guadalupe Onate, Soren Lehmann, Brian J P Huntly, Ian Thomas, Felicitas R Thol, Florian Heidel, Peter J. M. Valk, Konstanze Döhner, Torsten Haferlach, Ken I Mills, Hartmut Döhner, Gastone Castellani, Gert Ossenkoppele, Jesus Maria Hernandez Rivas, Lars Bullinger, Michael Heuser
Journal: Blood
Blood (2024) 144 (Supplement 1): 844.
https://doi.org/10.1182/blood-2024-202362
Published: 2024
Journal Articles

ROP-ET: A Prospective Phase III Trial Investigating the Efficacy and Safety of Ropeginterferon Alfa-2b in Essential Thrombocythemia Patients with Limited Treatment Options

Jean-Jacques Kiladjian, Francisca Ferrer Marin, Haifa Kathrin Al-Ali, Alberto Alvarez-Larran, Eloise Beggiato, Maria Bieniaszewska, Massimo Breccia, Veronika Buxhofer-Ausch, Olga Cerna, Ana Manuela Crisan, Catalin Danaila, Valerio De Stefano, Konstanze Döhner, Victoria Empson, Joanna Gora Tybor, Martin Griesshammer, Sebastian Grosicki, Paola Guglielmelli, Valentín García Gutiérrez, Sr., Florian Heidel, Arpad Illes, Chloe James, Steffen Koschmieder, Krauth Maria-Theresa, Kurt Krejcy, Mihaela Cornelia Lazaroiu, Jiri Mayer, Zsolt Nagy, Francesca Palandri, Vasiliki Pappa, Andreas Reiter, Tomasz Sacha, Stefanie Schlager, Stefan Ulrich Schmidt, Evangelos Terpos, Ciprian Tomuleasa, Jose Miguel Torregrosa Diaz, Martin Unger, Albert Woelfler, Blanca Xicoy, Christoph Klade
Journal: Blood
Blood (2024) 144 (Supplement 1): 6635.
https://doi.org/10.1182/blood-2024-199028
Published: 2024
Journal Articles

Idecabtagene Vicleucel (ide-cel) Shows Similar Efficacy and Toxicity in Patients with Multiple Myeloma Aged 70 and Older Compared to Younger Patients: A Multicenter Cohort Study

Philipp Berning, Markus Maulhardt, Hristo Boyadzhiev, Anca Maria Albici, Snjezana Janjetovic, Anna Ossami Saidy, Christian R Schultze-Florey, Simon Call, Natalie Schub, Annamaria Brioli, Michael Daskalakis, Juliane Knust, Justin Hasenkamp, Matthias Stelljes, Cyrus Khandanpour, Ulrike Bacher, Christine Hanoun, Florian Heidel, Hans Christian Reinhardt, Georg Lenz, Gerald Wulf, Friedrich Stölzel, Bastian von Tresckow, Thomas Pabst, Evgenii Shumilov
Journal: Blood
Blood (2024) 144 (Supplement 1): 3383.
https://doi.org/10.1182/blood-2024-198763
Published: 2024
Journal Articles

Characterization of TREM-1 Signaling in Human Neutrophils By Kinome Array and RNA-Seq

Frederic Ries, Matthias Klein, Nora Sophia Lindhauer, Sophie Többen, Florian Heidel, Markus P. Radsak
Journal: Blood
Blood (2023) 142 (Supplement 1): 3913.
https://doi.org/10.1182/blood-2023-178717
Published: 2023
Journal Articles

Firstline Treatment with Ruxolitinib Versus Best Available Therapy in Patients with Polycythemia Vera: Pre-Specified Interim Analysis of the Randomized Phase 2b Ruxobeat Clinical Trial of the German Study Group for Myeloproliferative Neoplasms (GSG-MPN)

Steffen Koschmieder, Susanne Isfort, Lino L. Teichmann, Philippe Schafhausen, Florian Heidel, Andreas Hochhaus, Martin Griesshammer, Katja Sockel, Philipp Jost, Denise Wolleschak, Konstanze Döhner, Joachim R. Goethert, Markus P. Radsak, Marinela Augustin, Heiko Becker, Aristoteles Giagounidis, Markus Schaich, Martine Klausmann, Nikolas Von Bubnoff, Frank Stegelmann, Maike Kortmann, Julia Frank, Martin Hellmich, Tim H. Brümmendorf
Journal: Blood
Blood (2023) 142 (Supplement 1): 619.
https://doi.org/10.1182/blood-2023-173225
Published: 2023
Journal Articles

Neutrophil Functionalities in Patients with Paroxysmal Nocturnal Haemoglobinuria Are Not Affected By Complement C5- Inhibition

Nora Sophia Lindhauer, Cornelia Sabine Schmidt, Frederic Ries, Eva-Marie Fehr, Markus P. Radsak, Florian Heidel
Journal: Blood
Blood (2023) 142 (Supplement 1): 5646.
https://doi.org/10.1182/blood-2023-187076
Published: 2023
Journal Articles

Impact of Ruxolitinib-Response Feature on Outcome in Myelofibrosis: A Multicentre Study on 356 Patients

Giulia Benevolo, MD, Giuseppe A Palumbo, MD, Massimiliano Bonifacio, MD, Mario Tiribelli, MD, Maura Nicolosi, MD, Andrea Evangelista, Bruno Martino, Elisabetta Abruzzese, MD, Mariella D'adda, Nicola Polverelli, MD, Micaela Bergamaschi, MD, Alessandra Tieghi, MD, Francesco Cavazzini, MD, Adalberto Ibatici, MD, Monica Crugnola, MD, Costanza Bosi, MD, Roberto Latagliata, Lucia Catani, MD, Franco Aversa, MD, Francesco Di Raimondo, MD, Umberto Vitolo, MD, Roberto Massimo Lemoli, MD, Renato Fanin, MD, Francesco Merli, Antonio Cuneo, MD, Michele Cavo, MD, Massimo Breccia, MD PhD, Nicola Vianelli, MD, Florian Heidel, MD, Francesca Palandri, PhD MD
Journal: Blood
Blood (2017) 130 (Supplement 1): 1639.
https://doi.org/10.1182/blood.V130.Suppl_1.1639.1639
Published: 2017
Journal Articles

The JAK2 Kinase Inhibitor LS104 Induces Growth-Arrest and Apoptosis in JAK2V617F Positive Cells.

Daniel B. Lipka, MD, Linda S. Hoffmann, MSc, Florian Heidel, MD, Boyka Markova, PhD, Stefan Kasper, MD, Frank Breitenbuecher, PhD, Thomas Kindler, MD, Ross Levine, MD, Joseph Elliot, PhD, Christoph Huber, MD, Thomas Fischer, MD
Journal: Blood
Blood (2007) 110 (11): 3544.
https://doi.org/10.1182/blood.V110.11.3544.3544
Published: 2007
Journal Articles

A neoepitope generated by an FLT3 internal tandem duplication ( FLT3-ITD ) is recognized by leukemia-reactive autologous CD8 + T cells

Brief Report
Claudine Graf, Florian Heidel, Stefan Tenzer, Markus P. Radsak, Fian K. Solem, Cedrik M. Britten, Christoph Huber, Thomas Fischer, Thomas Wölfel
Journal: Blood
Blood (2006) 109 (7): 2985–2988.
https://doi.org/10.1182/blood-2006-07-032839
Published: 2006
Includes: Supplemental data
Journal Articles

Bis(1 H -indol-2yl)methanones Are Effective Inhibitors of Mutated FLT3 Tyrosine Kinase, Overcome Resistance to PKC412A In Vitro and Show Synergy with Chemotherapy.

Florian Heidel, Fian K. Mirea, Frank Breitenbucher, Stefan Dove, Christoph Huber, Frank D. Bohmer, Thomas Fischer
Journal: Blood
Blood (2006) 108 (11): 1369.
https://doi.org/10.1182/blood.V108.11.1369.1369
Published: 2006
Journal Articles

Clinical resistance to the kinase inhibitor PKC412 in acute myeloid leukemia by mutation of Asn-676 in the FLT3 tyrosine kinase domain

Clinical Trials & Observations
Florian Heidel, Fian K. Solem, Frank Breitenbuecher, Daniel B. Lipka, Stefan Kasper, M. H. Thiede, Christian Brandts, Hubert Serve, Johannes Roesel, Francis Giles, Eric Feldman, Gerhard Ehninger, Gary J. Schiller, Stephen Nimer, Richard M. Stone, Yanfeng Wang, Thomas Kindler, Pamela S. Cohen, Christoph Huber, Thomas Fischer
Journal: Blood
Blood (2006) 107 (1): 293–300.
https://doi.org/10.1182/blood-2005-06-2469
Published: 2006
Journal Articles

LS104, a Novel Kinase Inhibitor, Induces Apoptosis, Synergizes with Cytostatic Drugs and Is Targeting the Receptor Tyrosine Kinase FLT3.

Stefan Kasper, Thomas Kindler, MD, Florian Heidel, MD, Frank Breitenbuecher, PhD, Yvette Hoehn, MD, Daniel Lipka, Helmut Thomas, PhD, Christoph Huber, MD, Thomas Fischer, MD
Journal: Blood
Blood (2005) 106 (11): 3362.
https://doi.org/10.1182/blood.V106.11.3362.3362
Published: 2005